{"id":"https://openalex.org/W2042847488","doi":"https://doi.org/10.1262/jrd.2012-136","title":"Electrophysiological and Morphological Evidence for Synchronized GnRH Pulse Generator Activity Among Kisspeptin/Neurokinin B/Dynorphin A (KNDy) Neurons in Goats","display_name":"Electrophysiological and Morphological Evidence for Synchronized GnRH Pulse Generator Activity Among Kisspeptin/Neurokinin B/Dynorphin A (KNDy) Neurons in Goats","publication_year":2012,"publication_date":"2012-10-18","ids":{"openalex":"https://openalex.org/W2042847488","doi":"https://doi.org/10.1262/jrd.2012-136","mag":"2042847488","pmid":"https://pubmed.ncbi.nlm.nih.gov/23080371","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3943231"},"language":"en","primary_location":{"id":"doi:10.1262/jrd.2012-136","doi":"https://doi.org/10.1262/jrd.2012-136","is_oa":true,"landing_page_url":"https://doi.org/10.1262/jrd.2012-136","pdf_url":"https://www.jstage.jst.go.jp/article/jrd/59/1/59_2012-136/_pdf","source":{"id":"https://openalex.org/S192692459","display_name":"Journal of Reproduction and Development","issn_l":"0916-8818","issn":["0916-8818","1348-4400"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313575","host_organization_name":"Japanese Society of Animal Reproduction","host_organization_lineage":["https://openalex.org/P4310313575"],"host_organization_lineage_names":["Japanese Society of Animal Reproduction"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Reproduction and Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jstage.jst.go.jp/article/jrd/59/1/59_2012-136/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076910568","display_name":"Yoshihiro Wakabayashi","orcid":"https://orcid.org/0000-0002-6241-2487","observed_orcids":["https://orcid.org/0000-0002-6241-2487"]},"institutions":[{"id":"https://openalex.org/I3018761593","display_name":"Institute of Agrobiological Sciences","ror":"https://ror.org/01786mp71","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1323638106","https://openalex.org/I3018761593"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro WAKABAYASHI","raw_affiliation_strings":["Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-0862, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-0862, Japan","institution_ids":["https://openalex.org/I3018761593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028864982","display_name":"Takashi Yamamura","orcid":"https://orcid.org/0000-0001-9048-0375","observed_orcids":["https://orcid.org/0000-0001-9048-0375"]},"institutions":[{"id":"https://openalex.org/I3018761593","display_name":"Institute of Agrobiological Sciences","ror":"https://ror.org/01786mp71","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1323638106","https://openalex.org/I3018761593"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi YAMAMURA","raw_affiliation_strings":["Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-0862, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-0862, Japan","institution_ids":["https://openalex.org/I3018761593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108635166","display_name":"Kohei Sakamoto","orcid":"https://orcid.org/0009-0002-1178-6419","observed_orcids":["https://orcid.org/0009-0002-1178-6419"]},"institutions":[{"id":"https://openalex.org/I3018761593","display_name":"Institute of Agrobiological Sciences","ror":"https://ror.org/01786mp71","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1323638106","https://openalex.org/I3018761593"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei SAKAMOTO","raw_affiliation_strings":["Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-0862, Japan","Laboratory of Veterinary Ethology, The University of Tokyo, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-0862, Japan","institution_ids":["https://openalex.org/I3018761593"]},{"raw_affiliation_string":"Laboratory of Veterinary Ethology, The University of Tokyo, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110268267","display_name":"Yuji Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji MORI","raw_affiliation_strings":["Laboratory of Veterinary Ethology, The University of Tokyo, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Ethology, The University of Tokyo, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":null,"display_name":"Hiroaki OKAMURA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018761593","display_name":"Institute of Agrobiological Sciences","ror":"https://ror.org/01786mp71","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1323638106","https://openalex.org/I3018761593"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki OKAMURA","raw_affiliation_strings":["Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-0862, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-0862, Japan","institution_ids":["https://openalex.org/I3018761593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":110000,"currency":"JPY","value_usd":828},"apc_paid":{"value":110000,"currency":"JPY","value_usd":828},"fwci":7.7131,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.97948497,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"59","issue":"1","first_page":"40","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kisspeptin","display_name":"kisspeptin","score":0.8119999766349792},{"id":"https://openalex.org/keywords/neurokinin-b","display_name":"neurokinin B","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dynorphin-a","display_name":"dynorphin A","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kndy-neurons","display_name":"KNDy neurons","score":0.9929999709129333},{"id":"https://openalex.org/keywords/arcuate-nucleus","display_name":"arcuate nucleus","score":0.8659999966621399},{"id":"https://openalex.org/keywords/gnrh-pulse-generator","display_name":"GnRH pulse generator","score":0.906000018119812},{"id":"https://openalex.org/keywords/pulsatile-gnrh-secretion","display_name":"pulsatile GnRH secretion","score":0.9750000238418579},{"id":"https://openalex.org/keywords/neural-circuits","display_name":"neural circuits","score":0.5989999771118164},{"id":"https://openalex.org/keywords/senktide","display_name":"senktide","score":0.7409999966621399},{"id":"https://openalex.org/keywords/goats","display_name":"goats","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2781359426","wikidata":"https://www.wikidata.org/wiki/Q412604","display_name":"Neurokinin B","level":5,"score":0.8938471078872681},{"id":"https://openalex.org/C2776808119","wikidata":"https://www.wikidata.org/wiki/Q909371","display_name":"Kisspeptin","level":3,"score":0.8879519701004028},{"id":"https://openalex.org/C151077648","wikidata":"https://www.wikidata.org/wiki/Q324076","display_name":"Dynorphin","level":5,"score":0.727455198764801},{"id":"https://openalex.org/C83415579","wikidata":"https://www.wikidata.org/wiki/Q161973","display_name":"Arc (geometry)","level":2,"score":0.6794186234474182},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.5159652829170227},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.4743689000606537},{"id":"https://openalex.org/C2777368234","wikidata":"https://www.wikidata.org/wiki/Q4915368","display_name":"Biotinylated dextran amine","level":3,"score":0.4711177349090576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45714759826660156},{"id":"https://openalex.org/C2778458369","wikidata":"https://www.wikidata.org/wiki/Q253246","display_name":"Arcuate nucleus","level":3,"score":0.45660829544067383},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.4144488573074341},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.41268154978752136},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4035624861717224},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39771202206611633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3816777169704437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3691791296005249},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.29752156138420105},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.24011674523353577},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1880687177181244},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.17505967617034912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1742153763771057},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17155981063842773},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.1679297387599945},{"id":"https://openalex.org/C88016717","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Opioid peptide","level":4,"score":0.1620503067970276},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.0999642014503479},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.09660258889198303},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.09148558974266052},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.08014816045761108},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07200631499290466},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001111","descriptor_name":"Arcuate Nucleus of Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004399","descriptor_name":"Dynorphins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006041","descriptor_name":"Goats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010675","descriptor_name":"Pheromones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015287","descriptor_name":"Neurokinin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059648","descriptor_name":"Kisspeptins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1262/jrd.2012-136","doi":"https://doi.org/10.1262/jrd.2012-136","is_oa":true,"landing_page_url":"https://doi.org/10.1262/jrd.2012-136","pdf_url":"https://www.jstage.jst.go.jp/article/jrd/59/1/59_2012-136/_pdf","source":{"id":"https://openalex.org/S192692459","display_name":"Journal of Reproduction and Development","issn_l":"0916-8818","issn":["0916-8818","1348-4400"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313575","host_organization_name":"Japanese Society of Animal Reproduction","host_organization_lineage":["https://openalex.org/P4310313575"],"host_organization_lineage_names":["Japanese Society of Animal Reproduction"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Reproduction and Development","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2929643","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3943231","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3943231","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3943231","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Reprod Dev","raw_type":"Text"},{"id":"pmid:23080371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23080371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of reproduction and development","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.795.9202","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.795.9202","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7b/01/jrd-59-040.PMC3943231.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1262/jrd.2012-136","doi":"https://doi.org/10.1262/jrd.2012-136","is_oa":true,"landing_page_url":"https://doi.org/10.1262/jrd.2012-136","pdf_url":"https://www.jstage.jst.go.jp/article/jrd/59/1/59_2012-136/_pdf","source":{"id":"https://openalex.org/S192692459","display_name":"Journal of Reproduction and Development","issn_l":"0916-8818","issn":["0916-8818","1348-4400"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313575","host_organization_name":"Japanese Society of Animal Reproduction","host_organization_lineage":["https://openalex.org/P4310313575"],"host_organization_lineage_names":["Japanese Society of Animal Reproduction"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Reproduction and Development","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2694829108","display_name":"Control of physiological function and behavior by mammalian pheromone","funder_award_id":"21228006","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2910074731","display_name":"Research for a mechanism for generation of GnRH pulse regulated by neural activity of kisspeptin neurons in the arcuate nucleus","funder_award_id":"23780285","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8010214655","display_name":"The role of neurokinin B and dynorphin A in GnRH pulse generation","funder_award_id":"24780275","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320322266","display_name":"Ministry of Agriculture, Forestry and Fisheries","ror":"https://ror.org/02zdz1m23"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2042847488.pdf","grobid_xml":"https://content.openalex.org/works/W2042847488.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W122625909","https://openalex.org/W167836349","https://openalex.org/W1506749112","https://openalex.org/W1565139074","https://openalex.org/W1972602091","https://openalex.org/W1977013546","https://openalex.org/W1977946309","https://openalex.org/W1980564487","https://openalex.org/W1984902037","https://openalex.org/W1986089127","https://openalex.org/W1992474567","https://openalex.org/W2001294899","https://openalex.org/W2010141304","https://openalex.org/W2010920434","https://openalex.org/W2016237494","https://openalex.org/W2019501332","https://openalex.org/W2025295789","https://openalex.org/W2026507149","https://openalex.org/W2026612675","https://openalex.org/W2028307321","https://openalex.org/W2030585597","https://openalex.org/W2035465319","https://openalex.org/W2035954641","https://openalex.org/W2036074652","https://openalex.org/W2039399283","https://openalex.org/W2041506924","https://openalex.org/W2045555035","https://openalex.org/W2047386718","https://openalex.org/W2049969388","https://openalex.org/W2051177586","https://openalex.org/W2054869546","https://openalex.org/W2057416030","https://openalex.org/W2058157139","https://openalex.org/W2058657335","https://openalex.org/W2058782486","https://openalex.org/W2061031708","https://openalex.org/W2066627511","https://openalex.org/W2068426167","https://openalex.org/W2076133996","https://openalex.org/W2084810464","https://openalex.org/W2088370861","https://openalex.org/W2091398724","https://openalex.org/W2100335727","https://openalex.org/W2102025357","https://openalex.org/W2111824942","https://openalex.org/W2115455824","https://openalex.org/W2116934373","https://openalex.org/W2135835427","https://openalex.org/W2143506157","https://openalex.org/W2150490881","https://openalex.org/W2156621206","https://openalex.org/W2162193378","https://openalex.org/W2164127780","https://openalex.org/W2167619569"],"related_works":["https://openalex.org/W7098306134","https://openalex.org/W3202793634","https://openalex.org/W2045555035","https://openalex.org/W3000978200","https://openalex.org/W4390538038","https://openalex.org/W4387222497","https://openalex.org/W3217261154","https://openalex.org/W1977013546","https://openalex.org/W4234596209","https://openalex.org/W2125072756"],"abstract_inverted_index":{"Neurons":[0],"in":[1,65,86,179,192,211,220],"the":[2,25,111,125,132,162,168,180,193,209,221,228],"arcuate":[3],"nucleus":[4],"(ARC)":[5],"that":[6,35,48,149,173,198,214,231,251],"concomitantly":[7],"express":[8],"kisspeptin,":[9],"neurokinin":[10],"B":[11],"(NKB)":[12],"and":[13,20,40,62,77,94,131,139,164,213,245],"dynorphin":[14],"A":[15],"are":[16,21,38,217],"termed":[17],"KNDy":[18,36,70,215,232,243],"neurons":[19,37,71,178,216,233,244],"likely":[22],"candidates":[23],"for":[24],"intrinsic":[26],"gonadotropin-releasing":[27],"hormone":[28],"(GnRH)":[29],"pulse":[30,79,200],"generator.":[31],"Our":[32,53],"hypothesis":[33,59],"is":[34],"functionally":[39],"anatomically":[41],"interconnected":[42,219],"to":[43,56,185,238],"generate":[44,247],"discrete":[45,248],"neural":[46,249],"signals":[47,250],"govern":[49,252],"pulsatile":[50,253],"GnRH":[51,78,199,254],"secretion.":[52,255],"goal":[54],"was":[55,91,120,141],"address":[57],"this":[58],"using":[60,143],"electrophysiological":[61],"anatomical":[63],"experiments":[64],"goats.":[66],"Bilateral":[67],"electrodes":[68],"targeting":[69],"were":[72,104,182],"implanted":[73],"into":[74,124],"ovariectomized":[75],"goats,":[76,130],"generator":[80,201],"activity,":[81],"represented":[82],"by":[83],"characteristic":[84],"increases":[85],"multiple-unit":[87],"activity":[88,202,241],"(MUA":[89],"volleys),":[90],"measured.":[92],"Spontaneous":[93],"pheromone-":[95],"or":[96,156],"senktide":[97],"(an":[98],"NKB":[99,140,177,187],"receptor":[100],"agonist)-induced":[101],"MUA":[102,150],"volleys":[103],"simultaneously":[105,160],"recorded":[106],"from":[107,176],"both":[108,137,206],"sides":[109,166,207],"of":[110,127,134,153,167,208],"ARC.":[112,169,194],"An":[113],"anterograde":[114],"tracer,":[115],"biotinylated":[116],"dextran":[117],"amine":[118],"(BDA),":[119],"also":[121],"injected":[122],"unilaterally":[123],"ARC":[126,181,210,222],"castrated":[128],"male":[129],"distribution":[133],"fibers":[135],"containing":[136],"BDA":[138],"examined":[142],"dual-labeling":[144],"histochemistry.":[145],"The":[146],"results":[147,196,229],"showed":[148],"volleys,":[151],"regardless":[152],"origin":[154],"(spontaneous":[155],"experimentally":[157],"induced),":[158],"occur":[159],"between":[161,205],"right":[163],"left":[165],"Tract":[170],"tracing":[171],"indicated":[172],"axons":[174],"projecting":[175],"directly":[183],"apposed":[184],"other":[186],"neuronal":[188,236],"cells":[189],"located":[190],"bilaterally":[191,218],"These":[195],"demonstrate":[197],"occurs":[203],"synchronously":[204],"goats":[212],"via":[223],"NKB-containing":[224],"fibers.":[225],"Taken":[226],"together,":[227],"suggest":[230],"form":[234],"a":[235],"circuit":[237],"synchronize":[239],"burst":[240],"among":[242],"thereby":[246]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}