{"id":"https://openalex.org/W2042987139","doi":"https://doi.org/10.1111/j.1540-8167.1995.tb00445.x","title":"A Randomized, Double\u2010Blind, Placebo\u2010Controlled, Dose\u2010Ranging Study of Dofetilide in Patients with Inducible Sustained Ventricular Tachyarrhythmias","display_name":"A Randomized, Double\u2010Blind, Placebo\u2010Controlled, Dose\u2010Ranging Study of Dofetilide in Patients with Inducible Sustained Ventricular Tachyarrhythmias","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W2042987139","doi":"https://doi.org/10.1111/j.1540-8167.1995.tb00445.x","mag":"2042987139","pmid":"https://pubmed.ncbi.nlm.nih.gov/8556189"},"language":"en","primary_location":{"id":"doi:10.1111/j.1540-8167.1995.tb00445.x","doi":"https://doi.org/10.1111/j.1540-8167.1995.tb00445.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1540-8167.1995.tb00445.x","pdf_url":null,"source":{"id":"https://openalex.org/S143832381","display_name":"Journal of Cardiovascular Electrophysiology","issn_l":"1045-3873","issn":["1045-3873","1540-8167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Electrophysiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030437592","display_name":"Debra S. Echt","orcid":"https://orcid.org/0009-0006-2991-8124","observed_orcids":["https://orcid.org/0009-0006-2991-8124"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"DEBRA S. ECHT","raw_affiliation_strings":["Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA","Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114034888","display_name":"John Tayu Lee","orcid":"https://orcid.org/0000-0002-1551-4923","observed_orcids":["https://orcid.org/0000-0002-1551-4923"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN T. LEE","raw_affiliation_strings":["Department of Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035271993","display_name":"Katherine T. Murray","orcid":"https://orcid.org/0000-0002-1342-4457","observed_orcids":["https://orcid.org/0000-0002-1342-4457"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KATHERINE T. MURRAY","raw_affiliation_strings":["Department of Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075945583","display_name":"VICKEN R. VORPERIAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"VICKEN VORPERIAN","raw_affiliation_strings":["Department of Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091892554","display_name":"S. MARCUS BORGANEELI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. MARCUS BORGANEELI","raw_affiliation_strings":["Department of Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027563344","display_name":"Diane M. Crawford","orcid":"https://orcid.org/0000-0002-6160-2828","observed_orcids":["https://orcid.org/0000-0002-6160-2828"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DIANE M. CRAWFORD","raw_affiliation_strings":["Department of Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111676422","display_name":"Tilman Friedrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"TIEMAN FRIEDRICH","raw_affiliation_strings":["Pfizer Central Research, Groton, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Central Research, Groton, Connecticut","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058141203","display_name":"Dan M. Roden","orcid":"https://orcid.org/0000-0002-6302-0389","observed_orcids":["https://orcid.org/0000-0002-6302-0389"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DAN M. RODEN","raw_affiliation_strings":["Department of Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and Pharmacology, Vanderbilt University School of Medicine, Nashville Tennessee","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030437592"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.3018,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.92289204,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"6","issue":"9","first_page":"687","last_page":"699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.05979999899864197,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dofetilide","display_name":"dofetilide","score":1.0},{"id":"https://openalex.org/keywords/antiarrhythmic-drugs","display_name":"antiarrhythmic drugs","score":0.8259999752044678},{"id":"https://openalex.org/keywords/ventricular-fibrillation","display_name":"ventricular fibrillation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/qtc-prolongation","display_name":"QTc prolongation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/effective-refractory-period","display_name":"effective refractory period","score":0.9589999914169312},{"id":"https://openalex.org/keywords/torsades-de-pointes","display_name":"torsades de pointes","score":0.9169999957084656},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.31200000643730164},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C2777796741","wikidata":"https://www.wikidata.org/wiki/Q3712521","display_name":"Dofetilide","level":3,"score":0.9551266431808472},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8818438053131104},{"id":"https://openalex.org/C2776331378","wikidata":"https://www.wikidata.org/wiki/Q56002","display_name":"Ventricular tachycardia","level":2,"score":0.7820200324058533},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7003793120384216},{"id":"https://openalex.org/C2780486423","wikidata":"https://www.wikidata.org/wiki/Q1625433","display_name":"Torsades de pointes","level":3,"score":0.6817102432250977},{"id":"https://openalex.org/C2776312127","wikidata":"https://www.wikidata.org/wiki/Q5299247","display_name":"Dose-ranging study","level":5,"score":0.6152226328849792},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.610630989074707},{"id":"https://openalex.org/C2781005686","wikidata":"https://www.wikidata.org/wiki/Q848662","display_name":"Ventricular fibrillation","level":2,"score":0.595248818397522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5573465824127197},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5529553294181824},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5305405259132385},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4688509404659271},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.46261411905288696},{"id":"https://openalex.org/C2777008848","wikidata":"https://www.wikidata.org/wiki/Q7246836","display_name":"Proarrhythmia","level":3,"score":0.41860431432724},{"id":"https://openalex.org/C2780283014","wikidata":"https://www.wikidata.org/wiki/Q209583","display_name":"Tachycardia","level":2,"score":0.4118438959121704},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.1621987521648407},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010627","descriptor_name":"Phenethylamines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010627","descriptor_name":"Phenethylamines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017180","descriptor_name":"Tachycardia, Ventricular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017180","descriptor_name":"Tachycardia, Ventricular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017180","descriptor_name":"Tachycardia, Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1540-8167.1995.tb00445.x","doi":"https://doi.org/10.1111/j.1540-8167.1995.tb00445.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1540-8167.1995.tb00445.x","pdf_url":null,"source":{"id":"https://openalex.org/S143832381","display_name":"Journal of Cardiovascular Electrophysiology","issn_l":"1045-3873","issn":["1045-3873","1540-8167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Electrophysiology","raw_type":"journal-article"},{"id":"pmid:8556189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8556189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular electrophysiology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1857240286","https://openalex.org/W1926137227","https://openalex.org/W1967151871","https://openalex.org/W1975869151","https://openalex.org/W1980647285","https://openalex.org/W1990011953","https://openalex.org/W2002374666","https://openalex.org/W2004145281","https://openalex.org/W2006768264","https://openalex.org/W2024012318","https://openalex.org/W2028813212","https://openalex.org/W2029777311","https://openalex.org/W2036673003","https://openalex.org/W2039291883","https://openalex.org/W2040852871","https://openalex.org/W2058678940","https://openalex.org/W2064191735","https://openalex.org/W2082520477","https://openalex.org/W2083805297","https://openalex.org/W2093731719","https://openalex.org/W2094799286","https://openalex.org/W2096561881","https://openalex.org/W2133376208","https://openalex.org/W2141121342","https://openalex.org/W2168806904","https://openalex.org/W2244658434","https://openalex.org/W2331274093","https://openalex.org/W4236770673","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1998813410","https://openalex.org/W4236284766","https://openalex.org/W4252152260","https://openalex.org/W2141121342","https://openalex.org/W2112983524","https://openalex.org/W2017622412","https://openalex.org/W4403144391","https://openalex.org/W4412978953","https://openalex.org/W1983052022","https://openalex.org/W601097743"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Dofetilide":[1,103],"is":[2],"a":[3,16,206,243],"new":[4],"antiarrhythmic":[5],"agent":[6],"with":[7],"potent":[8],"IK":[9,219],"blocking":[10,220],"properties":[11],"in":[12,37,39,66,111,157,172,194,222,231],"vitro.":[13],"We":[14,212],"developed":[15,201],"dose-ranging,":[17],"placebo-controlled":[18],"study":[19,228],"design":[20,229],"to":[21,29,87,105,186,250],"define":[22],"the":[23,31,112,233],"range":[24,234],"of":[25,34,69,79,115,159,174,181,196,235,253,261],"effective":[26,140],"doses":[27,62,236],"and":[28,99,137,179,240,257,264],"evaluate":[30],"clinical":[32],"electrophysiology":[33],"intravenous":[35],"dofetilide":[36,184,216],"patients":[38,59,92,176],"whom":[40],"sustained":[41],"ventricular":[42,139,163,166,190],"tachycardia":[43,164,191],"or":[44,165],"fibrillation":[45,167],"was":[46,84,168,192],"reproducibly":[47],"inducible":[48,171],"at":[49,95,205],"baseline":[50],"electrophysiologic":[51,238],"testing.":[52],"METHODS":[53],"AND":[54],"RESULTS:":[55],"The":[56],"initial":[57],"four":[58,70,80],"received":[60],"low":[61],"that":[63],"were":[64,74,93],"increased":[65],"subsequent":[67],"groups":[68],"if":[71],"adverse":[72],"effects":[73,221,239],"absent.":[75],"In":[76],"each":[77],"group":[78,246],"patients,":[81],"one":[82],"patient":[83,200],"randomly":[85],"assigned":[86],"placebo":[88,178,245],"(double":[89],"blind).":[90],"Twenty-four":[91],"studied":[94],"six":[96],"incremental":[97,226],"loading":[98],"maintenance":[100],"infusion":[101],"regimens.":[102],"(0.1":[104],"8.0":[106],"ng/mL)":[107],"produced":[108,154],"concentration-related":[109,218],"increases":[110],"%":[113],"delta":[114],"QT":[116],"(r":[117,124,131],"=":[118,125,128,132,148,151],"0.79,":[119],"P":[120,127,134,150],"<":[121,135],"0.001),":[122],"QTc":[123],"0.60,":[126],"0.02),":[129,136],"RR":[130],"0.62,":[133],"right":[138],"refractory":[141],"period":[142],"(cycle":[143],"length":[144],"600":[145],"msec;":[146],"r":[147],"0.68,":[149],"0.04).":[152],"Placebo":[153],"no":[155,169],"changes":[156],"any":[158],"these":[160,197],"measurements.":[161],"Sustained":[162],"longer":[170],"1":[173],"6":[175],"receiving":[177,183],"8":[180],"18":[182],"(4":[185],"13":[187],"sec":[188],"nonsustained":[189],"induced":[193],"4":[195],"8).":[198],"One":[199],"torsades":[202],"de":[203],"pointes":[204],"high":[207],"concentration":[208],"(5.3":[209],"ng/mL).":[210],"CONCLUSIONS:":[211],"conclude":[213],"that:":[214],"(1)":[215],"produces":[217],"patients;":[223],"(2)":[224],"an":[225],"dose-ranging":[227],"aids":[230],"identifying":[232],"demonstrating":[237],"efficacy;":[241],"(3)":[242],"concomitant":[244],"provides":[247],"important":[248],"data":[249],"assess":[251],"reproducibility":[252],"results":[254],"over":[255],"time;":[256],"(4)":[258],"further":[259],"studies":[260],"dofetilide's":[262],"efficacy":[263],"toxicity":[265],"should":[266],"be":[267],"conducted.":[268]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
