{"id":"https://openalex.org/W2042890278","doi":"https://doi.org/10.1186/1471-2407-9-372","title":"Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults","display_name":"Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults","publication_year":2009,"publication_date":"2009-10-19","ids":{"openalex":"https://openalex.org/W2042890278","doi":"https://doi.org/10.1186/1471-2407-9-372","mag":"2042890278","pmid":"https://pubmed.ncbi.nlm.nih.gov/19840379","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2771045"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2407-9-372","doi":"https://doi.org/10.1186/1471-2407-9-372","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-9-372","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-9-372","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-9-372","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013779863","display_name":"Pierre A. J. T. Robe","orcid":"https://orcid.org/0000-0001-7845-6196","observed_orcids":["https://orcid.org/0000-0001-7845-6196"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Pierre A Robe","raw_affiliation_strings":["Department of Surgery (Neurosurgery), University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000 Li\u00e8ge, Belgium. p.robe@umcutrecht.nl","Department of Surgery (Neurosurgery), University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery (Neurosurgery), University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000 Li\u00e8ge, Belgium. p.robe@umcutrecht.nl","institution_ids":["https://openalex.org/I157674565"]},{"raw_affiliation_string":"Department of Surgery (Neurosurgery), University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069550484","display_name":"Didier Martin","orcid":"https://orcid.org/0000-0001-7325-4958","observed_orcids":["https://orcid.org/0000-0001-7325-4958"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Didier H Martin","raw_affiliation_strings":["Department of Surgery (Neurosurgery), University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery (Neurosurgery), University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111733353","display_name":"Minh Nguyen-Khac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Minh T Nguyen-Khac","raw_affiliation_strings":["Department of Surgery (Neurosurgery), University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery (Neurosurgery), University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016648328","display_name":"Maria Artesi","orcid":"https://orcid.org/0009-0002-5003-6143","observed_orcids":["https://orcid.org/0009-0002-5003-6143"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maria Artesi","raw_affiliation_strings":["Department of Human Genetic - CBIG Research Center, University of Li\u00e8ge, Domaine du Sart Tilman, 4000, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetic - CBIG Research Center, University of Li\u00e8ge, Domaine du Sart Tilman, 4000, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040121537","display_name":"Manuel Deprez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Manuel Deprez","raw_affiliation_strings":["Department of Pathology (Neuropathology), University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology (Neuropathology), University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103265305","display_name":"Adelin Albert","orcid":"https://orcid.org/0000-0003-3844-3774","observed_orcids":["https://orcid.org/0000-0003-3844-3774","https://orcid.org/0000-0003-1012-7331"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Adelin Albert","raw_affiliation_strings":["Department of Medical Statistics, University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Statistics, University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048679258","display_name":"Sophie Vanbelle","orcid":"https://orcid.org/0000-0001-6584-2522","observed_orcids":["https://orcid.org/0000-0001-6584-2522"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sophie Vanbelle","raw_affiliation_strings":["Department of Medical Statistics, University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Statistics, University of Li\u00e8ge, Domaine du Sart Tilman, B35, 4000, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017207324","display_name":"St\u00e8phane Califice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephane Califice","raw_affiliation_strings":["Oncomethylome Sciences SA, Avenue de l'Hopital 11, 4000, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncomethylome Sciences SA, Avenue de l'Hopital 11, 4000, Li\u00e8ge, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068526964","display_name":"Markus Bredel","orcid":"https://orcid.org/0000-0002-1436-2526","observed_orcids":["https://orcid.org/0000-0002-1436-2526","https://orcid.org/0000-0002-7828-0984"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus Bredel","raw_affiliation_strings":["Department of Neurological Surgery, Northwestern Brain Tumor Institute, Northwestern University, 303 E Superior Street, 60611-3015, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Northwestern Brain Tumor Institute, Northwestern University, 303 E Superior Street, 60611-3015, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083510035","display_name":"Vincent Bours","orcid":"https://orcid.org/0000-0002-5934-6247","observed_orcids":["https://orcid.org/0000-0002-5934-6247"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Vincent Bours","raw_affiliation_strings":["Department of Human Genetic - CBIG Research Center, University of Li\u00e8ge, Domaine du Sart Tilman, 4000, Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetic - CBIG Research Center, University of Li\u00e8ge, Domaine du Sart Tilman, 4000, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013779863"],"corresponding_institution_ids":["https://openalex.org/I157674565"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":3.6511,"has_fulltext":true,"cited_by_count":190,"citation_normalized_percentile":{"value":0.93268942,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"372","last_page":"372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfasalazine","display_name":"sulfasalazine","score":1.0},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.9229999780654907},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9089999794960022},{"id":"https://openalex.org/keywords/anaplastic-astrocytoma","display_name":"anaplastic astrocytoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/recurrent-glioma","display_name":"recurrent glioma","score":0.8059999942779541},{"id":"https://openalex.org/keywords/nf-kappab-inhibition","display_name":"NF-\u03baB inhibition","score":0.8769999742507935},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7160000205039978},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6269999742507935},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6420000195503235},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7549999952316284},{"id":"https://openalex.org/keywords/trial-termination","display_name":"trial termination","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9206498861312866},{"id":"https://openalex.org/C2779383735","wikidata":"https://www.wikidata.org/wiki/Q420035","display_name":"Sulfasalazine","level":4,"score":0.798795223236084},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.630580723285675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5707914233207703},{"id":"https://openalex.org/C61943457","wikidata":"https://www.wikidata.org/wiki/Q6046661","display_name":"Interim analysis","level":3,"score":0.5499958395957947},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5120278000831604},{"id":"https://openalex.org/C2779083369","wikidata":"https://www.wikidata.org/wiki/Q486092","display_name":"Anaplastic astrocytoma","level":4,"score":0.5066428780555725},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4312620759010315},{"id":"https://openalex.org/C2779434656","wikidata":"https://www.wikidata.org/wiki/Q415378","display_name":"Lomustine","level":5,"score":0.4261637032032013},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4126836359500885},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4015599191188812},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3953731060028076},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3303077220916748},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.29752177000045776},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.1781136393547058},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1027032732963562},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.09199544787406921},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.08531296253204346},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012460","descriptor_name":"Sulfasalazine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012460","descriptor_name":"Sulfasalazine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057239","descriptor_name":"Early Termination of Clinical Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2407-9-372","doi":"https://doi.org/10.1186/1471-2407-9-372","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-9-372","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-9-372","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2771045","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2771045","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmid:19840379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19840379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/40280","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/40280","pdf_url":"https://orbi.uliege.be/bitstream/2268/40280/1/1-Early%20termination.pdf","source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, 9, 372 (2009)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:d4470e89e00b458eb659ff400bae7ed1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d4470e89e00b458eb659ff400bae7ed1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 9, Iss 1, p 372 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2407-9-372","doi":"https://doi.org/10.1186/1471-2407-9-372","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-9-372","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-9-372","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320328144","display_name":"Fondation contre le Cancer","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2042890278.pdf","grobid_xml":"https://content.openalex.org/works/W2042890278.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W31962449","https://openalex.org/W618788809","https://openalex.org/W1509372252","https://openalex.org/W1959628099","https://openalex.org/W1965841245","https://openalex.org/W1973249583","https://openalex.org/W1999997714","https://openalex.org/W2001580102","https://openalex.org/W2004231706","https://openalex.org/W2011496352","https://openalex.org/W2013513313","https://openalex.org/W2025634492","https://openalex.org/W2039107130","https://openalex.org/W2042293617","https://openalex.org/W2045691261","https://openalex.org/W2045694644","https://openalex.org/W2046727390","https://openalex.org/W2076598729","https://openalex.org/W2084147384","https://openalex.org/W2084826448","https://openalex.org/W2086123367","https://openalex.org/W2086371412","https://openalex.org/W2090880672","https://openalex.org/W2094803435","https://openalex.org/W2096287682","https://openalex.org/W2105100844","https://openalex.org/W2107979823","https://openalex.org/W2128066516","https://openalex.org/W2145743086","https://openalex.org/W2149098798","https://openalex.org/W2151528005","https://openalex.org/W2151974759","https://openalex.org/W2183849896","https://openalex.org/W2316716290","https://openalex.org/W2409672023","https://openalex.org/W4200531859","https://openalex.org/W4313333804"],"related_works":["https://openalex.org/W2151528005","https://openalex.org/W7096819053","https://openalex.org/W2029320499","https://openalex.org/W4308976577","https://openalex.org/W7162851155","https://openalex.org/W4416139753","https://openalex.org/W7155160810","https://openalex.org/W4409319835","https://openalex.org/W50592810","https://openalex.org/W2112537558"],"abstract_inverted_index":{"BACKGROUND:":[0],"Sulfasalazine,":[1],"a":[2,10,29,223],"NF-kappaB":[3],"and":[4,46,99,130],"x(c)-cystine/glutamate":[5],"antiport":[6],"inhibitor,":[7],"has":[8],"demonstrated":[9],"strong":[11],"antitumoral":[12],"potential":[13],"in":[14,50,218,244],"preclinical":[15],"models":[16],"of":[17,34,41,79,89,96,106,112,123,133,162,208,247,252],"malignant":[18,253],"gliomas.":[19,254],"As":[20],"it":[21],"presents":[22],"an":[23],"excellent":[24],"safety":[25],"profile,":[26],"we":[27],"initiated":[28],"phase":[30],"1/2":[31],"clinical":[32,102,143],"study":[33,239],"this":[35],"anti-inflammatory":[36],"drug":[37],"for":[38,151,249],"the":[39,75,80,110,121,127,131,158,163,205,250],"treatment":[40,197,210,251],"recurrent":[42,57],"WHO":[43],"grade":[44,180,189],"3":[45],"4":[47,190],"astrocytic":[48],"gliomas":[49],"adults.":[51],"METHODS:":[52],"10":[53],"patients":[54,178,187,193,221],"with":[55,154,222],"advanced":[56],"anaplastic":[58],"astrocytoma":[59],"(n":[60,65],"=":[61,66,229],"2)":[62],"or":[63,93,103,109,114,198],"glioblastoma":[64],"8)":[67],"aged":[68],"32-62":[69],"years":[70],"were":[71,83,120,174],"recruited":[72],"prior":[73],"to":[74,86,126,216,241],"planned":[76],"interim":[77,236],"analysis":[78],"study.":[81],"Subjects":[82],"randomly":[84],"assigned":[85],"daily":[87,160],"doses":[88],"1.5,":[90],"3,":[91],"4.5,":[92],"6":[94],"grams":[95],"oral":[97],"sulfasalazine,":[98],"treated":[100],"until":[101],"radiological":[104,134],"evidence":[105],"disease":[107],"progression":[108],"development":[111],"serious":[113],"unbearable":[115],"side":[116],"effects.":[117],"Primary":[118],"endpoints":[119],"evaluation":[122],"toxicities":[124],"according":[125],"CTCAE":[128],"v.3.0,":[129],"observation":[132],"tumor":[135,148,225],"responses":[136],"based":[137],"on":[138,196,211],"MacDonald":[139],"criteria.":[140],"RESULTS:":[141],"No":[142],"response":[144],"was":[145,169,214,232],"observed.":[146],"One":[147],"remained":[149],"stable":[150],"2":[152],"months":[153],"sulfasalazine":[155,209],"treatment,":[156],"at":[157],"lowest":[159],"dose":[161],"drug.":[164],"The":[165],"median":[166],"progression-free":[167],"survival":[168],"32":[170],"days.":[171],"Side":[172],"effects":[173],"common,":[175],"as":[176],"all":[177],"developed":[179,188],"1-3":[181],"adverse":[182],"events":[183],"(mean:":[184],"7.2/patient),":[185],"four":[186],"toxicity.":[191],"Two":[192],"died":[194],"while":[195],"shortly":[199],"after":[200,234],"its":[201,235],"discontinuation.":[202],"CONCLUSION:":[203],"Although":[204],"proper":[206],"influence":[207],"patient":[212],"outcome":[213],"difficult":[215],"ascertain":[217],"these":[219],"debilitated":[220],"large":[224],"burden":[226],"(median":[227],"KPS":[228],"50),":[230],"ISRCTN45828668":[231],"terminated":[233],"analysis.":[237],"This":[238],"urges":[240],"exert":[242],"cautiousness":[243],"future":[245],"trials":[246],"Sulfasalazine":[248],"TRIAL":[255],"REGISTRATION:":[256],"Current":[257],"Controlled":[258],"Trials":[259],"ISRCTN45828668.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
