{"id":"https://openalex.org/W2043166016","doi":"https://doi.org/10.1007/s00232-013-9525-z","title":"Hemolytic Activity of Membrane-Active Peptides Correlates with the Thermodynamics of Binding to 1-Palmitoyl-2-Oleoyl-sn-Glycero-3-Phosphocholine Bilayers","display_name":"Hemolytic Activity of Membrane-Active Peptides Correlates with the Thermodynamics of Binding to 1-Palmitoyl-2-Oleoyl-sn-Glycero-3-Phosphocholine Bilayers","publication_year":2013,"publication_date":"2013-01-17","ids":{"openalex":"https://openalex.org/W2043166016","doi":"https://doi.org/10.1007/s00232-013-9525-z","mag":"2043166016","pmid":"https://pubmed.ncbi.nlm.nih.gov/23329339","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3584441"},"language":"en","primary_location":{"id":"doi:10.1007/s00232-013-9525-z","doi":"https://doi.org/10.1007/s00232-013-9525-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00232-013-9525-z","pdf_url":null,"source":{"id":"https://openalex.org/S967762373","display_name":"The Journal of Membrane Biology","issn_l":"0022-2631","issn":["0022-2631","1432-1424"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Membrane Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3584441","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069036865","display_name":"B. Logan Spaller","orcid":"https://orcid.org/0009-0006-8860-2285","observed_orcids":["https://orcid.org/0009-0006-8860-2285"]},"institutions":[{"id":"https://openalex.org/I153901656","display_name":"University of North Carolina Wilmington","ror":"https://ror.org/02t0qr014","country_code":"US","type":"education","lineage":["https://openalex.org/I153901656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Logan Spaller","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC 28403, USA","University of North Carolina-Wilmington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC 28403, USA","institution_ids":["https://openalex.org/I153901656"]},{"raw_affiliation_string":"University of North Carolina-Wilmington","institution_ids":["https://openalex.org/I153901656"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058245932","display_name":"Julie M. Trieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153901656","display_name":"University of North Carolina Wilmington","ror":"https://ror.org/02t0qr014","country_code":"US","type":"education","lineage":["https://openalex.org/I153901656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie M. Trieu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC, 28403, USA","University of North Carolina-Wilmington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC, 28403, USA","institution_ids":["https://openalex.org/I153901656"]},{"raw_affiliation_string":"University of North Carolina-Wilmington","institution_ids":["https://openalex.org/I153901656"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014122045","display_name":"Paulo F. F. Almeida","orcid":"https://orcid.org/0000-0003-4591-938X","observed_orcids":["https://orcid.org/0000-0003-4591-938X"]},"institutions":[{"id":"https://openalex.org/I153901656","display_name":"University of North Carolina Wilmington","ror":"https://ror.org/02t0qr014","country_code":"US","type":"education","lineage":["https://openalex.org/I153901656"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paulo F. Almeida","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC, 28403, USA","University of North Carolina-Wilmington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC, 28403, USA","institution_ids":["https://openalex.org/I153901656"]},{"raw_affiliation_string":"University of North Carolina-Wilmington","institution_ids":["https://openalex.org/I153901656"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014122045"],"corresponding_institution_ids":["https://openalex.org/I153901656"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":0.612,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.72474831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"246","issue":"3","first_page":"257","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.25760000944137573,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemolytic-activity","display_name":"hemolytic activity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/membrane-active-peptides","display_name":"membrane-active peptides","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":0.7860000133514404},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9010000228881836},{"id":"https://openalex.org/keywords/gibbs-free-energy-of-binding","display_name":"Gibbs free energy of binding","score":0.843999981880188},{"id":"https://openalex.org/keywords/popc-vesicles","display_name":"POPC vesicles","score":0.9190000295639038},{"id":"https://openalex.org/keywords/sheep-red-blood-cells","display_name":"sheep red blood cells","score":0.7139999866485596},{"id":"https://openalex.org/keywords/peptide-design","display_name":"peptide design","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2780943371","wikidata":"https://www.wikidata.org/wiki/Q10860475","display_name":"POPC","level":4,"score":0.9769461154937744},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7551218867301941},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6570071578025818},{"id":"https://openalex.org/C146477669","wikidata":"https://www.wikidata.org/wiki/Q334631","display_name":"Gibbs free energy","level":2,"score":0.6104913353919983},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6047071814537048},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5172260999679565},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.5076760053634644},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.49978089332580566},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4786283075809479},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.4542666971683502},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.42862969636917114},{"id":"https://openalex.org/C7070889","wikidata":"https://www.wikidata.org/wiki/Q902488","display_name":"Monolayer","level":2,"score":0.41670578718185425},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36376452445983887},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3277376592159271},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.153285950422287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10179126262664795},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D057846","descriptor_name":"Cell-Penetrating Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057846","descriptor_name":"Cell-Penetrating Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00232-013-9525-z","doi":"https://doi.org/10.1007/s00232-013-9525-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00232-013-9525-z","pdf_url":null,"source":{"id":"https://openalex.org/S967762373","display_name":"The Journal of Membrane Biology","issn_l":"0022-2631","issn":["0022-2631","1432-1424"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Membrane Biology","raw_type":"journal-article"},{"id":"pmid:23329339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23329339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of membrane biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2919697","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3584441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3584441","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3584441","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Membr Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2919697","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3584441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6779616363","display_name":null,"funder_award_id":"GM072507","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7729950208","display_name":"Mechanism of Amphipathic and Cargo-Delivery Peptides","funder_award_id":"R15GM072507","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W151064715","https://openalex.org/W1981336176","https://openalex.org/W1993614570","https://openalex.org/W1994528031","https://openalex.org/W2028869026","https://openalex.org/W2043153340","https://openalex.org/W2050535413","https://openalex.org/W2052519099","https://openalex.org/W2066343236","https://openalex.org/W2068001811","https://openalex.org/W2073817244","https://openalex.org/W2074176239","https://openalex.org/W2078326306","https://openalex.org/W2078918986","https://openalex.org/W2084246486","https://openalex.org/W2119323848","https://openalex.org/W4232166467"],"related_works":["https://openalex.org/W2049786547","https://openalex.org/W2995146175","https://openalex.org/W2013534554","https://openalex.org/W2588261767","https://openalex.org/W2143860865","https://openalex.org/W2233229479","https://openalex.org/W2043153340","https://openalex.org/W1965613322","https://openalex.org/W2006371387","https://openalex.org/W2027479493"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}