{"id":"https://openalex.org/W2043192551","doi":"https://doi.org/10.1038/aps.2010.158","title":"Apoptosis induced by genipin in human leukemia K562 cells: involvement of c-Jun N-terminal kinase in G2/M arrest","display_name":"Apoptosis induced by genipin in human leukemia K562 cells: involvement of c-Jun N-terminal kinase in G2/M arrest","publication_year":2011,"publication_date":"2011-03-14","ids":{"openalex":"https://openalex.org/W2043192551","doi":"https://doi.org/10.1038/aps.2010.158","mag":"2043192551","pmid":"https://pubmed.ncbi.nlm.nih.gov/21399655","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4001971"},"language":"en","primary_location":{"id":"doi:10.1038/aps.2010.158","doi":"https://doi.org/10.1038/aps.2010.158","is_oa":false,"landing_page_url":"https://doi.org/10.1038/aps.2010.158","pdf_url":null,"source":{"id":"https://openalex.org/S4210186974","display_name":"Acta Pharmacologica Sinica","issn_l":"0253-9756","issn":["0253-9756","1671-4083","1745-7254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacologica Sinica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4001971","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Qian Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Feng","raw_affiliation_strings":["Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053512949","display_name":"Houli Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hou-li Cao","raw_affiliation_strings":["Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, 610064, Chengdu, China","Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, 610064, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100717026","display_name":"Wei Xu","orcid":"https://orcid.org/0000-0002-9725-4335","observed_orcids":["https://orcid.org/0000-0002-9725-4335"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Xu","raw_affiliation_strings":["Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, 610064, Chengdu, China","Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, 610064, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109910831","display_name":"Xiao-rong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-rong Li","raw_affiliation_strings":["Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, 610064, Chengdu, China","Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, 610064, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109155343","display_name":"Yan-qin Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-qin Ren","raw_affiliation_strings":["Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, 610064, Chengdu, China","Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, 610064, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102131704","display_name":"Linfang Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin-fang Du","raw_affiliation_strings":["Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, 610064, Chengdu, China","Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, 610064, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Key Laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Science, Sichuan University, China","institution_ids":["https://openalex.org/I24185976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102131704"],"corresponding_institution_ids":["https://openalex.org/I24185976"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.9748,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.72549114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"32","issue":"4","first_page":"519","last_page":"527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.09969999641180038,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genipin","display_name":"genipin","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.875},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8870000243186951},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.9399999976158142},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.8059999942779541},{"id":"https://openalex.org/keywords/p63","display_name":"p63","score":0.7900000214576721},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.7730000019073486},{"id":"https://openalex.org/keywords/dicoumarol","display_name":"dicumarol","score":0.8379999995231628},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2781438746","wikidata":"https://www.wikidata.org/wiki/Q1463401","display_name":"Genipin","level":3,"score":0.8922555446624756},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6681077480316162},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.666947066783905},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.6204419732093811},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.599371075630188},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.4447668194770813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4426315724849701},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.4372151792049408},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.43339473009109497},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42258352041244507},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4167029857635498},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3691254258155823},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2664150595664978},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016195","descriptor_name":"G2 Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039823","descriptor_name":"Iridoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057889","descriptor_name":"Iridoid Glycosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/aps.2010.158","doi":"https://doi.org/10.1038/aps.2010.158","is_oa":false,"landing_page_url":"https://doi.org/10.1038/aps.2010.158","pdf_url":null,"source":{"id":"https://openalex.org/S4210186974","display_name":"Acta Pharmacologica Sinica","issn_l":"0253-9756","issn":["0253-9756","1671-4083","1745-7254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacologica Sinica","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4001971","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4001971","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacol Sin","raw_type":"Text"},{"id":"pmid:21399655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21399655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:3139740970","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/95561A/201104/37863737.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542255","display_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4001971","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4001971","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacol Sin","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322990","display_name":"Sichuan University","ror":"https://ror.org/011ashp19"},{"id":"https://openalex.org/F4320334924","display_name":"Program for New Century Excellent Talents in University","ror":"https://ror.org/01mv9t934"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W274770","https://openalex.org/W1979955228","https://openalex.org/W1982893010","https://openalex.org/W1983200183","https://openalex.org/W1988063350","https://openalex.org/W1992135097","https://openalex.org/W1992301657","https://openalex.org/W1992430132","https://openalex.org/W1993786423","https://openalex.org/W1997518805","https://openalex.org/W1998110345","https://openalex.org/W2002408013","https://openalex.org/W2008732699","https://openalex.org/W2011212667","https://openalex.org/W2011902778","https://openalex.org/W2012099220","https://openalex.org/W2014663247","https://openalex.org/W2021129338","https://openalex.org/W2027578116","https://openalex.org/W2047170514","https://openalex.org/W2056324134","https://openalex.org/W2060630008","https://openalex.org/W2063751533","https://openalex.org/W2075226068","https://openalex.org/W2080059880","https://openalex.org/W2091057614","https://openalex.org/W2092409818","https://openalex.org/W2093930054","https://openalex.org/W2100901254","https://openalex.org/W2114870033","https://openalex.org/W2119807130","https://openalex.org/W2119835397","https://openalex.org/W2120782487","https://openalex.org/W2126979641","https://openalex.org/W2160736925"],"related_works":["https://openalex.org/W3139740970","https://openalex.org/W1970897333","https://openalex.org/W1982893010","https://openalex.org/W1992135097","https://openalex.org/W1965429355","https://openalex.org/W1988063350","https://openalex.org/W4387344283","https://openalex.org/W1973138368","https://openalex.org/W2387413490","https://openalex.org/W2364532440"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}