{"id":"https://openalex.org/W2042994271","doi":"https://doi.org/10.1021/ja0512881","title":"Tunable Inhibition and Denaturation of \u03b1-Chymotrypsin with Amino Acid-Functionalized Gold Nanoparticles","display_name":"Tunable Inhibition and Denaturation of \u03b1-Chymotrypsin with Amino Acid-Functionalized Gold Nanoparticles","publication_year":2005,"publication_date":"2005-08-23","ids":{"openalex":"https://openalex.org/W2042994271","doi":"https://doi.org/10.1021/ja0512881","mag":"2042994271","pmid":"https://pubmed.ncbi.nlm.nih.gov/16159281"},"language":"en","primary_location":{"id":"doi:10.1021/ja0512881","doi":"https://doi.org/10.1021/ja0512881","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja0512881","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2042994271"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109155145","display_name":"Chang\u2010Cheng You","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang-Cheng You","raw_affiliation_strings":["Contribution from the Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086739027","display_name":"Mrinmoy De","orcid":"https://orcid.org/0000-0001-8394-9059","observed_orcids":["https://orcid.org/0000-0001-8394-9059"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mrinmoy De","raw_affiliation_strings":["Contribution from the Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067381195","display_name":"Gang Han","orcid":"https://orcid.org/0000-0002-2300-5862","observed_orcids":["https://orcid.org/0000-0002-2300-5862"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gang Han","raw_affiliation_strings":["Contribution from the Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076949431","display_name":"Vincent M. Rotello","orcid":"https://orcid.org/0000-0002-5184-5439","observed_orcids":["https://orcid.org/0000-0002-5184-5439","https://orcid.org/0000-0002-9227-8514"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent M. Rotello","raw_affiliation_strings":["Contribution from the Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Contribution from the Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":6.4899,"has_fulltext":false,"cited_by_count":255,"citation_normalized_percentile":{"value":0.97716133,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"127","issue":"37","first_page":"12873","last_page":"12881"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.08590000122785568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-chymotrypsin","display_name":"alpha-chymotrypsin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/protein-denaturation","display_name":"protein denaturation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/protein-nanoparticle-binding","display_name":"protein-nanoparticle binding","score":0.7829999923706055},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.9950000047683716},{"id":"https://openalex.org/keywords/salt-bridge-disruption","display_name":"salt bridge disruption","score":0.5450000166893005},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hydrophobicity-index","display_name":"hydrophobicity index","score":0.7900000214576721},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/surface-charge-density","display_name":"surface charge density","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9356803894042969},{"id":"https://openalex.org/C2776923230","wikidata":"https://www.wikidata.org/wiki/Q16955798","display_name":"Denaturation (fissile materials)","level":2,"score":0.7058725357055664},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.678772509098053},{"id":"https://openalex.org/C90260826","wikidata":"https://www.wikidata.org/wiki/Q899157","display_name":"Hydrophobic effect","level":2,"score":0.658255934715271},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.6192610263824463},{"id":"https://openalex.org/C2778401398","wikidata":"https://www.wikidata.org/wiki/Q383836","display_name":"Chymotrypsin","level":4,"score":0.5707458853721619},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.5491131544113159},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.541702926158905},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.5353235602378845},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.5227397084236145},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5131629109382629},{"id":"https://openalex.org/C2776207055","wikidata":"https://www.wikidata.org/wiki/Q187980","display_name":"Polyglutamic acid","level":2,"score":0.4385172724723816},{"id":"https://openalex.org/C2780358262","wikidata":"https://www.wikidata.org/wiki/Q1540423","display_name":"Surface charge","level":2,"score":0.42274945974349976},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.4138239026069641},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.40263432264328003},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33170783519744873},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.2395641803741455},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22299295663833618},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.19995713233947754},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.17524731159210205},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16422370076179504},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.15825995802879333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13118773698806763},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.12205767631530762},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.1016673743724823},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002918","descriptor_name":"Chymotrypsin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D002918","descriptor_name":"Chymotrypsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja0512881","doi":"https://doi.org/10.1021/ja0512881","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja0512881","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:16159281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16159281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2673880665","display_name":"Monolayer Protected Nanoparticles Flavoenzyme Models","funder_award_id":"R01GM059249","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W115238100","https://openalex.org/W1505269754","https://openalex.org/W1566080486","https://openalex.org/W1965630099","https://openalex.org/W1969285549","https://openalex.org/W1971237107","https://openalex.org/W1982258330","https://openalex.org/W1983970916","https://openalex.org/W1998856395","https://openalex.org/W2000759509","https://openalex.org/W2003151156","https://openalex.org/W2011939807","https://openalex.org/W2012701289","https://openalex.org/W2017631057","https://openalex.org/W2017744970","https://openalex.org/W2022416858","https://openalex.org/W2024031821","https://openalex.org/W2033096857","https://openalex.org/W2034801992","https://openalex.org/W2040159113","https://openalex.org/W2042551540","https://openalex.org/W2047471297","https://openalex.org/W2051710717","https://openalex.org/W2053658752","https://openalex.org/W2061232098","https://openalex.org/W2075770210","https://openalex.org/W2083136425","https://openalex.org/W2090477922","https://openalex.org/W2092406887","https://openalex.org/W2094569181","https://openalex.org/W2101019741","https://openalex.org/W2105457117","https://openalex.org/W2108441660","https://openalex.org/W2132891463","https://openalex.org/W2141930154","https://openalex.org/W2153998193","https://openalex.org/W2157377686","https://openalex.org/W2168397058","https://openalex.org/W2482531400","https://openalex.org/W2907227701","https://openalex.org/W2951890323","https://openalex.org/W3035579699","https://openalex.org/W4236678350","https://openalex.org/W4250136162","https://openalex.org/W4302414012"],"related_works":["https://openalex.org/W2090241203","https://openalex.org/W2079238885","https://openalex.org/W2165363178","https://openalex.org/W1992250605","https://openalex.org/W2043717686","https://openalex.org/W1973254329","https://openalex.org/W4296691830","https://openalex.org/W2014960272","https://openalex.org/W2064907816","https://openalex.org/W2106162493"],"abstract_inverted_index":{"Water-soluble":[0],"gold":[1],"nanoparticles":[2,26],"bearing":[3],"diverse":[4],"l-amino":[5],"acid":[6,131,142],"terminals":[7],"have":[8],"been":[9],"fabricated":[10],"to":[11,62,86],"probe":[12],"the":[13,53,59,63,66,80,83,105,110,137,146],"effect":[14],"of":[15,24,56,65,82,120,140],"receptor":[16],"surface":[17,20,93,97],"on":[18],"protein":[19,60],"binding.":[21],"The":[22,43,68],"interaction":[23],"these":[25,73],"with":[27,79,128],"alpha-chymotrypsin":[28],"(ChT)":[29],"was":[30,125,152],"investigated":[31],"by":[32,90],"activity":[33],"assay,":[34],"gel":[35],"electrophoresis,":[36],"zeta-potential,":[37],"circular":[38],"dichroism,":[39],"and":[40,49,58,95,145,149],"fluorescence":[41],"spectroscopy.":[42],"results":[44],"show":[45],"that":[46,104],"both":[47,91],"electrostatic":[48],"hydrophobic":[50,54,129],"interactions":[51],"between":[52,136],"patches":[55],"receptors":[57,85],"contribute":[61],"stability":[64],"complex.":[67],"microscopic":[69],"binding":[70,147],"constants":[71],"for":[72],"receptor-protein":[74],"systems":[75],"are":[76],"10(6)-10(7)":[77],"M(-1),":[78],"capacity":[81],"nanoparticle":[84],"bind":[87],"proteins":[88],"determined":[89],"their":[92,96],"area":[94],"charge":[98],"density.":[99],"Furthermore,":[100],"it":[101],"is":[102],"found":[103],"hydrophilic":[106],"side":[107,132,143],"chains":[108,144],"destabilize":[109],"ChT":[111],"structure":[112],"through":[113],"either":[114],"competitive":[115],"hydrogen":[116],"bonding":[117],"or":[118],"breakage":[119],"salt":[121],"bridges,":[122],"whereas":[123],"denaturation":[124,150],"much":[126],"slower":[127],"amino":[130,141],"chains.":[133],"Significantly,":[134],"correlation":[135],"hydrophobicity":[138],"index":[139],"affinity":[148],"rates":[151],"observed.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
