{"id":"https://openalex.org/W2043718895","doi":"https://doi.org/10.1001/archneur.1988.00520250084025","title":"Brain Glucose Metabolism in Neurologically Normal Patients With Sickle Cell Disease","display_name":"Brain Glucose Metabolism in Neurologically Normal Patients With Sickle Cell Disease","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2043718895","doi":"https://doi.org/10.1001/archneur.1988.00520250084025","mag":"2043718895","pmid":"https://pubmed.ncbi.nlm.nih.gov/3257387"},"language":"en","primary_location":{"id":"doi:10.1001/archneur.1988.00520250084025","doi":"https://doi.org/10.1001/archneur.1988.00520250084025","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.1988.00520250084025","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111847583","display_name":"Griffin P. Rodgers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Griffin P. Rodgers","raw_affiliation_strings":["Laboratory of Chemical Biology, NIDDK, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Biology, NIDDK, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111847583"],"corresponding_institution_ids":["https://openalex.org/I4210090567"],"apc_list":null,"apc_paid":null,"fwci":1.0885,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.76365947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"45","issue":"1","first_page":"78","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":1.0},{"id":"https://openalex.org/keywords/cerebral-glucose-metabolism","display_name":"brain glucose metabolism","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cerebral-metabolic-rate-of-glucose","display_name":"cerebral metabolic rate of glucose","score":0.8529999852180481},{"id":"https://openalex.org/keywords/frontal-lobe","display_name":"frontal lobe","score":0.6600000262260437},{"id":"https://openalex.org/keywords/neurologic-dysfunction","display_name":"neurologic dysfunction","score":0.8180000185966492},{"id":"https://openalex.org/keywords/regional-cerebral-glucose-metabolism","display_name":"regional cerebral glucose metabolism","score":0.5479999780654907},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"neuroimaging","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.6637310981750488},{"id":"https://openalex.org/C2777127467","wikidata":"https://www.wikidata.org/wiki/Q749520","display_name":"Frontal lobe","level":2,"score":0.6159089207649231},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6135841608047485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5897080302238464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44260287284851074},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4403703212738037},{"id":"https://openalex.org/C2778046553","wikidata":"https://www.wikidata.org/wiki/Q848340","display_name":"Occipital lobe","level":2,"score":0.43586868047714233},{"id":"https://openalex.org/C2985771010","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomographic","level":3,"score":0.4326087236404419},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.4322527050971985},{"id":"https://openalex.org/C2777415128","wikidata":"https://www.wikidata.org/wiki/Q419849","display_name":"Fluorodeoxyglucose","level":3,"score":0.4295962154865265},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35819125175476074},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.31615954637527466},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.26852893829345703},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08373045921325684},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.06787177920341492}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003847","descriptor_name":"Deoxyglucose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/archneur.1988.00520250084025","doi":"https://doi.org/10.1001/archneur.1988.00520250084025","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.1988.00520250084025","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},{"id":"pmid:3257387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3257387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W176663286","https://openalex.org/W1545827831","https://openalex.org/W1595484500","https://openalex.org/W1834888087","https://openalex.org/W1951442280","https://openalex.org/W1973151471","https://openalex.org/W1978116310","https://openalex.org/W1992575642","https://openalex.org/W1992879118","https://openalex.org/W2019805036","https://openalex.org/W2042673855","https://openalex.org/W2059955089","https://openalex.org/W2085149684","https://openalex.org/W2088886391","https://openalex.org/W2121716202","https://openalex.org/W2134654456","https://openalex.org/W2142915976","https://openalex.org/W2161633295","https://openalex.org/W2188141079","https://openalex.org/W2323003522","https://openalex.org/W2398492177","https://openalex.org/W2409272224","https://openalex.org/W3025645147"],"related_works":["https://openalex.org/W2761768194","https://openalex.org/W3147375751","https://openalex.org/W4299983552","https://openalex.org/W2028591508","https://openalex.org/W2115346439","https://openalex.org/W2089638317","https://openalex.org/W2024252666","https://openalex.org/W2039377493","https://openalex.org/W2133506632","https://openalex.org/W3082333393"],"abstract_inverted_index":{"Neurologic":[0],"dysfunction":[1],"is":[2],"a":[3,17],"significant":[4,91],"source":[5],"of":[6,19,41,108,120],"morbidity":[7],"and":[8,81],"mortality":[9],"in":[10,25,49,93,116,136],"the":[11,39,94,99,117],"sickle":[12,58,137],"cell":[13,59,138],"diseases,":[14],"occurring":[15],"with":[16,45,57,66,72,77,143],"prevalence":[18],"6%":[20],"to":[21,53,79],"34%.":[22],"Because":[23],"changes":[24],"brain":[26],"glucose":[27,115],"metabolism":[28],"may":[29,132],"precede":[30],"gross":[31],"functional":[32],"or":[33],"morphologic":[34],"alterations,":[35],"we":[36,103],"recently":[37],"applied":[38],"technique":[40],"positron":[42],"emission":[43],"tomography":[44],"fluorodeoxyglucose":[46],"F":[47],"18":[48],"an":[50,105],"exploratory":[51],"study":[52],"compare":[54],"six":[55,73],"patients":[56],"disease":[60],"without":[61],"prior":[62],"neurologic":[63],"abnormalities":[64],"(and":[65],"normal":[67,144],"cranial":[68],"computed":[69,145],"tomographic":[70,146],"scans)":[71],"healthy":[74],"age-matched":[75],"controls,":[76],"respect":[78],"overall":[80],"regional":[82,110],"cerebral":[83,111],"metabolic":[84,96,112],"rates":[85,97,113],"for":[86,98,114],"glucose.":[87],"We":[88],"found":[89],"no":[90],"difference":[92],"global":[95],"two":[100],"groups.":[101],"However,":[102],"observed":[104],"unusual":[106],"clustering":[107],"abnormal":[109],"frontal":[118,129],"lobes":[119],"these":[121],"subjects.":[122],"These":[123],"results":[124],"support":[125],"previous":[126],"observations":[127],"that":[128],"lobe":[130],"involvement":[131],"be":[133],"quite":[134],"prevalent":[135],"disease,":[139],"even":[140],"among":[141],"individuals":[142],"scans.":[147]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
