{"id":"https://openalex.org/W2042838239","doi":"https://doi.org/10.1002/jcp.10113","title":"CTGF/Hcs24, a hypertrophic chondrocyte\u2010specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes","display_name":"CTGF/Hcs24, a hypertrophic chondrocyte\u2010specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes","publication_year":2002,"publication_date":"2002-05-09","ids":{"openalex":"https://openalex.org/W2042838239","doi":"https://doi.org/10.1002/jcp.10113","mag":"2042838239","pmid":"https://pubmed.ncbi.nlm.nih.gov/12115736"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.10113","doi":"https://doi.org/10.1002/jcp.10113","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.10113","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101886808","display_name":"Takashi Nishida","orcid":"https://orcid.org/0000-0002-6138-4648","observed_orcids":["https://orcid.org/0000-0002-6138-4648"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nishida","raw_affiliation_strings":["Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019500344","display_name":"Satoshi Kubota","orcid":"https://orcid.org/0000-0003-0795-5072","observed_orcids":["https://orcid.org/0000-0003-0795-5072"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Kubota","raw_affiliation_strings":["Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056265260","display_name":"Tohru Nakanishi","orcid":"https://orcid.org/0000-0001-7927-6525","observed_orcids":["https://orcid.org/0000-0001-7927-6525"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Nakanishi","raw_affiliation_strings":["Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073754156","display_name":"Takuo Kuboki","orcid":"https://orcid.org/0000-0003-3756-2835","observed_orcids":["https://orcid.org/0000-0003-3756-2835"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuo Kuboki","raw_affiliation_strings":["Department of Oral and Maxillofacial Rehabilitation, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Rehabilitation, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073290317","display_name":"Gen Yosimichi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Gen Yosimichi","raw_affiliation_strings":["Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016395681","display_name":"Seiji Kondo","orcid":"https://orcid.org/0000-0001-9341-5069","observed_orcids":["https://orcid.org/0000-0001-9341-5069"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiji Kondo","raw_affiliation_strings":["Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015963255","display_name":"Masaharu Takigawa","orcid":"https://orcid.org/0000-0002-1068-1677","observed_orcids":["https://orcid.org/0000-0002-1068-1677"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaharu Takigawa","raw_affiliation_strings":["Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015963255"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":4.1526,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.93965419,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"192","issue":"1","first_page":"55","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.9509999752044678},{"id":"https://openalex.org/keywords/articular-chondrocytes","display_name":"articular chondrocytes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/chondrocyte-proliferation","display_name":"chondrocyte proliferation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/chondrocyte-hypertrophy","display_name":"chondrocyte hypertrophy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.6840000152587891},{"id":"https://openalex.org/keywords/proteoglycan-synthesis","display_name":"proteoglycan synthesis","score":0.925000011920929},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.9789999723434448},{"id":"https://openalex.org/keywords/aggrecan","display_name":"aggrecan","score":0.9229999780654907},{"id":"https://openalex.org/keywords/type-x-collagen","display_name":"type X collagen","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tenascin-c","display_name":"tenascin-C","score":0.9909999966621399},{"id":"https://openalex.org/keywords/matrix-calcification","display_name":"matrix calcification","score":0.8640000224113464},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cartilage-repair","display_name":"cartilage repair","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.7964475750923157},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.7747402191162109},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.6042003035545349},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5003221035003662},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48676371574401855},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4840042293071747},{"id":"https://openalex.org/C2781013607","wikidata":"https://www.wikidata.org/wiki/Q14877666","display_name":"Type II collagen","level":3,"score":0.47582200169563293},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46292591094970703},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.44135695695877075},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.43365633487701416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3379143178462982},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11963972449302673},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11761361360549927},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.11622220277786255},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0994422435760498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0825456976890564},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07666286826133728},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055513","descriptor_name":"Connective Tissue Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.10113","doi":"https://doi.org/10.1002/jcp.10113","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.10113","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:12115736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12115736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309785","display_name":"Naito Foundation","ror":"https://ror.org/02s016q17"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W569944157","https://openalex.org/W1540384225","https://openalex.org/W1607010134","https://openalex.org/W1979093446","https://openalex.org/W1985109410","https://openalex.org/W1996794823","https://openalex.org/W2005463323","https://openalex.org/W2018381916","https://openalex.org/W2031304372","https://openalex.org/W2034812824","https://openalex.org/W2039957138","https://openalex.org/W2042249648","https://openalex.org/W2057126191","https://openalex.org/W2061798549","https://openalex.org/W2066504997","https://openalex.org/W2066969290","https://openalex.org/W2072156048","https://openalex.org/W2082207304","https://openalex.org/W2090619182","https://openalex.org/W2097734037","https://openalex.org/W2098118477","https://openalex.org/W2106232223","https://openalex.org/W2111602420","https://openalex.org/W2112417973","https://openalex.org/W2114224241","https://openalex.org/W2130671879","https://openalex.org/W2264351090","https://openalex.org/W2301681118","https://openalex.org/W2407372429","https://openalex.org/W2993782230","https://openalex.org/W4211112402"],"related_works":["https://openalex.org/W2090619182","https://openalex.org/W4233417918","https://openalex.org/W7097842205","https://openalex.org/W2039957138","https://openalex.org/W2156553323","https://openalex.org/W1663461089","https://openalex.org/W2088583888","https://openalex.org/W2080211548","https://openalex.org/W2166371031","https://openalex.org/W2289134833"],"abstract_inverted_index":{"We":[0],"previously":[1],"reported":[2],"that":[3,87,185,208,222],"connective":[4],"tissue":[5],"growth":[6,20,213],"factor/hypertrophic":[7],"chondrocyte-specific":[8],"gene":[9,92,116,141],"product":[10],"24":[11],"(CTGF/Hcs24)":[12],"stimulated":[13,90,128,151],"the":[14,31,36,62,88,91,115,188,205,228],"proliferation":[15,37,189],"and":[16,38,76,98,111,171,190,214,220],"differentiation":[17,39,191,215],"of":[18,33,40,67,94,105,118,124,143,147,174,179,192,230],"rabbit":[19,41],"cartilage":[21,43],"(RGC)":[22],"cells":[23,45,49,69],"in":[24,46,79,108,132,137,154,159],"vitro.":[25,47],"In":[26],"this":[27],"study,":[28],"we":[29],"investigated":[30],"effects":[32],"CTGF/Hcs24":[34,57,72,186,209],"on":[35],"articular":[42,148,193,218,231],"(RAC)":[44],"RAC":[48,68,112,138,155,180],"transduced":[50],"by":[51,129,152],"recombinant":[52,71],"adenoviruses":[53],"generating":[54],"mRNA":[55],"for":[56,217,227],"synthesized":[58],"more":[59],"proteoglycan":[60,77],"than":[61],"control":[63],"cells.":[64,113,139,161,181],"Also,":[65],"treatment":[66],"with":[70],"(rCTGF/Hcs24)":[73],"increased":[74,165],"DNA":[75],"syntheses":[78],"a":[80,122,145,211],"dose-dependent":[81],"manner.":[82],"Northern":[83],"blot":[84],"analysis":[85],"revealed":[86],"rCTGF/Hcs24":[89,130,153,163],"expression":[93,117,142],"type":[95,119],"II":[96],"collagen":[97],"aggrecan":[99],"core":[100],"protein,":[101],"which":[102],"are":[103],"markers":[104],"chondrocyte":[106],"maturation,":[107],"both":[109,166],"RGC":[110,133,160,175],"However,":[114],"X":[120],"collagen,":[121],"marker":[123,146],"hypertrophic":[125],"chondrocytes,":[126,149,194],"was":[127,150],"only":[131],"cells,":[134,156,176],"but":[135,157,177,195],"not":[136,158,178,197],"Oppositely,":[140],"tenascin-C,":[144],"Moreover,":[162],"effectively":[164],"alkaline":[167],"phosphatase":[168],"(ALPase)":[169],"activity":[170],"matrix":[172],"calcification":[173],"These":[182],"results":[183],"indicate":[184],"promotes":[187],"does":[196],"promote":[198],"their":[199],"hypertrophy":[200],"or":[201],"calcification.":[202],"Taken":[203],"together,":[204],"data":[206],"show":[207],"is":[210],"direct":[212],"factor":[216],"cartilage,":[219],"suggest":[221],"it":[223],"may":[224],"be":[225],"useful":[226],"repair":[229],"cartilage.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
