{"id":"https://openalex.org/W2043191111","doi":"https://doi.org/10.1016/0012-1606(87)90502-1","title":"Expression of fast and slow isoforms of the Ca2+-ATPase in developing chick skeletal muscle","display_name":"Expression of fast and slow isoforms of the Ca2+-ATPase in developing chick skeletal muscle","publication_year":1987,"publication_date":"1987-12-01","ids":{"openalex":"https://openalex.org/W2043191111","doi":"https://doi.org/10.1016/0012-1606(87)90502-1","mag":"2043191111","pmid":"https://pubmed.ncbi.nlm.nih.gov/2960578"},"language":"en","primary_location":{"id":"doi:10.1016/0012-1606(87)90502-1","doi":"https://doi.org/10.1016/0012-1606(87)90502-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0012-1606(87)90502-1","pdf_url":null,"source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/0012-1606(87)90502-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072848943","display_name":"Zaven Kaprielian","orcid":"https://orcid.org/0000-0003-3364-3806","observed_orcids":["https://orcid.org/0000-0003-3364-3806"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zaven Kaprielian","raw_affiliation_strings":["Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218","Department of Biophysics, The Johns Hopkins University, Baltimore, Maryland 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biophysics, The Johns Hopkins University, Baltimore, Maryland 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109050052","display_name":"Douglas M. Fambrough","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas M. Fambrough","raw_affiliation_strings":["Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218 USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072848943"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":{"value":3550,"currency":"USD","value_usd":3550},"fwci":3.5811,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.93930208,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"124","issue":"2","first_page":"490","last_page":"503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-ca2-atpase","display_name":"sarcoplasmic reticulum Ca2+-ATPase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/muscle-fiber-type","display_name":"muscle fiber type","score":0.6010000109672546},{"id":"https://openalex.org/keywords/myoblasts","display_name":"myoblasts","score":0.703000009059906},{"id":"https://openalex.org/keywords/myotubes","display_name":"myotubes","score":0.7160000205039978},{"id":"https://openalex.org/keywords/myosin-heavy-chain-isoforms","display_name":"myosin heavy chain isoforms","score":0.777999997138977},{"id":"https://openalex.org/keywords/isoform-expression","display_name":"isoform expression","score":0.6150000095367432},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.8935611248016357},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.8920998573303223},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8013248443603516},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.7688906192779541},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.729539155960083},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6359654664993286},{"id":"https://openalex.org/C74581901","wikidata":"https://www.wikidata.org/wiki/Q14876107","display_name":"MYH7","level":4,"score":0.5972846746444702},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.4403470456600189},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.4355854392051697},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41682377457618713},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36728668212890625},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.362617552280426},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.3596324920654297},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22014066576957703},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1724487543106079},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.085259348154068},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07260596752166748}],"mesh":[{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0012-1606(87)90502-1","doi":"https://doi.org/10.1016/0012-1606(87)90502-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0012-1606(87)90502-1","pdf_url":null,"source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},{"id":"pmid:2960578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2960578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0012-1606(87)90502-1","doi":"https://doi.org/10.1016/0012-1606(87)90502-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0012-1606(87)90502-1","pdf_url":null,"source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1965936037","display_name":null,"funder_award_id":"HL27867","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1481185790","https://openalex.org/W1499131945","https://openalex.org/W1532133113","https://openalex.org/W1532893533","https://openalex.org/W1533713329","https://openalex.org/W1555444114","https://openalex.org/W1558794683","https://openalex.org/W1561552296","https://openalex.org/W1617847244","https://openalex.org/W1799879229","https://openalex.org/W1970823660","https://openalex.org/W1976692427","https://openalex.org/W1979311249","https://openalex.org/W1993693200","https://openalex.org/W1998397793","https://openalex.org/W2002265951","https://openalex.org/W2003585900","https://openalex.org/W2006640683","https://openalex.org/W2011651049","https://openalex.org/W2013137776","https://openalex.org/W2019071295","https://openalex.org/W2021138337","https://openalex.org/W2031540833","https://openalex.org/W2035477530","https://openalex.org/W2051646835","https://openalex.org/W2056348303","https://openalex.org/W2061918648","https://openalex.org/W2063721373","https://openalex.org/W2063824870","https://openalex.org/W2065404759","https://openalex.org/W2065637839","https://openalex.org/W2070813187","https://openalex.org/W2071642479","https://openalex.org/W2077266797","https://openalex.org/W2080498410","https://openalex.org/W2085096561","https://openalex.org/W2092197701","https://openalex.org/W2099703541","https://openalex.org/W2100837269","https://openalex.org/W2101392773","https://openalex.org/W2131288823","https://openalex.org/W2139046781","https://openalex.org/W2140994672","https://openalex.org/W2145897147","https://openalex.org/W2172587676","https://openalex.org/W2177590416","https://openalex.org/W2187063188","https://openalex.org/W2494237239","https://openalex.org/W2798940429"],"related_works":["https://openalex.org/W2083996054","https://openalex.org/W2007955191","https://openalex.org/W1980914770","https://openalex.org/W2052242337","https://openalex.org/W1533713329","https://openalex.org/W2081974948","https://openalex.org/W2018246442","https://openalex.org/W1970665132","https://openalex.org/W2060992319","https://openalex.org/W2027797690"],"abstract_inverted_index":{"The":[0],"expression":[1,38,98,113],"of":[2,7,33,37,39,79,90,99,114,140,149,177],"fast":[3,116],"and":[4,19,155,180],"slow":[5,67,101],"isoforms":[6,41,56,74,82,139,176],"the":[8,15,66,80,97,100,115,141,178],"sarcoplasmic":[9],"reticulum":[10],"Ca2+-ATPase":[11,40,142,179],"was":[12],"studied":[13],"in":[14,20,42,85,171,188],"developing":[16,189],"chick":[17,43,129,158,190],"embryo":[18],"tissue-cultured":[21],"myotubes.":[22],"Monoclonal":[23],"antibodies":[24],"specific":[25,175],"for":[26],"each":[27],"isoform":[28,102,117],"were":[29],"used":[30],"as":[31],"probes":[32],"protein":[34],"expression.":[35],"Analysis":[36],"thigh":[44,92,130,159],"muscles":[45,160],"by":[46],"immunofluorescence":[47],"microscopy":[48],"revealed":[49],"that":[50,96,162],"all":[51,163],"muscle":[52,62,93,131,164],"fibers":[53,63,71],"expressed":[54,64,72,137,166,187],"both":[55,73,138,167],"during":[57],"their":[58],"development.":[59,87],"Primary":[60],"generation":[61,70],"predominantly":[65],"isoform.":[68],"Secondary":[69],"at":[75,134,143],"comparable":[76],"levels.":[77,146],"Loss":[78],"\"inappropriate\"":[81],"occurred":[83],"late":[84,156],"embryonic":[86,91,106],"Immunoblot":[88],"analysis":[89,148],"proteins":[94],"indicated":[95],"varied":[103],"little":[104],"from":[105,127,152],"Day":[107],"6":[108],"(ED6)":[109,154],"to":[110,122],"ED19,":[111],"while":[112],"increased":[118],"dramatically":[119],"just":[120],"prior":[121],"ED19.":[123],"Tissue-cultured":[124],"myotubes":[125],"derived":[126],"ED12":[128],"myoblasts,":[132],"plated":[133],"high":[135],"density,":[136],"very":[144],"similar":[145],"Clonal":[147],"myoblasts":[150],"taken":[151],"early":[153],"(ED12)":[157],"showed":[161],"colonies":[165],"forms,":[168],"consistent":[169],"with":[170],"vivo":[172],"results.":[173],"Fiber-type":[174],"myosin":[181],"heavy":[182],"chain":[183],"are":[184],"not":[185],"coordinately":[186],"skeletal":[191],"muscle.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}