{"id":"https://openalex.org/W2043342016","doi":"https://doi.org/10.1593/tlo.10106","title":"A Polymorphic Variant of AFAP-110 Enhances cSrc Activity","display_name":"A Polymorphic Variant of AFAP-110 Enhances cSrc Activity","publication_year":2010,"publication_date":"2010-08-01","ids":{"openalex":"https://openalex.org/W2043342016","doi":"https://doi.org/10.1593/tlo.10106","mag":"2043342016","pmid":"https://pubmed.ncbi.nlm.nih.gov/20689769","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2915419"},"language":"en","primary_location":{"id":"doi:10.1593/tlo.10106","doi":"https://doi.org/10.1593/tlo.10106","is_oa":true,"landing_page_url":"https://doi.org/10.1593/tlo.10106","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1936523310800178/pdf","source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1936523310800178/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114021113","display_name":"David Anthony Clump","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Clump","raw_affiliation_strings":["The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104275159","display_name":"Jing Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Jie Yu","raw_affiliation_strings":["The Mary Babb Randolph Cancer Center and the Department of Biochemistry, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary Babb Randolph Cancer Center and the Department of Biochemistry, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101619123","display_name":"Youngjin Cho","orcid":"https://orcid.org/0000-0002-1435-6070","observed_orcids":["https://orcid.org/0000-0002-1435-6070"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YoungJin Cho","raw_affiliation_strings":["The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090447845","display_name":"Rui Gao","orcid":"https://orcid.org/0000-0001-5266-9126","observed_orcids":["https://orcid.org/0000-0001-5266-9126"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Gao","raw_affiliation_strings":["Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033229467","display_name":"John E. Jett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Jett","raw_affiliation_strings":["Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA","Department of Basic Pharmaceutical Sciences; West Virginia University; Morgantown; WV; USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences; West Virginia University; Morgantown; WV; USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056688456","display_name":"Henry G. Zot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5950314","display_name":"University of West Georgia","ror":"https://ror.org/01cqxk816","country_code":"US","type":"education","lineage":["https://openalex.org/I5950314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Zot","raw_affiliation_strings":["Department of Biology, University of West Georgia, Carrolton, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of West Georgia, Carrolton, GA, USA","institution_ids":["https://openalex.org/I5950314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103408244","display_name":"Jess M. Cunnick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jess M. Cunnick","raw_affiliation_strings":["The Mary Babb Randolph Cancer Center and the Department of Pathology, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary Babb Randolph Cancer Center and the Department of Pathology, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062958991","display_name":"Brandi Nicole Snyder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandi Snyder","raw_affiliation_strings":["The Mary Babb Randolph Cancer Center and the Department of Biochemistry, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary Babb Randolph Cancer Center and the Department of Biochemistry, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011998029","display_name":"Anne C. Clump","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne C. Clump","raw_affiliation_strings":["The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008044701","display_name":"Melissa Dodrill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Dodrill","raw_affiliation_strings":["The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091796188","display_name":"Peter M. Gannett","orcid":"https://orcid.org/0000-0002-7859-5468","observed_orcids":["https://orcid.org/0000-0002-7859-5468"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Gannett","raw_affiliation_strings":["Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA","Department of Basic Pharmaceutical Sciences; West Virginia University; Morgantown; WV; USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences; West Virginia University; Morgantown; WV; USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018597486","display_name":"James E. Coad","orcid":"https://orcid.org/0000-0002-7913-2561","observed_orcids":["https://orcid.org/0000-0002-7913-2561"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Coad","raw_affiliation_strings":["Department of Pathology, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081243376","display_name":"Robert D. Shurina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18283598","display_name":"Wheeling Jesuit University","ror":"https://ror.org/02z310y44","country_code":"US","type":"education","lineage":["https://openalex.org/I18283598"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Shurina","raw_affiliation_strings":["Department of Biology, Wheeling Jesuit University, Wheeling, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Wheeling Jesuit University, Wheeling, WV, USA","institution_ids":["https://openalex.org/I18283598"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079418869","display_name":"William Douglas Figg","orcid":"https://orcid.org/0000-0003-2428-5613","observed_orcids":["https://orcid.org/0000-0003-2428-5613"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Douglas Figg","raw_affiliation_strings":["Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110090307","display_name":"Eddie Reed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210113004","display_name":"National Center for Chronic Disease Prevention and Health Promotion","ror":"https://ror.org/021rths28","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210113004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eddie Reed","raw_affiliation_strings":["Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CoCHP, The Centers for Disease Control and Prevention, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CoCHP, The Centers for Disease Control and Prevention, Atlanta, GA, USA","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210113004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019873684","display_name":"Daniel C. Flynn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel C. Flynn","raw_affiliation_strings":["The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5019873684"],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.3786,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.7358589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"4","first_page":"276","last_page":"IN9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.6395999789237976,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.6395999789237976,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.24549999833106995,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.060100000351667404,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/csrc","display_name":"CsrC","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.7039999961853027},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9760000109672546},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6899999976158142},{"id":"https://openalex.org/keywords/podosomes","display_name":"podosomes","score":0.7689999938011169},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.43700000643730164},{"id":"https://openalex.org/keywords/targeted-therapy-response","display_name":"targeted therapy response","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C149904235","wikidata":"https://www.wikidata.org/wiki/Q7049620","display_name":"Nonsynonymous substitution","level":4,"score":0.7190660238265991},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6998845934867859},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5104471445083618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47605133056640625},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.43825334310531616},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26536035537719727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14396575093269348},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13465729355812073},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1593/tlo.10106","doi":"https://doi.org/10.1593/tlo.10106","is_oa":true,"landing_page_url":"https://doi.org/10.1593/tlo.10106","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1936523310800178/pdf","source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2006503","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2915419","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2915419","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2915419","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Oncol","raw_type":"Text"},{"id":"pmid:20689769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20689769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational oncology","raw_type":"Journal Article"},{"id":"pmh:oai:researchrepository.wvu.edu:faculty_publications-3726","doi":null,"is_oa":false,"landing_page_url":"https://researchrepository.wvu.edu/faculty_publications/2755","pdf_url":null,"source":{"id":"https://openalex.org/S4306402612","display_name":"The Research Repository @ WVU (West Virginia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12097938","host_organization_name":"West Virginia University","host_organization_lineage":["https://openalex.org/I12097938"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty & Staff Scholarship","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1593/tlo.10106","doi":"https://doi.org/10.1593/tlo.10106","is_oa":true,"landing_page_url":"https://doi.org/10.1593/tlo.10106","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1936523310800178/pdf","source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1656996701","display_name":"West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)","funder_award_id":"2p20rr016477-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2461264676","display_name":null,"funder_award_id":"P20-RR016477","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4975506147","display_name":"AFAP-110 as a cSrc activator in breast cancer","funder_award_id":"R01CA060731","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5417591456","display_name":"Cobre for Signal Transduction and Cancer","funder_award_id":"P20RR016440","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000062380","display_name":null,"funder_award_id":"RR16440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306470","display_name":"Elsa U. Pardee Foundation","ror":"https://ror.org/05sjnvv07"},{"id":"https://openalex.org/F4320311274","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043342016.pdf","grobid_xml":"https://content.openalex.org/works/W2043342016.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1484356204","https://openalex.org/W1687602549","https://openalex.org/W1752645701","https://openalex.org/W1965734230","https://openalex.org/W1965878299","https://openalex.org/W1971646616","https://openalex.org/W1988803183","https://openalex.org/W1989836432","https://openalex.org/W1995959598","https://openalex.org/W1997784032","https://openalex.org/W2000269194","https://openalex.org/W2009722391","https://openalex.org/W2011073796","https://openalex.org/W2015089043","https://openalex.org/W2021075508","https://openalex.org/W2034368878","https://openalex.org/W2036988959","https://openalex.org/W2042802568","https://openalex.org/W2048596844","https://openalex.org/W2056280890","https://openalex.org/W2060071841","https://openalex.org/W2061698542","https://openalex.org/W2065292076","https://openalex.org/W2072979040","https://openalex.org/W2094173028","https://openalex.org/W2117450824","https://openalex.org/W2132419409","https://openalex.org/W2136929338","https://openalex.org/W2137033600","https://openalex.org/W2137137973","https://openalex.org/W2166104074","https://openalex.org/W2169862738","https://openalex.org/W2170770186","https://openalex.org/W2193231867","https://openalex.org/W2267681417","https://openalex.org/W4239979702"],"related_works":["https://openalex.org/W4409626303","https://openalex.org/W2102658672","https://openalex.org/W2514567198","https://openalex.org/W2070155678","https://openalex.org/W1128705587","https://openalex.org/W1594706458","https://openalex.org/W1992635950","https://openalex.org/W2279684844","https://openalex.org/W2009722391","https://openalex.org/W2951002746"],"abstract_inverted_index":{"Enhanced":[0],"expression":[1,47],"and":[2,75,119,165],"activity":[3,21],"of":[4,48,73,83,91,101,111,117,122,125,139,145],"cSrc":[5,13,55,76,118,140,148],"are":[6],"associated":[7],"with":[8],"ovarian":[9,42,78,162],"cancer":[10,43,79,163],"progression.":[11],"Generally,":[12],"does":[14],"not":[15],"contain":[16],"activating":[17],"mutations;":[18],"rather,":[19],"its":[20,35,64],"is":[22],"increased":[23],"in":[24,77,98,128],"response":[25,172],"to":[26,103,130,169,173],"signals":[27],"that":[28,33,60,96,107],"affect":[29],"a":[30,49,57,70,92,99],"conformational":[31],"change":[32,100],"releases":[34,61],"autoinhibition.":[36],"In":[37,105],"this":[38],"report,":[39],"we":[40],"analyzed":[41],"tissues":[44],"for":[45],"the":[46,84,89,115,120,142,171],"cSrc-activating":[50],"protein,":[51],"AFAP-110.":[52,132],"AFAP-110":[53,74,85,146],"activates":[54],"through":[56],"direct":[58],"interaction":[59],"it":[62],"from":[63],"autoinhibited":[65],"conformation.":[66],"Immunohistochemical":[67],"analysis":[68,82],"revealed":[69,88],"concomitant":[71],"increase":[72],"tissues.":[80],"An":[81],"coding":[86],"sequence":[87],"presence":[90],"nonsynonymous,":[93],"single-nucleotide":[94],"polymorphism":[95],"resulted":[97],"Ser403":[102],"Cys403.":[104],"cells":[106],"express":[108],"enhanced":[109],"levels":[110],"cSrc,":[112],"AFAP-110(403C)":[113],"directed":[114],"activation":[116],"formation":[121],"podosomes":[123],"independently":[124],"input":[126],"signals,":[127],"contrast":[129],"wild-type":[131],"We":[133],"therefore":[134],"propose":[135],"that,":[136],"under":[137],"conditions":[138],"overexpression,":[141],"polymorphic":[143],"variant":[144],"promotes":[147],"activation.":[149],"Further,":[150],"these":[151],"data":[152],"indicate":[153],"amechanismby":[154],"which":[155],"an":[156],"inherited":[157],"genetic":[158],"variation":[159],"could":[160,166],"influence":[161],"progression":[164],"be":[167],"used":[168],"predict":[170],"targeted":[174],"therapy.":[175]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
