{"id":"https://openalex.org/W2042826767","doi":"https://doi.org/10.1159/000067109","title":"Risk Factors for Dementia in the Cardiovascular Health Cognition Study","display_name":"Risk Factors for Dementia in the Cardiovascular Health Cognition Study","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2042826767","doi":"https://doi.org/10.1159/000067109","mag":"2042826767","pmid":"https://pubmed.ncbi.nlm.nih.gov/12566949"},"language":"en","primary_location":{"id":"doi:10.1159/000067109","doi":"https://doi.org/10.1159/000067109","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000067109","pdf_url":null,"source":{"id":"https://openalex.org/S21771311","display_name":"Neuroepidemiology","issn_l":"0251-5350","issn":["0251-5350","1423-0208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroepidemiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2042826767"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087916636","display_name":"Lewis H. Kuller","orcid":"https://orcid.org/0000-0002-7148-8416","observed_orcids":["https://orcid.org/0000-0002-7148-8416"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lewis H. Kuller","raw_affiliation_strings":["Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pa 15261, USA. kuller@pitt.edu","Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pa 15261, USA. kuller@pitt.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, and","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619838","display_name":"Oscar L. L\u00f3pez","orcid":"https://orcid.org/0000-0002-8546-8256","observed_orcids":["https://orcid.org/0000-0002-8546-8256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oscar L. Lopez","raw_affiliation_strings":["Department of Neurology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089458669","display_name":"Anne B. Newman","orcid":"https://orcid.org/0000-0002-0106-1150","observed_orcids":["https://orcid.org/0000-0002-0106-1150"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Newman","raw_affiliation_strings":["Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pa","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111746536","display_name":"Norman J. Beauchamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman J. Beauchamp","raw_affiliation_strings":["Neuroradiology Division, Johns Hopkins Radiology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroradiology Division, Johns Hopkins Radiology, and","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110904348","display_name":"Greg L. Burke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Greg Burke","raw_affiliation_strings":["Department of Public Health Sciences, WFU School of Medicine, Winston-Salem, N.C","Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, WFU School of Medicine, Winston-Salem, N.C","institution_ids":[]},{"raw_affiliation_string":"Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110255583","display_name":"Corinne S. Dulberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Corinne Dulberg","raw_affiliation_strings":["Biostatistics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107836541","display_name":"Annette L. Fitzpatrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annette Fitzpatrick","raw_affiliation_strings":["Epidemiology, University of Washington, Seattle, Wash., and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology, University of Washington, Seattle, Wash., and","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079554237","display_name":"Linda P. Fried","orcid":"https://orcid.org/0000-0002-0815-1706","observed_orcids":["https://orcid.org/0000-0002-0815-1706"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Fried","raw_affiliation_strings":["The Johns Hopkins Medical Institutions, Baltimore, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins Medical Institutions, Baltimore, Md","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037758542","display_name":"Mary N. Haan","orcid":"https://orcid.org/0000-0001-9312-4501","observed_orcids":["https://orcid.org/0000-0001-9312-4501"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary N. Haan","raw_affiliation_strings":["Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Mich., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Mich., USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.5414,"has_fulltext":false,"cited_by_count":297,"citation_normalized_percentile":{"value":0.98222757,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"22","issue":"1","first_page":"13","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/risk-factors-for-dementia","display_name":"dementia risk factors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8790000081062317},{"id":"https://openalex.org/keywords/white-matter-hyperintensities","display_name":"white matter hyperintensities","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cerebral-infarction","display_name":"cerebral infarction","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.9459999799728394},{"id":"https://openalex.org/keywords/modified-mini-mental-state-examination","display_name":"Modified Mini-Mental State Examination","score":0.8579999804496765},{"id":"https://openalex.org/keywords/brain-mri","display_name":"brain MRI","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.8739882707595825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8155603408813477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6257805228233337},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5883951783180237},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.56710284948349},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.49220719933509827},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.47578394412994385},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4676612913608551},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4614950120449066},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.44734546542167664},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3414309024810791},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.13987872004508972},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.10967856645584106}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000067109","doi":"https://doi.org/10.1159/000067109","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000067109","pdf_url":null,"source":{"id":"https://openalex.org/S21771311","display_name":"Neuroepidemiology","issn_l":"0251-5350","issn":["0251-5350","1423-0208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroepidemiology","raw_type":"journal-article"},{"id":"pmid:12566949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12566949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroepidemiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G161289361","display_name":"CORONARY HEART DISEASE AND STROKE","funder_award_id":"n01hc085079-024","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2800149121","display_name":null,"funder_award_id":"N01 HC85086","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3993082116","display_name":"CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS","funder_award_id":"n01hc085086-022","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7651489270","display_name":"CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY","funder_award_id":"n01hc035129-010","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G905887895","display_name":null,"funder_award_id":"N01-HC85079","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G960597250","display_name":null,"funder_award_id":"N01HC35129","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W17230872","https://openalex.org/W617985983","https://openalex.org/W628634945","https://openalex.org/W1837608575","https://openalex.org/W1870043354","https://openalex.org/W1964756042","https://openalex.org/W1972509050","https://openalex.org/W1981802311","https://openalex.org/W1983185375","https://openalex.org/W1992841111","https://openalex.org/W2004602458","https://openalex.org/W2016282507","https://openalex.org/W2019485855","https://openalex.org/W2020402787","https://openalex.org/W2020961569","https://openalex.org/W2024430285","https://openalex.org/W2025923959","https://openalex.org/W2028398764","https://openalex.org/W2038880656","https://openalex.org/W2057162011","https://openalex.org/W2060629467","https://openalex.org/W2076732678","https://openalex.org/W2078350791","https://openalex.org/W2090819718","https://openalex.org/W2096529213","https://openalex.org/W2102447768","https://openalex.org/W2109982307","https://openalex.org/W2131720165","https://openalex.org/W2132851971","https://openalex.org/W2156311276","https://openalex.org/W2159122349","https://openalex.org/W2161197885","https://openalex.org/W2165828128","https://openalex.org/W2170128453"],"related_works":["https://openalex.org/W180957169","https://openalex.org/W2101997275","https://openalex.org/W2059996547","https://openalex.org/W2170128453","https://openalex.org/W2116620918","https://openalex.org/W7163053614","https://openalex.org/W2126579393","https://openalex.org/W7162123428","https://openalex.org/W2768070062","https://openalex.org/W2012290039"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,169],"Cardiovascular":[2],"Health":[3],"Cognition":[4],"Study":[5],"has":[6],"evaluated":[7],"the":[8,23,54,62,77,91,107,138,190,193,214,225],"determinants":[9,111],"of":[10,22,79,84,103,112,123,155,167,171,192,205,213,219,224,230,234],"dementia":[11,37,80,206,232],"among":[12],"3,608":[13],"participants":[14],"that":[15],"had":[16],"a":[17,101,120,126,198],"magnetic":[18],"resonance":[19],"imaging":[20],"(MRI)":[21],"brain":[24,104,226],"in":[25,71],"1991":[26],"and":[27,60,136,161,222,233],"were":[28,34,41,81,109,164,195],"followed":[29],"to":[30,76,209],"1998-1999.":[31],"METHODS:":[32],"There":[33],"480":[35],"incident":[36],"cases,":[38],"330":[39],"(69%)":[40],"classified":[42],"as":[43,67,69,94,96,207],"Alzheimer's":[44],"disease":[45],"(AD).":[46],"RESULTS:":[47],"In":[48,125],"univariate":[49],"analysis,":[50],"low":[51],"scores":[52,72],"on":[53,61,90,106],"Modified":[55],"Mini-Mental":[56],"State":[57],"Examination":[58],"(3MSE)":[59],"Digit":[63],"Symbol":[64],"Substitution":[65],"Test":[66],"well":[68,95],"declines":[70],"over":[73],"time":[74,191],"prior":[75],"development":[78],"significant":[82,165],"predictors":[83,166,229],"dementia.":[85,113,124,168],"A":[86],"high":[87,97],"ventricular":[88,147,181],"grade":[89,152,188],"MRI":[92,108,194,223],"(atrophy)":[93],"white":[98,150,186],"matter":[99,151,187],"grade,":[100,137,182],"number":[102],"infarcts":[105,157],"all":[110],"Apolipoprotein":[114],"E":[115],"epsilon4":[116],"(Apo(E-4))":[117],"was":[118],"also":[119],"powerful":[121],"predictor":[122],"multivariate":[127],"Cox":[128],"proportional":[129],"hazards":[130],"model":[131],"controlling":[132],"for":[133,141],"race,":[134],"gender":[135],"hazard":[139],"ratios":[140],"age":[142],"(1.1),":[143],"3MSE":[144,175],"score":[145,176],"(0.9),":[146],"size":[148],"(1.4),":[149],"(1.8),":[153],"presence":[154],"large":[156],">3":[158],"mm":[159],"(1.3)":[160],"Apo(E-4)":[162,173,221],"(2.1)":[163],"combination":[170],"an":[172],"genotype,":[174],"<90,":[177],">":[178,183],"or":[179,184],"=5":[180],"=3":[185],"at":[189],"associated":[196],"with":[197,211],"17-fold":[199],"increased":[200],"risk":[201],"(95%":[202],"CI:":[203],"8.6-34.9)":[204],"compared":[208],"individuals":[210],"none":[212],"above":[215],"attributes.":[216],"CONCLUSIONS:":[217],"Measures":[218],"cognition,":[220],"are":[227],"strong":[228],"both":[231],"AD.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}