{"id":"https://openalex.org/W2043638353","doi":"https://doi.org/10.1074/jbc.m510628200","title":"Identification of Amino Acids in HIV-1 and Avian Sarcoma Virus Integrase Subsites Required for Specific Recognition of the Long Terminal Repeat Ends","display_name":"Identification of Amino Acids in HIV-1 and Avian Sarcoma Virus Integrase Subsites Required for Specific Recognition of the Long Terminal Repeat Ends","publication_year":2005,"publication_date":"2005-11-19","ids":{"openalex":"https://openalex.org/W2043638353","doi":"https://doi.org/10.1074/jbc.m510628200","mag":"2043638353","pmid":"https://pubmed.ncbi.nlm.nih.gov/16298997","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2656937"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m510628200","doi":"https://doi.org/10.1074/jbc.m510628200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m510628200","pdf_url":"http://www.jbc.org/article/S0021925819484007/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819484007/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058589650","display_name":"Aiping Chen","orcid":"https://orcid.org/0000-0002-0103-5008","observed_orcids":["https://orcid.org/0000-0002-0103-5008"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aiping Chen","raw_affiliation_strings":["Department of Microbiology and Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA","Department of Microbiology and Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077368913","display_name":"Irene T. Weber","orcid":"https://orcid.org/0000-0003-4876-7393","observed_orcids":["https://orcid.org/0000-0003-4876-7393"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene T. Weber","raw_affiliation_strings":["Department of Biology, Georgia State University, Atlanta, Georgia 30303"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Georgia State University, Atlanta, Georgia 30303","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007378854","display_name":"Robert W. Harrison","orcid":"https://orcid.org/0000-0003-2449-1214","observed_orcids":["https://orcid.org/0000-0003-2449-1214"]},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Harrison","raw_affiliation_strings":["Department of Computer Science, Georgia State University, Atlanta, Georgia 30303"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Georgia State University, Atlanta, Georgia 30303","institution_ids":["https://openalex.org/I181565077"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017138813","display_name":"Jonathan P. Leis","orcid":"https://orcid.org/0000-0003-1625-1296","observed_orcids":["https://orcid.org/0000-0003-1625-1296"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan Leis","raw_affiliation_strings":["Department of Microbiology and Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017138813"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5381,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.79564366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"281","issue":"7","first_page":"4173","last_page":"4182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.6182000041007996,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.6182000041007996,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.33180001378059387,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-integrase","display_name":"HIV-1 integrase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/long-terminal-repeat","display_name":"long terminal repeat","score":0.734000027179718},{"id":"https://openalex.org/keywords/integrase-dna-complex","display_name":"integrase-DNA complex","score":0.6579999923706055},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.5839999914169312},{"id":"https://openalex.org/keywords/3-processing","display_name":"3'-processing","score":0.6990000009536743},{"id":"https://openalex.org/keywords/integrase-inhibitors","display_name":"integrase inhibitors","score":0.5370000004768372},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9129999876022339}],"concepts":[{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.9066094160079956},{"id":"https://openalex.org/C199491388","wikidata":"https://www.wikidata.org/wiki/Q1869477","display_name":"Long terminal repeat","level":4,"score":0.6560542583465576},{"id":"https://openalex.org/C2779664074","wikidata":"https://www.wikidata.org/wiki/Q3518405","display_name":"Terminal (telecommunication)","level":2,"score":0.6466739773750305},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5955187082290649},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5914960503578186},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5786418914794922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4652140438556671},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43797656893730164},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4279111921787262},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.42288467288017273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4196043014526367},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24178773164749146},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.19361940026283264},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16850778460502625},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001358","descriptor_name":"Avian Sarcoma Viruses","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016325","descriptor_name":"HIV Long Terminal Repeat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019429","descriptor_name":"Integrase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020079","descriptor_name":"Terminal Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m510628200","doi":"https://doi.org/10.1074/jbc.m510628200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m510628200","pdf_url":"http://www.jbc.org/article/S0021925819484007/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16298997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16298997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2656937","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2656937","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m510628200","doi":"https://doi.org/10.1074/jbc.m510628200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m510628200","pdf_url":"http://www.jbc.org/article/S0021925819484007/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3581477646","display_name":"Activity of Resistant Variants of HIV Protease","funder_award_id":"R01GM062920","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5504049364","display_name":null,"funder_award_id":"GM065762","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G6952773419","display_name":"Georgia State University Biomedical Computing Center","funder_award_id":"P20GM065762","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G803258200","display_name":null,"funder_award_id":"GM 62920","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8086733083","display_name":"Inhibition of Resistant Variants of HIV Protease","funder_award_id":"U01GM062920","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8456365351","display_name":"Late Replication Functions of Retroviruses","funder_award_id":"R01CA052047","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306352","display_name":"Georgia Cancer Coalition","ror":"https://ror.org/0009gvn90"},{"id":"https://openalex.org/F4320310224","display_name":"Georgia Research Alliance","ror":"https://ror.org/030689123"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043638353.pdf","grobid_xml":"https://content.openalex.org/works/W2043638353.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W218277912","https://openalex.org/W243075437","https://openalex.org/W1581248668","https://openalex.org/W1601304840","https://openalex.org/W1629201894","https://openalex.org/W1639318658","https://openalex.org/W1668032639","https://openalex.org/W1763828525","https://openalex.org/W1966815449","https://openalex.org/W1966876898","https://openalex.org/W1967108405","https://openalex.org/W1970513059","https://openalex.org/W1971876468","https://openalex.org/W1971927521","https://openalex.org/W1972252864","https://openalex.org/W1972824210","https://openalex.org/W1976396232","https://openalex.org/W1978523876","https://openalex.org/W1978909186","https://openalex.org/W1979989142","https://openalex.org/W1980189596","https://openalex.org/W1984675480","https://openalex.org/W1994576403","https://openalex.org/W1996161025","https://openalex.org/W1997614299","https://openalex.org/W2000074281","https://openalex.org/W2001131743","https://openalex.org/W2001789973","https://openalex.org/W2008914226","https://openalex.org/W2013083986","https://openalex.org/W2014711863","https://openalex.org/W2025107875","https://openalex.org/W2032891258","https://openalex.org/W2034124053","https://openalex.org/W2042471904","https://openalex.org/W2048072877","https://openalex.org/W2051530245","https://openalex.org/W2059559197","https://openalex.org/W2062638179","https://openalex.org/W2066661888","https://openalex.org/W2071817010","https://openalex.org/W2075107877","https://openalex.org/W2078425785","https://openalex.org/W2084182355","https://openalex.org/W2085992210","https://openalex.org/W2087400133","https://openalex.org/W2089128598","https://openalex.org/W2113540822","https://openalex.org/W2118146222","https://openalex.org/W2124211547","https://openalex.org/W2126628372","https://openalex.org/W2130479394","https://openalex.org/W2131567422","https://openalex.org/W2131934220","https://openalex.org/W2132100443","https://openalex.org/W2132289602","https://openalex.org/W2135779026","https://openalex.org/W2139601584","https://openalex.org/W2144026217","https://openalex.org/W2144666203","https://openalex.org/W2145883097","https://openalex.org/W2147466111","https://openalex.org/W2151389386","https://openalex.org/W2155439940","https://openalex.org/W2156079813","https://openalex.org/W2158733225","https://openalex.org/W2159693659","https://openalex.org/W2164153625","https://openalex.org/W2166420278","https://openalex.org/W2167278859","https://openalex.org/W2169552983","https://openalex.org/W2171711893"],"related_works":["https://openalex.org/W2019549300","https://openalex.org/W2008914226","https://openalex.org/W7096081626","https://openalex.org/W2129878840","https://openalex.org/W2105648514","https://openalex.org/W1972130106","https://openalex.org/W2151125384","https://openalex.org/W2107777256","https://openalex.org/W1580662015","https://openalex.org/W1965883561"],"abstract_inverted_index":{"A":[0,49],"tetramer":[1],"model":[2],"for":[3,79],"HIV-1":[4,100,113,148,168,170,237],"integrase":[5],"(IN)":[6],"with":[7,45,130,157,209,211,225],"DNA":[8],"representing":[9],"20":[10],"bp":[11],"of":[12,53,67,82,99,105,136,143,189,195,197,221,265,276],"the":[13,39,46,83,86,95,103,106,131,144,162,166,198,219,222,226,229,266],"U3":[14],"and":[15,26,29,59,102,133,181,234,252],"U5":[16,112,199],"long":[17],"terminal":[18],"repeats":[19],"(LTR)":[20],"termini":[21],"was":[22,118],"assembled":[23],"using":[24],"structural":[25,51],"biochemical":[27],"data":[28],"molecular":[30],"dynamics":[31],"simulations.":[32],"It":[33],"predicted":[34,65],"amino":[35,87,127,139,213,259],"acid":[36,128,214,260],"residues":[37,69,76,172,232,261],"on":[38],"enzyme":[40],"surface":[41],"that":[42,123,134,173,186,218,242,246,272],"can":[43],"interact":[44],"LTR":[47,84],"termini.":[48],"separate":[50],"alignment":[52],"HIV-1,":[54],"simian":[55],"sarcoma":[56,61],"virus":[57,62],"(SIV),":[58],"avian":[60],"(ASV)":[63],"INs":[64],"which":[66],"these":[68,75,190,270],"were":[70,77,92],"unique.":[71],"To":[72],"determine":[73],"whether":[74],"responsible":[78],"specific":[80],"recognition":[81,264],"termini,":[85],"acids":[88,140],"from":[89],"ASV":[90,115,137,155,200,206],"IN":[91,138,149,171,207,223,238],"substituted":[93],"into":[94],"structurally":[96],"equivalent":[97],"positions":[98,146,271],"IN,":[101],"ability":[104,152,163],"chimeras":[107,210],"to":[108,153,164,203,249],"3":[109],"'":[110],"process":[111],"or":[114],"duplex":[116],"oligos":[117],"determined.":[119],"This":[120],"analysis":[121],"demonstrated":[122],"there":[124],"are":[125,239,268],"multiple":[126],"contacts":[129],"LTRs":[132,227,267],"substitution":[135],"at":[141],"many":[142],"analogous":[145],"in":[147,161,236,244,256,263,274],"conferred":[150],"partial":[151],"cleave":[154,165],"substrates":[156],"a":[158,184,193],"concomitant":[159],"loss":[160],"homologous":[167],"substrate.":[169],"changed":[174],"specificity":[175,194],"include":[176],"Val(72),":[177],"Ser(153),":[178],"Lys(160)-Ile(161),":[179],"Gly(163)-Val(165),":[180],"His(171)-Leu(172).":[182],"Because":[183],"chimera":[185],"combines":[187],"several":[188],"substitutions":[191],"showed":[192],"cleavage":[196],"substrate":[201],"closer":[202],"wild":[204],"type":[205],"compared":[208],"individual":[212],"substitutions,":[215],"it":[216],"appears":[217],"sum":[220],"interactions":[224],"determines":[228],"specificity.":[230],"Finally,":[231],"Ser(153)":[233],"Val(72)":[235],"among":[240,269],"those":[241],"change":[243,273],"enzymes":[245],"develop":[247],"resistance":[248],"naphthyridine":[250],"carboxamide-":[251],"diketo":[253],"acid-related":[254],"inhibitors":[255],"cells.":[257],"Thus,":[258],"involved":[262],"development":[275],"drug":[277],"resistance.":[278]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
