{"id":"https://openalex.org/W2043547351","doi":"https://doi.org/10.1002/art.1780400219","title":"HLA markers and prediction of clinical course and outcome in rheumatoid arthritis","display_name":"HLA markers and prediction of clinical course and outcome in rheumatoid arthritis","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W2043547351","doi":"https://doi.org/10.1002/art.1780400219","mag":"2043547351","pmid":"https://pubmed.ncbi.nlm.nih.gov/9041946"},"language":"en","primary_location":{"id":"doi:10.1002/art.1780400219","doi":"https://doi.org/10.1002/art.1780400219","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780400219","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080266763","display_name":"Ulf G. Wagner","orcid":"https://orcid.org/0000-0002-8106-4924","observed_orcids":["https://orcid.org/0000-0002-8106-4924"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulf Wagner","raw_affiliation_strings":["University of Leipzig, Germany","University of Leipzig, Leipzig, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"University of Leipzig, Leipzig, Germany,","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003382603","display_name":"Sylke Kaltenh\u00e4user","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sylke Kaltenh\u00e4user","raw_affiliation_strings":["University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005067611","display_name":"Heidemarie Sauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heidemarie Sauer","raw_affiliation_strings":["University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033904095","display_name":"Sybille Arnold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sybille Arnold","raw_affiliation_strings":["University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wolfram Seidel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfram Seidel","raw_affiliation_strings":["University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113760028","display_name":"Holm Ha\u0308ntzschel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Holm H\u00e4ntzschel","raw_affiliation_strings":["University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105366464","display_name":"Joachim R. Kalden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim R. Kalden","raw_affiliation_strings":["University of Erlangen-Nuremberg, Erlangen, Germany","University of Erlangen - Nuremberg, Erlangen, Germany#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Erlangen-Nuremberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"University of Erlangen - Nuremberg, Erlangen, Germany#TAB#","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087250571","display_name":"Ralf Wa\u00dfmuth","orcid":"https://orcid.org/0000-0002-9481-3533","observed_orcids":["https://orcid.org/0000-0002-9481-3533"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ralf Wassmuth","raw_affiliation_strings":["University of Erlangen-Nuremberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Erlangen-Nuremberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087250571"],"corresponding_institution_ids":["https://openalex.org/I181369854"],"apc_list":null,"apc_paid":null,"fwci":9.7858,"has_fulltext":false,"cited_by_count":164,"citation_normalized_percentile":{"value":0.98713378,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"40","issue":"2","first_page":"341","last_page":"351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-dr4","display_name":"HLA-DR4","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hla-drb1","display_name":"HLA-DRB1","score":0.800000011920929},{"id":"https://openalex.org/keywords/shared-epitope","display_name":"shared epitope","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hla-b27","display_name":"HLA-B27","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hla-typing","display_name":"HLA typing","score":0.7390000224113464},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.5889999866485596},{"id":"https://openalex.org/keywords/joint-damage","display_name":"joint destruction","score":0.8510000109672546},{"id":"https://openalex.org/keywords/larsen-score","display_name":"Larsen score","score":0.7900000214576721},{"id":"https://openalex.org/keywords/bony-erosion","display_name":"bony erosion","score":0.8420000076293945},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7390000224113464},{"id":"https://openalex.org/keywords/hla-dqb1","display_name":"HLA-DQB1","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7605697512626648},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.697218656539917},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6426396369934082},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6261507272720337},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5649926662445068},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5417332053184509},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5229307413101196},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.4960215985774994},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4906074106693268},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4830211102962494},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4647231698036194},{"id":"https://openalex.org/C2781142222","wikidata":"https://www.wikidata.org/wiki/Q20771631","display_name":"HLA-DRB1","level":4,"score":0.46011167764663696},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.45548975467681885},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4125218391418457},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.38265836238861084},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2252253293991089},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.19852083921432495},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1893576681613922},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14204037189483643},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12864983081817627},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05371859669685364}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.1780400219","doi":"https://doi.org/10.1002/art.1780400219","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.1780400219","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},{"id":"pmid:9041946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9041946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W63164486","https://openalex.org/W85496269","https://openalex.org/W1770937742","https://openalex.org/W1943930181","https://openalex.org/W1981729436","https://openalex.org/W1991776074","https://openalex.org/W1994532401","https://openalex.org/W1995907576","https://openalex.org/W2000332027","https://openalex.org/W2000677694","https://openalex.org/W2000784101","https://openalex.org/W2004305229","https://openalex.org/W2005817811","https://openalex.org/W2009188224","https://openalex.org/W2012603448","https://openalex.org/W2015865604","https://openalex.org/W2018867904","https://openalex.org/W2018972580","https://openalex.org/W2026794605","https://openalex.org/W2033316593","https://openalex.org/W2033714424","https://openalex.org/W2035064373","https://openalex.org/W2039933977","https://openalex.org/W2049232082","https://openalex.org/W2053921549","https://openalex.org/W2055713807","https://openalex.org/W2056194258","https://openalex.org/W2058253357","https://openalex.org/W2059274025","https://openalex.org/W2063136106","https://openalex.org/W2063273369","https://openalex.org/W2065419533","https://openalex.org/W2067360524","https://openalex.org/W2067601762","https://openalex.org/W2067808278","https://openalex.org/W2072973878","https://openalex.org/W2072994428","https://openalex.org/W2074957160","https://openalex.org/W2088180658","https://openalex.org/W2091943129","https://openalex.org/W2092479353","https://openalex.org/W2118347756","https://openalex.org/W2120218143","https://openalex.org/W2126695984","https://openalex.org/W2129120773","https://openalex.org/W2129926417","https://openalex.org/W2130709219","https://openalex.org/W2133692536","https://openalex.org/W2135577623","https://openalex.org/W2141425840","https://openalex.org/W2144634347","https://openalex.org/W2146503957","https://openalex.org/W2150000105","https://openalex.org/W2151680402","https://openalex.org/W2152348310","https://openalex.org/W2163424852","https://openalex.org/W2182205274","https://openalex.org/W2206746226","https://openalex.org/W2314225431","https://openalex.org/W2400683346","https://openalex.org/W2407086039","https://openalex.org/W2409302360","https://openalex.org/W4211121166","https://openalex.org/W4285719527","https://openalex.org/W4293874313"],"related_works":["https://openalex.org/W2239684587","https://openalex.org/W2131736368","https://openalex.org/W1967671306","https://openalex.org/W2411345769","https://openalex.org/W2135762853","https://openalex.org/W2080988284","https://openalex.org/W2049232082","https://openalex.org/W2110562282","https://openalex.org/W2154266855","https://openalex.org/W2088408525"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"HLA":[3,17,77,284],"markers":[4,78,302],"as":[5,58,60],"early":[6,253],"prognostic":[7],"factors":[8],"for":[9,48,175,303],"disease":[10,255],"severity":[11],"in":[12,22,31,84,110,143,149,244,309],"rheumatoid":[13],"arthritis":[14],"(RA).":[15],"METHODS:":[16],"genotyping":[18,295],"was":[19,67,79,139,277],"carried":[20],"out":[21],"a":[23,32,188,201,247,259,269],"retrospective":[24],"analysis":[25,167],"of":[26,35,65,76,131,168,178,211,237,251,262,271,283,290,306],"66":[27],"RA":[28,37,66,109,291],"patients":[29,38,147,151,199,229],"and":[30,39,53,71,99,117,119,123,296],"prospective":[33,196],"study":[34],"55":[36],"87":[40],"healthy":[41],"controls":[42],"using":[43,88],"polymerase":[44],"chain":[45],"reaction-based":[46],"methods":[47],"HLA-DRB1":[49],"specificities,":[50],"DR4":[51,97,189,242,297],"alleles,":[52,57],"their":[54],"linked":[55],"DQB1":[56],"well":[59],"HLA-B27.":[61],"The":[62,74],"clinical":[63,70],"course":[64],"assessed":[68],"by":[69,81],"radiologic":[72,129],"scores.":[73],"impact":[75],"evaluated":[80],"epidemiologic":[82],"means":[83],"addition":[85],"to":[86,268,286],"modeling":[87],"multiple":[89],"logistic":[90],"regression":[91],"analysis.":[92],"RESULTS:":[93],"Shared":[94],"epitope-positive":[95,146,218],"(HVR3+)":[96],"alleles":[98],"the":[100,176,179,195,235,238,265,274,281,288,304],"HVR3":[101,144,181,217,239,275],"amino":[102],"acid":[103],"cassette":[104],"QKRAA":[105],"were":[106],"associated":[107],"with":[108,257],"both":[111],"longstanding":[112,127],"(relative":[113],"risk":[114,204,261],"[RR]":[115],"3.34":[116],"3.19)":[118],"recent-onset":[120],"(RR":[121],"2.1":[122],"2.37)":[124],"RA.":[125,310],"In":[126,194,215,233],"RA,":[128],"evidence":[130],"severe":[132],"joint":[133,307],"destruction":[134,308],"(Larsen":[135],"score":[136],">":[137],"1.62)":[138],"seen":[140],"more":[141],"often":[142],"shared":[145],"than":[148,226],"epitope-negative":[150,228],"(odds":[152],"ratio":[153],"[OR]":[154],"=":[155,159,162,206,209,231],"25.67,":[156],"chi":[157],"2":[158],"13.59,":[160],"P":[161,208],"0.0003).":[163],"Moreover,":[164],"rank":[165],"sum":[166],"Larsen":[169,224],"indices":[170,225],"indicated":[171],"significantly":[172,202,222],"higher":[173,223],"ranking":[174],"presence":[177,236],"RA-associated":[180],"cassettes":[182],"(QKRAA,":[183],"QRRAA)":[184],"when":[185,273],"expressed":[186],"on":[187,241],"allele":[190],"(P":[191,230],"<":[192],"0.0001).":[193],"study,":[197],"DR4-positive":[198,219],"had":[200,221],"increased":[203,246],"(OR":[205],"13.75,":[207],"0.00083)":[210],"developing":[212,252],"bony":[213],"erosions.":[214],"addition,":[216],"individuals":[220],"did":[227],"0.0083).":[232],"particular,":[234],"epitope":[240,276],"resulted":[243],"an":[245,258],"posteriori":[248],"likelihood":[249,266],"(0.91)":[250],"erosive":[254],"compared":[256],"priori":[260],"0.62.":[263],"Conversely,":[264],"decreased":[267],"minimum":[270],"0.35":[272],"absent.":[278],"CONCLUSION:":[279],"While":[280],"contribution":[282],"typing":[285],"establishing":[287],"diagnosis":[289],"is":[292],"limited,":[293],"HLA-DR":[294],"subtype":[298],"determination":[299],"provide":[300],"valuable":[301],"prognosis":[305]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}