{"id":"https://openalex.org/W2042811228","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p6-04-17","title":"Abstract P6-04-17: The irreversible c-Jun N-terminal kinase (JNK) inhibitor, JNK-IN-8, sensitizes basal-like breast cancer cells to lapatinib","display_name":"Abstract P6-04-17: The irreversible c-Jun N-terminal kinase (JNK) inhibitor, JNK-IN-8, sensitizes basal-like breast cancer cells to lapatinib","publication_year":2013,"publication_date":"2013-12-15","ids":{"openalex":"https://openalex.org/W2042811228","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p6-04-17","mag":"2042811228"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.sabcs13-p6-04-17","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p6-04-17","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.sabcs13-p6-04-17","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070843634","display_name":"ND Ebelt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ND Ebelt","raw_affiliation_strings":["The University of Texas at Austin, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110080677","display_name":"CL Van Den Berg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"CL Van Den Berg","raw_affiliation_strings":["The University of Texas at Austin, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"24_Supplement","first_page":"P6","last_page":"04"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.13510000705718994,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.06949999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.8790000081062317},{"id":"https://openalex.org/keywords/jnk-in-8","display_name":"JNK-IN-8","score":0.9909999966621399},{"id":"https://openalex.org/keywords/jnk2","display_name":"JNK2","score":0.6840000152587891},{"id":"https://openalex.org/keywords/lapatinib","display_name":"lapatinib","score":0.9750000238418579},{"id":"https://openalex.org/keywords/drug-sensitization","display_name":"drug sensitization","score":0.7319999933242798},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.6230000257492065},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8370000123977661},{"id":"https://openalex.org/keywords/endoreduplication","display_name":"endoreduplication","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mad2","display_name":"Mad2","score":0.8510000109672546},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/trastuzumab-resistance","display_name":"trastuzumab resistance","score":0.7509999871253967},{"id":"https://openalex.org/keywords/targeted-therapy-resistance","display_name":"targeted therapy resistance","score":0.6370000243186951},{"id":"https://openalex.org/keywords/jnk-inhibitor","display_name":"JNK inhibitor","score":0.5979999899864197},{"id":"https://openalex.org/keywords/chromosome-segregation","display_name":"chromosome segregation","score":0.5759999752044678},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7350000143051147},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2777329042","wikidata":"https://www.wikidata.org/wiki/Q420323","display_name":"Lapatinib","level":5,"score":0.8820362091064453},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7029826641082764},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6280835270881653},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.48369914293289185},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4833259582519531},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4779241681098938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.451546847820282},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.446214497089386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3895186483860016},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.3463838994503021},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2919352650642395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16425082087516785}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.sabcs13-p6-04-17","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p6-04-17","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.sabcs13-p6-04-17","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2336776084","https://openalex.org/W2635812475","https://openalex.org/W2751689603","https://openalex.org/W2033794021","https://openalex.org/W1984655708","https://openalex.org/W2323645249","https://openalex.org/W2027423872","https://openalex.org/W4300953724","https://openalex.org/W2407790564","https://openalex.org/W6889885426"],"abstract_inverted_index":{"Abstract":[0,381],"Basal-like":[1],"breast":[2,7,120,136,188,285],"cancers":[3,8],"represent":[4],"15-20%":[5],"of":[6,27,48,69,90,144,150,164,183,230,295,351,362,368],"diagnosed":[9],"each":[10],"year.":[11],"These":[12,122],"tumors":[13,77,300,326],"appear":[14],"earlier":[15],"in":[16,78,94,116,299,325,336],"life":[17],"and":[18,30,92,105,185,206,217,227,257,273,280,317,340,364],"have":[19,82,146],"the":[20,79,88,126,155,173,225,248,349],"worst":[21],"prognosis":[22],"due":[23],"to":[24,96,99,102,196,214,288,304,312,322],"high":[25,46,56,108],"prevalence":[26],"metastasis.":[28,106],"Endocrine":[29],"molecularly":[31],"targeted":[32,70,289,353],"therapies":[33,71,354],"such":[34],"as":[35,355],"trastuzumab":[36],"or":[37,306],"lapatinib":[38,256],"are":[39,302,334],"ineffective":[40],"against":[41],"this":[42],"tumor":[43],"subtype.":[44],"A":[45],"frequency":[47],"p53":[49,91],"mutations,":[50],"low":[51],"BRCA1":[52,93],"expression":[53,62,89,110,226],"along":[54,219],"with":[55,113,118,192,220,314],"epidermal":[57],"growth":[58],"factor":[59],"receptor":[60,337],"(EGFR)":[61],"provide":[63],"some":[64],"insight":[65],"into":[66],"what":[67],"types":[68],"may":[72,129,309,318,347],"be":[73,130],"useful":[74],"for":[75,134,152],"basal-like":[76,119],"future.":[80],"We":[81,291],"recently":[83,158],"shown":[84],"that":[85,125,181,270,293,301,327,332],"JNK2":[86,109],"mediates":[87],"response":[95],"EGFR":[97],"activation":[98],"promote":[100],"epithelial":[101],"mesenchymal":[103],"transition":[104],"Further,":[107,224],"is":[111,176],"associated":[112],"poorer":[114],"survival":[115],"patients":[117],"cancer.":[121],"findings":[123],"suggest":[124],"JNK":[127,145,165,272,297],"pathway":[128],"a":[131],"promising":[132],"target":[133,275],"basal-type":[135,284],"cancer":[137,189,286],"treatment.":[138],"Commonly":[139],"used":[140],"competitive":[141],"ATP":[142],"inhibitors":[143,163,298,367],"suffered":[147],"from":[148],"lack":[149],"specificity":[151],"JNK.":[153],"However,":[154],"Gray":[156],"laboratory":[157],"developed":[159],"highly":[160],"specific":[161,296],"covalent":[162,366],"(Zhang,":[166],"et":[167,359],"al.":[168,360],"2012).":[169],"The":[170],"agent":[171],"showing":[172],"best":[174],"properties":[175],"JNK-IN-8.":[177],"Our":[178],"data":[179],"show":[180],"treatment":[182,212,244,254,346],"human":[184],"mouse":[186],"basal-like,":[187],"cell":[190,204,207],"lines":[191],"JNK-IN-8":[193,258,345],"sensitizes":[194],"them":[195,311],"lapatinib.":[197],"Single":[198],"agents":[199],"had":[200],"minor":[201],"affects":[202],"on":[203],"viability":[205],"cycle":[208],"regulation,":[209],"but":[210],"combination":[211,243],"led":[213],"G2/M":[215,276],"arrest":[216,232],"endoreduplication":[218],"synergistic":[221],"apoptotic":[222],"responses.":[223],"electrophoretic":[228],"mobility":[229],"mitotic":[231],"deficient":[233],"2":[234],"(MAD2)":[235],"(a":[236],"protein":[237],"mediating":[238],"chromosomal":[239,249],"segregation)":[240],"decreased":[241],"after":[242],"which":[245],"could":[246],"explain":[247],"duplication":[250],"abnormalities":[251],"observed.":[252],"Combination":[253],"using":[255],"modulates":[259],"extracellular":[260],"signal-regulated":[261],"kinase":[262,339],"(ERK)":[263],"phosphorylation":[264],"unlike":[265],"either":[266],"drug":[267],"alone":[268],"suggesting":[269],"both":[271],"ERK":[274],"check":[277],"point":[278],"proteins,":[279],"when":[281],"perturbed,":[282],"sensitize":[283,310],"cells":[287],"therapies.":[290],"conclude":[292],"use":[294],"resistant":[303],"lapatinib,":[305],"perhaps":[307],"trastuzumab,":[308],"treatments":[313],"these":[315,323],"drugs,":[316],"also":[319],"prevent":[320],"resistance":[321],"drugs":[324],"were":[328],"initially":[329],"responsive.":[330],"Considering":[331],"JNKs":[333],"nodes":[335],"tyrosine":[338],"many":[341],"other":[342,352],"signaling":[343],"pathways,":[344],"improve":[348],"efficacy":[350],"well.":[356],"Zhang,":[357],"T.":[358],"\u201cDiscovery":[361],"potent":[363],"selective":[365],"JNK\u201d.":[369],"Chem":[370],"Biol.":[371],"2012":[372],"Jan":[373],"27;19(1):140-54.":[374],"Citation":[375],"Information:":[376],"Cancer":[377],"Res":[378],"2013;73(24":[379],"Suppl):":[380],"nr":[382],"P6-04-17.":[383]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
