{"id":"https://openalex.org/W2043681998","doi":"https://doi.org/10.1248/cpb.47.1451","title":"Preparation and Evaluation of Tablets Rapidly Disintegrating in Saliva Containing Bitter-Taste-Masked Granules by the Compression Method.","display_name":"Preparation and Evaluation of Tablets Rapidly Disintegrating in Saliva Containing Bitter-Taste-Masked Granules by the Compression Method.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2043681998","doi":"https://doi.org/10.1248/cpb.47.1451","mag":"2043681998","pmid":"https://pubmed.ncbi.nlm.nih.gov/10553641"},"language":"en","primary_location":{"id":"doi:10.1248/cpb.47.1451","doi":"https://doi.org/10.1248/cpb.47.1451","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.47.1451","pdf_url":"https://www.jstage.jst.go.jp/article/cpb1958/47/10/47_10_1451/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/cpb1958/47/10/47_10_1451/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001078030","display_name":"Tatsuya Ishikawa","orcid":"https://orcid.org/0000-0002-6699-9940","observed_orcids":["https://orcid.org/0000-0002-6699-9940"]},"institutions":[{"id":"https://openalex.org/I8873088","display_name":"Showa Pharmaceutical University","ror":"https://ror.org/053e8a708","country_code":"JP","type":"education","lineage":["https://openalex.org/I8873088"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya ISHIKAWA","raw_affiliation_strings":["Department of Pharmaceutics, Showa College of Pharmaceutical Sciences, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Showa College of Pharmaceutical Sciences, Tokyo, Japan","institution_ids":["https://openalex.org/I8873088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100805701","display_name":"Yoshiteru Watanabe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshiteru WATANABE","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028852633","display_name":"Naoki Utoguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoki UTOGUCHI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102795808","display_name":"Mitsuo Matsumoto","orcid":"https://orcid.org/0000-0001-8698-7472","observed_orcids":["https://orcid.org/0000-0001-8698-7472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsuo MATSUMOTO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9526,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.66357874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"47","issue":"10","first_page":"1451","last_page":"1454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.05550000071525574,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapidly-disintegrating-tablets","display_name":"fast disintegrating tablets","score":0.9399999976158142},{"id":"https://openalex.org/keywords/bitter-taste-masking","display_name":"bitter taste masking","score":0.7300000190734863},{"id":"https://openalex.org/keywords/oxybutynin-hydrochloride","display_name":"oxybutynin hydrochloride","score":0.9990000128746033},{"id":"https://openalex.org/keywords/eudragit-e100","display_name":"Eudragit E100","score":0.9670000076293945},{"id":"https://openalex.org/keywords/extrusion","display_name":"extrusion","score":0.6330000162124634},{"id":"https://openalex.org/keywords/crystalline-cellulose","display_name":"crystalline cellulose","score":0.871999979019165},{"id":"https://openalex.org/keywords/tablet-compression","display_name":"tablet compression","score":0.6299999952316284},{"id":"https://openalex.org/keywords/tablet-strength","display_name":"tablet strength","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8118252754211426},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7109403610229492},{"id":"https://openalex.org/C3020017864","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Bitter taste","level":3,"score":0.6077013611793518},{"id":"https://openalex.org/C191168616","wikidata":"https://www.wikidata.org/wiki/Q5503337","display_name":"Friability","level":4,"score":0.5650132894515991},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.5467601418495178},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.5355961322784424},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.4965818524360657},{"id":"https://openalex.org/C2778572730","wikidata":"https://www.wikidata.org/wiki/Q416713","display_name":"Magnesium stearate","level":3,"score":0.4834921658039093},{"id":"https://openalex.org/C14029885","wikidata":"https://www.wikidata.org/wiki/Q5282807","display_name":"Dissolution testing","level":4,"score":0.4807586371898651},{"id":"https://openalex.org/C2781218482","wikidata":"https://www.wikidata.org/wiki/Q724426","display_name":"Hydroxypropyl cellulose","level":3,"score":0.4425087571144104},{"id":"https://openalex.org/C2779351475","wikidata":"https://www.wikidata.org/wiki/Q417374","display_name":"Microcrystalline cellulose","level":3,"score":0.4144516587257385},{"id":"https://openalex.org/C200215109","wikidata":"https://www.wikidata.org/wiki/Q1952715","display_name":"Mouthfeel","level":3,"score":0.4129672646522522},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.32465723156929016},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2859737277030945},{"id":"https://openalex.org/C2776035855","wikidata":"https://www.wikidata.org/wiki/Q420113","display_name":"Ethyl cellulose","level":3,"score":0.2352089285850525},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.18330848217010498},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.17005354166030884},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16398444771766663},{"id":"https://openalex.org/C2781430271","wikidata":"https://www.wikidata.org/wiki/Q278760","display_name":"Biopharmaceutics Classification System","level":3,"score":0.07220330834388733},{"id":"https://openalex.org/C206139338","wikidata":"https://www.wikidata.org/wiki/Q192355","display_name":"Raw material","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008333","descriptor_name":"Mandelic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008333","descriptor_name":"Mandelic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008689","descriptor_name":"Methacrylates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010890","descriptor_name":"Pirenzepine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010890","descriptor_name":"Pirenzepine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018680","descriptor_name":"Cholinergic Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018680","descriptor_name":"Cholinergic Antagonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/cpb.47.1451","doi":"https://doi.org/10.1248/cpb.47.1451","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.47.1451","pdf_url":"https://www.jstage.jst.go.jp/article/cpb1958/47/10/47_10_1451/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:10553641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10553641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/cpb.47.1451","doi":"https://doi.org/10.1248/cpb.47.1451","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.47.1451","pdf_url":"https://www.jstage.jst.go.jp/article/cpb1958/47/10/47_10_1451/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043681998.pdf","grobid_xml":"https://content.openalex.org/works/W2043681998.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052673067","https://openalex.org/W2156140470","https://openalex.org/W1998607289","https://openalex.org/W2606735725","https://openalex.org/W2337899829","https://openalex.org/W3160378298","https://openalex.org/W2116914610","https://openalex.org/W2093517267","https://openalex.org/W2136306477","https://openalex.org/W2530891941"],"abstract_inverted_index":{"The":[0,31,111,142],"aim":[1],"of":[2,21,47,55,98,101,180,184,194],"this":[3],"study":[4],"was":[5,175],"to":[6],"prepare,":[7],"using":[8,36,90,212],"taste-masked":[9,32,93,151,200,214],"granules,":[10,94],"tablets":[11,87,144,208],"which":[12,197,218],"can":[13,209],"rapidly":[14,74,206],"disintegrate":[15],"in":[16,66,75,81,137,177,222],"saliva":[17,179],"(rapidly":[18],"disintegrating":[19,86,207],"tablet),":[20],"drugs":[22,49,72],"with":[23,127],"bitter":[24,189],"taste":[25,190],"(pirenzepine":[26],"HCl":[27],"or":[28],"oxybutynin":[29,159],"HCl).":[30],"granules":[33,53,112,152,215],"were":[34,88,115],"prepared":[35,89,92,143,211],"aminoalkyl":[37],"methacrylate":[38],"copolymers":[39],"(Eudragit":[40],"E-100)":[41],"by":[42,120],"the":[43,48,52,67,71,76,82,91,150,178,185,192,195,199,205],"extrusion":[44],"method.":[45],"None":[46,183],"dissolved":[50,73],"from":[51],"(%":[54],"dissolved,":[56],"<":[57],"5%)":[58],"even":[59],"at":[60,63,78,134,146],"480":[61],"min":[62],"pH":[64,79],"6.8":[65],"dissolution":[68,83],"test.":[69,84],"However,":[70],"medium":[77],"1.2":[80],"Rapidly":[85],"and":[95,106,113,131,167,216],"a":[96,138,168],"mixture":[97],"excipients":[99,114,217],"consisting":[100],"crystalline":[102,122],"cellulose":[103],"(Avicel":[104],"PH-102)":[105],"low-substituted":[107],"hydroxypropylcellulose":[108],"(L-HPC,":[109],"LH-11).":[110],"mixed":[116],"well":[117],"(mixing":[118],"ratio":[119],"weight,":[121],"cellulose:":[123],"L-HPC":[124],"=":[125],"8:2)":[126],"1%":[128],"magnesium":[129],"stearate,":[130],"subsequently":[132],"compressed":[133],"500-1500":[135],"kgf":[136],"single-punch":[139],"tableting":[140],"machine.":[141],"(compressed":[145],"500":[147],"kgf)":[148],"containing":[149],"have":[153],"sufficient":[154],"strength":[155],"(the":[156],"crushing":[157],"strength:":[158],"tablet,":[160,164],"3.5":[161],"kg;":[162],"pirenzepine":[163],"2.2":[165],"kg),":[166],"rapid":[169],"disintegration":[170,193],"time":[171],"(within":[172],"20":[173],"s)":[174],"observed":[176],"healthy":[181],"volunteers.":[182],"volunteers":[186],"felt":[187],"any":[188],"after":[191],"tablet":[196,223],"contained":[198],"granules.":[201],"We":[202],"confirmed":[203],"that":[204],"be":[210],"these":[213],"are":[219],"commonly":[220],"used":[221],"preparation.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}