{"id":"https://openalex.org/W2043721723","doi":"https://doi.org/10.1182/blood-2010-01-264358","title":"Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus","display_name":"Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus","publication_year":2010,"publication_date":"2010-06-05","ids":{"openalex":"https://openalex.org/W2043721723","doi":"https://doi.org/10.1182/blood-2010-01-264358","mag":"2043721723","pmid":"https://pubmed.ncbi.nlm.nih.gov/20525921","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2953838"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2010-01-264358","doi":"https://doi.org/10.1182/blood-2010-01-264358","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2010-01-264358","pdf_url":"https://ashpublications.org/blood/article-pdf/116/13/2336/1329497/zh803910002336.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ashpublications.org/blood/article-pdf/116/13/2336/1329497/zh803910002336.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100441523","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0001-8679-6713","observed_orcids":["https://orcid.org/0000-0001-8679-6713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Departments of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389115","display_name":"Yongsheng Li","orcid":"https://orcid.org/0000-0002-0285-0493","observed_orcids":["https://orcid.org/0000-0002-0285-0493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-Sheng Li","raw_affiliation_strings":["Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088340058","display_name":"Michael A. Nardi","orcid":"https://orcid.org/0000-0002-3276-3198","observed_orcids":["https://orcid.org/0000-0002-3276-3198"]},"institutions":[{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Nardi","raw_affiliation_strings":["Pediatrics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics,","institution_ids":["https://openalex.org/I4210147155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103136840","display_name":"Suying Dang","orcid":"https://orcid.org/0000-0003-4911-6920","observed_orcids":["https://orcid.org/0000-0003-4911-6920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suying Dang","raw_affiliation_strings":["Departments of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075054175","display_name":"Jing Liang Yang","orcid":"https://orcid.org/0000-0003-1780-1659","observed_orcids":["https://orcid.org/0000-0003-1780-1659"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Yang","raw_affiliation_strings":["Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043526437","display_name":"Yong Ji","orcid":"https://orcid.org/0000-0002-2191-6996","observed_orcids":["https://orcid.org/0000-0002-2191-6996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Ji","raw_affiliation_strings":["Neurology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024322327","display_name":"Zongdong Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zongdong Li","raw_affiliation_strings":["Departments of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074077148","display_name":"Simon Karpatkin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Karpatkin","raw_affiliation_strings":["Departments of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060656369","display_name":"Thomas W\u0131sn\u0131ewsk\u0131","orcid":"https://orcid.org/0000-0002-3379-8966","observed_orcids":["https://orcid.org/0000-0002-3379-8966"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Wisniewski","raw_affiliation_strings":["Neurology,","Pathology, New York University School of Medicine, New York, NY","Psychiatry, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology,","institution_ids":[]},{"raw_affiliation_string":"Pathology, New York University School of Medicine, New York, NY","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Psychiatry, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":{"value":5500,"currency":"USD","value_usd":5500},"fwci":2.0028,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.87339378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"116","issue":"13","first_page":"2336","last_page":"2344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-chain-antibody","display_name":"single-chain antibody","score":0.8119999766349792},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/12-lipoxygenase","display_name":"12-lipoxygenase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8569999933242798},{"id":"https://openalex.org/keywords/carotid-occlusion","display_name":"carotid artery occlusion","score":0.7739999890327454},{"id":"https://openalex.org/keywords/middle-cerebral-artery-stroke","display_name":"middle cerebral artery stroke","score":0.8920000195503235},{"id":"https://openalex.org/keywords/antithrombotic-agents","display_name":"antithrombotic agents","score":0.777999997138977},{"id":"https://openalex.org/keywords/thrombus-clearance","display_name":"thrombus clearance","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7957497239112854},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.7392140030860901},{"id":"https://openalex.org/C2777015399","wikidata":"https://www.wikidata.org/wiki/Q4775337","display_name":"Antithrombotic","level":2,"score":0.6544042229652405},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.5731483697891235},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5315539240837097},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5026967525482178},{"id":"https://openalex.org/C2910542480","wikidata":"https://www.wikidata.org/wiki/Q2335787","display_name":"Platelet Glycoprotein GPIIb-IIIa Complex","level":4,"score":0.488800972700119},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48344501852989197},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.4799497425556183},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4583330750465393},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3245466351509094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26360052824020386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13714662194252014},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002341","descriptor_name":"Carotid Artery Thrombosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002341","descriptor_name":"Carotid Artery Thrombosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019039","descriptor_name":"Platelet Glycoprotein GPIIb-IIIa Complex","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019039","descriptor_name":"Platelet Glycoprotein GPIIb-IIIa Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019039","descriptor_name":"Platelet Glycoprotein GPIIb-IIIa Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2010-01-264358","doi":"https://doi.org/10.1182/blood-2010-01-264358","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2010-01-264358","pdf_url":"https://ashpublications.org/blood/article-pdf/116/13/2336/1329497/zh803910002336.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2953838","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2953838","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:20525921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20525921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood-2010-01-264358","doi":"https://doi.org/10.1182/blood-2010-01-264358","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2010-01-264358","pdf_url":"https://ashpublications.org/blood/article-pdf/116/13/2336/1329497/zh803910002336.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2318429317","display_name":null,"funder_award_id":"DA 020816","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3773717444","display_name":null,"funder_award_id":"AG15408","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4352596056","display_name":"Amyloid beta Peptide and Apolipoprotein E","funder_award_id":"R01AG015408","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4759998666","display_name":null,"funder_award_id":"DA004315","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5165658185","display_name":null,"funder_award_id":"AG20245","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5935928581","display_name":"Alzheimer's Disease Core Center","funder_award_id":"P30AG008051","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7266270790","display_name":"HIV Associated Thrombocytopenia","funder_award_id":"K01DA020816","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7981884307","display_name":"Detection and Clearance of AD Lesions","funder_award_id":"R01AG020245","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8669177979","display_name":"AIDS and Thrombocytopenia: Drug Abusers and Homosexuals","funder_award_id":"R01DA004315","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320319918","display_name":"York University","ror":"https://ror.org/05fq50484"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043721723.pdf","grobid_xml":"https://content.openalex.org/works/W2043721723.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1941497446","https://openalex.org/W1968168309","https://openalex.org/W1970693925","https://openalex.org/W1976425448","https://openalex.org/W1977900178","https://openalex.org/W1986171030","https://openalex.org/W1993394765","https://openalex.org/W1998907224","https://openalex.org/W2003506380","https://openalex.org/W2004069543","https://openalex.org/W2006987466","https://openalex.org/W2011284847","https://openalex.org/W2014369252","https://openalex.org/W2021828275","https://openalex.org/W2025510606","https://openalex.org/W2038212228","https://openalex.org/W2043167284","https://openalex.org/W2044190048","https://openalex.org/W2044796857","https://openalex.org/W2056503876","https://openalex.org/W2077259124","https://openalex.org/W2077365027","https://openalex.org/W2082508710","https://openalex.org/W2083332835","https://openalex.org/W2084276037","https://openalex.org/W2099745384","https://openalex.org/W2102828922","https://openalex.org/W2142848477","https://openalex.org/W2152601266","https://openalex.org/W2160034002","https://openalex.org/W3142512722"],"related_works":["https://openalex.org/W2980270109","https://openalex.org/W7096067184","https://openalex.org/W2143057111","https://openalex.org/W1996509671","https://openalex.org/W2076991332","https://openalex.org/W2293220210","https://openalex.org/W2006987466","https://openalex.org/W4407260973","https://openalex.org/W2014369252","https://openalex.org/W2126789213"],"abstract_inverted_index":{"Patients":[0],"with":[1],"HIV-1":[2],"immune-related":[3],"thrombocytopenia":[4,81,127],"have":[5],"a":[6,36,45,141,193],"unique":[7],"antibody":[8,40],"(Ab)":[9],"against":[10,51],"integrin":[11],"GPIIIa49-66":[12,52],"capable":[13,55],"of":[14,22,56,59,71,91,109,137,181],"inducing":[15,57],"oxidative":[16],"platelet":[17,23,84,159,200],"fragmentation":[18,58],"via":[19],"Ab":[20,50],"activation":[21],"nicotinamide":[24],"adenine":[25],"dinucleotide":[26],"phosphate":[27],"oxidase":[28],"and":[29,100,156],"12-lipoxygenase":[30],"releasing":[31],"reactive":[32],"oxygen":[33],"species.":[34],"Using":[35],"phage":[37],"display":[38],"single-chain":[39],"(scFv)":[41],"library,":[42],"we":[43,65,139],"developed":[44,198],"novel":[46],"human":[47],"monoclonal":[48],"scFv":[49],"(named":[53],"A11)":[54],"activated":[60],"platelets.":[61,166],"In":[62,112],"this":[63],"study,":[64],"investigated":[66],"the":[67,89,102,134,158],"in":[68],"vivo":[69],"use":[70],"A11.":[72],"We":[73],"show":[74],"that":[75],"A11":[76,86,114,185],"does":[77],"not":[78],"induce":[79],"significant":[80],"or":[82,128],"inhibit":[83],"function.":[85],"can":[87,115],"prevent":[88],"cessation":[90,108,180],"carotid":[92,175],"artery":[93,98,124],"flow":[94],"produced":[95,140],"by":[96],"induced":[97,103],"injury":[99],"dissolve":[101],"thrombus":[104,201],"2":[105],"hours":[106,178],"after":[107,179],"blood":[110,182],"flow.":[111],"addition,":[113],"prevent,":[116],"as":[117,119],"well":[118],"ameliorate,":[120],"murine":[121],"middle":[122],"cerebral":[123],"stroke,":[125],"without":[126],"brain":[129],"hemorrhage.":[130],"To":[131],"further":[132],"optimize":[133],"antithrombotic":[135,195],"activity":[136],"A11,":[138],"bifunctional":[142],"A11-plasminogen":[143],"first":[144],"kringle":[145],"agent":[146,196],"(SLK),":[147],"which":[148],"homes":[149],"to":[150,171],"newly":[151],"deposited":[152],"fibrin":[153],"strands":[154],"within":[155],"surrounding":[157],"thrombus,":[160],"reducing":[161],"effects":[162],"on":[163],"nonactivated":[164],"circulating":[165],"Indeed,":[167],"SLK":[168],"is":[169],"able":[170],"completely":[172],"reopen":[173],"occluded":[174],"vessels":[176],"4":[177,190],"flow,":[183],"whereas":[184],"had":[186],"no":[187],"effect":[188],"at":[189],"hours.":[191],"Thus,":[192],"new":[194],"was":[197],"for":[199],"clearance.":[202]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
