{"id":"https://openalex.org/W2043730018","doi":"https://doi.org/10.1073/pnas.0705069104","title":"Quaternary structures of tumor suppressor p53 and a specific p53\u2013DNA complex","display_name":"Quaternary structures of tumor suppressor p53 and a specific p53\u2013DNA complex","publication_year":2007,"publication_date":"2007-07-09","ids":{"openalex":"https://openalex.org/W2043730018","doi":"https://doi.org/10.1073/pnas.0705069104","mag":"2043730018","pmid":"https://pubmed.ncbi.nlm.nih.gov/17620598","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1941468"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0705069104","doi":"https://doi.org/10.1073/pnas.0705069104","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0705069104","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1941468","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044919510","display_name":"Henning Tidow","orcid":"https://orcid.org/0000-0002-4702-9332","observed_orcids":["https://orcid.org/0000-0002-4702-9332","https://orcid.org/0000-0002-7618-3291"]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Henning Tidow","raw_affiliation_strings":["*Medical Research Council Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Medical Research Council Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, United Kingdom;","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046531994","display_name":"Roberto Melero","orcid":"https://orcid.org/0000-0001-9467-9381","observed_orcids":["https://orcid.org/0000-0001-9467-9381"]},"institutions":[{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Roberto Melero","raw_affiliation_strings":["Centro Nacional de Biotecnolog\u00eda, Darwin 3, Cantoblanco 28049 Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Biotecnolog\u00eda, Darwin 3, Cantoblanco 28049 Madrid, Spain;","institution_ids":["https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010826630","display_name":"Efstratios Mylonas","orcid":"https://orcid.org/0000-0003-4476-3010","observed_orcids":["https://orcid.org/0000-0003-4476-3010"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Efstratios Mylonas","raw_affiliation_strings":["European Molecular Biology Laboratory, Hamburg Outstation, Notkestrasse 85, 22603 Hamburg, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, Hamburg Outstation, Notkestrasse 85, 22603 Hamburg, Germany;","institution_ids":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018808014","display_name":"Stefan M.V. Freund","orcid":"https://orcid.org/0000-0002-7031-9872","observed_orcids":["https://orcid.org/0000-0002-7031-9872"]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stefan M. V. Freund","raw_affiliation_strings":["*Medical Research Council Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Medical Research Council Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, United Kingdom;","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111662087","display_name":"Joachim Gro\u00dfmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802015276","display_name":"Daresbury Laboratory","ror":"https://ror.org/0089bg420","country_code":"GB","type":"facility","lineage":["https://openalex.org/I162524378","https://openalex.org/I2802015276","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Guenter Grossmann","raw_affiliation_strings":["Molecular Biophysics Group, Council for the Central Laboratory of the Research Councils (CCLRC) Daresbury Laboratory, Warrington, Cheshire WA4 4AD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biophysics Group, Council for the Central Laboratory of the Research Councils (CCLRC) Daresbury Laboratory, Warrington, Cheshire WA4 4AD, United Kingdom","institution_ids":["https://openalex.org/I2802015276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046960969","display_name":"J.M. Carazo","orcid":"https://orcid.org/0000-0003-0788-8447","observed_orcids":["https://orcid.org/0000-0003-0788-8447"]},"institutions":[{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Mar\u00eda Carazo","raw_affiliation_strings":["Centro Nacional de Biotecnolog\u00eda, Darwin 3, Cantoblanco 28049 Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Biotecnolog\u00eda, Darwin 3, Cantoblanco 28049 Madrid, Spain;","institution_ids":["https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081712139","display_name":"Dmitri I. Svergun","orcid":"https://orcid.org/0000-0003-0830-5696","observed_orcids":["https://orcid.org/0000-0003-0830-5696"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210132917","display_name":"A.V. Shubnikov Institute of Crystallography","ror":"https://ror.org/049ecjx61","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210096333","https://openalex.org/I4210132917"]},{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE","RU"],"is_corresponding":false,"raw_author_name":"Dmitri I. Svergun","raw_affiliation_strings":["European Molecular Biology Laboratory, Hamburg Outstation, Notkestrasse 85, 22603 Hamburg, Germany;","Institute of Crystallography, Russian Academy of Sciences, Leninsky pr. 59, 117333 Moscow, Russia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, Hamburg Outstation, Notkestrasse 85, 22603 Hamburg, Germany;","institution_ids":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]},{"raw_affiliation_string":"Institute of Crystallography, Russian Academy of Sciences, Leninsky pr. 59, 117333 Moscow, Russia; and","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210132917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021757579","display_name":"Mikel Valle","orcid":"https://orcid.org/0000-0001-8268-6912","observed_orcids":["https://orcid.org/0000-0001-8268-6912"]},"institutions":[{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]},{"id":"https://openalex.org/I4210112728","display_name":"CIC bioGUNE","ror":"https://ror.org/02x5c5y60","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210112728"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mikel Valle","raw_affiliation_strings":["**CIC-bioGUNE, Parque Tecnol\u00f3gico de Bizkaia, 48160 Derio, Spain;","Centro Nacional de Biotecnolog\u00eda, Darwin 3, Cantoblanco 28049 Madrid, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"**CIC-bioGUNE, Parque Tecnol\u00f3gico de Bizkaia, 48160 Derio, Spain;","institution_ids":["https://openalex.org/I4210112728"]},{"raw_affiliation_string":"Centro Nacional de Biotecnolog\u00eda, Darwin 3, Cantoblanco 28049 Madrid, Spain;","institution_ids":["https://openalex.org/I4210104776"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105886219","display_name":"Alan Roy Fersht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan R. Fersht","raw_affiliation_strings":["*Medical Research Council Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Medical Research Council Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, United Kingdom;","institution_ids":["https://openalex.org/I90344618"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.9427,"has_fulltext":false,"cited_by_count":185,"citation_normalized_percentile":{"value":0.98784378,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"104","issue":"30","first_page":"12324","last_page":"12329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9729999899864197},{"id":"https://openalex.org/keywords/quaternary-structure","display_name":"quaternary structure","score":0.8730000257492065},{"id":"https://openalex.org/keywords/core-domain","display_name":"core domain","score":0.5199999809265137},{"id":"https://openalex.org/keywords/tetramerization-domain","display_name":"tetramerization domain","score":0.890999972820282},{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.9890000224113464},{"id":"https://openalex.org/keywords/multidomain-proteins","display_name":"multidomain proteins","score":0.7620000243186951},{"id":"https://openalex.org/keywords/dna-response-elements","display_name":"DNA response elements","score":0.7279999852180481},{"id":"https://openalex.org/keywords/protein-conformational-ensembles","display_name":"protein conformational ensembles","score":0.7070000171661377},{"id":"https://openalex.org/keywords/solution-structure","display_name":"solution structure","score":0.5659999847412109},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.6665618419647217},{"id":"https://openalex.org/C7927669","wikidata":"https://www.wikidata.org/wiki/Q898529","display_name":"Protein quaternary structure","level":4,"score":0.6304582953453064},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5551780462265015},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5399219393730164},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.5045944452285767},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.48062771558761597},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.45613130927085876},{"id":"https://openalex.org/C131888329","wikidata":"https://www.wikidata.org/wiki/Q3027679","display_name":"Small-angle X-ray scattering","level":3,"score":0.455110639333725},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.4224720597267151},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.4112272560596466},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38562971353530884},{"id":"https://openalex.org/C191486275","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Scattering","level":2,"score":0.3504311442375183},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2859160602092743},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1917327344417572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19059526920318604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16015052795410156},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15777185559272766},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.14068704843521118},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.0705069104","doi":"https://doi.org/10.1073/pnas.0705069104","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0705069104","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1941468","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1941468","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:17620598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17620598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:bib-pubdb1.desy.de:81715","doi":null,"is_oa":false,"landing_page_url":"https://bib-pubdb1.desy.de/record/81715","pdf_url":null,"source":{"id":"https://openalex.org/S4377196278","display_name":"Desy Publications Database (Deutsches Elektronen-Synchrotron DESY)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801876189","host_organization_name":"Deutsches Elektronen-Synchrotron DESY","host_organization_lineage":["https://openalex.org/I2801876189"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America 104, 12324-12329 (2007). doi:10.1073/pnas.0705069104","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:epubs.cclrc.ac.uk:work/59751","doi":null,"is_oa":false,"landing_page_url":"http://purl.org/net/epubs/work/59751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400334","display_name":"Science and Technology Facilities Council","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I162524378","host_organization_name":"Science and Technology Facilities Council","host_organization_lineage":["https://openalex.org/I162524378"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1941468","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1941468","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1514900105","https://openalex.org/W1520645352","https://openalex.org/W1573139575","https://openalex.org/W1650797637","https://openalex.org/W1806610286","https://openalex.org/W1965127482","https://openalex.org/W1976261939","https://openalex.org/W1978518304","https://openalex.org/W1988565419","https://openalex.org/W1995856480","https://openalex.org/W1996899753","https://openalex.org/W1998735636","https://openalex.org/W2000511163","https://openalex.org/W2002705413","https://openalex.org/W2004350008","https://openalex.org/W2008765876","https://openalex.org/W2016888788","https://openalex.org/W2019577939","https://openalex.org/W2021375991","https://openalex.org/W2046557655","https://openalex.org/W2052606462","https://openalex.org/W2063694826","https://openalex.org/W2064194464","https://openalex.org/W2064308761","https://openalex.org/W2072674961","https://openalex.org/W2072763798","https://openalex.org/W2074222004","https://openalex.org/W2075334136","https://openalex.org/W2079328211","https://openalex.org/W2081288740","https://openalex.org/W2087700426","https://openalex.org/W2089106375","https://openalex.org/W2089289562","https://openalex.org/W2089623038","https://openalex.org/W2093059615","https://openalex.org/W2096276671","https://openalex.org/W2099459640","https://openalex.org/W2109998141","https://openalex.org/W2118000816","https://openalex.org/W2118001641","https://openalex.org/W2118505770","https://openalex.org/W2123575677","https://openalex.org/W2130275102","https://openalex.org/W2132261408","https://openalex.org/W2141114863","https://openalex.org/W2143939925","https://openalex.org/W2159099751","https://openalex.org/W2168497623","https://openalex.org/W2171407623","https://openalex.org/W4212962560","https://openalex.org/W7097037694"],"related_works":["https://openalex.org/W6980820957","https://openalex.org/W2149573413","https://openalex.org/W338908504","https://openalex.org/W1995659378","https://openalex.org/W2069904905","https://openalex.org/W2118505770","https://openalex.org/W7140255116","https://openalex.org/W2082103873","https://openalex.org/W2141114863","https://openalex.org/W2070299383"],"abstract_inverted_index":{"The":[0,128,155],"homotetrameric":[1],"tumor":[2],"suppressor":[3],"p53":[4,36,193],"consists":[5],"of":[6,34,42,98,109,157,165,168,207,223,228],"folded":[7,62],"core":[8,55,112,129,171],"and":[9,13,26,50,58,94,125,173,181],"tetramerization":[10],"domains,":[11],"linked":[12],"flanked":[14],"by":[15,23,39,152,178,184],"intrinsically":[16,232],"disordered":[17,233],"segments":[18],"that":[19,60,86,132,164],"impede":[20],"structure":[21,33,67,105,148,156],"analysis":[22],"x-ray":[24,44,179],"crystallography":[25,180],"NMR.":[27,185],"Here,":[28],"we":[29],"solved":[30,177],"the":[31,54,61,65,69,77,116,158,166,189,201,205,220,224],"quaternary":[32],"human":[35],"in":[37,68,73,131],"solution":[38,78],"a":[40,107,137,144,195],"combination":[41],"small-angle":[43],"scattering,":[45],"which":[46,52,118,199],"defined":[47],"its":[48],"shape,":[49],"NMR,":[51],"identified":[53,183],"domain":[56,113],"interfaces":[57],"showed":[59],"domains":[63,130,172],"had":[64],"same":[66],"intact":[70],"protein":[71],"as":[72],"fragments.":[74],"We":[75],"combined":[76],"data":[79,100],"with":[80,106,163,231],"electron":[81,153],"microscopy":[82,187],"on":[83,188],"immobilized":[84],"samples":[85],"provided":[87],"medium":[88],"resolution":[89],"3D":[90],"maps.":[91],"Ab":[92],"initio":[93],"rigid":[95],"body":[96],"modeling":[97],"scattering":[99],"revealed":[101],"an":[102],"elongated":[103],"cross-shaped":[104],"pair":[108],"loosely":[110],"coupled":[111],"dimers":[114],"at":[115],"ends,":[117],"are":[119],"accessible":[120],"for":[121,219],"binding":[122],"to":[123,142],"DNA":[124,139,159],"partner":[126],"proteins.":[127],"open":[133,209],"conformation":[134],"closed":[135,202],"around":[136],"specific":[138],"response":[140,174],"element":[141,175],"form":[143],"compact":[145,197],"complex":[146,160,167],"whose":[147],"was":[149],"independently":[150],"determined":[151],"microscopy.":[154],"is":[161],"consistent":[162],"four":[169],"separate":[170],"fragments":[176],"contacts":[182],"Electron":[186],"conformationally":[190],"mobile,":[191],"unbound":[192],"selected":[194],"minor":[196],"conformation,":[198,203],"resembled":[200],"from":[204],"ensemble":[206],"predominantly":[208],"conformations.":[210],"A":[211],"multipronged":[212],"structural":[213,221],"approach":[214],"could":[215],"be":[216],"generally":[217],"useful":[218],"characterization":[222],"rapidly":[225],"growing":[226],"number":[227],"multidomain":[229],"proteins":[230],"regions.":[234]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}