{"id":"https://openalex.org/W2042939701","doi":"https://doi.org/10.1016/1043-6618(89)90133-3","title":"Effects of medroxyprogesterone acetate (MPA) on phosphodiesterase (PDE) activity in DMBA-induced rat mammary tumours","display_name":"Effects of medroxyprogesterone acetate (MPA) on phosphodiesterase (PDE) activity in DMBA-induced rat mammary tumours","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2042939701","doi":"https://doi.org/10.1016/1043-6618(89)90133-3","mag":"2042939701","pmid":"https://pubmed.ncbi.nlm.nih.gov/2542917"},"language":"en","primary_location":{"id":"doi:10.1016/1043-6618(89)90133-3","doi":"https://doi.org/10.1016/1043-6618(89)90133-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/1043-6618(89)90133-3","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006834545","display_name":"Silvia Racca","orcid":"https://orcid.org/0000-0002-5918-652X","observed_orcids":["https://orcid.org/0000-0002-5918-652X"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S RACCA","raw_affiliation_strings":["Istituto di Farmacologia e Terapia Sperimentale, Universit\u00e0 di Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Farmacologia e Terapia Sperimentale, Universit\u00e0 di Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044157950","display_name":"P. Squillario","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P SQUILLARIO","raw_affiliation_strings":["Istituto di Farmacologia e Terapia Sperimentale, Universit\u00e0 di Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Farmacologia e Terapia Sperimentale, Universit\u00e0 di Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097881551","display_name":"S CAROM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S CAROM","raw_affiliation_strings":["Istituto di Farmacologia e Terapia Sperimentale, Universit\u00e0 di Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Farmacologia e Terapia Sperimentale, Universit\u00e0 di Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016787512","display_name":"Sergio Bedino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S BEDINO","raw_affiliation_strings":["Dipartimento di Medicina e Oncologia Sperimentale (Sez. Biochimica), Universit\u00e0 di Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina e Oncologia Sperimentale (Sez. Biochimica), Universit\u00e0 di Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090572013","display_name":"Giovanni Testore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G TESTORE","raw_affiliation_strings":["Dipartimento di Medicina e Oncologia Sperimentale (Sez. Biochimica), Universit\u00e0 di Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina e Oncologia Sperimentale (Sez. Biochimica), Universit\u00e0 di Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034558489","display_name":"Maura Giubertoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M GIUBERTONI","raw_affiliation_strings":["Istituto di Farmacologia e Terapia Sperimentale, Universit\u00e0 di Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Farmacologia e Terapia Sperimentale, Universit\u00e0 di Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056116883","display_name":"Frederick J. DiCarlo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F DICARLO","raw_affiliation_strings":["Istituto di Farmacologia e Terapia Sperimentale, Universit\u00e0 di Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Farmacologia e Terapia Sperimentale, Universit\u00e0 di Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":null,"fwci":0.1289,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.40987814,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"1","first_page":"101","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.052299998700618744,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medroxyprogesterone-acetate","display_name":"medroxyprogesterone acetate","score":1.0},{"id":"https://openalex.org/keywords/phosphodiesterase-activity","display_name":"phosphodiesterase activity","score":0.9399999976158142},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.4970000088214874},{"id":"https://openalex.org/keywords/oocyte-quality","display_name":"oocyte quality","score":0.6430000066757202},{"id":"https://openalex.org/keywords/maternal-aging","display_name":"maternal aging","score":0.6119999885559082},{"id":"https://openalex.org/keywords/embryo-developmental-competence","display_name":"embryo developmental competence","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.6340000033378601},{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.8349088430404663},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6360577344894409},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6347947120666504},{"id":"https://openalex.org/C201604863","wikidata":"https://www.wikidata.org/wiki/Q1890716","display_name":"Polar body","level":4,"score":0.611732006072998},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4655950963497162},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4650403559207916},{"id":"https://openalex.org/C163949779","wikidata":"https://www.wikidata.org/wiki/Q507032","display_name":"Oogenesis","level":4,"score":0.42084527015686035},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.415494441986084},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33141952753067017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1571526825428009},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08746033906936646}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008525","descriptor_name":"Medroxyprogesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015127","descriptor_name":"9,10-Dimethyl-1,2-benzanthracene","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/1043-6618(89)90133-3","doi":"https://doi.org/10.1016/1043-6618(89)90133-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/1043-6618(89)90133-3","pdf_url":null,"source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:2542917","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2542917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/30463","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/30463","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322651","display_name":"Consiglio Nazionale delle Ricerche","ror":"https://ror.org/04zaypm56"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082649278","https://openalex.org/W7214165740","https://openalex.org/W2954789283","https://openalex.org/W2006649493","https://openalex.org/W2903068484","https://openalex.org/W3015946933","https://openalex.org/W2513354348","https://openalex.org/W4362595019","https://openalex.org/W2946130191","https://openalex.org/W2089676165"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}