{"id":"https://openalex.org/W2043660985","doi":"https://doi.org/10.1055/s-2007-967822","title":"Telomere shortening and p21-checkpoint inactivation characterize multistep hepatocarcinogenesis in humans","display_name":"Telomere shortening and p21-checkpoint inactivation characterize multistep hepatocarcinogenesis in humans","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2043660985","doi":"https://doi.org/10.1055/s-2007-967822","mag":"2043660985"},"language":"de","primary_location":{"id":"doi:10.1055/s-2007-967822","doi":"https://doi.org/10.1055/s-2007-967822","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-967822","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103338850","display_name":"Ruben R. Plentz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RR Plentz","raw_affiliation_strings":["MGH Cancer Center, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MGH Cancer Center, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081513822","display_name":"A Lechel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Lechel","raw_affiliation_strings":["Abt. Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abt. Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056005137","display_name":"Park Yn","orcid":"https://orcid.org/0000-0003-0357-7967","observed_orcids":["https://orcid.org/0000-0003-0357-7967"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"YN Park","raw_affiliation_strings":["Department of Pathology, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024773415","display_name":"H Kim","orcid":"https://orcid.org/0009-0009-4590-0276","observed_orcids":["https://orcid.org/0009-0009-4590-0276"]},"institutions":[{"id":"https://openalex.org/I2803058125","display_name":"Seoul National University Bundang Hospital","ror":"https://ror.org/00cb3km46","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I139264467","https://openalex.org/I2802835388","https://openalex.org/I2803058125"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"H Kim","raw_affiliation_strings":["Department of Pathology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I2803058125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000738447","display_name":"Friederike Nellessen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F Nellessen","raw_affiliation_strings":["Abt. Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abt. Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015557658","display_name":"Britta Heike Eva Langkopf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"BHE Langkopf","raw_affiliation_strings":["Abt. Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abt. Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068356365","display_name":"Ludwig Wilkens","orcid":"https://orcid.org/0009-0001-0944-2003","observed_orcids":["https://orcid.org/0009-0001-0944-2003"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Wilkens","raw_affiliation_strings":["Abt. f\u00fcr Zell- und Molekularpathologie, Medizinische Hochschule Hannover, Hannover"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abt. f\u00fcr Zell- und Molekularpathologie, Medizinische Hochschule Hannover, Hannover","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108640388","display_name":"MP Manns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"MP Manns","raw_affiliation_strings":["Abt. Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abt. Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087772154","display_name":"Annarita Destro","orcid":"https://orcid.org/0000-0001-5388-0353","observed_orcids":["https://orcid.org/0000-0001-5388-0353"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Destro","raw_affiliation_strings":["Department of Pathology, University of Milan and Humanitas Clinical Institute of Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Milan and Humanitas Clinical Institute of Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026754989","display_name":"Barbara Fiamengo","orcid":"https://orcid.org/0000-0001-6351-8964","observed_orcids":["https://orcid.org/0000-0001-6351-8964"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"B Fiamengo","raw_affiliation_strings":["Department of Pathology, University of Milan and Humanitas Clinical Institute of Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Milan and Humanitas Clinical Institute of Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041255789","display_name":"Massimo G. Roncalli","orcid":"https://orcid.org/0000-0002-7901-8910","observed_orcids":["https://orcid.org/0000-0002-7901-8910"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Roncalli","raw_affiliation_strings":["Department of Pathology, University of Milan and Humanitas Clinical Institute of Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Milan and Humanitas Clinical Institute of Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103423138","display_name":"KL Rudolph","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"KL Rudolph","raw_affiliation_strings":["Abt. Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abt. Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1878,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.4732489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"45","issue":"01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8859999775886536},{"id":"https://openalex.org/keywords/multistep-carcinogenesis","display_name":"multistep carcinogenesis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.9860000014305115},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.7379999756813049},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7329999804496765},{"id":"https://openalex.org/keywords/precursor-lesions","display_name":"precursor lesions","score":0.8370000123977661},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.7400000095367432},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.907616376876831},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.731168806552887},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.717125654220581},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5456765294075012},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.520638644695282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4982919692993164},{"id":"https://openalex.org/C2910325170","wikidata":"https://www.wikidata.org/wiki/Q14912280","display_name":"Checkpoint Kinase 2","level":5,"score":0.48150452971458435},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4139418601989746},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3587215542793274},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.35279083251953125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3306601047515869},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3305402100086212},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2225944995880127},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.13767313957214355}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-2007-967822","doi":"https://doi.org/10.1055/s-2007-967822","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-967822","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2086424163","https://openalex.org/W2060423420","https://openalex.org/W2106420936","https://openalex.org/W2324770700","https://openalex.org/W2013534239","https://openalex.org/W2036360678","https://openalex.org/W1965858031","https://openalex.org/W1968495771","https://openalex.org/W2000298128","https://openalex.org/W1975396342"],"abstract_inverted_index":{"Telomere":[0,238],"shortening":[1,136,210],"and":[2,49,79,113,132,142,152,183,196,206,211,223],"DNA-damage-checkpoint":[3],"inactivation":[4,213],"have":[5],"been":[6],"identified":[7],"as":[8],"molecular":[9,22,59],"hallmarks":[10],"characterizing":[11],"early":[12],"carcinogenesis":[13,30],"in":[14,31,72,120,123,139,175],"humans":[15],"but":[16],"it":[17],"is":[18,41],"unknown,":[19],"whether":[20],"these":[21,62],"features":[23],"coincide":[24],"at":[25,168,215],"specific":[26],"stages":[27],"of":[28,36,61,83,92,137,160,179,201],"multistep":[29,70,221],"humans.":[32,73],"The":[33,58],"preneoplasia-carcinoma":[34],"sequence":[35],"human":[37,220],"hepatocellular":[38,76],"carcinoma":[39],"(HCC)":[40],"not":[42],"well":[43],"defined.":[44],"Small":[45],"cell":[46,51,85],"changes":[47,52],"(SCC)":[48],"large":[50],"(LCC)":[53],"are":[54],"possible":[55],"precursor":[56,64,102,230],"lesions.":[57],"characterization":[60],"potential":[63],"lesions":[65,103,231],"could":[66],"help":[67],"to":[68,129,233],"define":[69],"hepatocarcinogenesis":[71,222],"We":[74,116],"analyzed":[75],"telomere":[77,121,158,209],"length":[78,122],"labeling":[80],"index":[81],"(LI)":[82],"the":[84,146,157,169,176],"cycle":[86],"inhibitor":[87],"p21":[88,241],"on":[89],"liver":[90,96,106,127,131],"biopsies":[91],"patients":[93],"with":[94,156,203],"chronic":[95],"disease":[97],"(n=24)":[98],"that":[99,193,208,225],"showed":[100,164,185],"different":[101],"and/or":[104],"HCC:":[105],"cirrhosis":[107,161,170],"(n=22),":[108],"LCC":[109,195],"(n=24),":[110],"SCC":[111,151,182,197,226],"(n=10),":[112],"HCC":[114,144,184],"(n=12).":[115],"found":[117],"a":[118,133,186,216],"decrease":[119],"non":[124],"dysplastic":[125],"cirrhotic":[126],"compared":[128,232],"normal":[130],"further":[134],"significant":[135],"telomeres":[138,148,205],"LCC,":[140],"SCC,":[141],"HCC.":[143],"had":[145],"shortest":[147],"followed":[149],"by":[150],"LCC.":[153,180,234],"In":[154],"line":[155],"hypothesis":[159],"development,":[162],"hepatocytes":[163,202],"an":[165],"increased":[166],"p21-LI":[167],"stage,":[171],"which":[172],"remained":[173],"elevated":[174],"vast":[177],"majority":[178],"Most":[181],"strongly":[187],"reduced":[188],"p21-LI.":[189],"Our":[190],"data":[191],"suggest":[192,224],"both":[194],"represent":[198,227],"clonal":[199],"expansion":[200],"shortened":[204],"indicate":[207],"p21-checkpoint":[212],"occur":[214],"defined":[217],"stage":[218],"during":[219],"more":[228],"advanced":[229],"Multistep":[235],"Hepatocarcinogenesis":[236],"-":[237,240],"Shortening":[239]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
