{"id":"https://openalex.org/W2042900882","doi":"https://doi.org/10.1158/1538-7445.am2013-lb-339","title":"Abstract LB-339: Increase in tumor-associated macrophages (TAMs) after antiangiogenic therapy is associated with poor survival in recurrent glioblastoma (GBM) patients.","display_name":"Abstract LB-339: Increase in tumor-associated macrophages (TAMs) after antiangiogenic therapy is associated with poor survival in recurrent glioblastoma (GBM) patients.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2042900882","doi":"https://doi.org/10.1158/1538-7445.am2013-lb-339","mag":"2042900882"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-lb-339","doi":"https://doi.org/10.1158/1538-7445.am2013-lb-339","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-lb-339","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050628137","display_name":"Christine Lu\u2010Emerson","orcid":"https://orcid.org/0000-0002-6817-6657","observed_orcids":["https://orcid.org/0000-0002-6817-6657"]},"institutions":[{"id":"https://openalex.org/I1334536514","display_name":"Maine Medical Center","ror":"https://ror.org/03g5f5777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334536514"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Lu-Emerson","raw_affiliation_strings":["1Maine Medical Center, Scarborough, ME;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Maine Medical Center, Scarborough, ME;","institution_ids":["https://openalex.org/I1334536514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078452073","display_name":"Matija Snuderl","orcid":"https://orcid.org/0000-0003-0752-0917","observed_orcids":["https://orcid.org/0000-0003-0752-0917"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matija Snuderl","raw_affiliation_strings":["2New York University Langone Medical Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2New York University Langone Medical Center, New York, NY;","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065908337","display_name":"Nathaniel D. Kirkpatrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel D. Kirkpatrick","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090423367","display_name":"Jermaine Goveia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jermaine Goveia","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083711110","display_name":"Jennie Webster Taylor","orcid":"https://orcid.org/0000-0003-3980-5626","observed_orcids":["https://orcid.org/0000-0003-3980-5626"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennie Taylor","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079348727","display_name":"Christian J. Davidson","orcid":"https://orcid.org/0009-0007-7250-213X","observed_orcids":["https://orcid.org/0009-0007-7250-213X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Davidson","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051870010","display_name":"Yuhui Huang","orcid":"https://orcid.org/0000-0003-1985-3575","observed_orcids":["https://orcid.org/0000-0003-1985-3575"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhui Huang","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077600835","display_name":"Lars Riedemann","orcid":"https://orcid.org/0009-0005-4729-926X","observed_orcids":["https://orcid.org/0009-0005-4729-926X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lars Riedemann","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080736692","display_name":"S. Percy Ivy","orcid":"https://orcid.org/0000-0001-7747-072X","observed_orcids":["https://orcid.org/0000-0001-7747-072X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Percy Ivy","raw_affiliation_strings":["4National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023809464","display_name":"Gabriel Dan Duda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Dan Duda","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048844031","display_name":"Marek Ancukiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marek Ancukiewicz3","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059797681","display_name":"Scott Randall Plotkin","orcid":"https://orcid.org/0000-0002-6109-6419","observed_orcids":["https://orcid.org/0000-0002-6109-6419"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott R. Plotkin","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079177784","display_name":"Andrew S. Chi","orcid":"https://orcid.org/0000-0002-6642-1620","observed_orcids":["https://orcid.org/0000-0002-6642-1620"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Chi","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082835319","display_name":"Elizabeth Robins Gerstner","orcid":"https://orcid.org/0000-0003-2382-3838","observed_orcids":["https://orcid.org/0000-0003-2382-3838"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth R. Gerstner","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046746416","display_name":"April F. Eichler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"April F. Eichler","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049734695","display_name":"J\u00f6rg Dietrich","orcid":"https://orcid.org/0000-0001-8291-0136","observed_orcids":["https://orcid.org/0000-0001-8291-0136"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorg Dietrich","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091816977","display_name":"Anat O Stemmer-Rachamimov","orcid":"https://orcid.org/0000-0003-3846-5295","observed_orcids":["https://orcid.org/0000-0003-3846-5295"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anat O. Stemmer-Rachamimov","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069527451","display_name":"Tracy T. Batchelor","orcid":"https://orcid.org/0000-0001-7568-6607","observed_orcids":["https://orcid.org/0000-0001-7568-6607"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy T. Batchelor","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":null,"display_name":"Rakesh K. Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rakesh K. Jain","raw_affiliation_strings":["3Massachusetts General Hospital, Boston, MA;","#N# 3Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Massachusetts General Hospital, Boston, MA;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"#N# 3Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"LB","last_page":"339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.6625999808311462,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.6625999808311462,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.2992999851703644,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9330000281333923},{"id":"https://openalex.org/keywords/recurrent-glioblastoma","display_name":"recurrent glioblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cd11b","display_name":"CD11b","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cd68","display_name":"CD68","score":0.871999979019165},{"id":"https://openalex.org/keywords/cd163","display_name":"CD163","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tumor-infiltrating-macrophages","display_name":"tumor-infiltrating macrophages","score":0.6779999732971191},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.5299999713897705},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7329999804496765},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8059999942779541},{"id":"https://openalex.org/keywords/myeloid-cell-infiltration","display_name":"myeloid cell infiltration","score":0.7799999713897705},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.738444447517395},{"id":"https://openalex.org/C2776460901","wikidata":"https://www.wikidata.org/wiki/Q21109693","display_name":"CD68","level":3,"score":0.7098406553268433},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5713455080986023},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5687779188156128},{"id":"https://openalex.org/C2775858924","wikidata":"https://www.wikidata.org/wiki/Q18034009","display_name":"CD163","level":4,"score":0.5630945563316345},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5478188991546631},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.49909067153930664},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.4942059814929962},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48543792963027954},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.438950777053833},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.4227212965488434},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.42096197605133057},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3879280686378479},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37091031670570374},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.32452529668807983},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23943376541137695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13494345545768738},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.1139165461063385},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-lb-339","doi":"https://doi.org/10.1158/1538-7445.am2013-lb-339","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-lb-339","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2600248371","https://openalex.org/W2025770283","https://openalex.org/W1236447075","https://openalex.org/W2757347726","https://openalex.org/W4386420795","https://openalex.org/W1985364674","https://openalex.org/W3207147813","https://openalex.org/W3127905780","https://openalex.org/W2617586373","https://openalex.org/W4319035179"],"abstract_inverted_index":{"Abstract":[0],"Antiangiogenic":[1],"therapy":[2,28,175,223,295],"is":[3,296],"associated":[4,297],"with":[5,165,206,298],"increased":[6,150,183],"radiographic":[7],"responses":[8],"in":[9,29,38,98,100,109,112,121,129,132,140,143,155,169,185,188,193,209,219,237,289,301],"glioblastomas":[10],"(GBMs),":[11],"but":[12],"tumors":[13],"invariably":[14],"recur.":[15],"Because":[16],"tumor-associated":[17,290],"macrophages":[18,291],"(TAMs)":[19,292],"have":[20],"been":[21],"shown":[22],"to":[23,59],"mediate":[24],"escape":[25,220],"from":[26,48,221],"antiangiogenic":[27,54,68,174,198,222,294],"preclinical":[30],"models,":[31],"we":[32],"examined":[33],"the":[34,101,113,133,189,194,310,315],"role":[35],"of":[36,152,202,230,309,314],"TAMs":[37,74,99,111,142,216],"recurrent":[39,302],"glioblastoma":[40,303],"(rGBM)":[41],"patients.":[42,103,123,211,305],"We":[43,124],"compared":[44],"autopsy":[45],"brain":[46],"specimens":[47],"20":[49],"rGBM":[50,210],"patients":[51,61,170],"who":[52,62,171],"received":[53,63,173],"treatment":[55,72],"and":[56,77,83,90,117,137,157,161,192,224,232],"chemoradiation":[57],"(AAT+)":[58],"8":[60],"chemotherapy":[64],"and/or":[65],"radiotherapy":[66],"without":[67],"therapy,":[69],"or":[70],"no":[71],"(AAT-).":[73],"were":[75],"morphologically":[76],"phenotypically":[78],"analyzed":[79],"using":[80],"flow":[81],"cytometry":[82,94],"immunohistochemistry":[84],"(IHC)":[85],"for":[86,318],"CD68,":[87],"CD14,":[88],"CD163,":[89],"CD11b":[91],"expression.":[92],"Flow":[93],"showed":[95,181],"an":[96,107,127,138,149,182],"increase":[97,108,128,139],"AAT+":[102,122],"IHC":[104],"analysis":[105],"demonstrated":[106],"CD68+":[110],"tumor":[114,134,145,159,190],"bulk":[115,135,156,191],"(p<0.01)":[116,136],"infiltrative":[118,144,158,195],"areas":[119],"(p=0.02)":[120],"also":[125],"observed":[126],"CD11b+":[130,153,203],"cells":[131,154,204],"CD163+":[141],"(p=0.02).":[146],"Of":[147],"note,":[148],"number":[151],"(p=0.05":[160],"p=0.05,":[162],"respectively)":[163],"correlated":[164,205],"poor":[166,207,299],"overall":[167],"survival":[168,208,300],"first":[172],"at":[176],"recurrence.":[177],"In":[178],"summary,":[179],"rGBMs":[180],"infiltration":[184],"myeloid":[186],"populations":[187],"regions":[196],"after":[197,293],"therapy.":[199],"Higher":[200],"numbers":[201],"These":[212],"data":[213],"suggest":[214],"that":[215],"may":[217,225],"participate":[218],"represent":[226],"a":[227,233],"potential":[228,234],"biomarker":[229],"resistance":[231],"therapeutic":[235],"target":[236],"rGBM.":[238],"Citation":[239],"Format:":[240],"Christine":[241],"Lu-Emerson,":[242],"Matija":[243],"Snuderl,":[244],"Nathaniel":[245],"D.":[246],"Kirkpatrick,":[247],"Jermaine":[248],"Goveia,":[249],"Jennie":[250],"Taylor,":[251],"Christian":[252],"Davidson,":[253],"Yuhui":[254],"Huang,":[255],"Lars":[256],"Riedemann,":[257],"S.":[258],"Percy":[259],"Ivy,":[260],"G.":[261],"Dan":[262],"Duda,":[263],"Marek":[264],"Ancukiewicz3,":[265],"Scott":[266],"R.":[267,272],"Plotkin,":[268],"Andrew":[269],"Chi,":[270],"Elizabeth":[271],"Gerstner,":[273],"April":[274],"F.":[275],"Eichler,":[276],"Jorg":[277],"Dietrich,":[278],"Anat":[279],"O.":[280],"Stemmer-Rachamimov,":[281],"Tracy":[282],"T.":[283],"Batchelor,":[284],"Rakesh":[285],"K.":[286],"Jain.":[287],"Increase":[288],"(GBM)":[304],"[abstract].":[306],"In:":[307],"Proceedings":[308],"104th":[311],"Annual":[312],"Meeting":[313],"American":[316],"Association":[317],"Cancer":[319,329],"Research;":[320],"2013":[321],"Apr":[322],"6-10;":[323],"Washington,":[324],"DC.":[325],"Philadelphia":[326],"(PA):":[327],"AACR;":[328],"Res":[330],"2013;73(8":[331],"Suppl):Abstract":[332],"nr":[333],"LB-339.":[334],"doi:10.1158/1538-7445.AM2013-LB-339":[335]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}