{"id":"https://openalex.org/W2043636588","doi":"https://doi.org/10.1111/1523-1747.ep12482303","title":"Adrenocortical Hydroxylase Deficiencies In Acne Vulgaris","display_name":"Adrenocortical Hydroxylase Deficiencies In Acne Vulgaris","publication_year":1976,"publication_date":"1976-05-01","ids":{"openalex":"https://openalex.org/W2043636588","doi":"https://doi.org/10.1111/1523-1747.ep12482303","mag":"2043636588","pmid":"https://pubmed.ncbi.nlm.nih.gov/178807"},"language":"en","primary_location":{"id":"doi:10.1111/1523-1747.ep12482303","doi":"https://doi.org/10.1111/1523-1747.ep12482303","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1523-1747.ep12482303","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1111/1523-1747.ep12482303","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110052335","display_name":"Leslie I. Rose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie I. Rose","raw_affiliation_strings":["Department of Dermatology, Boston University Medical Center, Boston, Massachusetts, U. S. A","Endocrine-Metabolic Unit, Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Boston, Massachusetts, U. S. A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Boston University Medical Center, Boston, Massachusetts, U. S. A","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"Endocrine-Metabolic Unit, Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Boston, Massachusetts, U. S. A","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054246070","display_name":"Stephen R. Newmark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen R. Newmark","raw_affiliation_strings":["Department of Dermatology, Boston University Medical Center, Boston, Massachusetts, U. S. A","Endocrine-Metabolic Unit, Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Boston, Massachusetts, U. S. A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Boston University Medical Center, Boston, Massachusetts, U. S. A","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"Endocrine-Metabolic Unit, Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Boston, Massachusetts, U. S. A","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039084377","display_name":"John S. Strauss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S. Strauss","raw_affiliation_strings":["Department of Dermatology, Boston University Medical Center, Boston, Massachusetts, U. S. A","Endocrine-Metabolic Unit, Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Boston, Massachusetts, U. S. A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Boston University Medical Center, Boston, Massachusetts, U. S. A","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"Endocrine-Metabolic Unit, Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Boston, Massachusetts, U. S. A","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067757102","display_name":"Peter E. Pochi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter E. Pochi","raw_affiliation_strings":["Department of Dermatology, Boston University Medical Center, Boston, Massachusetts, U. S. A","Endocrine-Metabolic Unit, Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Boston, Massachusetts, U. S. A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Boston University Medical Center, Boston, Massachusetts, U. S. A","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]},{"raw_affiliation_string":"Endocrine-Metabolic Unit, Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School, Boston, Massachusetts, U. S. A","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":4.4781,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.94246436,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"66","issue":"5","first_page":"324","last_page":"326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.573199987411499,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.573199987411499,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.3700999915599823,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.9300000071525574},{"id":"https://openalex.org/keywords/nodulocystic-acne","display_name":"nodulocystic acne","score":0.8960000276565552},{"id":"https://openalex.org/keywords/11beta-hydroxylase-deficiency","display_name":"11beta-hydroxylase deficiency","score":0.8379999995231628},{"id":"https://openalex.org/keywords/21-hydroxylase-deficiency","display_name":"21-hydroxylase deficiency","score":0.996999979019165},{"id":"https://openalex.org/keywords/adrenal-insufficiency","display_name":"adrenal insufficiency","score":0.8600000143051147},{"id":"https://openalex.org/keywords/acth-stimulation-test","display_name":"ACTH stimulation test","score":0.718999981880188},{"id":"https://openalex.org/keywords/tetrahydrocortisone","display_name":"tetrahydrocortisone","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pregnanetriol","display_name":"pregnanetriol","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.8974990844726562},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.600598156452179},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5753405690193176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5574656128883362},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.5254853367805481},{"id":"https://openalex.org/C2780321258","wikidata":"https://www.wikidata.org/wiki/Q21110736","display_name":"21-Hydroxylase","level":3,"score":0.5214866399765015},{"id":"https://openalex.org/C203531881","wikidata":"https://www.wikidata.org/wiki/Q415762","display_name":"Dopamine beta-monooxygenase","level":3,"score":0.50209641456604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4801163673400879},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.32998186349868774},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.22880324721336365},{"id":"https://openalex.org/C2777767042","wikidata":"https://www.wikidata.org/wiki/Q366868","display_name":"Congenital adrenal hyperplasia","level":2,"score":0.13944339752197266},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.0955469012260437}],"mesh":[{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003350","descriptor_name":"Cortodoxone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003350","descriptor_name":"Cortodoxone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011279","descriptor_name":"Pregnanetriol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013760","descriptor_name":"Tetrahydrocortisol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/1523-1747.ep12482303","doi":"https://doi.org/10.1111/1523-1747.ep12482303","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1523-1747.ep12482303","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},{"id":"pmid:178807","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/178807","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of investigative dermatology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/1523-1747.ep12482303","doi":"https://doi.org/10.1111/1523-1747.ep12482303","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1523-1747.ep12482303","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7400000095367432}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W394593572","https://openalex.org/W405219730","https://openalex.org/W1991321898","https://openalex.org/W2052482165","https://openalex.org/W2055337436","https://openalex.org/W2073342616","https://openalex.org/W2169859155","https://openalex.org/W2336011011","https://openalex.org/W2406063469","https://openalex.org/W2412616868","https://openalex.org/W2474292480","https://openalex.org/W7073776192"],"related_works":["https://openalex.org/W2405623538","https://openalex.org/W2113812502","https://openalex.org/W2008982824","https://openalex.org/W3151866245","https://openalex.org/W2162518053","https://openalex.org/W2949298804","https://openalex.org/W2072881978","https://openalex.org/W2050981793","https://openalex.org/W2414153383","https://openalex.org/W4319706183"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}