{"id":"https://openalex.org/W2043091876","doi":"https://doi.org/10.5301/jn.5000044","title":"Effect of early conversion from CNI to sirolimus on outcomes in kidney transplant recipients with allograft dysfunction","display_name":"Effect of early conversion from CNI to sirolimus on outcomes in kidney transplant recipients with allograft dysfunction","publication_year":2011,"publication_date":"2011-10-24","ids":{"openalex":"https://openalex.org/W2043091876","doi":"https://doi.org/10.5301/jn.5000044","mag":"2043091876","pmid":"https://pubmed.ncbi.nlm.nih.gov/22038336"},"language":"en","primary_location":{"id":"doi:10.5301/jn.5000044","doi":"https://doi.org/10.5301/jn.5000044","is_oa":false,"landing_page_url":"https://doi.org/10.5301/jn.5000044","pdf_url":null,"source":{"id":"https://openalex.org/S201014839","display_name":"Journal of Nephrology","issn_l":"1121-8428","issn":["1121-8428","1724-6059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079361114","display_name":"Ernesto Paoletti","orcid":"https://orcid.org/0000-0002-5509-6252","observed_orcids":["https://orcid.org/0000-0002-5509-6252"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ernesto Paoletti","raw_affiliation_strings":["Department of Nephrology, Dialysis and Transplantation, San Martino Hospital, Genova, Italy. ernesto.paoletti@hsanmartino.it","Department of Nephrology, Dialysis and Transplantation, San Martino Hospital, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Dialysis and Transplantation, San Martino Hospital, Genova, Italy. ernesto.paoletti@hsanmartino.it","institution_ids":["https://openalex.org/I4210146472"]},{"raw_affiliation_string":"Department of Nephrology, Dialysis and Transplantation, San Martino Hospital, Genova, Italy","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086626117","display_name":"Elena Ratto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Ratto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113510769","display_name":"Diego Bellino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diego Bellino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025733060","display_name":"Luigina Marsano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luigina Marsano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076201267","display_name":"Paolo Cassottana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo Cassottana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045507293","display_name":"Giuseppe Cannella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giuseppe Cannella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4337,"currency":"USD","value_usd":4337},"apc_paid":null,"fwci":2.0389,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.85669782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"5","first_page":"709","last_page":"718"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.953000009059906},{"id":"https://openalex.org/keywords/calcineurin-inhibitor-withdrawal","display_name":"calcineurin inhibitor withdrawal","score":0.8569999933242798},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/chronic-allograft-dysfunction","display_name":"chronic allograft dysfunction","score":0.9490000009536743},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.9200000166893005},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.843999981880188},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cardiac-hypertrophy-regression","display_name":"cardiac hypertrophy regression","score":0.8870000243186951},{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.949999988079071},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9333453178405762},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.7070611119270325},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6928957104682922},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6788184642791748},{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.675234854221344},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.6160354614257812},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5835821032524109},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5593125820159912},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.500495433807373},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.45553186535835266},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.43123891949653625},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.39980432391166687},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.37000906467437744}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009173","descriptor_name":"Mycophenolic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009173","descriptor_name":"Mycophenolic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057915","descriptor_name":"Drug Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065095","descriptor_name":"Calcineurin Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.5301/jn.5000044","doi":"https://doi.org/10.5301/jn.5000044","is_oa":false,"landing_page_url":"https://doi.org/10.5301/jn.5000044","pdf_url":null,"source":{"id":"https://openalex.org/S201014839","display_name":"Journal of Nephrology","issn_l":"1121-8428","issn":["1121-8428","1724-6059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nephrology","raw_type":"journal-article"},{"id":"pmid:22038336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22038336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nephrology","raw_type":"Controlled Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2145337089","https://openalex.org/W93612277","https://openalex.org/W2369609260","https://openalex.org/W2009042731","https://openalex.org/W2120243011","https://openalex.org/W2127860995","https://openalex.org/W1969510397","https://openalex.org/W2411386277","https://openalex.org/W1996950371","https://openalex.org/W2079955997"],"abstract_inverted_index":{"BACKGROUND:":[0],"Studies":[1],"evaluating":[2],"the":[3,39,197,220],"effect":[4],"of":[5,105,122,201,223,266],"conversion":[6,78],"from":[7,62,79,244],"calcineurin":[8],"inhibitor":[9],"(CNI)":[10],"to":[11,43,64,81,102,246,254],"sirolimus":[12],"(SRL)":[13],"in":[14,31,53,120,124,194,248],"renal":[15,49,261],"transplant":[16],"recipients":[17],"(RTRs)":[18],"have":[19],"shown":[20],"conflicting":[21],"results,":[22],"and":[23,47,50,83,96,117,135,187,231,264],"only":[24,198],"few":[25],"short-term":[26],"uncontrolled":[27],"studies":[28],"are":[29],"available":[30],"patients":[32,149],"with":[33,56,71,86,147,250,257],"chronic":[34],"allograft":[35,57,73,251],"dysfunction.":[36],"This":[37],"is":[38],"first":[40],"controlled":[41],"study":[42],"evaluate":[44],"long-term":[45],"survival":[46,156,203],"both":[48,94,224],"cardiac":[51,267],"outcomes":[52],"nondiabetic":[54],"RTRs":[55,70,249],"dysfunction":[58,74,252],"who":[59,75],"were":[60],"converted":[61],"CNI":[63,80,245],"SRL.":[65],"METHODS:":[66],"We":[67],"evaluated":[68],"13":[69],"biopsy-proven":[72],"underwent":[76],"early":[77],"SRL,":[82],"26":[84],"controls":[85],"normal":[87],"graft":[88,262],"function":[89,263],"taking":[90],"CNI.":[91],"All":[92],"continued":[93],"steroids":[95],"mycophenolate":[97],"mofetil.":[98],"SRL":[99,151,218,247],"was":[100,196,219],"titrated":[101],"trough":[103],"levels":[104],"4-8":[106],"ng/mL.":[107],"Outcome":[108],"measures":[109],"included":[110],"3-year":[111,118,154],"event-free":[112,155,202],"survival,":[113,259],"acute":[114,189],"rejection":[115,190],"rate":[116,133],"changes":[119],"Modification":[121],"Diet":[123],"Renal":[125],"Disease":[126],"(MDRD)":[127],"Study":[128],"equation":[129],"estimated":[130],"glomerular":[131],"filtration":[132],"(eGFR)":[134],"left":[136],"ventricular":[137],"mass":[138],"index":[139],"(LVMi)":[140],"as":[141],"assessed":[142],"by":[143,204,238],"echocardiography.":[144],"RESULTS:":[145],"Compared":[146],"controls,":[148],"on":[150],"showed":[152],"better":[153,258],"(p=0.024;":[157],"log-rank":[158],"test),":[159],"significant":[160,199],"eGFR":[161,195,225],"increase":[162,226],"(+5.5":[163],"\u00b1":[164,168,178,183],"8.9":[165],"vs,":[166],"-6.4":[167],"14.7":[169],"ml/min":[170],"per":[171],"1.73":[172],"m2,":[173],"p=0.011),":[174],"LVMi":[175],"regression":[176,206,240,265],"(-9.0":[177],"7.6":[179],"g/m(2.7)":[180],"vs.":[181],"1.0":[182],"10.1":[184],"g/m(2.7),":[185],"p=0.0038)":[186],"similar":[188],"rate.":[191],"Three-year":[192],"change":[193],"predictor":[200,222],"Cox":[205],"analysis":[207],"(hazard":[208],"ratio":[209],"=":[210],"0.96;":[211],"95%":[212],"confidence":[213],"interval,":[214],"0.93-0.99;":[215],"p=0.017),":[216],"whereas":[217],"strongest":[221],"(beta":[227,234],"coefficient,":[228,235],"0.342;":[229],"p=0.01)":[230],"LVM":[232],"reduction":[233],"-0.609;":[236],"p=0.0001)":[237],"multivariate":[239],"analysis.":[241],"CONCLUSIONS:":[242],"Conversion":[243],"proved":[253],"be":[255],"associated":[256],"improved":[260],"hypertrophy.":[268]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}