{"id":"https://openalex.org/W2042756832","doi":"https://doi.org/10.2174/138920309789351985","title":"Crystallographic Cryoenzymology and the Legacy of Tony Fink","display_name":"Crystallographic Cryoenzymology and the Legacy of Tony Fink","publication_year":2009,"publication_date":"2009-09-14","ids":{"openalex":"https://openalex.org/W2042756832","doi":"https://doi.org/10.2174/138920309789351985","mag":"2042756832","pmid":"https://pubmed.ncbi.nlm.nih.gov/19538155"},"language":"en","primary_location":{"id":"doi:10.2174/138920309789351985","doi":"https://doi.org/10.2174/138920309789351985","is_oa":false,"landing_page_url":"https://doi.org/10.2174/138920309789351985","pdf_url":null,"source":{"id":"https://openalex.org/S67737920","display_name":"Current Protein and Peptide Science","issn_l":"1389-2037","issn":["1389-2037","1875-5550"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protein & Peptide Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007934367","display_name":"Gregory A. Petsko","orcid":"https://orcid.org/0000-0003-3668-3694","observed_orcids":["https://orcid.org/0000-0003-3668-3694"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory Petsko","raw_affiliation_strings":["Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street Waltham, MA 02454-9110, USA. petsko@brandeis.edu","Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street,Waltham, MA 02454\u20139110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street Waltham, MA 02454-9110, USA. petsko@brandeis.edu","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street,Waltham, MA 02454\u20139110, USA","institution_ids":["https://openalex.org/I6902469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007934367"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.14044414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"10","issue":"5","first_page":"416","last_page":"423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14475","display_name":"History of Science and Medicine","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13495","display_name":"Biographical and Historical Analysis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1202","display_name":"History"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzyme-catalysis","display_name":"enzyme catalysis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/enzyme-substrate-complex","display_name":"enzyme-substrate complex","score":0.9549999833106995},{"id":"https://openalex.org/keywords/subzero-temperatures","display_name":"subzero temperatures","score":0.5680000185966492},{"id":"https://openalex.org/keywords/history-of-science","display_name":"history of science","score":0.5070000290870667},{"id":"https://openalex.org/keywords/research-collaboration","display_name":"research collaboration","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.6596017479896545},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.43435025215148926},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.34319794178009033},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15882572531700134},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12715548276901245},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.08801102638244629},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.05487486720085144}],"mesh":[{"descriptor_ui":"D001671","descriptor_name":"Biochemistry","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":false},{"descriptor_ui":"D001671","descriptor_name":"Biochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005962","descriptor_name":"Glucosylceramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/138920309789351985","doi":"https://doi.org/10.2174/138920309789351985","is_oa":false,"landing_page_url":"https://doi.org/10.2174/138920309789351985","pdf_url":null,"source":{"id":"https://openalex.org/S67737920","display_name":"Current Protein and Peptide Science","issn_l":"1389-2037","issn":["1389-2037","1875-5550"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Protein & Peptide Science","raw_type":"journal-article"},{"id":"pmid:19538155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19538155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current protein & peptide science","raw_type":"Historical Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2058889403","https://openalex.org/W2053478413","https://openalex.org/W4300506916","https://openalex.org/W2056288338","https://openalex.org/W4211208839","https://openalex.org/W2019456042","https://openalex.org/W121424397","https://openalex.org/W2040040533","https://openalex.org/W2488688448","https://openalex.org/W1972482906"],"abstract_inverted_index":{"During":[0],"the":[1,11,15,58,67,95],"past":[2],"thirty":[3],"years":[4],"significant":[5],"contributions":[6,68],"to":[7],"our":[8],"understanding":[9],"of":[10,14,18,27,60,69],"structural":[12],"origins":[13],"catalytic":[16],"power":[17],"enzymes":[19],"have":[20],"come":[21],"from":[22,54],"solution":[23],"and":[24,29,48],"crystallographic":[25,61],"studies":[26],"enzyme-substrate":[28],"enzyme-intermediate":[30],"complexes":[31],"trapped":[32],"at":[33],"subzero":[34],"temperatures,":[35],"a":[36,55,75],"field":[37],"that":[38],"was":[39],"pioneered":[40],"in":[41],"large":[42],"part":[43],"by":[44],"Anthony":[45],"L.":[46],"Fink":[47],"Pierre":[49],"Douzou.":[50],"Here":[51],"I":[52],"review,":[53],"personal":[56],"perspective,":[57],"history":[59],"cryoenzymology,":[62],"with":[63],"an":[64],"emphasis":[65],"on":[66,85,91],"Tony":[70],"Fink.":[71],"The":[72],"story":[73],"has":[74],"moral:":[76],"if":[77],"you":[78],"choose":[79],"your":[80,100],"collaborators":[81],"based":[82],"not":[83],"only":[84],"their":[86,92],"scientific":[87],"prowess":[88],"but":[89],"also":[90],"human":[93],"qualities,":[94],"resulting":[96],"friendships":[97],"will":[98],"enrich":[99],"life.":[101]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}