{"id":"https://openalex.org/W2043764313","doi":"https://doi.org/10.1165/ajrcmb.16.4.9115759","title":"A Novel Role for Murine IL-4 In Vivo: Induction of MUC5AC Gene Expression and Mucin Hypersecretion","display_name":"A Novel Role for Murine IL-4 In Vivo: Induction of MUC5AC Gene Expression and Mucin Hypersecretion","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2043764313","doi":"https://doi.org/10.1165/ajrcmb.16.4.9115759","mag":"2043764313","pmid":"https://pubmed.ncbi.nlm.nih.gov/9115759"},"language":"en","primary_location":{"id":"doi:10.1165/ajrcmb.16.4.9115759","doi":"https://doi.org/10.1165/ajrcmb.16.4.9115759","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb.16.4.9115759","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075644285","display_name":"Ulla-Angela Temann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U A Temann","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA","institution_ids":["https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048071496","display_name":"B Prasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Prasad","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA","institution_ids":["https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066048441","display_name":"Marianne Gallup","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M W Gallup","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA","institution_ids":["https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113732625","display_name":"Carol B. Basbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Basbaum","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA","institution_ids":["https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074446717","display_name":"Samuel B. Ho","orcid":"https://orcid.org/0000-0001-6730-6512","observed_orcids":["https://orcid.org/0000-0001-6730-6512"]},"institutions":[{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S B Ho","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA","institution_ids":["https://openalex.org/I4210086971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064443404","display_name":"Richard Anthony Flavell","orcid":"https://orcid.org/0000-0003-4461-0778","observed_orcids":["https://orcid.org/0000-0003-4461-0778"]},"institutions":[{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R A Flavell","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA","institution_ids":["https://openalex.org/I4210086971"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111735671","display_name":"John A. Rankin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Rankin","raw_affiliation_strings":["Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care Medicine, West Haven VAMC, Connecticut 06516, USA","institution_ids":["https://openalex.org/I4210086971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210086971"],"apc_list":null,"apc_paid":null,"fwci":10.7028,"has_fulltext":false,"cited_by_count":262,"citation_normalized_percentile":{"value":0.98748458,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"4","first_page":"471","last_page":"478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/muc5ac","display_name":"MUC5AC","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mucin-gene-expression","display_name":"mucin gene expression","score":0.8050000071525574},{"id":"https://openalex.org/keywords/mucus-hypersecretion","display_name":"mucus hypersecretion","score":0.9610000252723694},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8769999742507935},{"id":"https://openalex.org/keywords/club-cells","display_name":"Clara cells","score":0.7649999856948853},{"id":"https://openalex.org/keywords/airway-mucus-plugging","display_name":"airway mucus plugging","score":0.6600000262260437},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.47099998593330383},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.8611294031143188},{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.8355607390403748},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5798540115356445},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5711596012115479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5586495995521545},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.556648850440979},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44838380813598633},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4310896694660187},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2684594392776489},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0998346209526062},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000423","descriptor_name":"Alcian Blue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000423","descriptor_name":"Alcian Blue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000423","descriptor_name":"Alcian Blue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010503","descriptor_name":"Periodic Acid-Schiff Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010503","descriptor_name":"Periodic Acid-Schiff Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010503","descriptor_name":"Periodic Acid-Schiff Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1165/ajrcmb.16.4.9115759","doi":"https://doi.org/10.1165/ajrcmb.16.4.9115759","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb.16.4.9115759","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:9115759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9115759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1934136719","display_name":"SMOKE INDUCED MUCIN TRANSCRIPTION AND MITOGENESIS","funder_award_id":"2r01hl043762-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2692838629","display_name":null,"funder_award_id":"HL 24136","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4300507803","display_name":"Evolving Microenvironments in Airway Inflammation","funder_award_id":"P01HL024136","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G906426337","display_name":null,"funder_award_id":"HL43762","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W108101182","https://openalex.org/W1492833857","https://openalex.org/W1524914308","https://openalex.org/W1546171722","https://openalex.org/W1763742850","https://openalex.org/W1826845578","https://openalex.org/W1942668068","https://openalex.org/W1974419017","https://openalex.org/W1976165020","https://openalex.org/W1980479493","https://openalex.org/W1981309200","https://openalex.org/W1982035022","https://openalex.org/W1991017533","https://openalex.org/W2004482750","https://openalex.org/W2013891650","https://openalex.org/W2020977425","https://openalex.org/W2028395097","https://openalex.org/W2045015941","https://openalex.org/W2045310165","https://openalex.org/W2048510114","https://openalex.org/W2052172628","https://openalex.org/W2064864590","https://openalex.org/W2072815966","https://openalex.org/W2078772336","https://openalex.org/W2088293221","https://openalex.org/W2092957238","https://openalex.org/W2104112797","https://openalex.org/W2109068081","https://openalex.org/W2118122421","https://openalex.org/W2120012263","https://openalex.org/W2120184224","https://openalex.org/W2128635872","https://openalex.org/W2134828784","https://openalex.org/W2140612321","https://openalex.org/W2142800802","https://openalex.org/W2410028122"],"related_works":["https://openalex.org/W1914691072","https://openalex.org/W2051939473","https://openalex.org/W2046545314","https://openalex.org/W4211140651","https://openalex.org/W2152696500","https://openalex.org/W2430545656","https://openalex.org/W1974477809","https://openalex.org/W2889319600","https://openalex.org/W2999769701","https://openalex.org/W111579719"],"abstract_inverted_index":{"Mucus":[0],"hypersecretion":[1],"and":[2,13,53,99,174,218],"plugging":[3],"of":[4,27,46,58,82,87,123,136,146,193,211,222,234,247,250],"lower":[5],"respiratory":[6],"tract":[7],"airways":[8,71],"contributes":[9],"to":[10,42,79,162,169,187],"the":[11,38,44,80,129,144,147,191,197,209,220,225,232,248,253],"morbidity":[12],"mortality":[14],"associated":[15],"with":[16,240],"asthma.":[17,28],"Interleukin":[18],"(IL)-4":[19],"plays":[20],"a":[21,167,244],"putative":[22],"role":[23],"in":[24,77,119,128,157,172,179,208,214,237],"some":[25,238],"forms":[26],"Thus,":[29,190],"transgenic":[30,131,159],"mice":[31,63,125,160,185],"that":[32,65,143,231],"overexpress":[33],"murine":[34],"IL-4":[35,47,62,130,158,183,194,251],"selectively":[36],"within":[37,196,252],"lung":[39,59,140,198],"were":[40,72,105,126],"used":[41],"study":[43],"effect":[45],"on":[48],"mucus":[49,83,200,212,223,235],"glycoprotein":[50,201,213],"gene":[51,153,205],"expression":[52,145],"mucin":[54,152],"release.":[55],"Histologic":[56],"examination":[57],"sections":[60],"from":[61,69,139,182],"revealed":[64,142],"nonciliated":[66,120,215],"epithelial":[67,216],"cells":[68,89,104,122],"conducting":[70],"hypertrophic,":[73],"due":[74],"at":[75],"least":[76],"part":[78],"accumulation":[81,210],"glycoprotein.":[84],"The":[85],"cytoplasm":[86],"these":[88],"stained":[90],"positively":[91],"for":[92],"glycoproteins":[93],"using":[94],"mucicarmine,":[95],"alcian":[96],"blue":[97],"(AB),":[98],"periodic":[100],"acid-Schiff":[101],"(PAS).":[102],"Ciliated":[103],"also":[106],"enlarged":[107],"but":[108,149],"did":[109],"not":[110,150],"show":[111],"any":[112],"mucin-specific":[113],"staining.":[114],"Inclusion":[115],"granules":[116],"typically":[117],"found":[118,178],"(Clara)":[121],"control":[124],"absent":[127],"mice.":[132],"Northern":[133],"blot":[134],"analysis":[135],"total":[137],"RNA":[138],"tissue":[141],"MUC5AC,":[148],"MUC2,":[151],"was":[154,177],"distinctly":[155],"upgraded":[156],"compared":[161,186],"transgene-negative":[163,188],"controls.":[164,189],"In":[165],"addition,":[166],"5-":[168],"10-fold":[170],"increase":[171],"AB-":[173],"PAS-positive":[175],"material":[176],"lavage":[180],"fluid":[181],"overexpressing":[184],"overexpression":[192],"locally":[195],"enhances":[199],"synthesis":[202],"by":[203],"altering":[204],"expression,":[206],"results":[207],"cells,":[217],"induces":[219],"release":[221],"into":[224],"airway":[226],"lumen.":[227],"We":[228],"therefore":[229],"hypothesize":[230],"overproduction":[233],"seen":[236],"patients":[239],"asthma":[241],"may":[242],"be":[243],"direct":[245],"result":[246],"action":[249],"inflamed":[254],"lung.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}