{"id":"https://openalex.org/W2042862016","doi":"https://doi.org/10.1016/j.ygyno.2014.02.017","title":"mTOR inhibitors and their clinical application in cervical, endometrial and ovarian cancers: A critical review","display_name":"mTOR inhibitors and their clinical application in cervical, endometrial and ovarian cancers: A critical review","publication_year":2014,"publication_date":"2014-02-18","ids":{"openalex":"https://openalex.org/W2042862016","doi":"https://doi.org/10.1016/j.ygyno.2014.02.017","mag":"2042862016","pmid":"https://pubmed.ncbi.nlm.nih.gov/24556063"},"language":"en","primary_location":{"id":"doi:10.1016/j.ygyno.2014.02.017","doi":"https://doi.org/10.1016/j.ygyno.2014.02.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ygyno.2014.02.017","pdf_url":null,"source":{"id":"https://openalex.org/S2574783","display_name":"Gynecologic Oncology","issn_l":"0090-8258","issn":["0090-8258","1095-6859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051078404","display_name":"Nader Husseinzadeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nader Husseinzadeh","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Cincinnati, 231 Albert Sabin Way Cincinnati, OH 45267-0526, USA. Electronic address: nader.husseinzadeh@uc.edu","Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Cincinnati, 231 Albert Sabin Way Cincinnati, OH 45267-0526, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Cincinnati, 231 Albert Sabin Way Cincinnati, OH 45267-0526, USA. Electronic address: nader.husseinzadeh@uc.edu","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Cincinnati, 231 Albert Sabin Way Cincinnati, OH 45267-0526, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005451978","display_name":"Holleh D. Husseinzadeh","orcid":"https://orcid.org/0000-0002-6205-8756","observed_orcids":["https://orcid.org/0000-0002-6205-8756"]},"institutions":[{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holleh D. Husseinzadeh","raw_affiliation_strings":["Abramson Cancer Center, Division of Hematology-Oncology, University of Pennsylvania, 200 Penn Tower, 3400 Spruce St., Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abramson Cancer Center, Division of Hematology-Oncology, University of Pennsylvania, 200 Penn Tower, 3400 Spruce St., Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4380,"currency":"USD","value_usd":4380},"apc_paid":null,"fwci":1.4488,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.8227704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"133","issue":"2","first_page":"375","last_page":"381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":1.0},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.777999997138977},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":1.0},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":1.0},{"id":"https://openalex.org/keywords/gynecologic-cancer","display_name":"gynecologic cancer","score":0.8349999785423279},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.968999981880188},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.4830000102519989},{"id":"https://openalex.org/keywords/hormone-therapy","display_name":"hormone therapy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8848389387130737},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8143625259399414},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.7070739269256592},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6706023812294006},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.5558934211730957},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5326342582702637},{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.5195751190185547},{"id":"https://openalex.org/C2780435969","wikidata":"https://www.wikidata.org/wiki/Q5625186","display_name":"Gynecologic oncology","level":2,"score":0.5178492665290833},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5167088508605957},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4696347713470459},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.44318902492523193},{"id":"https://openalex.org/C2994372414","wikidata":"https://www.wikidata.org/wiki/Q5625186","display_name":"Gynecologic cancer","level":4,"score":0.44053131341934204},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4263540208339691},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41417741775512695},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.41240236163139343},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15960779786109924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09151086211204529},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068338","descriptor_name":"Everolimus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ygyno.2014.02.017","doi":"https://doi.org/10.1016/j.ygyno.2014.02.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ygyno.2014.02.017","pdf_url":null,"source":{"id":"https://openalex.org/S2574783","display_name":"Gynecologic Oncology","issn_l":"0090-8258","issn":["0090-8258","1095-6859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic Oncology","raw_type":"journal-article"},{"id":"pmid:24556063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24556063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W100364503","https://openalex.org/W302807093","https://openalex.org/W1488538842","https://openalex.org/W1506225106","https://openalex.org/W1832914877","https://openalex.org/W1885232396","https://openalex.org/W1965766554","https://openalex.org/W1965976637","https://openalex.org/W1968109047","https://openalex.org/W1971924476","https://openalex.org/W1972568719","https://openalex.org/W1973296923","https://openalex.org/W1974952755","https://openalex.org/W1975352300","https://openalex.org/W1977787536","https://openalex.org/W1979652171","https://openalex.org/W1980451446","https://openalex.org/W1985119544","https://openalex.org/W1986026265","https://openalex.org/W1995197723","https://openalex.org/W1996193504","https://openalex.org/W2000127756","https://openalex.org/W2015173256","https://openalex.org/W2020658557","https://openalex.org/W2024649650","https://openalex.org/W2025480694","https://openalex.org/W2026569756","https://openalex.org/W2036287069","https://openalex.org/W2037454422","https://openalex.org/W2038440449","https://openalex.org/W2048755498","https://openalex.org/W2057009983","https://openalex.org/W2062997257","https://openalex.org/W2065703106","https://openalex.org/W2065949107","https://openalex.org/W2069950132","https://openalex.org/W2071394735","https://openalex.org/W2075993596","https://openalex.org/W2080100938","https://openalex.org/W2081378712","https://openalex.org/W2096308078","https://openalex.org/W2099712757","https://openalex.org/W2110443482","https://openalex.org/W2113190292","https://openalex.org/W2114813165","https://openalex.org/W2115009664","https://openalex.org/W2116355318","https://openalex.org/W2118137523","https://openalex.org/W2119607431","https://openalex.org/W2120129511","https://openalex.org/W2120577072","https://openalex.org/W2127063807","https://openalex.org/W2127930047","https://openalex.org/W2129172946","https://openalex.org/W2129585918","https://openalex.org/W2132510467","https://openalex.org/W2134138119","https://openalex.org/W2136272779","https://openalex.org/W2139712038","https://openalex.org/W2142188958","https://openalex.org/W2146823823","https://openalex.org/W2147394591","https://openalex.org/W2150178760","https://openalex.org/W2160082612","https://openalex.org/W2161817637","https://openalex.org/W2245082787","https://openalex.org/W2249582441","https://openalex.org/W2505281917","https://openalex.org/W2601626987","https://openalex.org/W4285719527","https://openalex.org/W6676965818","https://openalex.org/W6690791789"],"related_works":["https://openalex.org/W2498726581","https://openalex.org/W2000127756","https://openalex.org/W2588723373","https://openalex.org/W2162440188","https://openalex.org/W2588053311","https://openalex.org/W2118468639","https://openalex.org/W2535134162","https://openalex.org/W2999958973","https://openalex.org/W4403548078","https://openalex.org/W2157079036"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
