{"id":"https://openalex.org/W2043393405","doi":"https://doi.org/10.1097/00006123-198511000-00009","title":"Cerebrospinal Fluid Anion Transport: Studies of Pertechnetate in Unanesthetized Sheep","display_name":"Cerebrospinal Fluid Anion Transport: Studies of Pertechnetate in Unanesthetized Sheep","publication_year":1985,"publication_date":"1985-11-01","ids":{"openalex":"https://openalex.org/W2043393405","doi":"https://doi.org/10.1097/00006123-198511000-00009","mag":"2043393405","pmid":"https://pubmed.ncbi.nlm.nih.gov/2999637"},"language":"en","primary_location":{"id":"doi:10.1097/00006123-198511000-00009","doi":"https://doi.org/10.1097/00006123-198511000-00009","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006123-198511000-00009","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109221140","display_name":"Joseph R. Madsen","orcid":"https://orcid.org/0009-0001-5377-8997","observed_orcids":["https://orcid.org/0009-0001-5377-8997"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J R Madsen","raw_affiliation_strings":["Neurosurgical Service, Massachusetts General Hospital (J.R.M., P.McL.B.)","Surgical Service and Department of Radiology, Beth Israel Hospital (J.R.M., H.D.R., S.F.)","and the Harvard Medical School (J.R.M., P.McL.B., S.F., H.D.R.). Boston, Massachusetts","Massachusetts","P.McL.B.)","S.F.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgical Service, Massachusetts General Hospital (J.R.M., P.McL.B.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Surgical Service and Department of Radiology, Beth Israel Hospital (J.R.M., H.D.R., S.F.)","institution_ids":[]},{"raw_affiliation_string":"and the Harvard Medical School (J.R.M., P.McL.B., S.F., H.D.R.). Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts","institution_ids":[]},{"raw_affiliation_string":"P.McL.B.)","institution_ids":[]},{"raw_affiliation_string":"S.F.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032667508","display_name":"Peter McL. Black","orcid":"https://orcid.org/0000-0003-3810-5898","observed_orcids":["https://orcid.org/0000-0003-3810-5898"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P M Black","raw_affiliation_strings":["Neurosurgical Service, Massachusetts General Hospital (J.R.M., P.McL.B.)","Surgical Service and Department of Radiology, Beth Israel Hospital (J.R.M., H.D.R., S.F.)","and the Harvard Medical School (J.R.M., P.McL.B., S.F., H.D.R.). Boston, Massachusetts","Massachusetts","P.McL.B.)","S.F.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgical Service, Massachusetts General Hospital (J.R.M., P.McL.B.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Surgical Service and Department of Radiology, Beth Israel Hospital (J.R.M., H.D.R., S.F.)","institution_ids":[]},{"raw_affiliation_string":"and the Harvard Medical School (J.R.M., P.McL.B., S.F., H.D.R.). Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts","institution_ids":[]},{"raw_affiliation_string":"P.McL.B.)","institution_ids":[]},{"raw_affiliation_string":"S.F.)","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Flynn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Flynn","raw_affiliation_strings":["Neurosurgical Service, Massachusetts General Hospital (J.R.M., P.McL.B.)","Surgical Service and Department of Radiology, Beth Israel Hospital (J.R.M., H.D.R., S.F.)","and the Harvard Medical School (J.R.M., P.McL.B., S.F., H.D.R.). Boston, Massachusetts","Massachusetts","P.McL.B.)","S.F.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgical Service, Massachusetts General Hospital (J.R.M., P.McL.B.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Surgical Service and Department of Radiology, Beth Israel Hospital (J.R.M., H.D.R., S.F.)","institution_ids":[]},{"raw_affiliation_string":"and the Harvard Medical School (J.R.M., P.McL.B., S.F., H.D.R.). Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts","institution_ids":[]},{"raw_affiliation_string":"P.McL.B.)","institution_ids":[]},{"raw_affiliation_string":"S.F.)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017259886","display_name":"Henry D. Royal","orcid":"https://orcid.org/0000-0002-5998-6201","observed_orcids":["https://orcid.org/0000-0002-5998-6201"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H D Royal","raw_affiliation_strings":["Neurosurgical Service, Massachusetts General Hospital (J.R.M., P.McL.B.)","Surgical Service and Department of Radiology, Beth Israel Hospital (J.R.M., H.D.R., S.F.)","and the Harvard Medical School (J.R.M., P.McL.B., S.F., H.D.R.). Boston, Massachusetts","Massachusetts","P.McL.B.)","S.F.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgical Service, Massachusetts General Hospital (J.R.M., P.McL.B.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Surgical Service and Department of Radiology, Beth Israel Hospital (J.R.M., H.D.R., S.F.)","institution_ids":[]},{"raw_affiliation_string":"and the Harvard Medical School (J.R.M., P.McL.B., S.F., H.D.R.). Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts","institution_ids":[]},{"raw_affiliation_string":"P.McL.B.)","institution_ids":[]},{"raw_affiliation_string":"S.F.)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.13443831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"17","issue":"5","first_page":"778","last_page":"778???83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9290000200271606},{"id":"https://openalex.org/keywords/anion-transport","display_name":"anion transport","score":0.9309999942779541},{"id":"https://openalex.org/keywords/pertechnetate","display_name":"pertechnetate","score":0.996999979019165},{"id":"https://openalex.org/keywords/iodide","display_name":"iodide","score":0.8650000095367432},{"id":"https://openalex.org/keywords/ventriculocisternal-perfusion","display_name":"ventriculocisternal perfusion","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cisterna-magna","display_name":"cisterna magna","score":0.8450000286102295},{"id":"https://openalex.org/keywords/arachnoid-villi","display_name":"arachnoid villi","score":0.9580000042915344},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2778200158","wikidata":"https://www.wikidata.org/wiki/Q5122306","display_name":"Cisterna magna","level":3,"score":0.9349980354309082},{"id":"https://openalex.org/C2778136224","wikidata":"https://www.wikidata.org/wiki/Q1632520","display_name":"Pertechnetate","level":3,"score":0.8593112230300903},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.845312237739563},{"id":"https://openalex.org/C2778870691","wikidata":"https://www.wikidata.org/wiki/Q44794658","display_name":"Iodide","level":2,"score":0.6737086176872253},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6128698587417603},{"id":"https://openalex.org/C2113261","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Extracellular fluid","level":3,"score":0.5293691158294678},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4759778082370758},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.34690743684768677},{"id":"https://openalex.org/C522557706","wikidata":"https://www.wikidata.org/wiki/Q1054","display_name":"Technetium","level":2,"score":0.34010475873947144},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3206366300582886},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.31122711300849915},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2631572186946869},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24723803997039795},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22223395109176636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18831714987754822},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.08692735433578491}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D007454","descriptor_name":"Iodides","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013670","descriptor_name":"Sodium Pertechnetate Tc 99m","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00006123-198511000-00009","doi":"https://doi.org/10.1097/00006123-198511000-00009","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006123-198511000-00009","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"doi:10.1227/00006123-198511000-00009","doi":"https://doi.org/10.1227/00006123-198511000-00009","is_oa":false,"landing_page_url":"https://doi.org/10.1227/00006123-198511000-00009","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:2999637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2999637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5078481162","display_name":"VASOPRESSIN FUNCTION IN CEREBROSPINAL FLUID","funder_award_id":"K07NS000553","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4234610278","https://openalex.org/W2399632490","https://openalex.org/W2017197813","https://openalex.org/W1988810856","https://openalex.org/W4312698564","https://openalex.org/W4409057675","https://openalex.org/W2339657704","https://openalex.org/W1978457748","https://openalex.org/W6940392890","https://openalex.org/W2258375517"],"abstract_inverted_index":{"Perfusion":[0],"of":[1,55,63,73,83,97,104,123,129,139],"the":[2,12,16,22,34,39,51,56,61,64,74,80,87,95,117,120,136,140],"ventriculocisternal":[3],"system":[4],"in":[5,50,60,135],"unanesthetized":[6],"sheep":[7],"was":[8,31,44,77],"used":[9],"to":[10,113],"quantify":[11],"pathways":[13],"by":[14,47,116],"which":[15],"pertechnetate":[17,58,76,107],"anion":[18],"(TcO4-)":[19],"may":[20,126],"leave":[21],"cerebrospinal":[23,84],"fluid":[24,35,85,138],"space.":[25],"The":[26],"largest":[27],"fraction":[28],"(about":[29],"89%)":[30],"removed":[32],"from":[33],"before":[36],"it":[37],"reached":[38],"cisterna":[40],"magna;":[41],"this":[42,124],"extraction":[43],"significantly":[45],"inhibited":[46],"iodide":[48,109,133],"ion":[49,110],"perfusion":[52],"fluid.":[53],"One-fifth":[54],"extracted":[57],"remained":[59],"head":[62],"animal":[65],"for":[66,102],"over":[67],"3":[68],"hours.":[69],"Only":[70],"about":[71],"3%":[72],"infused":[75],"resorbed":[78],"with":[79,94],"bulk":[81],"flow":[82],"through":[86],"arachnoid":[88],"villi.":[89],"These":[90],"results":[91],"are":[92,111],"consistent":[93],"concept":[96],"a":[98,130],"specific":[99],"brain":[100],"channel":[101,125],"removal":[103],"anions.":[105],"As":[106],"and":[108],"thought":[112],"be":[114,127],"transported":[115],"same":[118],"mechanisms,":[119],"physiological":[121],"role":[122],"maintenance":[128],"very":[131],"low":[132],"concentration":[134],"extracellular":[137],"brain.":[141]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
