{"id":"https://openalex.org/W2043744136","doi":"https://doi.org/10.1210/en.135.3.1256","title":"Progesterone regulation of heparin-binding epidermal growth factor-like growth factor gene expression during sensitization and decidualization in the rat uterus: effects of the antiprogestin, ZK 98.299","display_name":"Progesterone regulation of heparin-binding epidermal growth factor-like growth factor gene expression during sensitization and decidualization in the rat uterus: effects of the antiprogestin, ZK 98.299","publication_year":1994,"publication_date":"1994-09-01","ids":{"openalex":"https://openalex.org/W2043744136","doi":"https://doi.org/10.1210/en.135.3.1256","mag":"2043744136","pmid":"https://pubmed.ncbi.nlm.nih.gov/8070371"},"language":"en","primary_location":{"id":"doi:10.1210/en.135.3.1256","doi":"https://doi.org/10.1210/en.135.3.1256","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.135.3.1256","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082497934","display_name":"Z Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z Zhang","raw_affiliation_strings":["Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017868584","display_name":"Cindee R. Funk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Funk","raw_affiliation_strings":["Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110116185","display_name":"S.R. Glasser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S R Glasser","raw_affiliation_strings":["Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070917623","display_name":"Joy Mulholland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Mulholland","raw_affiliation_strings":["Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.112,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.78722832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"135","issue":"3","first_page":"1256","last_page":"1263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hb-egf","display_name":"HB-EGF","score":0.9660000205039978},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6140000224113464},{"id":"https://openalex.org/keywords/decidualization","display_name":"decidualization","score":0.828000009059906},{"id":"https://openalex.org/keywords/uterine-stromal-cells","display_name":"uterine stromal cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/onapristone","display_name":"onapristone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antiprogestins","display_name":"antiprogestins","score":0.8920000195503235},{"id":"https://openalex.org/keywords/sensitization","display_name":"sensitization","score":0.550000011920929},{"id":"https://openalex.org/keywords/autocrine-paracrine-signaling","display_name":"autocrine and paracrine signaling","score":0.8220000267028809},{"id":"https://openalex.org/keywords/stromal-proliferation","display_name":"stromal cell proliferation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/embryo-attachment","display_name":"embryo attachment","score":0.6110000014305115},{"id":"https://openalex.org/keywords/rat-uterus","display_name":"rat uterus","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2778316770","wikidata":"https://www.wikidata.org/wiki/Q1207365","display_name":"Decidualization","level":3,"score":0.950838565826416},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.8562901616096497},{"id":"https://openalex.org/C2781107390","wikidata":"https://www.wikidata.org/wiki/Q5249153","display_name":"Decidual cells","level":5,"score":0.7609049081802368},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.7158028483390808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6945009827613831},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6899340748786926},{"id":"https://openalex.org/C159048773","wikidata":"https://www.wikidata.org/wiki/Q14914537","display_name":"Heparin-binding EGF-like growth factor","level":4,"score":0.6819503903388977},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.6435984373092651},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.609054446220398},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5901498794555664},{"id":"https://openalex.org/C2780197806","wikidata":"https://www.wikidata.org/wiki/Q2531387","display_name":"Decidua","level":5,"score":0.573354184627533},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4527187943458557},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3991788327693939},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3546565771102905},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.1087837815284729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09744268655776978},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.06470727920532227},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.04886984825134277},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003656","descriptor_name":"Decidua","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006067","descriptor_name":"Gonanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.135.3.1256","doi":"https://doi.org/10.1210/en.135.3.1256","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.135.3.1256","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/endo.135.3.8070371","doi":"https://doi.org/10.1210/endo.135.3.8070371","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.135.3.8070371","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:8070371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8070371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1896133581","display_name":"REGULATION OF UTERINE STROMAL CELL SENSITIZATION","funder_award_id":"R01HD022785","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2105260081"],"related_works":["https://openalex.org/W1992181632","https://openalex.org/W7098383495","https://openalex.org/W2115913720","https://openalex.org/W2022260285","https://openalex.org/W2009855861","https://openalex.org/W2040362497","https://openalex.org/W2013642882","https://openalex.org/W2804327315","https://openalex.org/W2020802351","https://openalex.org/W2014528646"],"abstract_inverted_index":{"The":[0],"ability":[1],"of":[2,21,45,68,123,131,179,203],"uterine":[3,58],"stromal":[4,59,105,124,139,160,171,197],"cells":[5,23,140,161,174],"to":[6,8,97,99,127],"respond":[7,98],"embryo":[9],"attachment":[10],"or":[11,92],"an":[12,142,192],"artificial":[13,143],"decidual":[14,22,101,128,144,173],"stimulus":[15],"and":[16,19,172],"the":[17,43,66,121,155,176,201],"development":[18,122],"maintenance":[20],"are":[24,73,83],"primarily":[25],"regulated":[26],"by":[27,75],"progesterone":[28],"(P),":[29],"yet":[30],"few":[31],"P-induced":[32],"genes":[33],"have":[34],"been":[35],"described.":[36],"Previously,":[37],"we":[38],"reported":[39],"that":[40,65,81,104,115,170,188],"P":[41,69,95],"stimulated":[42],"expression":[44,72],"heparin-binding":[46],"epidermal":[47],"growth":[48,50],"factor-like":[49],"factor":[51,194],"(HB-EGF)":[52],"messenger":[53],"RNA":[54],"(mRNA)":[55],"in":[56,120,137,158,195],"rat":[57],"cells.":[60],"We":[61],"now":[62],"present":[63],"evidence":[64,114],"effects":[67],"on":[70],"HB-EGF":[71,116,132,146,180,189],"blocked":[74],"treatment":[76],"with":[77,89,94],"ZK98299":[78,90],"(onapristone),":[79],"indicating":[80],"they":[82],"receptor":[84],"mediated.":[85],"Additionally,":[86],"animals":[87],"treated":[88],"alone":[91],"together":[93],"failed":[96],"a":[100,118],"stimulus,":[102],"suggesting":[103],"cell":[106,125,198],"sensitivity":[107,126],"was":[108,134],"inhibited.":[109],"These":[110,185],"results":[111,186],"provide":[112],"further":[113],"plays":[117],"role":[119],"stimuli.":[129],"Expression":[130],"mRNA":[133,147,181],"also":[135],"investigated":[136],"differentiating":[138],"after":[141,153,200],"stimulus.":[145],"levels":[148],"increased":[149],"from":[150],"8-48":[151],"h":[152],"stimulation,":[154],"same":[156],"interval":[157],"which":[159],"exhibit":[162],"maximal":[163],"mitotic":[164],"activity.":[165],"In":[166],"situ":[167],"hybridization":[168],"revealed":[169],"were":[175],"major":[177],"sources":[178],"during":[182],"this":[183],"period.":[184],"suggest":[187],"acts":[190],"as":[191],"autocrine/paracrine":[193],"stimulating":[196],"proliferation":[199],"induction":[202],"decidualization.":[204]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}