{"id":"https://openalex.org/W2043096859","doi":"https://doi.org/10.1213/00000539-199010000-00010","title":"Depression of Ventilatory Responses to Hypoxia and Hypercapnia After Pentamorphone","display_name":"Depression of Ventilatory Responses to Hypoxia and Hypercapnia After Pentamorphone","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W2043096859","doi":"https://doi.org/10.1213/00000539-199010000-00010","mag":"2043096859","pmid":"https://pubmed.ncbi.nlm.nih.gov/1698039"},"language":"en","primary_location":{"id":"doi:10.1213/00000539-199010000-00010","doi":"https://doi.org/10.1213/00000539-199010000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-199010000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051946941","display_name":"Mostafa Afifi","orcid":"https://orcid.org/0000-0002-6949-3021","observed_orcids":["https://orcid.org/0000-0002-6949-3021"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Sherif Afifi","raw_affiliation_strings":["Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina","Accepted for publication June 4, 1990","Received from the Departments of Anesthesiology and Cell Biology, Duke University Medical Center, Durham, North Carolina","Supported in part by a grant from Anaquest, Princeton, New Jersey","We thank Carmen Hurst for her continuing editorial help"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Accepted for publication June 4, 1990","institution_ids":[]},{"raw_affiliation_string":"Received from the Departments of Anesthesiology and Cell Biology, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Supported in part by a grant from Anaquest, Princeton, New Jersey","institution_ids":[]},{"raw_affiliation_string":"We thank Carmen Hurst for her continuing editorial help","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108585350","display_name":"Peter S. A. Glass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter S. A. Glass","raw_affiliation_strings":["We thank Carmen Hurst for her continuing editorial help","to Dr. Camporesi, Department of Anesthesiology, SUNY Health Science Center, 750 East Adams Street, Syracuse, NY 13210","Accepted for publication June 4, 1990","Received from the Departments of Anesthesiology and Cell Biology, Duke University Medical Center, Durham, North Carolina","Supported in part by a grant from Anaquest, Princeton, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"We thank Carmen Hurst for her continuing editorial help","institution_ids":[]},{"raw_affiliation_string":"to Dr. Camporesi, Department of Anesthesiology, SUNY Health Science Center, 750 East Adams Street, Syracuse, NY 13210","institution_ids":["https://openalex.org/I1327163397"]},{"raw_affiliation_string":"Accepted for publication June 4, 1990","institution_ids":[]},{"raw_affiliation_string":"Received from the Departments of Anesthesiology and Cell Biology, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Supported in part by a grant from Anaquest, Princeton, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072640276","display_name":"Norman A. Cohen","orcid":"https://orcid.org/0000-0001-9245-0268","observed_orcids":["https://orcid.org/0000-0001-9245-0268"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman A. Cohen","raw_affiliation_strings":["We thank Carmen Hurst for her continuing editorial help","to Dr. Camporesi, Department of Anesthesiology, SUNY Health Science Center, 750 East Adams Street, Syracuse, NY 13210","Accepted for publication June 4, 1990","Received from the Departments of Anesthesiology and Cell Biology, Duke University Medical Center, Durham, North Carolina","Supported in part by a grant from Anaquest, Princeton, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"We thank Carmen Hurst for her continuing editorial help","institution_ids":[]},{"raw_affiliation_string":"to Dr. Camporesi, Department of Anesthesiology, SUNY Health Science Center, 750 East Adams Street, Syracuse, NY 13210","institution_ids":["https://openalex.org/I1327163397"]},{"raw_affiliation_string":"Accepted for publication June 4, 1990","institution_ids":[]},{"raw_affiliation_string":"Received from the Departments of Anesthesiology and Cell Biology, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Supported in part by a grant from Anaquest, Princeton, New Jersey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034502773","display_name":"Jennifer E. Shook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer E. Shook","raw_affiliation_strings":["We thank Carmen Hurst for her continuing editorial help","to Dr. Camporesi, Department of Anesthesiology, SUNY Health Science Center, 750 East Adams Street, Syracuse, NY 13210","Accepted for publication June 4, 1990","Received from the Departments of Anesthesiology and Cell Biology, Duke University Medical Center, Durham, North Carolina","Supported in part by a grant from Anaquest, Princeton, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"We thank Carmen Hurst for her continuing editorial help","institution_ids":[]},{"raw_affiliation_string":"to Dr. Camporesi, Department of Anesthesiology, SUNY Health Science Center, 750 East Adams Street, Syracuse, NY 13210","institution_ids":["https://openalex.org/I1327163397"]},{"raw_affiliation_string":"Accepted for publication June 4, 1990","institution_ids":[]},{"raw_affiliation_string":"Received from the Departments of Anesthesiology and Cell Biology, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Supported in part by a grant from Anaquest, Princeton, New Jersey","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111600842","display_name":"Enrico\u00a0M. Camporesi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Enrico M. Camporesi","raw_affiliation_strings":["We thank Carmen Hurst for her continuing editorial help","to Dr. Camporesi, Department of Anesthesiology, SUNY Health Science Center, 750 East Adams Street, Syracuse, NY 13210","Accepted for publication June 4, 1990","Received from the Departments of Anesthesiology and Cell Biology, Duke University Medical Center, Durham, North Carolina","Supported in part by a grant from Anaquest, Princeton, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"We thank Carmen Hurst for her continuing editorial help","institution_ids":[]},{"raw_affiliation_string":"to Dr. Camporesi, Department of Anesthesiology, SUNY Health Science Center, 750 East Adams Street, Syracuse, NY 13210","institution_ids":["https://openalex.org/I1327163397"]},{"raw_affiliation_string":"Accepted for publication June 4, 1990","institution_ids":[]},{"raw_affiliation_string":"Received from the Departments of Anesthesiology and Cell Biology, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Supported in part by a grant from Anaquest, Princeton, New Jersey","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111600842"],"corresponding_institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I4210126298"],"apc_list":null,"apc_paid":null,"fwci":0.7317,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.62879939,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"71","issue":"4","first_page":"377???383","last_page":"377???383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.08139999955892563,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-analgesics","display_name":"opioid analgesics","score":0.6970000267028809},{"id":"https://openalex.org/keywords/respiratory-depression","display_name":"respiratory depression","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hypercapnia","display_name":"hypercapnia","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/respiratory-drive","display_name":"respiratory drive","score":0.527999997138977},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5329999923706055},{"id":"https://openalex.org/keywords/rebreathing","display_name":"rebreathing","score":0.5860000252723694},{"id":"https://openalex.org/keywords/end-tidal-carbon-dioxide","display_name":"end-tidal carbon dioxide","score":0.7839999794960022},{"id":"https://openalex.org/keywords/arterial-oxygen-saturation","display_name":"arterial oxygen saturation","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C2777037550","wikidata":"https://www.wikidata.org/wiki/Q615759","display_name":"Hypercapnia","level":3,"score":0.93828284740448},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8150426149368286},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7078803777694702},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6723887920379639},{"id":"https://openalex.org/C2777140959","wikidata":"https://www.wikidata.org/wiki/Q10343041","display_name":"pCO2","level":2,"score":0.6081039309501648},{"id":"https://openalex.org/C79959777","wikidata":"https://www.wikidata.org/wiki/Q754333","display_name":"Respiratory minute volume","level":3,"score":0.5972626805305481},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.48542723059654236},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.47110679745674133},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.4525938034057617},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.4450664222240448},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.25547483563423157},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.24410760402679443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23859110474586487},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.06786999106407166},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.06492656469345093},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004091","descriptor_name":"Hydromorphone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D004091","descriptor_name":"Hydromorphone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1213/00000539-199010000-00010","doi":"https://doi.org/10.1213/00000539-199010000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-199010000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"pmid:1698039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1698039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2000885549","https://openalex.org/W2007919501","https://openalex.org/W1978009168","https://openalex.org/W3129492897","https://openalex.org/W2041971778","https://openalex.org/W2030887087","https://openalex.org/W2051524240","https://openalex.org/W315489048","https://openalex.org/W2223342695","https://openalex.org/W1988831358"],"abstract_inverted_index":{"Pentamorphone":[0,127],"is":[1],"a":[2,57,79],"novel,":[3],"potent":[4],"opiate":[5],"with":[6,21,149,250],"rapid":[7],"onset":[8],"and":[9,34,43,51,73,91,95,97,107,116,121,138,159,165,167,169,175,216],"short":[10],"duration":[11],"of":[12,24,30,86,147,187],"action":[13],"that":[14,232,243],"has":[15,234],"been":[16,248],"reported":[17],"to":[18,41,135,179,195],"produce":[19],"analgesia":[20],"limited":[22,235],"depression":[23,141],"ventilation.":[25],"We":[26],"quantified":[27],"the":[28,87,103,117,132,152,224],"effects":[29,213,219,238],"pentamorphone":[31,148,188,233],"(0.08,":[32],"0.24,":[33],"0.60":[35],"micrograms/kg,":[36],"IV)":[37],"on":[38],"ventilatory":[39,133,212,236],"responses":[40,134],"hypercapnia":[42,50,94,137],"hypoxia":[44,53],"in":[45,131,162,172,239,241],"12":[46],"healthy":[47],"volunteers.":[48],"Normoxic":[49],"isocapnic":[52],"were":[54,189,214,220],"induced":[55],"through":[56],"rebreathing":[58],"method.":[59],"During":[60],"each":[61],"test":[62],"we":[63,101],"recorded":[64],"ventilation":[65],"(VE),":[66],"end":[67],"tidal":[68],"carbon":[69],"dioxide":[70],"tension":[71],"(PETCO2),":[72],"arterial":[74],"oxygen":[75],"saturation":[76],"(SO2)":[77],"using":[78],"pulse":[80],"oximeter.":[81],"Using":[82],"linear":[83],"regression":[84],"analysis":[85],"relationships":[88],"between":[89],"VE":[90,96],"PCO2":[92,112],"during":[93,99],"SO2":[98,125],"hypoxia,":[100],"determined":[102],"slope":[104,118,163,173],"(slope":[105,119],"CO2)":[106],"intercept":[108,122],"(V55),":[109],"both":[110,136],"at":[111,124,223],"55":[113],"mm":[114],"Hg,":[115],"O2)":[120],"(V80)":[123],"80%.":[126],"produced":[128,157],"dose-related":[129],"reductions":[130,161,171],"hypoxia.":[139],"Maximal":[140],"occurred":[142],"15":[143],"min":[144,206],"after":[145,207],"injection":[146],"all":[150,192],"doses;":[151],"highest":[153,225],"dose":[154],"(0.60":[155],"micrograms/kg)":[156],"48%":[158],"53%":[160],"CO2":[164],"V55,":[166],"42%":[168],"22%":[170],"O2":[174],"V80,":[176],"respectively,":[177],"relative":[178],"parallel":[180],"saline":[181],"controls.":[182],"The":[183,227],"respiratory":[184],"depressant":[185,237],"actions":[186],"short-lived,":[190],"as":[191],"parameters":[193],"returned":[194],"baseline":[196],"levels":[197],"within":[198],"45":[199],"min.":[200],"Testing":[201],"was":[202],"continued":[203],"for":[204],"180":[205],"injection,":[208],"but":[209],"no":[210],"delayed":[211],"detected,":[215],"minimal":[217],"side":[218],"reported,":[221],"even":[222],"dose.":[226],"findings":[228],"confirm":[229],"previous":[230],"reports":[231],"humans":[240],"doses":[242],"(in":[244],"other":[245],"studies)":[246],"have":[247],"associated":[249],"clinically":[251],"effective":[252],"analgesia.":[253]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
