{"id":"https://openalex.org/W2043723796","doi":"https://doi.org/10.1016/j.micpath.2012.01.002","title":"Induction of TNF-alfa and CXCL-2 mRNAs in different organs of mice infected with pathogenic Leptospira","display_name":"Induction of TNF-alfa and CXCL-2 mRNAs in different organs of mice infected with pathogenic Leptospira","publication_year":2012,"publication_date":"2012-02-08","ids":{"openalex":"https://openalex.org/W2043723796","doi":"https://doi.org/10.1016/j.micpath.2012.01.002","mag":"2043723796","pmid":"https://pubmed.ncbi.nlm.nih.gov/22342618"},"language":"en","primary_location":{"id":"doi:10.1016/j.micpath.2012.01.002","doi":"https://doi.org/10.1016/j.micpath.2012.01.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.micpath.2012.01.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0882401012000034/pdf","source":{"id":"https://openalex.org/S113190374","display_name":"Microbial Pathogenesis","issn_l":"0882-4010","issn":["0882-4010","1096-1208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Pathogenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0882401012000034/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059991911","display_name":"Josefa Bezerra da Silva","orcid":"https://orcid.org/0000-0003-3884-7111","observed_orcids":["https://orcid.org/0000-0003-3884-7111"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Josefa B. da Silva","raw_affiliation_strings":["Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil. josilvab@butantan.gov.br","Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil","P\u00f3s-gradua\u00e7\u00e3o Interunidades em Biotecnologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil. josilvab@butantan.gov.br","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"P\u00f3s-gradua\u00e7\u00e3o Interunidades em Biotecnologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003229897","display_name":"En\u00e9as Carvalho","orcid":"https://orcid.org/0000-0002-8052-0975","observed_orcids":["https://orcid.org/0000-0002-8052-0975"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"En\u00e9as Carvalho","raw_affiliation_strings":["Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041212822","display_name":"Ambart E. Covarrubias","orcid":"https://orcid.org/0000-0001-6460-9980","observed_orcids":["https://orcid.org/0000-0001-6460-9980"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ambart E. Covarrubias","raw_affiliation_strings":["Laborat\u00f3rio de Biologia da Reprodu\u00e7\u00e3o e Matriz Extracelular, USP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Biologia da Reprodu\u00e7\u00e3o e Matriz Extracelular, USP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019945597","display_name":"Ana Tung Ching Ching","orcid":"https://orcid.org/0009-0004-2626-7894","observed_orcids":["https://orcid.org/0009-0004-2626-7894"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Tung C. Ching","raw_affiliation_strings":["Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070121272","display_name":"V\u00e2nia Gomes de Moura Mattaraia","orcid":"https://orcid.org/0000-0001-9099-3963","observed_orcids":["https://orcid.org/0000-0001-9099-3963","https://orcid.org/0000-0001-9986-4754"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vania G.M. Mattaraia","raw_affiliation_strings":["Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091782361","display_name":"Delhi Paiva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Delhi Paiva","raw_affiliation_strings":["Instituto de Matem\u00e1tica e Estat\u00edstica da Universidade de S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Matem\u00e1tica e Estat\u00edstica da Universidade de S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038897699","display_name":"Marcelo De Franco","orcid":"https://orcid.org/0000-0002-0417-8215","observed_orcids":["https://orcid.org/0000-0002-0417-8215"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo de Franco","raw_affiliation_strings":["Laborat\u00f3rio de Imunogen\u00e9tica, Instituto Butantan, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Imunogen\u00e9tica, Instituto Butantan, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008396621","display_name":"Regiane Degan F\u00e1varo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Regiane Degan F\u00e1varo","raw_affiliation_strings":["Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113910262","display_name":"Martha Mar\u00eda Pereira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Martha M. Pereira","raw_affiliation_strings":["WHO Collaborating Center for Leptospirosis, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WHO Collaborating Center for Leptospirosis, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017002489","display_name":"S\u00edlvio Arruda Vasconcellos","orcid":"https://orcid.org/0000-0002-7070-7920","observed_orcids":["https://orcid.org/0000-0002-7070-7920"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Silvio Vasconcellos","raw_affiliation_strings":["Laborat\u00f3rio de Zoonoses Bacterianas, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Zoonoses Bacterianas, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027227772","display_name":"Telma Tenorio Zorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Telma T.M. Zorn","raw_affiliation_strings":["Laborat\u00f3rio de Biologia da Reprodu\u00e7\u00e3o e Matriz Extracelular, USP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Biologia da Reprodu\u00e7\u00e3o e Matriz Extracelular, USP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066066519","display_name":"Paulo Lee Ho","orcid":"https://orcid.org/0000-0003-3652-241X","observed_orcids":["https://orcid.org/0000-0003-3652-241X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Paulo Lee Ho","raw_affiliation_strings":["Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil","P\u00f3s-gradua\u00e7\u00e3o Interunidades em Biotecnologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"P\u00f3s-gradua\u00e7\u00e3o Interunidades em Biotecnologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087783258","display_name":"Elizabeth A. L. Martins","orcid":"https://orcid.org/0000-0002-2333-9379","observed_orcids":["https://orcid.org/0000-0002-2333-9379"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Elizabeth A.L. Martins","raw_affiliation_strings":["Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil","P\u00f3s-gradua\u00e7\u00e3o Interunidades em Biotecnologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Instituto Butantan, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"P\u00f3s-gradua\u00e7\u00e3o Interunidades em Biotecnologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5059991911","https://openalex.org/A5066066519","https://openalex.org/A5087783258"],"corresponding_institution_ids":["https://openalex.org/I17974374","https://openalex.org/I2800423888"],"apc_list":{"value":3140,"currency":"USD","value_usd":3140},"apc_paid":null,"fwci":2.9009,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.89788694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"52","issue":"4","first_page":"206","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12223","display_name":"Leptospirosis research and findings","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12223","display_name":"Leptospirosis research and findings","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptospirosis","display_name":"leptospirosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/leptospira-interrogans-serovar-copenhageni","display_name":"Leptospira interrogans serovar Copenhageni","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7170000076293945},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.8360000252723694},{"id":"https://openalex.org/keywords/chemokine-expression","display_name":"chemokine expression","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.6700000166893005},{"id":"https://openalex.org/keywords/c3h-hej-mice","display_name":"C3H/HeJ mice","score":0.9449999928474426},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.9309999942779541},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.5559999942779541},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.8529999852180481},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.9940000176429749},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.5640000104904175},{"id":"https://openalex.org/keywords/natural-resistance-to-infection","display_name":"natural resistance to infection","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7159525752067566},{"id":"https://openalex.org/C179661763","wikidata":"https://www.wikidata.org/wiki/Q21113119","display_name":"CXCL2","level":5,"score":0.6531171798706055},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6334326267242432},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6268331408500671},{"id":"https://openalex.org/C2780542935","wikidata":"https://www.wikidata.org/wiki/Q133841","display_name":"Leptospira","level":3,"score":0.5874573588371277},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5640259981155396},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5517546534538269},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5473423600196838},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4454386234283447},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4252101182937622},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.35009193420410156},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3345208764076233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1942540407180786},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.1698645055294037},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.11089488863945007},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08701330423355103},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06323093175888062}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007919","descriptor_name":"Leptospira","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007919","descriptor_name":"Leptospira","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007922","descriptor_name":"Leptospirosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054426","descriptor_name":"Chemokine CXCL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054426","descriptor_name":"Chemokine CXCL2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D060467","descriptor_name":"Disease Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.micpath.2012.01.002","doi":"https://doi.org/10.1016/j.micpath.2012.01.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.micpath.2012.01.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0882401012000034/pdf","source":{"id":"https://openalex.org/S113190374","display_name":"Microbial Pathogenesis","issn_l":"0882-4010","issn":["0882-4010","1096-1208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Pathogenesis","raw_type":"journal-article"},{"id":"pmid:22342618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22342618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial pathogenesis","raw_type":"Journal Article"},{"id":"pmh:oai:www.producao.usp.br:BDPI/37574","doi":null,"is_oa":false,"landing_page_url":"http://www.producao.usp.br/handle/BDPI/37574","pdf_url":null,"source":{"id":"https://openalex.org/S4306401373","display_name":"Scientific Electronic Library Online (S\u00e3o Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2982035970","host_organization_name":"Costa Rican Department of Social Security","host_organization_lineage":["https://openalex.org/I2982035970"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.micpath.2012.01.002","doi":"https://doi.org/10.1016/j.micpath.2012.01.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.micpath.2012.01.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0882401012000034/pdf","source":{"id":"https://openalex.org/S113190374","display_name":"Microbial Pathogenesis","issn_l":"0882-4010","issn":["0882-4010","1096-1208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Pathogenesis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043723796.pdf","grobid_xml":"https://content.openalex.org/works/W2043723796.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1606631580","https://openalex.org/W1877916940","https://openalex.org/W1909004216","https://openalex.org/W1923608016","https://openalex.org/W1932214472","https://openalex.org/W1964146418","https://openalex.org/W1967980984","https://openalex.org/W1985787178","https://openalex.org/W1991797111","https://openalex.org/W1993635847","https://openalex.org/W2004711162","https://openalex.org/W2010800683","https://openalex.org/W2022323413","https://openalex.org/W2029410081","https://openalex.org/W2045791019","https://openalex.org/W2053986363","https://openalex.org/W2058012473","https://openalex.org/W2064470536","https://openalex.org/W2068457130","https://openalex.org/W2078900016","https://openalex.org/W2086610402","https://openalex.org/W2086685829","https://openalex.org/W2090163045","https://openalex.org/W2094829357","https://openalex.org/W2096174555","https://openalex.org/W2103736039","https://openalex.org/W2107277218","https://openalex.org/W2111911446","https://openalex.org/W2112373432","https://openalex.org/W2115730786","https://openalex.org/W2121542748","https://openalex.org/W2129176257","https://openalex.org/W2144617089","https://openalex.org/W2157801459","https://openalex.org/W2159594785","https://openalex.org/W2161685148","https://openalex.org/W2162995924","https://openalex.org/W2164394621","https://openalex.org/W2164892883","https://openalex.org/W2166875579","https://openalex.org/W2168442400","https://openalex.org/W2169521177","https://openalex.org/W2332370555","https://openalex.org/W2460332635","https://openalex.org/W2485168470","https://openalex.org/W4253009509"],"related_works":["https://openalex.org/W1544338452","https://openalex.org/W2094829357","https://openalex.org/W2620369087","https://openalex.org/W7120784808","https://openalex.org/W3092783236","https://openalex.org/W1981771097","https://openalex.org/W4408546607","https://openalex.org/W2947842949","https://openalex.org/W2052128850","https://openalex.org/W3174583522"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}