{"id":"https://openalex.org/W2042855708","doi":"https://doi.org/10.1001/archneur.1992.00530300077013","title":"Sleep Disturbance, Depression, and Lesion Site in Patients With Multiple Sclerosis","display_name":"Sleep Disturbance, Depression, and Lesion Site in Patients With Multiple Sclerosis","publication_year":1992,"publication_date":"1992-06-01","ids":{"openalex":"https://openalex.org/W2042855708","doi":"https://doi.org/10.1001/archneur.1992.00530300077013","mag":"2042855708","pmid":"https://pubmed.ncbi.nlm.nih.gov/1596200"},"language":"en","primary_location":{"id":"doi:10.1001/archneur.1992.00530300077013","doi":"https://doi.org/10.1001/archneur.1992.00530300077013","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.1992.00530300077013","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112895985","display_name":"C. M. Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C. M. Clark","raw_affiliation_strings":["Department of Psychiatry, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086026672","display_name":"J. A. Fleming","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. A. Fleming","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008586491","display_name":"D. Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111646177","display_name":"Joel J.-F. Oger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Oger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072151925","display_name":"Harry Klonoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Klonoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009487533","display_name":"D. W. Paty","orcid":"https://orcid.org/0009-0004-9585-526X","observed_orcids":["https://orcid.org/0009-0004-9585-526X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Paty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.4736,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.96186224,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"49","issue":"6","first_page":"641","last_page":"643"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.5400000214576721,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.5400000214576721,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.4490000009536743,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12569","display_name":"Restless Legs Syndrome Research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.9639999866485596},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8619999885559082},{"id":"https://openalex.org/keywords/lesion-site","display_name":"lesion site","score":0.8190000057220459},{"id":"https://openalex.org/keywords/supplemental-motor-area","display_name":"supplemental motor area","score":0.7039999961853027},{"id":"https://openalex.org/keywords/sleep-complaints","display_name":"sleep complaints","score":0.3720000088214874},{"id":"https://openalex.org/keywords/prevalence-of-sleep-problems","display_name":"prevalence of sleep problems","score":0.6179999709129333},{"id":"https://openalex.org/keywords/brain-lesions","display_name":"brain lesions","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.8033864498138428},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7626095414161682},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.7496447563171387},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.6522120237350464},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.6508582830429077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46954402327537537},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.43737921118736267},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36842435598373413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35759297013282776},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3446756601333618},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.33307918906211853},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.232398122549057},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1393463909626007},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012893","descriptor_name":"Sleep Wake Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1001/archneur.1992.00530300077013","doi":"https://doi.org/10.1001/archneur.1992.00530300077013","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.1992.00530300077013","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},{"id":"pmid:1596200","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1596200","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1517161296","https://openalex.org/W2018590161","https://openalex.org/W2112165124","https://openalex.org/W2130355701","https://openalex.org/W2772737993","https://openalex.org/W2915212263"],"related_works":["https://openalex.org/W2046084421","https://openalex.org/W75046977","https://openalex.org/W4385659185","https://openalex.org/W4403328481","https://openalex.org/W2321562399","https://openalex.org/W2015285136","https://openalex.org/W2403944563","https://openalex.org/W2995403909","https://openalex.org/W7213338213","https://openalex.org/W2085601475"],"abstract_inverted_index":{"We":[0],"examined":[1],"the":[2,32,38,53,72,75,78,93,99,106,130,156],"prevalence":[3,84],"of":[4,10,34,40,52,74,80,85,108,116,132,155],"sleep":[5,35,81,86,109,133,144],"problems":[6],"in":[7,92,149,160],"a":[8,29,50,69,153],"sample":[9],"patients":[11,54,94,141],"with":[12,55,95,113,142],"mild":[13],"but":[14],"clinically":[15],"definite":[16],"multiple":[17,56,96],"sclerosis":[18,57,97],"(n":[19,58],"=":[20,59],"143)":[21],"and":[22,37,77,146],"sought":[23],"to":[24,64,129],"determine":[25,65],"whether":[26,66],"there":[27,67],"was":[28,68,88,111],"relationship":[30,70],"between":[31,71],"presence":[33,79,107,131],"complaints":[36,110],"level":[39],"depression.":[41,117],"As":[42],"magnetic":[43],"resonance":[44],"imaging":[45],"scans":[46],"were":[47,126],"available":[48],"for":[49,139],"subsample":[51],"117),":[60],"we":[61],"also":[62],"wanted":[63],"site":[73,158],"lesion":[76,119,157],"difficulties.":[82],"The":[83],"difficulties":[87],"three":[89],"times":[90],"higher":[91,114],"than":[98],"control":[100],"group":[101],"(25.2%":[102],"vs":[103],"8.2%).":[104],"Moreover,":[105],"associated":[112],"levels":[115],"Three":[118],"sites":[120],"that":[121],"subserve":[122],"supplemental":[123],"motor":[124],"areas":[125],"significantly":[127],"related":[128],"complaints.":[134],"These":[135],"findings":[136],"suggest":[137],"that,":[138],"some":[140],"MS,":[143],"disturbance":[145],"accompanying":[147],"increases":[148],"depression":[150],"may":[151],"be":[152],"function":[154],"resulting":[159],"nocturnal":[161],"spasms.":[162]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}