{"id":"https://openalex.org/W2043714903","doi":"https://doi.org/10.1016/s0002-9343(01)00859-2","title":"The role of substance P release in the lung with esophageal acid","display_name":"The role of substance P release in the lung with esophageal acid","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2043714903","doi":"https://doi.org/10.1016/s0002-9343(01)00859-2","mag":"2043714903","pmid":"https://pubmed.ncbi.nlm.nih.gov/11749920"},"language":"en","primary_location":{"id":"doi:10.1016/s0002-9343(01)00859-2","doi":"https://doi.org/10.1016/s0002-9343(01)00859-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0002-9343(01)00859-2","pdf_url":null,"source":{"id":"https://openalex.org/S186920367","display_name":"The American Journal of Medicine","issn_l":"0002-9343","issn":["0002-9343","1555-7162"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061627868","display_name":"Hirotsugu Kohrogi","orcid":"https://orcid.org/0000-0002-1440-3383","observed_orcids":["https://orcid.org/0000-0002-1440-3383"]},"institutions":[{"id":"https://openalex.org/I4210122547","display_name":"Kumamoto University Hospital","ror":"https://ror.org/02vgs9327","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210122547"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotsugu Kohrogi","raw_affiliation_strings":["First Department of Internal Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo Kumamoto 860-8556, Japan","First Department of Internal Medicine, Kumamoto University School of Medicine Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo Kumamoto 860-8556, Japan","institution_ids":["https://openalex.org/I96036126"]},{"raw_affiliation_string":"First Department of Internal Medicine, Kumamoto University School of Medicine Kumamoto, Japan","institution_ids":["https://openalex.org/I4210122547","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032367738","display_name":"Junji Hamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122547","display_name":"Kumamoto University Hospital","ror":"https://ror.org/02vgs9327","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210122547"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junji Hamamoto","raw_affiliation_strings":["First Department of Internal Medicine, Kumamoto University School of Medicine Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kumamoto University School of Medicine Kumamoto, Japan","institution_ids":["https://openalex.org/I4210122547","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Osamu Kawano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Kawano","raw_affiliation_strings":["Department of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Kumamoto University School of Medicine, Kumamoto, Japan,","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005546492","display_name":"Hajime Iwagoe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122547","display_name":"Kumamoto University Hospital","ror":"https://ror.org/02vgs9327","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210122547"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Iwagoe","raw_affiliation_strings":["First Department of Internal Medicine, Kumamoto University School of Medicine Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kumamoto University School of Medicine Kumamoto, Japan","institution_ids":["https://openalex.org/I4210122547","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101822248","display_name":"Kazuhiko Fujii","orcid":"https://orcid.org/0000-0003-3711-256X","observed_orcids":["https://orcid.org/0000-0003-3711-256X"]},"institutions":[{"id":"https://openalex.org/I4210122547","display_name":"Kumamoto University Hospital","ror":"https://ror.org/02vgs9327","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210122547"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Fujii","raw_affiliation_strings":["First Department of Internal Medicine, Kumamoto University School of Medicine Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kumamoto University School of Medicine Kumamoto, Japan","institution_ids":["https://openalex.org/I4210122547","https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113925751","display_name":"Naomi Hirata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122547","display_name":"Kumamoto University Hospital","ror":"https://ror.org/02vgs9327","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210122547"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naomi Hirata","raw_affiliation_strings":["First Department of Internal Medicine, Kumamoto University School of Medicine Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kumamoto University School of Medicine Kumamoto, Japan","institution_ids":["https://openalex.org/I4210122547","https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111581083","display_name":"Masayuki Ando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122547","display_name":"Kumamoto University Hospital","ror":"https://ror.org/02vgs9327","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210122547"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Ando","raw_affiliation_strings":["First Department of Internal Medicine, Kumamoto University School of Medicine Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Kumamoto University School of Medicine Kumamoto, Japan","institution_ids":["https://openalex.org/I4210122547","https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3770,"currency":"USD","value_usd":3770},"apc_paid":null,"fwci":0.3161,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.46316998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"111","issue":"8","first_page":"25","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.49410000443458557,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.49410000443458557,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.24979999661445618,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.07349999994039536,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tachykinins","display_name":"tachykinins","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hydrochloric-acid","display_name":"hydrochloric acid","score":0.6800000071525574},{"id":"https://openalex.org/keywords/neutral-endopeptidase","display_name":"neutral endopeptidase","score":0.8289999961853027},{"id":"https://openalex.org/keywords/phosphoramidon","display_name":"phosphoramidon","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurokinin-1-receptor","display_name":"neurokinin-1 receptor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/vagotomy","display_name":"vagotomy","score":0.9100000262260437},{"id":"https://openalex.org/keywords/vagus-nerve","display_name":"vagus nerve","score":0.7720000147819519},{"id":"https://openalex.org/keywords/airway-reflexes","display_name":"airway reflexes","score":0.503000020980835},{"id":"https://openalex.org/keywords/evans-blue","display_name":"Evans blue","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.9610579609870911},{"id":"https://openalex.org/C2780268870","wikidata":"https://www.wikidata.org/wiki/Q7187544","display_name":"Phosphoramidon","level":4,"score":0.9239257574081421},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7569695115089417},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.5657610297203064},{"id":"https://openalex.org/C2777649898","wikidata":"https://www.wikidata.org/wiki/Q5415983","display_name":"Evans Blue","level":2,"score":0.5546193718910217},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4827101230621338},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.44301462173461914},{"id":"https://openalex.org/C2778720886","wikidata":"https://www.wikidata.org/wiki/Q1417507","display_name":"Vagotomy","level":2,"score":0.4380023777484894},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.4116096794605255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33097130060195923},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18602818250656128},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.12598565220832825},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10649937391281128}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005119","descriptor_name":"Extravasation of Diagnostic and Therapeutic Materials","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005119","descriptor_name":"Extravasation of Diagnostic and Therapeutic Materials","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006020","descriptor_name":"Glycopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006851","descriptor_name":"Hydrochloric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014628","descriptor_name":"Vagotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0002-9343(01)00859-2","doi":"https://doi.org/10.1016/s0002-9343(01)00859-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0002-9343(01)00859-2","pdf_url":null,"source":{"id":"https://openalex.org/S186920367","display_name":"The American Journal of Medicine","issn_l":"0002-9343","issn":["0002-9343","1555-7162"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:11749920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11749920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of medicine","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W53887727","https://openalex.org/W163575209","https://openalex.org/W167341932","https://openalex.org/W1528515077","https://openalex.org/W1695141762","https://openalex.org/W1866007716","https://openalex.org/W1890674621","https://openalex.org/W1967785035","https://openalex.org/W1973806783","https://openalex.org/W1974370682","https://openalex.org/W1975160072","https://openalex.org/W1978700752","https://openalex.org/W1979175857","https://openalex.org/W1987341100","https://openalex.org/W1990754610","https://openalex.org/W1995408834","https://openalex.org/W2005745468","https://openalex.org/W2006742100","https://openalex.org/W2008543322","https://openalex.org/W2010784234","https://openalex.org/W2011401052","https://openalex.org/W2014195246","https://openalex.org/W2016919586","https://openalex.org/W2024530755","https://openalex.org/W2033883876","https://openalex.org/W2054772097","https://openalex.org/W2066461253","https://openalex.org/W2077217512","https://openalex.org/W2082085431","https://openalex.org/W2086733746","https://openalex.org/W2093647914","https://openalex.org/W2101805877","https://openalex.org/W2124864374","https://openalex.org/W2133681050","https://openalex.org/W2155516336","https://openalex.org/W2167382039","https://openalex.org/W2212792209","https://openalex.org/W2274485104","https://openalex.org/W2279068563","https://openalex.org/W2418426503","https://openalex.org/W6712739616"],"related_works":["https://openalex.org/W2124864374","https://openalex.org/W2373312465","https://openalex.org/W2102401870","https://openalex.org/W2352523056","https://openalex.org/W2382603344","https://openalex.org/W2364026883","https://openalex.org/W1974440130","https://openalex.org/W3152285484","https://openalex.org/W1997714274","https://openalex.org/W2251178293"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
