{"id":"https://openalex.org/W2042950470","doi":"https://doi.org/10.1007/bf01219514","title":"The inhibition of insulin secretion from the perfused rat pancreas after thyroxine treatment","display_name":"The inhibition of insulin secretion from the perfused rat pancreas after thyroxine treatment","publication_year":1976,"publication_date":"1976-10-01","ids":{"openalex":"https://openalex.org/W2042950470","doi":"https://doi.org/10.1007/bf01219514","mag":"2042950470","pmid":"https://pubmed.ncbi.nlm.nih.gov/789164"},"language":"en","primary_location":{"id":"doi:10.1007/bf01219514","doi":"https://doi.org/10.1007/bf01219514","is_oa":true,"landing_page_url":"https://doi.org/10.1007/bf01219514","pdf_url":"https://link.springer.com/content/pdf/10.1007/BF01219514.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/BF01219514.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043148796","display_name":"Sigurd Lenzen","orcid":"https://orcid.org/0000-0003-2125-8193","observed_orcids":["https://orcid.org/0000-0003-2125-8193"]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Lenzen","raw_affiliation_strings":["Institut f\u00fcr Pharmakologie und Toxikologie, Universit\u00e4t G\u00f6ttingen, G\u00f6ttingen, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pharmakologie und Toxikologie, Universit\u00e4t G\u00f6ttingen, G\u00f6ttingen, Federal Republic of Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050114501","display_name":"Hans\u2010Georg Joost","orcid":"https://orcid.org/0000-0002-5860-606X","observed_orcids":["https://orcid.org/0000-0002-5860-606X"]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. G. Joost","raw_affiliation_strings":["Institut f\u00fcr Pharmakologie und Toxikologie, Universit\u00e4t G\u00f6ttingen, G\u00f6ttingen, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pharmakologie und Toxikologie, Universit\u00e4t G\u00f6ttingen, G\u00f6ttingen, Federal Republic of Germany","institution_ids":["https://openalex.org/I74656192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068599709","display_name":"A. Hasselblatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Hasselblatt","raw_affiliation_strings":["Institut f\u00fcr Pharmakologie und Toxikologie, Universit\u00e4t G\u00f6ttingen, G\u00f6ttingen, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Pharmakologie und Toxikologie, Universit\u00e4t G\u00f6ttingen, G\u00f6ttingen, Federal Republic of Germany","institution_ids":["https://openalex.org/I74656192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74656192"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":null,"fwci":2.1864,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.88021796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"5","first_page":"495","last_page":"500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.9760000109672546},{"id":"https://openalex.org/keywords/glucose-induced-insulin-release","display_name":"glucose-induced insulin release","score":0.7269999980926514},{"id":"https://openalex.org/keywords/alpha-ketobutyrate","display_name":"alpha-ketobutyrate","score":0.8519999980926514},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.9769999980926514},{"id":"https://openalex.org/keywords/glycolytic-intermediates","display_name":"glycolytic intermediates","score":0.9409999847412109},{"id":"https://openalex.org/keywords/d-glyceraldehyde","display_name":"D-glyceraldehyde","score":0.7590000033378601},{"id":"https://openalex.org/keywords/dihydroxyacetone","display_name":"dihydroxyacetone","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tolbutamide","display_name":"tolbutamide","score":0.7749999761581421},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.4410000145435333},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.625}],"concepts":[{"id":"https://openalex.org/C2776054734","wikidata":"https://www.wikidata.org/wiki/Q414275","display_name":"Tolbutamide","level":3,"score":0.8649750351905823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8149051666259766},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7688592672348022},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7424120306968689},{"id":"https://openalex.org/C2781272698","wikidata":"https://www.wikidata.org/wiki/Q423211","display_name":"Glyceraldehyde","level":4,"score":0.7175369262695312},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.6294808387756348},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46748822927474976},{"id":"https://openalex.org/C2776970464","wikidata":"https://www.wikidata.org/wiki/Q122043","display_name":"Fructose","level":2,"score":0.45774075388908386},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3951348662376404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34459763765335083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29301536083221436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1601525843143463},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0964154303073883},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.06741973757743835}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005985","descriptor_name":"Glyceraldehyde","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007651","descriptor_name":"Keto Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008358","descriptor_name":"Mannose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014044","descriptor_name":"Tolbutamide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01219514","doi":"https://doi.org/10.1007/bf01219514","is_oa":true,"landing_page_url":"https://doi.org/10.1007/bf01219514","pdf_url":"https://link.springer.com/content/pdf/10.1007/BF01219514.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},{"id":"pmid:789164","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/789164","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/bf01219514","doi":"https://doi.org/10.1007/bf01219514","is_oa":true,"landing_page_url":"https://doi.org/10.1007/bf01219514","pdf_url":"https://link.springer.com/content/pdf/10.1007/BF01219514.pdf","source":{"id":"https://openalex.org/S104375418","display_name":"Diabetologia","issn_l":"0012-186X","issn":["0012-186X","1432-0428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2042950470.pdf","grobid_xml":"https://content.openalex.org/works/W2042950470.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W157888209","https://openalex.org/W1600512256","https://openalex.org/W1965179614","https://openalex.org/W1973358565","https://openalex.org/W1981561049","https://openalex.org/W2011196179","https://openalex.org/W2012750294","https://openalex.org/W2052866364","https://openalex.org/W2073042401","https://openalex.org/W2075337005","https://openalex.org/W2117647378","https://openalex.org/W2148900667","https://openalex.org/W2211925726","https://openalex.org/W2409845375","https://openalex.org/W2414703635","https://openalex.org/W2415618938","https://openalex.org/W2416666161","https://openalex.org/W2424071767","https://openalex.org/W2500982271"],"related_works":["https://openalex.org/W1965179614","https://openalex.org/W2075337005","https://openalex.org/W2011196179","https://openalex.org/W2146194633","https://openalex.org/W2020087871","https://openalex.org/W2435539681","https://openalex.org/W2319597744","https://openalex.org/W2415618938","https://openalex.org/W2081795471","https://openalex.org/W2012460673"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}