{"id":"https://openalex.org/W204352806","doi":null,"title":"Studies on the mechanism of action of synthetic ligands of the vitamin D and estrogen receptor","display_name":"Studies on the mechanism of action of synthetic ligands of the vitamin D and estrogen receptor","publication_year":2000,"publication_date":"2000-06-21","ids":{"openalex":"https://openalex.org/W204352806","mag":"204352806"},"language":"en","primary_location":{"id":"pmh:eur:oai:pure.eur.nl:publications/68cab3b3-a4c5-448f-92da-07c728766aff","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/68cab3b3-a4c5-448f-92da-07c728766aff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.eur.nl/en/publications/68cab3b3-a4c5-448f-92da-07c728766aff","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110047777","display_name":"Gert-Jan C.M. van den Bemd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gert-Jan C.M. van den Bemd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110047777"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.8730000257492065},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/synthetic-ligands","display_name":"synthetic ligands","score":0.8610000014305115},{"id":"https://openalex.org/keywords/nuclear-receptor-superfamily","display_name":"nuclear receptor superfamily","score":0.8700000047683716},{"id":"https://openalex.org/keywords/nuclear-receptors","display_name":"nuclear receptors","score":0.7129999995231628},{"id":"https://openalex.org/keywords/orphan-receptors","display_name":"orphan receptors","score":0.6769999861717224},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7870000004768372},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/hormone-signaling","display_name":"hormone signaling","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.757195770740509},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5966148972511292},{"id":"https://openalex.org/C91977512","wikidata":"https://www.wikidata.org/wiki/Q5401840","display_name":"Estrogen-related receptor gamma","level":5,"score":0.5377711057662964},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5048304200172424},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.48023301362991333},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4662111699581146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4402565658092499},{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.4382559359073639},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4092247188091278},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39369094371795654},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3067401647567749},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17508074641227722},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09875151515007019},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.07299685478210449},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.06599920988082886},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:eur:oai:pure.eur.nl:publications/68cab3b3-a4c5-448f-92da-07c728766aff","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/68cab3b3-a4c5-448f-92da-07c728766aff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:eur:oai:repub.eur.nl:20903","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/20903","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:repub.eur.nl:20903","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/20903","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:204352806","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/20903/000621_BEMD,%20Gerardus%20Johannes%20Christianus%20Maria%20van%20den.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:eur:oai:pure.eur.nl:publications/68cab3b3-a4c5-448f-92da-07c728766aff","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/68cab3b3-a4c5-448f-92da-07c728766aff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":206,"referenced_works":["https://openalex.org/W8163034","https://openalex.org/W52464067","https://openalex.org/W74071586","https://openalex.org/W97058622","https://openalex.org/W141885532","https://openalex.org/W149653398","https://openalex.org/W172016679","https://openalex.org/W577903043","https://openalex.org/W1450960572","https://openalex.org/W1484077429","https://openalex.org/W1493268813","https://openalex.org/W1493670259","https://openalex.org/W1502127219","https://openalex.org/W1502667688","https://openalex.org/W1508371220","https://openalex.org/W1511815964","https://openalex.org/W1536741835","https://openalex.org/W1542612172","https://openalex.org/W1547137876","https://openalex.org/W1556751235","https://openalex.org/W1559756705","https://openalex.org/W1562960938","https://openalex.org/W1575847274","https://openalex.org/W1576708287","https://openalex.org/W1577399617","https://openalex.org/W1584929737","https://openalex.org/W1593089530","https://openalex.org/W1594016728","https://openalex.org/W1761190703","https://openalex.org/W1761203024","https://openalex.org/W1824560696","https://openalex.org/W1935820490","https://openalex.org/W1964520022","https://openalex.org/W1966089335","https://openalex.org/W1966543555","https://openalex.org/W1966840258","https://openalex.org/W1967725980","https://openalex.org/W1968905365","https://openalex.org/W1969872038","https://openalex.org/W1970028985","https://openalex.org/W1970536654","https://openalex.org/W1971960644","https://openalex.org/W1972051996","https://openalex.org/W1972626885","https://openalex.org/W1974985398","https://openalex.org/W1976535459","https://openalex.org/W1976727956","https://openalex.org/W1978313171","https://openalex.org/W1978593433","https://openalex.org/W1980915931","https://openalex.org/W1981686096","https://openalex.org/W1982886830","https://openalex.org/W1982925298","https://openalex.org/W1984593949","https://openalex.org/W1985780256","https://openalex.org/W1985793650","https://openalex.org/W1986445986","https://openalex.org/W1988094018","https://openalex.org/W1988474964","https://openalex.org/W1989254457","https://openalex.org/W1989569585","https://openalex.org/W1989946604","https://openalex.org/W1990613292","https://openalex.org/W1991385685","https://openalex.org/W1991530706","https://openalex.org/W1997883187","https://openalex.org/W1998389355","https://openalex.org/W1999426074","https://openalex.org/W1999466810","https://openalex.org/W2003065493","https://openalex.org/W2003991752","https://openalex.org/W2005198065","https://openalex.org/W2008071275","https://openalex.org/W2009354488","https://openalex.org/W2011158289","https://openalex.org/W2011230305","https://openalex.org/W2011306206","https://openalex.org/W2014996017","https://openalex.org/W2016677964","https://openalex.org/W2017872323","https://openalex.org/W2018312028","https://openalex.org/W2018397818","https://openalex.org/W2018434594","https://openalex.org/W2018872863","https://openalex.org/W2018992450","https://openalex.org/W2020383053","https://openalex.org/W2020475848","https://openalex.org/W2022402033","https://openalex.org/W2026927522","https://openalex.org/W2028995035","https://openalex.org/W2032250517","https://openalex.org/W2032314634","https://openalex.org/W2033535637","https://openalex.org/W2033845763","https://openalex.org/W2034830752","https://openalex.org/W2035325833","https://openalex.org/W2035966078","https://openalex.org/W2036095119","https://openalex.org/W2036684049","https://openalex.org/W2036739307","https://openalex.org/W2036915597","https://openalex.org/W2041149796","https://openalex.org/W2042571781","https://openalex.org/W2043935272","https://openalex.org/W2044898104","https://openalex.org/W2047182075","https://openalex.org/W2049469779","https://openalex.org/W2049970571","https://openalex.org/W2050415824","https://openalex.org/W2050585917","https://openalex.org/W2050712584","https://openalex.org/W2052190886","https://openalex.org/W2055170266","https://openalex.org/W2055255490","https://openalex.org/W2056475405","https://openalex.org/W2057770598","https://openalex.org/W2058649944","https://openalex.org/W2060513558","https://openalex.org/W2060868921","https://openalex.org/W2063115908","https://openalex.org/W2064072544","https://openalex.org/W2064148273","https://openalex.org/W2065065492","https://openalex.org/W2065251369","https://openalex.org/W2065581228","https://openalex.org/W2065897358","https://openalex.org/W2065939432","https://openalex.org/W2066441904","https://openalex.org/W2067016974","https://openalex.org/W2067827365","https://openalex.org/W2070440733","https://openalex.org/W2071482777","https://openalex.org/W2072787342","https://openalex.org/W2073069241","https://openalex.org/W2073353512","https://openalex.org/W2073870011","https://openalex.org/W2075788654","https://openalex.org/W2076452736","https://openalex.org/W2077247212","https://openalex.org/W2077769735","https://openalex.org/W2077901864","https://openalex.org/W2077990449","https://openalex.org/W2078061304","https://openalex.org/W2078537014","https://openalex.org/W2079706694","https://openalex.org/W2080859080","https://openalex.org/W2081008474","https://openalex.org/W2081684816","https://openalex.org/W2082267816","https://openalex.org/W2083629837","https://openalex.org/W2085039492","https://openalex.org/W2090185686","https://openalex.org/W2090464853","https://openalex.org/W2090507834","https://openalex.org/W2091189600","https://openalex.org/W2094532438","https://openalex.org/W2104161119","https://openalex.org/W2112284849","https://openalex.org/W2114849059","https://openalex.org/W2115642441","https://openalex.org/W2115704169","https://openalex.org/W2116861666","https://openalex.org/W2117717795","https://openalex.org/W2121096379","https://openalex.org/W2121331880","https://openalex.org/W2124669319","https://openalex.org/W2125528036","https://openalex.org/W2128517839","https://openalex.org/W2129716853","https://openalex.org/W2130906576","https://openalex.org/W2141269411","https://openalex.org/W2141883546","https://openalex.org/W2143995270","https://openalex.org/W2146408916","https://openalex.org/W2146868272","https://openalex.org/W2147673480","https://openalex.org/W2154377786","https://openalex.org/W2155391261","https://openalex.org/W2155557639","https://openalex.org/W2156422955","https://openalex.org/W2159196715","https://openalex.org/W2161623422","https://openalex.org/W2162741492","https://openalex.org/W2166517626","https://openalex.org/W2169357450","https://openalex.org/W2170521004","https://openalex.org/W2232187868","https://openalex.org/W2270618226","https://openalex.org/W2271404641","https://openalex.org/W2315992235","https://openalex.org/W2321613759","https://openalex.org/W2324075496","https://openalex.org/W2327168254","https://openalex.org/W2402734845","https://openalex.org/W2411375596","https://openalex.org/W2412455435","https://openalex.org/W2413810383","https://openalex.org/W2418219134","https://openalex.org/W2423286303","https://openalex.org/W2432454464","https://openalex.org/W2436737030","https://openalex.org/W2468086406","https://openalex.org/W2520916097","https://openalex.org/W2523151605","https://openalex.org/W2917608490","https://openalex.org/W4229813223"],"related_works":["https://openalex.org/W180493639","https://openalex.org/W60067182","https://openalex.org/W2906791280","https://openalex.org/W61832670","https://openalex.org/W1997344747","https://openalex.org/W2102631878","https://openalex.org/W3022744766","https://openalex.org/W7096947303","https://openalex.org/W2076452736","https://openalex.org/W2475190998"],"abstract_inverted_index":{"Nuclear":[0],"hormones":[1],"play":[2],"a":[3,24,58],"key":[4],"role":[5],"in":[6,16,32],"embtyonic":[7],"development,":[8],"growth":[9],"and\\\\ndifferentiation":[10],"of":[11,18,27,61],"cells":[12],"and":[13,15,55,69],"tissues,":[14],"maintenance":[17],"homeostasis.":[19],"They":[20],"exert\\\\ntheir":[21],"action":[22],"via":[23],"large":[25,59],"group":[26],"nuclear,":[28],"transctiption":[29],"factors":[30],"gathered":[31],"the\\\\nnuclear":[33],"receptor":[34],"superfamily.":[35],"This":[36],"superfamily":[37],"consists":[38],"of\\\\nreceptors":[39],"for":[40,49],"estrogen,":[41],"glucocorticoid,":[42],"mineralocotlicoid,":[43],"androgen,":[44],"progesterone,\\\\nbut":[45],"also":[46],"contains":[47],"receptors":[48,64],"vitamin":[50],"D,":[51],"retinoids,":[52],"fatty":[53],"acids,":[54],"thyroid\\\\nhormone.":[56],"Futlhetmore,":[57],"number":[60],"so-called":[62],"orphan":[63],"are":[65,71],"included\\\\nfor":[66],"which":[67],"ligands":[68],"functions":[70],"at":[72],"the":[73],"moment":[74],"unknown.":[75]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}