{"id":"https://openalex.org/W2043030760","doi":"https://doi.org/10.1289/ehp.98106587","title":"Exposure of Human Proximal Tubule Cells to Cd 2+ ,Zn 2+ , and Cu 2+ Induces Metallothionein Protein Accumulation but not Metallothionein Isoform 2 mRNA","display_name":"Exposure of Human Proximal Tubule Cells to Cd 2+ ,Zn 2+ , and Cu 2+ Induces Metallothionein Protein Accumulation but not Metallothionein Isoform 2 mRNA","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2043030760","doi":"https://doi.org/10.1289/ehp.98106587","mag":"2043030760","pmid":"https://pubmed.ncbi.nlm.nih.gov/9721259","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1533161"},"language":"en","primary_location":{"id":"doi:10.1289/ehp.98106587","doi":"https://doi.org/10.1289/ehp.98106587","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.98106587","pdf_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.98106587","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.98106587","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068566357","display_name":"Scott H. Garrett","orcid":"https://orcid.org/0000-0002-4398-9213","observed_orcids":["https://orcid.org/0000-0002-4398-9213"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S H Garrett","raw_affiliation_strings":["Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, WV 26506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, WV 26506, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009658338","display_name":"Seema Somji","orcid":"https://orcid.org/0000-0001-8044-5234","observed_orcids":["https://orcid.org/0000-0001-8044-5234"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Somji","raw_affiliation_strings":["Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, WV 26506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, WV 26506, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J H Todd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J H Todd","raw_affiliation_strings":["Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, WV 26506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, WV 26506, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081166985","display_name":"Donald A. Sens","orcid":"https://orcid.org/0000-0002-7163-5236","observed_orcids":["https://orcid.org/0000-0002-7163-5236"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D A Sens","raw_affiliation_strings":["Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, WV 26506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert C. Byrd Health Sciences Center, Department of Pathology, West Virginia University, Morgantown, WV 26506, USA","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":3.0969,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.91259921,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"106","issue":"9","first_page":"587","last_page":"587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.7246000170707703,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.7246000170707703,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.2720000147819519,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12780","display_name":"Heavy Metal Pollution Remediation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/metallothionein-isoforms","display_name":"metallothionein isoforms","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.8849999904632568},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.9990000128746033},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":1.0},{"id":"https://openalex.org/keywords/metal-toxicity","display_name":"metal toxicity","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C20719415","wikidata":"https://www.wikidata.org/wiki/Q416896","display_name":"Metallothionein","level":3,"score":0.936096727848053},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7300480008125305},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5912441611289978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5847707390785217},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5580317974090576},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5395805835723877},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5169379115104675},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47795963287353516},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39243894815444946},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28657251596450806},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23730620741844177}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019216","descriptor_name":"Metals, Heavy","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1289/ehp.98106587","doi":"https://doi.org/10.1289/ehp.98106587","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.98106587","pdf_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.98106587","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"doi:10.2307/3434234","doi":"https://doi.org/10.2307/3434234","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3434234","pdf_url":"https://www.jstor.org/institutionSearch?redirectUri=%2fstable%2f3434234","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"pmid:9721259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9721259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental health perspectives","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.276.5553","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.5553","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/95/ad/Environ_Health_Perspect_1998_Sep_106(9)_587-595.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1289/ehp.98106587","doi":"https://doi.org/10.1289/ehp.98106587","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.98106587","pdf_url":"https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.98106587","source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5167598382","display_name":"METALLOTHIONEIN ISOFORMS AND HUMAN NEPHROTOXICITY","funder_award_id":"R01ES007687","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2043030760.pdf","grobid_xml":"https://content.openalex.org/works/W2043030760.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W42422421","https://openalex.org/W149789775","https://openalex.org/W165455118","https://openalex.org/W199222544","https://openalex.org/W1781762976","https://openalex.org/W1946138606","https://openalex.org/W1968376121","https://openalex.org/W1972379271","https://openalex.org/W1985509310","https://openalex.org/W1985712270","https://openalex.org/W1999173548","https://openalex.org/W2001333369","https://openalex.org/W2003536815","https://openalex.org/W2003848376","https://openalex.org/W2014612933","https://openalex.org/W2020752108","https://openalex.org/W2022609273","https://openalex.org/W2022979323","https://openalex.org/W2026471826","https://openalex.org/W2027452172","https://openalex.org/W2032458072","https://openalex.org/W2034162815","https://openalex.org/W2041254257","https://openalex.org/W2041258906","https://openalex.org/W2041528098","https://openalex.org/W2042872172","https://openalex.org/W2044138044","https://openalex.org/W2061335018","https://openalex.org/W2061539842","https://openalex.org/W2063414493","https://openalex.org/W2065287297","https://openalex.org/W2067084274","https://openalex.org/W2072104803","https://openalex.org/W2073141448","https://openalex.org/W2076317340","https://openalex.org/W2091216190","https://openalex.org/W2143609309","https://openalex.org/W2145330633","https://openalex.org/W2150503085","https://openalex.org/W2153685597","https://openalex.org/W2155142285","https://openalex.org/W2203473369","https://openalex.org/W2232086804","https://openalex.org/W2296905967","https://openalex.org/W2315873339","https://openalex.org/W2404386769","https://openalex.org/W2411081953","https://openalex.org/W4250221563","https://openalex.org/W4256397837","https://openalex.org/W4256517050","https://openalex.org/W6600135713"],"related_works":["https://openalex.org/W7099817173","https://openalex.org/W2072637379","https://openalex.org/W1992083313","https://openalex.org/W7095635577","https://openalex.org/W2019615350","https://openalex.org/W2024161928","https://openalex.org/W2069259804","https://openalex.org/W1495299904","https://openalex.org/W2141158518","https://openalex.org/W1974981516"],"abstract_inverted_index":{"The":[0,20,105],"organization":[1],"of":[2,28,31,41,50,55,91,146,172,197,227,257],"the":[3,13,48,70,124,153,163,184,203,258],"human":[4,21,56,164,218],"metallothionein":[5],"(MT)":[6],"gene":[7,167],"family":[8,27],"is":[9,64],"more":[10],"complex":[11],"than":[12],"commonly":[14],"used":[15],"mouse":[16],"and":[17,34,88,97,99,138,179,216,247],"rat":[18],"models.":[19,76],"MTs":[22],"are":[23],"encoded":[24],"by":[25,195],"a":[26,169,206,224],"genes":[29,259],"consisting":[30],"10":[32],"functional":[33],"7":[35],"nonfunctional":[36],"MT":[37,51,100,147,156,239,261],"isoforms.":[38],"One":[39],"objective":[40],"this":[42,79,250],"study":[43],"was":[44,128,192],"to":[45,62,66,85,142,152,175,200,210,234],"determine":[46],"if":[47],"accumulation":[49],"protein":[52,101,148,157,240,262],"in":[53,108,121,155,208,212,222],"cultures":[54],"proximal":[57],"tubule":[58],"(HPT)":[59],"cells":[60,82,199],"exposed":[61,84],"metals":[63],"similar":[65,244],"that":[67,162,189,255],"expected":[68],"from":[69,74],"knowledge":[71],"base":[72],"obtained":[73,160],"rodent":[75],"To":[77],"accomplish":[78],"objective,":[80],"HPT":[81,198],"were":[83,103,107,117,140],"both":[86,176,213],"lethal":[87],"sublethal":[89],"concentrations":[90],"Cd2+,":[92,136],"Zn2+,":[93,137],"Cu2+,":[94],"Ag2+,":[95],"Hg2+,":[96],"Pb2+":[98],"levels":[102],"determined.":[104],"results":[106],"general":[109],"agreement":[110,132],"with":[111,133],"animal":[112,125,134,177,214,248],"model":[113,126],"studies,":[114],"although":[115],"there":[116],"some":[118],"exceptions,":[119],"mainly":[120],"areas":[122],"where":[123],"database":[127],"limited.":[129],"In":[130,150,183],"clear":[131],"models,":[135,249],"Cu2+":[139],"demonstrated":[141],"be":[143,243,265],"potent":[144],"inducers":[145],"accumulation.":[149],"contrast":[151,209],"similarity":[154],"expression,":[158],"we":[159,187],"evidence":[161,254],"renal":[165],"MT-2":[166,228],"has":[168],"unique":[170],"pattern":[171],"regulation":[173,256],"compared":[174],"models":[178,215],"human-derived":[180],"cell":[181,219],"cultures.":[182],"present":[185],"study,":[186],"determined":[188],"MT-2A":[190],"mRNA":[191,229],"not":[193],"induced":[194],"exposure":[196,233],"Cd2+":[201,235],"or":[202,236],"other":[204,217],"metals,":[205],"finding":[207,251],"studies":[211],"culture":[220],"systems":[221],"which":[223],"high":[225],"level":[226],"induction":[230],"occurs":[231],"upon":[232],"Zn2+.":[237],"While":[238],"expression":[241,263],"may":[242,264],"between":[245,267],"humans":[246],"provides":[252],"initial":[253],"underlying":[260],"divergent":[266],"species.":[268]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
