{"id":"https://openalex.org/W2043079388","doi":"https://doi.org/10.1126/science.1684251","title":"Oxidative Damage to Behavior During Aging","display_name":"Oxidative Damage to Behavior During Aging","publication_year":1991,"publication_date":"1991-12-13","ids":{"openalex":"https://openalex.org/W2043079388","doi":"https://doi.org/10.1126/science.1684251","mag":"2043079388","pmid":"https://pubmed.ncbi.nlm.nih.gov/1684251"},"language":"en","primary_location":{"id":"doi:10.1126/science.1684251","doi":"https://doi.org/10.1126/science.1684251","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1684251","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109321252","display_name":"Robert A. Floyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert A. Floyd","raw_affiliation_strings":["Molecular Toxicology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Toxicology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104","institution_ids":["https://openalex.org/I30558944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109321252"],"corresponding_institution_ids":["https://openalex.org/I30558944"],"apc_list":null,"apc_paid":null,"fwci":4.2239,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.94029851,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"254","issue":"5038","first_page":"1597","last_page":"1597"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.08389999717473984,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.05689999833703041,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.6480000019073486},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9639999866485596},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.9369999766349792},{"id":"https://openalex.org/keywords/oxidized-proteins","display_name":"oxidized proteins","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pbn","display_name":"PBN","score":0.6589999794960022},{"id":"https://openalex.org/keywords/spin-trapping","display_name":"spin trapping","score":0.8270000219345093},{"id":"https://openalex.org/keywords/glutamine-synthetase","display_name":"glutamine synthetase","score":0.7649999856948853},{"id":"https://openalex.org/keywords/neutral-protease","display_name":"neutral protease","score":0.9290000200271606},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.824999988079071},{"id":"https://openalex.org/keywords/radial-arm-maze","display_name":"radial maze","score":0.7599999904632568},{"id":"https://openalex.org/keywords/mongolian-gerbil","display_name":"Mongolian gerbil","score":0.8769999742507935},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.4729999899864197},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.6957984566688538},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5237812399864197},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4412471652030945},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27539190649986267},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10697764158248901}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005849","descriptor_name":"Gerbillinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005974","descriptor_name":"Glutamate-Ammonia Ligase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1684251","doi":"https://doi.org/10.1126/science.1684251","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1684251","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:1684251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1684251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1275455626","display_name":"MECHANISMS OF OXIDATIVE DAMAGE IN BRAIN","funder_award_id":"R01NS023307","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2546898247","display_name":"AGE INFLUENCE ON ISCHEMIA REPERFUSION IN BRAIN","funder_award_id":"R01AG009690","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1544390057","https://openalex.org/W1600728970","https://openalex.org/W1745925983","https://openalex.org/W1966490843","https://openalex.org/W2054360287","https://openalex.org/W2054526264","https://openalex.org/W2056168344","https://openalex.org/W2056620406","https://openalex.org/W2065264404","https://openalex.org/W4234604396"],"related_works":["https://openalex.org/W2054360287","https://openalex.org/W2023105087","https://openalex.org/W2001135895","https://openalex.org/W2444400341","https://openalex.org/W2082273865","https://openalex.org/W2188434730","https://openalex.org/W2121785931","https://openalex.org/W2045490373","https://openalex.org/W1975422962","https://openalex.org/W6995638597"],"abstract_inverted_index":{"The":[0,33],"proposition":[1],"that":[2,42,63,72],"free":[3,77,87,101],"radicals":[4,88,102],"may":[5,51,67],"be":[6,14,52,68],"an":[7,130],"important":[8],"factor":[9],"in":[10,26,38,58,123,132,140,147,153,180,211,221],"aging":[11,27,50,59],"remains":[12],"to":[13,106,117,175,207],"rigorously":[15],"proven;":[16],"but":[17],"the":[18,31,43,124,148,154,166,172,181,190,208],"presence":[19],"of":[20,23,35,45,55,110,115,126,150,171,187,192],"increased":[21],"amounts":[22],"oxidized":[24,127,194],"proteins":[25,48],"biological":[28],"systems":[29],"supports":[30],"notion.":[32],"results":[34],"new":[36],"experiments":[37],"Mongolian":[39],"gerbils":[40,119,174],"indicate":[41],"accumulation":[44],"oxidatively":[46],"damaged":[47],"during":[49],"a":[53,82,91,121,145],"cause":[54],"behavioral":[56,169],"deficits":[57],"experimental":[60,111],"animals":[61],"and":[62,75,89,99,108,129,136,168,201],"this":[64],"chronic":[65],"oxidation":[66],"reversible":[69],"with":[70,74,86],"compounds":[71],"react":[73],"stabilize":[76],"radicals.":[78],"PBN":[79,95,116,163,188,215],"(N-tert-butyl-{alpha}-phenyl":[80],"nitrone),":[81],"spin-trapping":[83],"compound,":[84],"reacts":[85],"yields":[90],"stable":[92],"nitroxyl":[93],"product.":[94],"offers":[96],"protection":[97],"from,":[98],"traps":[100],"during,":[103],"ischemia-reperfusion-mediated":[104],"injury":[105],"heart":[107],"brain":[109],"animals.":[112],"Daily":[113],"administration":[114,164],"old":[118],"causes":[120],"decrease":[122,146],"amount":[125,191],"protein":[128,195],"increase":[131],"both":[133,193],"glutamine":[134],"synthetase":[135,200],"neutral":[137,202],"protease":[138,203],"activity":[139],"brain,":[141],"as":[142,144,196,198],"well":[143,197],"number":[149],"errors":[151],"made":[152],"radial-arm":[155],"maze":[156],"test":[157],"for":[158],"memory.":[159],"In":[160],"other":[161],"words,":[162],"reversed":[165],"chemical":[167],"parameters":[170],"older":[173,213],"nearly":[176],"those":[177],"values":[178,209],"observed":[179],"younger":[182],"gerbils.":[183,214],"Furthermore,":[184],"after":[185],"cessation":[186],"administration,":[189],"glutaminemore\u00a0\u00bb":[199],"activities":[204],"gradually":[205],"returned":[206],"found":[210],"normal,":[212],"did":[216],"not":[217],"have":[218],"these":[219],"effects":[220],"young":[222],"gerbils.\u00ab\u00a0less":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
