{"id":"https://openalex.org/W2043085773","doi":"https://doi.org/10.1002/bdra.20307","title":"Trends of selected malformations in relation to folic acid recommendations and fortification: An international assessment","display_name":"Trends of selected malformations in relation to folic acid recommendations and fortification: An international assessment","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2043085773","doi":"https://doi.org/10.1002/bdra.20307","mag":"2043085773","pmid":"https://pubmed.ncbi.nlm.nih.gov/17029289"},"language":"en","primary_location":{"id":"doi:10.1002/bdra.20307","doi":"https://doi.org/10.1002/bdra.20307","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdra.20307","pdf_url":null,"source":{"id":"https://openalex.org/S4394736882","display_name":"Birth Defects Research Part A Clinical and Molecular Teratology","issn_l":"1542-0752","issn":["1542-0752","1542-0760"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-70"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part A: Clinical and Molecular Teratology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043230326","display_name":"Lorenzo D. Botto","orcid":"https://orcid.org/0000-0002-5322-7116","observed_orcids":["https://orcid.org/0000-0002-5322-7116"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenzo D. Botto","raw_affiliation_strings":["Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA","Department of Pediatrics, University of Utah and Utah Birth Defect Network, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Pediatrics, University of Utah and Utah Birth Defect Network, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060976038","display_name":"Alessandra Lisi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandra Lisi","raw_affiliation_strings":["Centre of the International Clearinghouse for Birth Surveillance and Research, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of the International Clearinghouse for Birth Surveillance and Research, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019665876","display_name":"Carol I Bower","orcid":"https://orcid.org/0000-0003-1138-2756","observed_orcids":["https://orcid.org/0000-0003-1138-2756"]},"institutions":[{"id":"https://openalex.org/I2801351171","display_name":"King Edward Memorial Hospital","ror":"https://ror.org/00ns3e792","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801351171"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Carol Bower","raw_affiliation_strings":["Western Australia Birth Defects Registry, King Edward Memorial Hospital, Subiaco, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western Australia Birth Defects Registry, King Edward Memorial Hospital, Subiaco, Australia","institution_ids":["https://openalex.org/I2801351171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070445571","display_name":"Mark A. Canfield","orcid":"https://orcid.org/0000-0001-8827-1881","observed_orcids":["https://orcid.org/0000-0001-8827-1881"]},"institutions":[{"id":"https://openalex.org/I1343568078","display_name":"Texas Department of State Health Services","ror":"https://ror.org/022zknp80","country_code":"US","type":"government","lineage":["https://openalex.org/I1343568078"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. Canfield","raw_affiliation_strings":["Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas","institution_ids":["https://openalex.org/I1343568078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078167062","display_name":"Nirupa Dattani","orcid":"https://orcid.org/0000-0001-9856-5904","observed_orcids":["https://orcid.org/0000-0001-9856-5904"]},"institutions":[{"id":"https://openalex.org/I1327095140","display_name":"Office for National Statistics","ror":"https://ror.org/021fhft25","country_code":"GB","type":"government","lineage":["https://openalex.org/I1327095140"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nirupa Dattani","raw_affiliation_strings":["Office for National Statistics, London, England, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office for National Statistics, London, England, United Kingdom","institution_ids":["https://openalex.org/I1327095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113660296","display_name":"Catherine De Vigan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine De Vigan","raw_affiliation_strings":["Paris Birth Defects Registry, INSERM U149, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paris Birth Defects Registry, INSERM U149, Villejuif, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005223095","display_name":"Hermien E. K. de Walle","orcid":"https://orcid.org/0000-0002-1418-8281","observed_orcids":["https://orcid.org/0000-0002-1418-8281"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hermien De Walle","raw_affiliation_strings":["EUROCAT Northern Netherlands, Department of Medical Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EUROCAT Northern Netherlands, Department of Medical Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David J. Erickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210109585","display_name":"National Center on Birth Defects and Developmental Disabilities","ror":"https://ror.org/021asz590","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Erickson","raw_affiliation_strings":["National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210109585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086543668","display_name":"Jane L. Halliday","orcid":"https://orcid.org/0000-0001-6206-3857","observed_orcids":["https://orcid.org/0000-0001-6206-3857"]},"institutions":[{"id":"https://openalex.org/I4210091014","display_name":"Department of Health and Human Services","ror":"https://ror.org/00b9jhh55","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801037857","https://openalex.org/I4210091014"]},{"id":"https://openalex.org/I4210142080","display_name":"Services Australia","ror":"https://ror.org/03gwaxw53","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801453606","https://openalex.org/I4210142080","https://openalex.org/I4210163987"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jane Halliday","raw_affiliation_strings":["Birth Defects Register, Public Health, Department of Human Services, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birth Defects Register, Public Health, Department of Human Services, Melbourne, Australia","institution_ids":["https://openalex.org/I4210091014","https://openalex.org/I4210142080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111994213","display_name":"Lorentz M. Irgens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1333353642","display_name":"Norwegian Institute of Public Health","ror":"https://ror.org/046nvst19","country_code":"NO","type":"government","lineage":["https://openalex.org/I1333353642","https://openalex.org/I4210149801","https://openalex.org/I4210163359"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Lorentz M. Irgens","raw_affiliation_strings":["Medical Birth Registry, Norwegian Institute of Public Health, Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Birth Registry, Norwegian Institute of Public Health, Bergen, Norway","institution_ids":["https://openalex.org/I1333353642"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018496504","display_name":"Robert Brian Lowry","orcid":"https://orcid.org/0000-0002-8568-7598","observed_orcids":["https://orcid.org/0000-0002-8568-7598"]},"institutions":[{"id":"https://openalex.org/I4210139508","display_name":"Alberta Health","ror":"https://ror.org/03pz1p187","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210139508"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. Brian Lowry","raw_affiliation_strings":["Alberta Congenital Anomalies Surveillance System, Alberta Health & Wellness, Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alberta Congenital Anomalies Surveillance System, Alberta Health & Wellness, Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I4210139508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110358324","display_name":"Robert McDonnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37076085","display_name":"Health Service Executive","ror":"https://ror.org/04zke5364","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I37076085","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Robert McDonnell","raw_affiliation_strings":["Dublin EUROCAT Registry of Congenital Anomalies, Population Health Directorate, Health Service Executive, Dr. Steeven's Hospital, Dublin, Republic of Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dublin EUROCAT Registry of Congenital Anomalies, Population Health Directorate, Health Service Executive, Dr. Steeven's Hospital, Dublin, Republic of Ireland","institution_ids":["https://openalex.org/I37076085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109814392","display_name":"J\u00falia M\u00e9tneki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151547","display_name":"National Center for Epidemiology","ror":"https://ror.org/05drnnd98","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210151547"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Julia Metneki","raw_affiliation_strings":["Hungarian Congenital Abnormality Registry, Department of Human Genetics and Teratology, National Centre for Epidemiology, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hungarian Congenital Abnormality Registry, Department of Human Genetics and Teratology, National Centre for Epidemiology, Budapest, Hungary","institution_ids":["https://openalex.org/I4210151547"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066930727","display_name":"Simone P\u00f6tzsch","orcid":"https://orcid.org/0000-0003-1081-1301","observed_orcids":["https://orcid.org/0000-0003-1081-1301"]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simone Poetzsch","raw_affiliation_strings":["Malformation Monitoring Saxony-Anhalt, Faculty of Medicine, Otto-von-Guericke University, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malformation Monitoring Saxony-Anhalt, Faculty of Medicine, Otto-von-Guericke University, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088544413","display_name":"Annukka Ritvanen","orcid":"https://orcid.org/0000-0002-8438-7219","observed_orcids":["https://orcid.org/0000-0002-8438-7219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annukka Ritvanen","raw_affiliation_strings":["Finnish Register of Congenital Malformations, National Research and Development Centre for Welfare and Health (STAKES), Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Finnish Register of Congenital Malformations, National Research and Development Centre for Welfare and Health (STAKES), Helsinki, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112462343","display_name":"Elisabeth Robert\u2010Gnansia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisabeth Robert-Gnansia","raw_affiliation_strings":["Institut Europe\u0301en de Ge\u0301nomutations, Lyon, France","Institut Europ\u00e9en de G\u00e9nomutations, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Europe\u0301en de Ge\u0301nomutations, Lyon, France","institution_ids":[]},{"raw_affiliation_string":"Institut Europ\u00e9en de G\u00e9nomutations, Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062219947","display_name":"Csaba Siffel","orcid":"https://orcid.org/0000-0002-6491-6953","observed_orcids":["https://orcid.org/0000-0002-6491-6953"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210109585","display_name":"National Center on Birth Defects and Developmental Disabilities","ror":"https://ror.org/021asz590","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I4210109585"]},{"id":"https://openalex.org/I4210151547","display_name":"National Center for Epidemiology","ror":"https://ror.org/05drnnd98","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210151547"]}],"countries":["HU","US"],"is_corresponding":false,"raw_author_name":"Csaba Siffel","raw_affiliation_strings":["Hungarian Congenital Abnormality Registry, Department of Human Genetics and Teratology, National Centre for Epidemiology, Budapest, Hungary","National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hungarian Congenital Abnormality Registry, Department of Human Genetics and Teratology, National Centre for Epidemiology, Budapest, Hungary","institution_ids":["https://openalex.org/I4210151547"]},{"raw_affiliation_string":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210109585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037644548","display_name":"Claude G. Stoll","orcid":"https://orcid.org/0000-0003-4280-9257","observed_orcids":["https://orcid.org/0000-0003-4280-9257"]},"institutions":[{"id":"https://openalex.org/I4394709158","display_name":"Laboratoire de G\u00e9n\u00e9tique M\u00e9dicale","ror":"https://ror.org/016wpzq40","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4394709158","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claude Stoll","raw_affiliation_strings":["Laboratoire de Ge\u0301netique Me\u0301dicale, Faculte\u0301 de Me\u0301decine, Strasbourg, France","Laboratoire de G\u00e9netique M\u00e9dicale, Facult\u00e9 de M\u00e9decine, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Ge\u0301netique Me\u0301dicale, Faculte\u0301 de Me\u0301decine, Strasbourg, France","institution_ids":["https://openalex.org/I4394709158"]},{"raw_affiliation_string":"Laboratoire de G\u00e9netique M\u00e9dicale, Facult\u00e9 de M\u00e9decine, Strasbourg, France","institution_ids":["https://openalex.org/I4394709158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084787851","display_name":"Pierpaolo Mastroiacovo","orcid":"https://orcid.org/0000-0002-8318-8664","observed_orcids":["https://orcid.org/0000-0002-8318-8664"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pierpaolo Mastroiacovo","raw_affiliation_strings":["Centre of the International Clearinghouse for Birth Surveillance and Research, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of the International Clearinghouse for Birth Surveillance and Research, Rome, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":10,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5084787851"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.0014,"has_fulltext":false,"cited_by_count":108,"citation_normalized_percentile":{"value":0.97457674,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"76","issue":"10","first_page":"693","last_page":"705"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12716","display_name":"Congenital Anomalies and Fetal Surgery","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.7639999985694885},{"id":"https://openalex.org/keywords/neural-tube-defects","display_name":"neural tube defects","score":0.765999972820282},{"id":"https://openalex.org/keywords/food-fortification","display_name":"food fortification","score":0.824999988079071},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.7829999923706055},{"id":"https://openalex.org/keywords/birth-defect-surveillance","display_name":"birth defects surveillance","score":0.5479999780654907},{"id":"https://openalex.org/keywords/abortion","display_name":"abortion","score":0.6209999918937683},{"id":"https://openalex.org/keywords/population-trends","display_name":"population trends","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C198211336","wikidata":"https://www.wikidata.org/wiki/Q57821","display_name":"Fortification","level":2,"score":0.73324054479599},{"id":"https://openalex.org/C73269764","wikidata":"https://www.wikidata.org/wiki/Q954529","display_name":"Poisson regression","level":3,"score":0.6799322962760925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6725409030914307},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.5960630774497986},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5648454427719116},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5377210974693298},{"id":"https://openalex.org/C2777900319","wikidata":"https://www.wikidata.org/wiki/Q15121266","display_name":"Food fortification","level":3,"score":0.46408459544181824},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.4549334943294525},{"id":"https://openalex.org/C37512671","wikidata":"https://www.wikidata.org/wiki/Q203516","display_name":"Birth rate","level":4,"score":0.45162078738212585},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.36472541093826294},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.2974434494972229},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.12764972448349},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07019487023353577},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005527","descriptor_name":"Food, Fortified","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007391","descriptor_name":"International Cooperation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017408","descriptor_name":"Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1002/bdra.20307","doi":"https://doi.org/10.1002/bdra.20307","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdra.20307","pdf_url":null,"source":{"id":"https://openalex.org/S4394736882","display_name":"Birth Defects Research Part A Clinical and Molecular Teratology","issn_l":"1542-0752","issn":["1542-0752","1542-0760"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-70"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part A: Clinical and Molecular Teratology","raw_type":"journal-article"},{"id":"pmid:17029289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17029289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth defects research. Part A, Clinical and molecular teratology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/1ae100db-79e7-4518-8fdf-ffe966bcab81","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/1ae100db-79e7-4518-8fdf-ffe966bcab81","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.julkari.fi:10024/96848","doi":null,"is_oa":false,"landing_page_url":"http://www.julkari.fi/handle/10024/96848","pdf_url":null,"source":{"id":"https://openalex.org/S4306402058","display_name":"STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"B1 Kirjoitus tieteellisess\u00e4 aikakauslehdess\u00e4 (Unrefereed journal articles)s"},{"id":"pmh:oai:www.lenus.ie:10147/323885","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10147/323885","pdf_url":null,"source":{"id":"https://openalex.org/S4306401756","display_name":"Lenus, The Irish Health Repository (Dr Steevens Hospital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/1ae100db-79e7-4518-8fdf-ffe966bcab81","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/1ae100db-79e7-4518-8fdf-ffe966bcab81","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Birth Defects Research. Part A: Clinical and Molecular Teratology, 76(10), 693 - 705. Wiley-Blackwell","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.6735000014305115,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4521508337","display_name":null,"funder_award_id":"U50/CCU207141","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W111621003","https://openalex.org/W1966880658","https://openalex.org/W1968159341","https://openalex.org/W1983803438","https://openalex.org/W2002262392","https://openalex.org/W2034641962","https://openalex.org/W2048151432","https://openalex.org/W2052314468","https://openalex.org/W2058778432","https://openalex.org/W2061839294","https://openalex.org/W2077216942","https://openalex.org/W2082643412","https://openalex.org/W2096528296","https://openalex.org/W2098453804","https://openalex.org/W2115609680","https://openalex.org/W2120700650","https://openalex.org/W2121099849","https://openalex.org/W2130693239","https://openalex.org/W2160059463","https://openalex.org/W2164632261","https://openalex.org/W2167358139","https://openalex.org/W2171408959","https://openalex.org/W2322037963","https://openalex.org/W2322115878","https://openalex.org/W2325417132","https://openalex.org/W2326564641","https://openalex.org/W2411646774","https://openalex.org/W4206832593","https://openalex.org/W4237533794"],"related_works":["https://openalex.org/W2115609680","https://openalex.org/W1980141163","https://openalex.org/W4293276836","https://openalex.org/W1986767566","https://openalex.org/W2392661871","https://openalex.org/W2767306601","https://openalex.org/W2010963165","https://openalex.org/W7123342220","https://openalex.org/W3116667537","https://openalex.org/W6931084910"],"abstract_inverted_index":{"BACKGROUND:":[0],"Two":[1],"crucial":[2],"issues":[3],"relative":[4],"to":[5,73,211],"the":[6,14,30,44,75,196],"benefits":[7],"and":[8,38,58,79,107,119,129],"impact":[9],"of":[10,16,33,46,60,77,85,112,166,200],"folic":[11,201],"acid":[12,202],"in":[13,28,66,138,144,150,184,194,203,206,214],"prevention":[15],"birth":[17,48,87,98,159,182,221],"defects":[18,36,99,183,222],"are":[19,26],"whether":[20,39],"supplementation":[21,153],"recommendations":[22,70,78,154,171],"alone,":[23],"without":[24],"fortification,":[25],"effective":[27,213],"reducing":[29,215],"population-wide":[31,204],"rates":[32,57],"neural":[34],"tube":[35],"(NTDs),":[37],"such":[40],"policies":[41,121],"can":[42],"reduce":[43],"occurrence":[45],"other":[47,157,220],"defects.":[49,88],"Using":[50],"data":[51,93],"from":[52,100,103],"15":[53],"registries,":[54],"we":[55],"assessed":[56,125],"trends":[59,139],"14":[61],"major":[62,86,97,158,167],"defects,":[63,160],"including":[64],"NTDs,":[65],"areas":[67,145,151],"with":[68,146,152],"official":[69],"or":[71,122,172],"fortification":[72,80,123,147],"assess":[74],"effectiveness":[76],"on":[81,96,219],"a":[82],"wide":[83],"range":[84],"METHODS:":[89],"We":[90],"evaluated":[91],"surveillance":[92],"through":[94],"2003":[95],"population-based":[101],"registries":[102],"Europe,":[104],"North":[105],"America,":[106],"Australia.":[108],"All":[109],"included":[110],"ascertainment":[111],"pregnancy":[113],"terminations":[114],"(where":[115],"legal).":[116],"Trends":[117],"before":[118],"after":[120,170],"were":[124,130,140,178],"via":[126,132],"Poisson":[127],"regression":[128],"compared":[131],"rate":[133],"ratios.":[134],"RESULTS:":[135],"Significant":[136],"changes":[137,169],"seen":[141],"for":[142,180],"NTDs":[143],"but":[148],"not":[149],"alone.":[155],"For":[156],"there":[161],"was":[162],"an":[163,191],"overall":[164],"lack":[165],"trend":[168],"fortification.":[173],"However,":[174],"some":[175],"significant":[176],"declines":[177],"observed":[179],"select":[181],"individual":[185],"areas.":[186],"CONCLUSIONS:":[187],"Recommendations":[188],"alone":[189],"remain":[190],"ineffective":[192],"approach":[193],"translating":[195],"known":[197],"protective":[198],"effect":[199,218],"decline":[205],"NTD":[207],"rates.":[208],"Fortification":[209],"appears":[210],"be":[212],"NTDs.":[216],"The":[217],"remains":[223],"unclear.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}