{"id":"https://openalex.org/W2043349477","doi":"https://doi.org/10.1371/journal.pone.0032661","title":"The 3\u2032 Untranslated Regions of Influenza Genomic Sequences Are 5\u2032PPP-Independent Ligands for RIG-I","display_name":"The 3\u2032 Untranslated Regions of Influenza Genomic Sequences Are 5\u2032PPP-Independent Ligands for RIG-I","publication_year":2012,"publication_date":"2012-03-15","ids":{"openalex":"https://openalex.org/W2043349477","doi":"https://doi.org/10.1371/journal.pone.0032661","mag":"2043349477","pmid":"https://pubmed.ncbi.nlm.nih.gov/22438882","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3305289"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0032661","doi":"https://doi.org/10.1371/journal.pone.0032661","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0032661","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032661&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032661&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010747113","display_name":"William G. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William G. Davis","raw_affiliation_strings":["Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I19085752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007340248","display_name":"J. Bradford Bowzard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Bradford Bowzard","raw_affiliation_strings":["Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I19085752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005572303","display_name":"Suresh D. Sharma","orcid":"https://orcid.org/0000-0002-8633-4145","observed_orcids":["https://orcid.org/0000-0002-8633-4145"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suresh D. Sharma","raw_affiliation_strings":["Pennsylvania State University, University Park, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035523763","display_name":"Mayim E. Wiens","orcid":"https://orcid.org/0000-0001-5518-9339","observed_orcids":["https://orcid.org/0000-0001-5518-9339"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mayim E. Wiens","raw_affiliation_strings":["Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I19085752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103442860","display_name":"Priya Ranjan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priya Ranjan","raw_affiliation_strings":["Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I19085752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066705529","display_name":"Shivaprakash Gangappa","orcid":"https://orcid.org/0000-0001-6217-9665","observed_orcids":["https://orcid.org/0000-0001-6217-9665"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shivaprakash Gangappa","raw_affiliation_strings":["Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I19085752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051985158","display_name":"Olga Stuchlik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210121439","display_name":"National Center for Emerging and Zoonotic Infectious Diseases","ror":"https://ror.org/02ggwpx62","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Stuchlik","raw_affiliation_strings":["Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210121439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112688903","display_name":"Jan Pohl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210121439","display_name":"National Center for Emerging and Zoonotic Infectious Diseases","ror":"https://ror.org/02ggwpx62","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109567","https://openalex.org/I4210121439"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Pohl","raw_affiliation_strings":["Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210121439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002540504","display_name":"Rub\u00e9n O. Donis","orcid":"https://orcid.org/0000-0001-6137-8312","observed_orcids":["https://orcid.org/0000-0001-6137-8312"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruben O. Donis","raw_affiliation_strings":["Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I19085752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079909471","display_name":"Jacqueline M. Katz","orcid":"https://orcid.org/0000-0002-9817-4839","observed_orcids":["https://orcid.org/0000-0002-9817-4839"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline M. Katz","raw_affiliation_strings":["Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I19085752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021526153","display_name":"Craig E. Cameron","orcid":"https://orcid.org/0000-0002-7564-5642","observed_orcids":["https://orcid.org/0000-0002-7564-5642"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig E. Cameron","raw_affiliation_strings":["Pennsylvania State University, University Park, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036953877","display_name":"Takashi Fujita","orcid":"https://orcid.org/0000-0001-9961-0535","observed_orcids":["https://orcid.org/0000-0001-9961-0535"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takashi Fujita","raw_affiliation_strings":["Kyoto University, Kyoto, Japan","Kyoto University, Kyoto, Japan#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Kyoto University, Kyoto, Japan#TAB#","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010891569","display_name":"Suryaprakash R. Sambhara","orcid":"https://orcid.org/0000-0002-4715-5793","observed_orcids":["https://orcid.org/0000-0002-4715-5793"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I19085752","display_name":"National Center for Immunization and Respiratory Diseases","ror":"https://ror.org/05je2tx78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I19085752","https://openalex.org/I4210109567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Suryaprakash Sambhara","raw_affiliation_strings":["Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I19085752"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5010891569","https://openalex.org/A5036953877"],"corresponding_institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I19085752","https://openalex.org/I22299242"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.3654,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.88191928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"3","first_page":"e32661","last_page":"e32661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rig-i","display_name":"RIG-I","score":0.9919999837875366},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.8809999823570251},{"id":"https://openalex.org/keywords/influenza-virus","display_name":"influenza virus","score":0.7720000147819519},{"id":"https://openalex.org/keywords/5-triphosphate","display_name":"5'-triphosphate","score":0.7450000047683716},{"id":"https://openalex.org/keywords/interferon-beta-induction","display_name":"interferon-beta induction","score":0.8669999837875366},{"id":"https://openalex.org/keywords/rna-secondary-structure","display_name":"RNA secondary structure","score":0.7599999904632568},{"id":"https://openalex.org/keywords/rna-length","display_name":"RNA length","score":0.7120000123977661},{"id":"https://openalex.org/keywords/rna-capping","display_name":"RNA capping","score":0.5460000038146973},{"id":"https://openalex.org/keywords/cip","display_name":"CIP","score":0.4359999895095825},{"id":"https://openalex.org/keywords/antiviral-innate-immunity","display_name":"antiviral innate immunity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/double-stranded-rna","display_name":"double-stranded RNA","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.7683770656585693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.652906060218811},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.6103141903877258},{"id":"https://openalex.org/C2776954689","wikidata":"https://www.wikidata.org/wiki/Q21100537","display_name":"RIG-I","level":4,"score":0.5345434546470642},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4758560359477997},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4704163372516632},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4513418674468994},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4443869888782501},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.43447747826576233},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4252031147480011},{"id":"https://openalex.org/C54985914","wikidata":"https://www.wikidata.org/wiki/Q1295754","display_name":"Consensus sequence","level":4,"score":0.4168476462364197},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3440641164779663},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2794540822505951}],"mesh":[{"descriptor_ui":"D000071457","descriptor_name":"DEAD Box Protein 58","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0032661","doi":"https://doi.org/10.1371/journal.pone.0032661","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0032661","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032661&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3305289","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3305289","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22438882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22438882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.349.9548","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.349.9548","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/5d/2e/PLoS_One_2012_Mar_15_7(3)_e32661.tar.gz","raw_type":"text"},{"id":"pmh:cdr.lib.unc.edu:pr76f874f","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/aedr-9c88","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 7(3)","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:66d23390265947ebbdb06c8d84ab63e7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/66d23390265947ebbdb06c8d84ab63e7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 3, p e32661 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/127558","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_3_Untranslated_Regions_of_Influenza_Genomic_Sequences_Are_5_PPP_Independent_Ligands_for_RIG_I/127558","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.17615/aedr-9c88","doi":"https://doi.org/10.17615/aedr-9c88","is_oa":true,"landing_page_url":"https://doi.org/10.17615/aedr-9c88","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0032661","doi":"https://doi.org/10.1371/journal.pone.0032661","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0032661","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032661&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043349477.pdf","grobid_xml":"https://content.openalex.org/works/W2043349477.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1514540900","https://openalex.org/W1967896668","https://openalex.org/W1969601023","https://openalex.org/W1994391392","https://openalex.org/W1995858580","https://openalex.org/W2009127910","https://openalex.org/W2009769910","https://openalex.org/W2011507014","https://openalex.org/W2014960200","https://openalex.org/W2015999301","https://openalex.org/W2016194523","https://openalex.org/W2017515700","https://openalex.org/W2028792773","https://openalex.org/W2032948492","https://openalex.org/W2034164226","https://openalex.org/W2039294169","https://openalex.org/W2062490839","https://openalex.org/W2065376186","https://openalex.org/W2076361525","https://openalex.org/W2084808255","https://openalex.org/W2091362446","https://openalex.org/W2118926211","https://openalex.org/W2125566625","https://openalex.org/W2141137217","https://openalex.org/W2141157874","https://openalex.org/W2148985310","https://openalex.org/W2161208630"],"related_works":["https://openalex.org/W2419024942","https://openalex.org/W3003865238","https://openalex.org/W4392787480","https://openalex.org/W1552800067","https://openalex.org/W2118694630","https://openalex.org/W1969601023","https://openalex.org/W2283695976","https://openalex.org/W7160653742","https://openalex.org/W2009127910","https://openalex.org/W2055512581"],"abstract_inverted_index":{"Retinoic":[0],"acid":[1],"inducible":[2],"gene-I":[3],"(RIG-I)":[4],"is":[5,13,39,201],"a":[6,23,126,147,160,171],"key":[7],"regulator":[8],"of":[9,59,75,92,111,125,132,168],"antiviral":[10],"immunity.":[11],"RIG-I":[12,133,164],"generally":[14],"thought":[15],"to":[16,32,62,194],"be":[17],"activated":[18],"by":[19,28,105,134,170,206],"ssRNA":[20],"species":[21],"containing":[22],"5'-triphosphate":[24],"(PPP)":[25],"group":[26],"or":[27,115,140,155,196],"unphosphorylated":[29],"dsRNA":[30],"up":[31],"~300":[33],"bp":[34],"in":[35,45,72,120,163],"length.":[36],"However,":[37],"it":[38],"not":[40,197],"yet":[41],"clear":[42],"how":[43],"changes":[44],"the":[46,57,73,85,93,108,112,123,135,152,176,198],"length,":[47,188],"nucleotide":[48],"sequence,":[49,187],"secondary":[50,190],"structure,":[51],"and":[52,64,87,189],"5'":[53,86,109,153],"end":[54,154],"modification":[55],"affect":[56],"abilities":[58],"these":[60,70],"ligands":[61],"bind":[63],"activate":[65],"RIG-I.":[66,207],"To":[67],"further":[68],"investigate":[69],"parameters":[71],"context":[74],"naturally":[76],"occurring":[77],"ligands,":[78],"we":[79],"examined":[80],"RNA":[81,186],"sequences":[82,106],"derived":[83],"from":[84,107],"3'":[88,136,177],"untranslated":[89],"regions":[90],"(UTR)":[91],"influenza":[94,113],"virus":[95],"NS1":[96],"gene":[97],"segment.":[98],"As":[99],"expected,":[100],"RIG-I-dependent":[101],"interferon-\u03b2":[102],"(IFN-\u03b2)":[103],"induction":[104,167,205],"UTR":[110,137,178],"cRNA":[114,138],"its":[116,141],"complement":[117,142],"(26":[118],"nt":[119],"length)":[121],"required":[122],"presence":[124],"5'PPP":[127,199],"group.":[128],"In":[129],"contrast,":[130],"activation":[131],"sequence":[139],"(172":[143],"nt)":[144],"exhibited":[145],"only":[146],"partial":[148],"5'PPP-dependence,":[149],"as":[150],"capping":[151],"treatment":[156],"with":[157],"CIP":[158],"showed":[159],"modest":[161],"reduction":[162],"activation.":[165],"Furthermore,":[166],"IFN-\u03b2":[169],"smaller,":[172],"U/A-rich":[173],"region":[174],"within":[175],"was":[179],"completely":[180],"5'PPP-independent.":[181],"Our":[182],"findings":[183],"demonstrated":[184],"that":[185],"structure":[191],"all":[192],"contributed":[193],"whether":[195],"moiety":[200],"needed":[202],"for":[203],"interferon":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}