{"id":"https://openalex.org/W2042823677","doi":"https://doi.org/10.1016/s0952-7915(99)80078-8","title":"Host genetic influences on HIV-1 pathogenesis","display_name":"Host genetic influences on HIV-1 pathogenesis","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2042823677","doi":"https://doi.org/10.1016/s0952-7915(99)80078-8","mag":"2042823677","pmid":"https://pubmed.ncbi.nlm.nih.gov/10448150"},"language":"en","primary_location":{"id":"doi:10.1016/s0952-7915(99)80078-8","doi":"https://doi.org/10.1016/s0952-7915(99)80078-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0952-7915(99)80078-8","pdf_url":null,"source":{"id":"https://openalex.org/S170047187","display_name":"Current Opinion in Immunology","issn_l":"0952-7915","issn":["0952-7915","1879-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036265394","display_name":"Nelson L. Michael","orcid":"https://orcid.org/0000-0001-5882-5548","observed_orcids":["https://orcid.org/0000-0001-5882-5548"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nelson L Michael","raw_affiliation_strings":["Department of Molecular Diagnostics and Pathogenesis, Division of Retrovirology, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA. nmichael@pasteur.hjf.org","Department of Molecular Diagnostics and Pathogenesis, Division of Retrovirology, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Diagnostics and Pathogenesis, Division of Retrovirology, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA. nmichael@pasteur.hjf.org","institution_ids":["https://openalex.org/I92664306"]},{"raw_affiliation_string":"Department of Molecular Diagnostics and Pathogenesis, Division of Retrovirology, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA","institution_ids":["https://openalex.org/I92664306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036265394"],"corresponding_institution_ids":["https://openalex.org/I92664306"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":1.1964,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.79220779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"4","first_page":"466","last_page":"474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-pathogenesis","display_name":"HIV-1 pathogenesis","score":0.984000027179718},{"id":"https://openalex.org/keywords/host-genetic-factors","display_name":"host genetic factors","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cd4","display_name":"CD4","score":0.7860000133514404},{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hiv-1-entry","display_name":"HIV-1 entry","score":0.5230000019073486},{"id":"https://openalex.org/keywords/hla-genes","display_name":"HLA genes","score":0.8190000057220459},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7832400798797607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6821959018707275},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.6694065928459167},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5683989524841309},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5620197057723999},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5434941649436951},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5426878929138184},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5191128253936768},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5145372748374939},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5138383507728577},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4386039078235626},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.10531264543533325}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015728","descriptor_name":"Receptors, HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0952-7915(99)80078-8","doi":"https://doi.org/10.1016/s0952-7915(99)80078-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0952-7915(99)80078-8","pdf_url":null,"source":{"id":"https://openalex.org/S170047187","display_name":"Current Opinion in Immunology","issn_l":"0952-7915","issn":["0952-7915","1879-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Immunology","raw_type":"journal-article"},{"id":"pmid:10448150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10448150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":133,"referenced_works":["https://openalex.org/W82820957","https://openalex.org/W154155894","https://openalex.org/W185366093","https://openalex.org/W1481422886","https://openalex.org/W1490341201","https://openalex.org/W1536029308","https://openalex.org/W1537629327","https://openalex.org/W1544916621","https://openalex.org/W1551243371","https://openalex.org/W1553382810","https://openalex.org/W1574590275","https://openalex.org/W1598711637","https://openalex.org/W1623426438","https://openalex.org/W1642524132","https://openalex.org/W1648071921","https://openalex.org/W1731073298","https://openalex.org/W1963855922","https://openalex.org/W1963984954","https://openalex.org/W1965019797","https://openalex.org/W1968057545","https://openalex.org/W1971057735","https://openalex.org/W1974132609","https://openalex.org/W1976505648","https://openalex.org/W1977998462","https://openalex.org/W1980074143","https://openalex.org/W1981164507","https://openalex.org/W1981440980","https://openalex.org/W1981644527","https://openalex.org/W1984811742","https://openalex.org/W1986574361","https://openalex.org/W1987108574","https://openalex.org/W1988952151","https://openalex.org/W1989701896","https://openalex.org/W1990679519","https://openalex.org/W1991676347","https://openalex.org/W1992302054","https://openalex.org/W1993591984","https://openalex.org/W1993634191","https://openalex.org/W1995314344","https://openalex.org/W1995453338","https://openalex.org/W1996183144","https://openalex.org/W2001805409","https://openalex.org/W2006734012","https://openalex.org/W2007021820","https://openalex.org/W2007062460","https://openalex.org/W2008130406","https://openalex.org/W2014569071","https://openalex.org/W2018982364","https://openalex.org/W2020396133","https://openalex.org/W2021932640","https://openalex.org/W2025708230","https://openalex.org/W2026330341","https://openalex.org/W2026444780","https://openalex.org/W2029083442","https://openalex.org/W2030050527","https://openalex.org/W2034053987","https://openalex.org/W2034430377","https://openalex.org/W2038048329","https://openalex.org/W2041525705","https://openalex.org/W2043637778","https://openalex.org/W2043842774","https://openalex.org/W2047146671","https://openalex.org/W2048112155","https://openalex.org/W2061489657","https://openalex.org/W2062148688","https://openalex.org/W2062433352","https://openalex.org/W2063023106","https://openalex.org/W2064558165","https://openalex.org/W2066163381","https://openalex.org/W2067714902","https://openalex.org/W2068020601","https://openalex.org/W2075817888","https://openalex.org/W2077787948","https://openalex.org/W2078778857","https://openalex.org/W2078888764","https://openalex.org/W2080350299","https://openalex.org/W2081769332","https://openalex.org/W2083131690","https://openalex.org/W2083612980","https://openalex.org/W2085724830","https://openalex.org/W2086322703","https://openalex.org/W2088287053","https://openalex.org/W2090630729","https://openalex.org/W2092540180","https://openalex.org/W2105397580","https://openalex.org/W2106915606","https://openalex.org/W2108256128","https://openalex.org/W2110898276","https://openalex.org/W2111105264","https://openalex.org/W2113263264","https://openalex.org/W2113282092","https://openalex.org/W2114279162","https://openalex.org/W2116296362","https://openalex.org/W2116789308","https://openalex.org/W2122575856","https://openalex.org/W2124267461","https://openalex.org/W2125759758","https://openalex.org/W2131376910","https://openalex.org/W2133021844","https://openalex.org/W2136602493","https://openalex.org/W2140472965","https://openalex.org/W2142992633","https://openalex.org/W2144172655","https://openalex.org/W2145544856","https://openalex.org/W2149579640","https://openalex.org/W2149730509","https://openalex.org/W2152453984","https://openalex.org/W2155691564","https://openalex.org/W2155989561","https://openalex.org/W2156117117","https://openalex.org/W2156694786","https://openalex.org/W2157285699","https://openalex.org/W2158850631","https://openalex.org/W2159511193","https://openalex.org/W2163611230","https://openalex.org/W2164953896","https://openalex.org/W2165226694","https://openalex.org/W2168325635","https://openalex.org/W2256003698","https://openalex.org/W2316549972","https://openalex.org/W2318886621","https://openalex.org/W2320041935","https://openalex.org/W2329871897","https://openalex.org/W2333260484","https://openalex.org/W2396520131","https://openalex.org/W2406258632","https://openalex.org/W2407589392","https://openalex.org/W2626151581","https://openalex.org/W4233080311","https://openalex.org/W4239357956","https://openalex.org/W6606251750","https://openalex.org/W6670111688","https://openalex.org/W7214167034"],"related_works":["https://openalex.org/W2184117828","https://openalex.org/W1997960621","https://openalex.org/W2336890426","https://openalex.org/W2042789047","https://openalex.org/W2115242638","https://openalex.org/W2156904056","https://openalex.org/W2044549799","https://openalex.org/W1534854496","https://openalex.org/W1986936069","https://openalex.org/W2085507725"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}