{"id":"https://openalex.org/W2043437007","doi":"https://doi.org/10.1158/1538-7445.am2014-1278","title":"Abstract 1278: Vitamin D receptor Fok1 gene polymorphisms may be associated with CRC among African American and Hispanic participants","display_name":"Abstract 1278: Vitamin D receptor Fok1 gene polymorphisms may be associated with CRC among African American and Hispanic participants","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2043437007","doi":"https://doi.org/10.1158/1538-7445.am2014-1278","mag":"2043437007"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-1278","doi":"https://doi.org/10.1158/1538-7445.am2014-1278","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-1278","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112904956","display_name":"Marianna Sarkissyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52710748","display_name":"Charles R. Drew University of Medicine and Science","ror":"https://ror.org/038x2fh14","country_code":"US","type":"education","lineage":["https://openalex.org/I52710748"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marianna Sarkissyan","raw_affiliation_strings":["Charles Drew University of Medicine & Science, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles Drew University of Medicine & Science, Los Angeles, CA","institution_ids":["https://openalex.org/I52710748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020933664","display_name":"Yanyuan Wu","orcid":"https://orcid.org/0000-0003-0286-1800","observed_orcids":["https://orcid.org/0000-0003-0286-1800"]},"institutions":[{"id":"https://openalex.org/I52710748","display_name":"Charles R. Drew University of Medicine and Science","ror":"https://ror.org/038x2fh14","country_code":"US","type":"education","lineage":["https://openalex.org/I52710748"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanyuan Wu","raw_affiliation_strings":["Charles Drew University of Medicine & Science, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles Drew University of Medicine & Science, Los Angeles, CA","institution_ids":["https://openalex.org/I52710748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067990385","display_name":"Zuijan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52710748","display_name":"Charles R. Drew University of Medicine and Science","ror":"https://ror.org/038x2fh14","country_code":"US","type":"education","lineage":["https://openalex.org/I52710748"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zuijan Chen","raw_affiliation_strings":["Charles Drew University of Medicine & Science, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles Drew University of Medicine & Science, Los Angeles, CA","institution_ids":["https://openalex.org/I52710748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049932826","display_name":"Dhruva Kumar Mishra","orcid":"https://orcid.org/0000-0001-8651-005X","observed_orcids":["https://orcid.org/0000-0001-8651-005X"]},"institutions":[{"id":"https://openalex.org/I52710748","display_name":"Charles R. Drew University of Medicine and Science","ror":"https://ror.org/038x2fh14","country_code":"US","type":"education","lineage":["https://openalex.org/I52710748"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhruva Mishra","raw_affiliation_strings":["Charles Drew University of Medicine & Science, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles Drew University of Medicine & Science, Los Angeles, CA","institution_ids":["https://openalex.org/I52710748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028396260","display_name":"Suren Sarkissyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52710748","display_name":"Charles R. Drew University of Medicine and Science","ror":"https://ror.org/038x2fh14","country_code":"US","type":"education","lineage":["https://openalex.org/I52710748"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suren Sarkissyan","raw_affiliation_strings":["Charles Drew University of Medicine & Science, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles Drew University of Medicine & Science, Los Angeles, CA","institution_ids":["https://openalex.org/I52710748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033780533","display_name":"Ioannis Giannikopoulos","orcid":"https://orcid.org/0000-0001-5410-2748","observed_orcids":["https://orcid.org/0000-0001-5410-2748"]},"institutions":[{"id":"https://openalex.org/I52710748","display_name":"Charles R. Drew University of Medicine and Science","ror":"https://ror.org/038x2fh14","country_code":"US","type":"education","lineage":["https://openalex.org/I52710748"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ioannis Giannikopoulos","raw_affiliation_strings":["Charles Drew University of Medicine & Science, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles Drew University of Medicine & Science, Los Angeles, CA","institution_ids":["https://openalex.org/I52710748"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012585441","display_name":"Jaydutt V. Vadgama","orcid":"https://orcid.org/0000-0002-0019-8622","observed_orcids":["https://orcid.org/0000-0002-0019-8622"]},"institutions":[{"id":"https://openalex.org/I52710748","display_name":"Charles R. Drew University of Medicine and Science","ror":"https://ror.org/038x2fh14","country_code":"US","type":"education","lineage":["https://openalex.org/I52710748"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaydutt V. Vadgama","raw_affiliation_strings":["Charles Drew University of Medicine & Science, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles Drew University of Medicine & Science, Los Angeles, CA","institution_ids":["https://openalex.org/I52710748"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52710748"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"1278","last_page":"1278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/foki-polymorphism","display_name":"FokI polymorphism","score":0.8069999814033508},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8700000047683716},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8149999976158142},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hispanic-latino-populations","display_name":"Hispanic/Latino populations","score":0.9589999914169312},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.5199999809265137},{"id":"https://openalex.org/keywords/vdr-bsmi-polymorphism","display_name":"VDR BsmI polymorphism","score":0.7829999923706055},{"id":"https://openalex.org/keywords/vitamin-d-status","display_name":"vitamin D status","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.5370000004768372},{"id":"https://openalex.org/keywords/colorectal-polyps","display_name":"colorectal polyps","score":0.7369999885559082},{"id":"https://openalex.org/keywords/genetic-screening","display_name":"genetic screening","score":0.46399998664855957},{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.9507836103439331},{"id":"https://openalex.org/C2781308329","wikidata":"https://www.wikidata.org/wiki/Q986838","display_name":"FokI","level":5,"score":0.9227858781814575},{"id":"https://openalex.org/C2779105492","wikidata":"https://www.wikidata.org/wiki/Q4385680","display_name":"TaqI","level":5,"score":0.8733131885528564},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6640053987503052},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6211812496185303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6099646091461182},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5553657412528992},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.48612260818481445},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48174217343330383},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4762996435165405},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3677069842815399},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.3207232356071472},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29003599286079407},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2812718152999878},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21334019303321838},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2061229944229126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-1278","doi":"https://doi.org/10.1158/1538-7445.am2014-1278","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-1278","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1541585098","https://openalex.org/W2337387073","https://openalex.org/W4412651607","https://openalex.org/W3118906451","https://openalex.org/W2026034244","https://openalex.org/W2561179236","https://openalex.org/W3136131733","https://openalex.org/W1984344439","https://openalex.org/W4399884747","https://openalex.org/W2915439489"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"The":[2,134,260],"vitamin":[3,12,28,32,316,326],"D":[4,13,29,33,317,327,373],"pathway":[5],"plays":[6],"a":[7,51,174,244,321,335],"significant":[8,38,175,250,338],"role":[9],"through":[10],"the":[11,24,75,104,125,178,181,196,216,228,239,279,289,304,329,347,393,398],"receptor":[14,374],"(VDR)":[15],"in":[16,40,47,87,103,138,177,222,234,243,276,297,312],"cancer":[17,41,64,352],"tumorogenesis.":[18],"Interestingly,":[19],"although":[20],"African":[21,89,119,186,223,298,384],"Americans":[22],"have":[23],"lowest":[25],"levels":[26],"of":[27,56,98,116,127,180,265,278,288,337,392,397],"serum":[30,318],"levels,":[31],"supplementation":[34],"has":[35],"not":[36,272],"yielded":[37],"improvement":[39],"risk":[42,324],"and":[43,62,91,110,124,147,157,183,188,192,227,256,269,328,386],"outcome.":[44],"Gene":[45],"polymorphisms":[46,61,311,377],"VDR":[48,59,80,139,254,266,310,330],"may":[49,292,333,378],"play":[50],"role.":[52],"There":[53,172],"is":[54,73],"lack":[55],"information":[57],"on":[58],"gene":[60,376],"colorectal":[63],"(CRC)":[65],"among":[66,74,383],"underrepresented":[67],"ethnic":[68],"groups.":[69],"Hence,":[70],"this":[71],"study":[72,93,105,283],"first":[76],"to":[77,307,341,350],"examine":[78],"whether":[79],"SNPs,":[81],"single-nucleotide-gene-polymorphisms,":[82],"are":[83],"associated":[84,201,273,380],"with":[85,106,202,208,252,274,314,346,381],"CRC":[86,108,203,257,275,294,344,382],"predominately":[88],"American":[90,187,224,299,385,399],"Hispanic":[92,189,387],"participants.":[94,113,388],"Methods:":[95],"A":[96],"total":[97],"378":[99],"participants":[100,117,128,190,225,236],"were":[101,118,122,151,271],"included":[102],"78":[107],"patients":[109],"300":[111],"non-CRC":[112],"Forty":[114],"percent":[115],"American,":[120],"56%":[121],"Hispanic/Latino,":[123],"remainder":[126],"self-identified":[129],"as":[130],"Caucasian":[131],"or":[132],"Asian.":[133],"four":[135],"polymorphic":[136,263],"SNPs":[137,291],"-":[140,150],"FokI":[141],"(rs2228570),":[142],"BsmI":[143],"(rs1544410),":[144],"TaqI":[145,268],"(rs731236)":[146],"ApaI":[148],"(rs7975232)":[149],"genotyped":[152],"by":[153,167,214],"polymerase":[154],"chain":[155],"reaction":[156],"restriction":[158],"fragment":[159],"length":[160],"polymorphism":[161,255],"methods.":[162],"Statistical":[163],"Analysis":[164],"was":[165,173,200,219,231,241,248],"performed":[166],"using":[168],"SPSS":[169],"software.":[170],"Results:":[171],"difference":[176],"distribution":[179],"VDR-Fok1":[182,197],"VDR-Apa1polymorphisms":[184],"between":[185],"(P=0.006":[191],"0.009,":[193],"respectively).":[194],"Furthermore,":[195],"FF":[198,217],"genotype":[199,218,230],"(OR=2.9;":[204],"P=0.036)":[205],"when":[206],"compared":[207],"Controls":[209],"without":[210],"polyps.":[211],"Upon":[212],"breakdown":[213],"ethnicity,":[215],"most":[220,232],"common":[221,233],"(61%),":[226],"Ff":[229],"Hispanic/Latino":[235],"(49%).":[237],"When":[238],"association":[240,251],"assessed":[242],"multivariate":[245],"model,":[246],"there":[247],"no":[249],"any":[253,277],"Cases":[258],"(P>0.05).":[259],"other":[261],"three":[262],"variants":[264],"(BsmI,":[267],"ApaI)":[270],"analyses.":[280],"Conclusions:":[281],"This":[282],"suggests":[284],"that":[285],"genetic":[286],"variation":[287],"VDR-FokI":[290],"influence":[293],"risk,":[295,345],"particularly":[296],"cohorts.":[300],"These":[301],"findings":[302],"suggest":[303],"potential":[305],"need":[306],"screen":[308],"for":[309,401],"conjunction":[313],"screening":[315],"levels.":[319],"As":[320],"potentially":[322],"modifiable":[323],"factor,":[325],"mediated":[331],"axis":[332],"be":[334,379],"point":[336],"interventional":[339],"opportunity":[340],"effectively":[342],"reduce":[343,351],"overarching":[348],"goal":[349],"health":[353],"disparities.":[354],"Citation":[355],"Format:":[356],"Marianna":[357],"Sarkissyan,":[358,366],"Yanyuan":[359],"Wu,":[360],"Zuijan":[361],"Chen,":[362],"Dhruva":[363],"Mishra,":[364],"Suren":[365],"Ioannis":[367],"Giannikopoulos,":[368],"Jaydutt":[369],"V.":[370],"Vadgama.":[371],"Vitamin":[372],"Fok1":[375],"[abstract].":[389],"In:":[390],"Proceedings":[391],"105th":[394],"Annual":[395],"Meeting":[396],"Association":[400],"Cancer":[402,413],"Research;":[403],"2014":[404],"Apr":[405],"5-9;":[406],"San":[407],"Diego,":[408],"CA.":[409],"Philadelphia":[410],"(PA):":[411],"AACR;":[412],"Res":[414],"2014;74(19":[415],"Suppl):Abstract":[416],"nr":[417],"1278.":[418],"doi:10.1158/1538-7445.AM2014-1278":[419]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}