{"id":"https://openalex.org/W2042879681","doi":"https://doi.org/10.1002/1097-4636(200009)53:5<457::aid-jbm3>3.0.co;2-2","title":"In vitro bioactive behavior of hydroxylapatite-coated porous Al2O3","display_name":"In vitro bioactive behavior of hydroxylapatite-coated porous Al2O3","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2042879681","doi":"https://doi.org/10.1002/1097-4636(200009)53:5<457::aid-jbm3>3.0.co;2-2","mag":"2042879681","pmid":"https://pubmed.ncbi.nlm.nih.gov/10984692"},"language":"en","primary_location":{"id":"doi:10.1002/1097-4636(200009)53:5<457::aid-jbm3>3.0.co;2-2","doi":"https://doi.org/10.1002/1097-4636(200009)53:5<457::aid-jbm3>3.0.co;2-2","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-4636(200009)53:5<457::aid-jbm3>3.0.co;2-2","pdf_url":null,"source":{"id":"https://openalex.org/S34814058","display_name":"Journal of Biomedical Materials Research","issn_l":"0021-9304","issn":["0021-9304","1097-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090757952","display_name":"Donglu Shi","orcid":"https://orcid.org/0000-0002-0837-7780","observed_orcids":["https://orcid.org/0000-0002-0837-7780"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donglu Shi","raw_affiliation_strings":["Department of Materials Science and Engineering, University of Cincinnati, Cincinnati, Ohio 45221-0012, USA. dshi@uceng.uc.edu","Department of Materials Science and Engineering, University of Cincinnati, Cincinnati, Ohio 45221\u20100012"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Cincinnati, Cincinnati, Ohio 45221-0012, USA. dshi@uceng.uc.edu","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Cincinnati, Cincinnati, Ohio 45221\u20100012","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074574091","display_name":"Gengwei Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gengwei Jiang","raw_affiliation_strings":["Department of Materials Science and Engineering, University of Cincinnati, Cincinnati, Ohio 45221-0012"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Cincinnati, Cincinnati, Ohio 45221-0012","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103526914","display_name":"Xuejun Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuejun Wen","raw_affiliation_strings":["Department of Materials Science and Engineering, University of Cincinnati, Cincinnati, Ohio 45221-0012"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Cincinnati, Cincinnati, Ohio 45221-0012","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090757952"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":1.3869,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.79519698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"53","issue":"5","first_page":"457","last_page":"466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13470","display_name":"Surface Treatment and Coatings","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyapatite-coating","display_name":"hydroxyapatite coating","score":0.9300000071525574},{"id":"https://openalex.org/keywords/anodic-aluminum-oxide","display_name":"anodic aluminum oxide","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bone-substitutes","display_name":"bone substitutes","score":0.8489999771118164},{"id":"https://openalex.org/keywords/bioactivity-biomaterials","display_name":"bioactivity (biomaterials)","score":0.7789999842643738},{"id":"https://openalex.org/keywords/suspension-coating","display_name":"suspension coating","score":0.5049999952316284},{"id":"https://openalex.org/keywords/thermal-deposition","display_name":"thermal deposition","score":0.9160000085830688},{"id":"https://openalex.org/keywords/crystallinity","display_name":"crystallinity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/specific-surface-area","display_name":"specific surface area","score":0.9950000047683716},{"id":"https://openalex.org/keywords/in-vitro-bioactivity","display_name":"in vitro bioactivity","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2777914628","wikidata":"https://www.wikidata.org/wiki/Q413478","display_name":"Hydroxylapatite","level":3,"score":0.9763637185096741},{"id":"https://openalex.org/C46275449","wikidata":"https://www.wikidata.org/wiki/Q2458815","display_name":"Crystallinity","level":2,"score":0.8435425162315369},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.8307108879089355},{"id":"https://openalex.org/C2777746296","wikidata":"https://www.wikidata.org/wiki/Q178397","display_name":"Apatite","level":2,"score":0.7811539173126221},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.6779053807258606},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.6010816693305969},{"id":"https://openalex.org/C114874019","wikidata":"https://www.wikidata.org/wiki/Q6379013","display_name":"Simulated body fluid","level":3,"score":0.5555899143218994},{"id":"https://openalex.org/C134132462","wikidata":"https://www.wikidata.org/wiki/Q45621","display_name":"Ceramic","level":2,"score":0.550647497177124},{"id":"https://openalex.org/C64297162","wikidata":"https://www.wikidata.org/wiki/Q1987070","display_name":"Deposition (geology)","level":3,"score":0.550101637840271},{"id":"https://openalex.org/C59061564","wikidata":"https://www.wikidata.org/wiki/Q7783071","display_name":"Thermal stability","level":2,"score":0.503642737865448},{"id":"https://openalex.org/C105341887","wikidata":"https://www.wikidata.org/wiki/Q1307987","display_name":"Suspension (topology)","level":3,"score":0.49360430240631104},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.36953458189964294},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.10700640082359314},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07754352688789368},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2816523","wikidata":"https://www.wikidata.org/wiki/Q180184","display_name":"Sediment","level":2,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C5961521","wikidata":"https://www.wikidata.org/wiki/Q746083","display_name":"Homotopy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000537","descriptor_name":"Aluminum Oxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000537","descriptor_name":"Aluminum Oxide","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000537","descriptor_name":"Aluminum Oxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001826","descriptor_name":"Body Fluids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017886","descriptor_name":"Durapatite","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017886","descriptor_name":"Durapatite","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D017886","descriptor_name":"Durapatite","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018786","descriptor_name":"Bone Substitutes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D020099","descriptor_name":"Coated Materials, Biocompatible","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/1097-4636(200009)53:5<457::aid-jbm3>3.0.co;2-2","doi":"https://doi.org/10.1002/1097-4636(200009)53:5<457::aid-jbm3>3.0.co;2-2","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-4636(200009)53:5<457::aid-jbm3>3.0.co;2-2","pdf_url":null,"source":{"id":"https://openalex.org/S34814058","display_name":"Journal of Biomedical Materials Research","issn_l":"0021-9304","issn":["0021-9304","1097-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research","raw_type":"journal-article"},{"id":"doi:10.1002/1097-4636(200009)53:5<457::aid-jbm3>3.3.co;2-u","doi":"https://doi.org/10.1002/1097-4636(200009)53:5<457::aid-jbm3>3.3.co;2-u","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-4636(200009)53:5<457::aid-jbm3>3.3.co;2-u","pdf_url":null,"source":{"id":"https://openalex.org/S34814058","display_name":"Journal of Biomedical Materials Research","issn_l":"0021-9304","issn":["0021-9304","1097-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research","raw_type":"journal-article"},{"id":"pmid:10984692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10984692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1976392205","https://openalex.org/W1998990281","https://openalex.org/W2037548005","https://openalex.org/W2047225735","https://openalex.org/W2054334357","https://openalex.org/W2071292298","https://openalex.org/W2079171823","https://openalex.org/W2080742362","https://openalex.org/W2111415695","https://openalex.org/W2145985595","https://openalex.org/W2155162953","https://openalex.org/W4211176342","https://openalex.org/W4236621789","https://openalex.org/W4253688551"],"related_works":["https://openalex.org/W2082193197","https://openalex.org/W1515055339","https://openalex.org/W1976392205","https://openalex.org/W2022299440","https://openalex.org/W2919628519","https://openalex.org/W2355371444","https://openalex.org/W2745557345","https://openalex.org/W46223337","https://openalex.org/W1883141367","https://openalex.org/W41702031"],"abstract_inverted_index":{"To":[0],"produce":[1],"bioactive":[2],"materials":[3],"for":[4,105],"bone":[5],"substitutes,":[6],"two":[7],"major":[8],"deposition":[9,15],"methods,":[10],"suspension":[11],"method":[12],"and":[13,24,59],"thermal":[14],"method,":[16],"were":[17],"employed":[18],"to":[19,79],"develop":[20],"bioactive,":[21],"mechanically":[22],"strong,":[23],"porous":[25],"ceramics.":[26],"Hydroxylapatite":[27],"(HA)":[28],"has":[29,42,69],"been":[30,43],"uniformly":[31],"coated":[32],"onto":[33],"inner":[34],"pore":[35],"surfaces":[36],"of":[37,50,85,93,108],"reticulated":[38],"alumina":[39],"substrates.":[40],"It":[41],"found":[44,78,89],"that":[45,90],"the":[46,82,91,94,100,106],"in":[47,71],"vitro":[48],"bioactivity":[49],"HA":[51,64,96],"coatings":[52],"was":[53,77],"affected":[54],"by":[55],"both":[56],"structural":[57],"crystallinity":[58],"specific":[60],"surface":[61,83],"area.":[62],"Well-crystallized":[63],"heat-treated":[65],"at":[66],"high":[67,101],"temperatures":[68],"resulted":[70],"reduced":[72],"bioactivity.":[73],"The":[74],"bio-reaction":[75],"rate":[76],"increase":[80],"with":[81,99],"area":[84],"HA.":[86],"We":[87],"have":[88],"stability":[92],"well-crystallized":[95],"is":[97],"associated":[98],"driving":[102],"force":[103],"required":[104],"formation":[107],"hydroxy-carbonate":[109],"apatite":[110],"(HCA)":[111],"phase.":[112]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}