{"id":"https://openalex.org/W2043093940","doi":"https://doi.org/10.1002/mc.2940030204","title":"Increased levels of phorbin, c\u2010myc, and ornithine decarboxylase RNAs in human colon cancer","display_name":"Increased levels of phorbin, c\u2010myc, and ornithine decarboxylase RNAs in human colon cancer","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2043093940","doi":"https://doi.org/10.1002/mc.2940030204","mag":"2043093940","pmid":"https://pubmed.ncbi.nlm.nih.gov/1693276"},"language":"en","primary_location":{"id":"doi:10.1002/mc.2940030204","doi":"https://doi.org/10.1002/mc.2940030204","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mc.2940030204","pdf_url":null,"source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025191979","display_name":"Jos\u00e9 G. Guillem","orcid":"https://orcid.org/0009-0002-5455-4749","observed_orcids":["https://orcid.org/0009-0002-5455-4749","https://orcid.org/0009-0002-3510-8276"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jose G. Guillem","raw_affiliation_strings":["Comprehensive Cancer Center, Columbia University, New York, New York","Department of Surgery, Columbia University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Surgery, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074361450","display_name":"Miriam F. Levy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam F. Levy","raw_affiliation_strings":["Comprehensive Cancer Center, Columbia University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108387170","display_name":"Ling-Ling Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Ling Hsieh","raw_affiliation_strings":["Comprehensive Cancer Center, Columbia University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101616644","display_name":"Mark D. Johnson","orcid":"https://orcid.org/0000-0001-6469-3959","observed_orcids":["https://orcid.org/0000-0001-6469-3959"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark D. Johnson","raw_affiliation_strings":["Comprehensive Cancer Center, Columbia University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113761957","display_name":"P LoGerfo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Logerfo","raw_affiliation_strings":["Comprehensive Cancer Center, Columbia University, New York, New York","Department of Surgery, Columbia University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Surgery, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112222120","display_name":"Kenneth A. Forde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth A. Forde","raw_affiliation_strings":["Comprehensive Cancer Center, Columbia University, New York, New York","Department of Surgery, Columbia University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Surgery, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112343735","display_name":"I. Bernard Weinstein","orcid":"https://orcid.org/0000-0001-5988-0901","observed_orcids":["https://orcid.org/0000-0001-5988-0901"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Bernard Weinstein","raw_affiliation_strings":["Department of Medicine, Columbia University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Columbia University, New York, New York","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025191979"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":null,"fwci":1.4352,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.80973855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"3","issue":"2","first_page":"68","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.15469999611377716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.05310000106692314,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8500000238418579},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ornithine-decarboxylase","display_name":"ornithine decarboxylase","score":1.0},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8930000066757202},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6420000195503235},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9150000214576721},{"id":"https://openalex.org/keywords/dukes-stage","display_name":"Dukes stage","score":0.5299999713897705},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5879999995231628},{"id":"https://openalex.org/keywords/colon-carcinogenesis","display_name":"colon carcinogenesis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/beta-actin","display_name":"beta-actin","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9518436193466187},{"id":"https://openalex.org/C121289238","wikidata":"https://www.wikidata.org/wiki/Q931579","display_name":"Ornithine decarboxylase","level":3,"score":0.7050922513008118},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5841184854507446},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.559100329875946},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5415163040161133},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42817947268486023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3360013961791992},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30117958784103394},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.26519864797592163}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009955","descriptor_name":"Ornithine Decarboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009955","descriptor_name":"Ornithine Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010703","descriptor_name":"Phorbol Esters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mc.2940030204","doi":"https://doi.org/10.1002/mc.2940030204","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mc.2940030204","pdf_url":null,"source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:1693276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1693276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G967081410","display_name":null,"funder_award_id":"CA-02111","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1531474138","https://openalex.org/W1878920905","https://openalex.org/W1973800266","https://openalex.org/W1978659501","https://openalex.org/W1979247639","https://openalex.org/W1980602157","https://openalex.org/W2000903132","https://openalex.org/W2002792058","https://openalex.org/W2003148533","https://openalex.org/W2003589757","https://openalex.org/W2006803901","https://openalex.org/W2032773367","https://openalex.org/W2036988662","https://openalex.org/W2063837791","https://openalex.org/W2067560990","https://openalex.org/W2071697240","https://openalex.org/W2072262157","https://openalex.org/W2076398473","https://openalex.org/W2101015327","https://openalex.org/W2127256987","https://openalex.org/W2144376894","https://openalex.org/W2144730417","https://openalex.org/W2166381838","https://openalex.org/W2168649383","https://openalex.org/W2170264926","https://openalex.org/W2171971082","https://openalex.org/W2281124822","https://openalex.org/W2302469444","https://openalex.org/W2316135868"],"related_works":["https://openalex.org/W2127256987","https://openalex.org/W7095569318","https://openalex.org/W2038330643","https://openalex.org/W2067109819","https://openalex.org/W7062336750","https://openalex.org/W2022190981","https://openalex.org/W7096382371","https://openalex.org/W2011791180","https://openalex.org/W4235325297","https://openalex.org/W1973245330"],"abstract_inverted_index":{"Our":[0],"previous":[1],"work":[2],"on":[3,264],"protein":[4],"kinase":[5],"C":[6],"(PKC)":[7],"and":[8,113,126,132,158,190,204,216,244],"colon":[9,20,29,44,66,87,143,165,235,266],"cancer":[10,144],"has":[11],"shown":[12,69],"altered":[13],"levels":[14,79,199,212,240],"of":[15,26,41,50,61,64,74,80,107,116,152,163,178,192,200,213,225,241],"PKC":[16,27,42,56],"activity":[17],"in":[18,43,58,85,91,110,140,160,175,250,262],"human":[19,65,142,234,265],"tumors,":[21],"as":[22,24,33,258],"well":[23],"activation":[25],"by":[28,55,70],"tumor":[30,88,166,194,226],"promoters":[31],"such":[32],"bile":[34],"acids.":[35],"To":[36],"understand":[37],"further":[38],"the":[39,48,105,111,114,150,176,223],"role":[40],"carcinogenesis,":[45],"we":[46],"analyzed":[47],"expression":[49,151],"phorbin,":[51],"a":[52,59,102,141,161,259],"gene":[53],"induced":[54],"activation,":[57],"series":[60],"different":[62],"stages":[63],"tumors.":[67],"As":[68],"northern":[71],"blot":[72],"analyses":[73],"poly":[75],"(A)+":[76],"RNA,":[77,208],"higher":[78],"phorbin":[81,108,120,243,251],"RNA":[82,109,121,136,180,218,252],"were":[83],"seen":[84],"26":[86],"samples":[89,195],"than":[90],"their":[92,183],"adjacent":[93,184],"normal":[94,185],"colonic":[95,186],"mucosa.":[96,187],"There":[97],"also":[98,138,148,196],"appeared":[99],"to":[100],"be":[101],"correlation":[103],"between":[104],"abundance":[106],"tumors":[112,169,236],"extent":[115,224],"invasion":[117],"(tumor-to-normal":[118],"tissue":[119],"ratio":[122],"=":[123],"4.2,":[124],"8.0,":[125],"11.9":[127],"for":[128],"Dukes'":[129],"A,":[130],"B,":[131],"C,":[133],"respectively).":[134],"Phorbin":[135],"was":[137],"abundant":[139],"line":[145],"(HT29).":[146],"We":[147],"examined":[149],"other":[153],"mitogen-responsive":[154],"genes":[155],"(c-myc,":[156],"ODC,":[157,215],"beta-actin)":[159],"set":[162],"19":[164],"samples.":[167],"All":[168],"displayed":[170],"significant":[171],"(mean":[172,202,206],"3.8-fold)":[173],"increases":[174,249],"level":[177],"c-myc":[179,245],"compared":[181],"with":[182,222],"About":[188],"47%":[189],"16%":[191],"these":[193,230],"showed":[197],"increased":[198,211,239],"ODC":[201],"3.1-fold)":[203],"beta-actin":[205,217],"1.6-fold)":[207],"respectively.":[209],"The":[210,247],"c-myc,":[214],"did":[219],"not":[220],"correlate":[221],"invasion.":[227],"Taken":[228],"together,":[229],"results":[231],"demonstrate":[232],"that":[233,254],"usually":[237],"display":[238],"both":[242],"RNAs.":[246],"marked":[248],"suggest":[253],"this":[255],"could":[256],"serve":[257],"useful":[260],"biomarker":[261],"studies":[263],"cancer.":[267]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}