{"id":"https://openalex.org/W2042754350","doi":"https://doi.org/10.3171/jns.1988.69.5.0653","title":"Detection of mRNA of prolactin and ACTH in clinically nonfunctioning pituitary adenomas","display_name":"Detection of mRNA of prolactin and ACTH in clinically nonfunctioning pituitary adenomas","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W2042754350","doi":"https://doi.org/10.3171/jns.1988.69.5.0653","mag":"2042754350","pmid":"https://pubmed.ncbi.nlm.nih.gov/2846798"},"language":"en","primary_location":{"id":"doi:10.3171/jns.1988.69.5.0653","doi":"https://doi.org/10.3171/jns.1988.69.5.0653","is_oa":false,"landing_page_url":"https://doi.org/10.3171/jns.1988.69.5.0653","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tsuyoshi Sakurai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Sakurai","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Nagoya University, Japan","Dept. of Endocrinology and Metabolism, Nagoya University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Nagoya University, Japan","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Dept. of Endocrinology and Metabolism, Nagoya University, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105817190","display_name":"Hisao Seo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisao Seo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Naohito Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naohito Yamamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111372405","display_name":"Takashi Nagaya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi Nagaya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110078646","display_name":"Toshichi Nakane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshichi Nakane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022374141","display_name":"Akio Kuwayama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akio Kuwayama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046275782","display_name":"Naoki Kageyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoki Kageyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036701940","display_name":"Nobuo Matsui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuo Matsui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.836,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.90784257,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"69","issue":"5","first_page":"653","last_page":"659"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonfunctioning-pituitary-adenoma","display_name":"non-functioning pituitary adenoma","score":0.9509999752044678},{"id":"https://openalex.org/keywords/prolactin-mrna","display_name":"prolactin mRNA","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mrna-hybridization","display_name":"mRNA hybridization","score":0.5519999861717224},{"id":"https://openalex.org/keywords/hyperprolactinemia","display_name":"hyperprolactinemia","score":0.8809999823570251},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.5170000195503235},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.7857133150100708},{"id":"https://openalex.org/C2779318953","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary adenoma","level":3,"score":0.6464593410491943},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.6158755421638489},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5940216779708862},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5885623693466187},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.5841609239578247},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.58379065990448},{"id":"https://openalex.org/C2781449511","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary tumors","level":2,"score":0.5807547569274902},{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.5709995627403259},{"id":"https://openalex.org/C54799321","wikidata":"https://www.wikidata.org/wiki/Q3016161","display_name":"Prolactin cell","level":4,"score":0.5562969446182251},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5470122694969177},{"id":"https://openalex.org/C2908910360","wikidata":"https://www.wikidata.org/wiki/Q7199538","display_name":"Pituitary neoplasm","level":4,"score":0.4897627830505371},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.4461628794670105},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4330519139766693},{"id":"https://openalex.org/C79381400","wikidata":"https://www.wikidata.org/wiki/Q5173293","display_name":"Corticotropic cell","level":4,"score":0.4243360459804535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3599396347999573},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35919731855392456},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.048003047704696655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.047813594341278076}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007120","descriptor_name":"Immunochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3171/jns.1988.69.5.0653","doi":"https://doi.org/10.3171/jns.1988.69.5.0653","is_oa":false,"landing_page_url":"https://doi.org/10.3171/jns.1988.69.5.0653","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},{"id":"pmid:2846798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2846798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1510707687","https://openalex.org/W1524316887","https://openalex.org/W1863962395","https://openalex.org/W1980292565","https://openalex.org/W1981450507","https://openalex.org/W2003589817","https://openalex.org/W2007495079","https://openalex.org/W2024120978","https://openalex.org/W2029533352","https://openalex.org/W2029987769","https://openalex.org/W2062082681","https://openalex.org/W2067674235","https://openalex.org/W2074485908","https://openalex.org/W2091921705","https://openalex.org/W2144509687","https://openalex.org/W2157355358","https://openalex.org/W2162953892"],"related_works":["https://openalex.org/W2097674585","https://openalex.org/W2091615908","https://openalex.org/W1983705188","https://openalex.org/W2338567511","https://openalex.org/W2060907798","https://openalex.org/W2081210013","https://openalex.org/W1970550466","https://openalex.org/W123329044","https://openalex.org/W2093363384","https://openalex.org/W2044008839"],"abstract_inverted_index":{"Clinically":[0],"nonfunctioning":[1,68,124,140],"pituitary":[2,10,36,45,141,154],"adenomas":[3,69,86,142],"have":[4],"been":[5],"thought":[6],"to":[7,80,105,122,149,158,180],"synthesize":[8],"some":[9,136],"hormones":[11],"as":[12],"shown":[13],"by":[14,72,170],"studies":[15],"involving":[16],"cell":[17],"culture,":[18],"immunocytochemistry,":[19],"or":[20],"measurement":[21],"of":[22,35,49,54,66,74,113,138,172],"hormone":[23,41,61,119,151],"levels":[24],"in":[25,43,63,93,116,135,153,162,174],"tumor":[26,163,176],"homogenates.":[27],"Nevertheless,":[28],"they":[29],"are":[30,133,147],"not":[31],"associated":[32],"with":[33],"hypersecretion":[34,181],"hormones.":[37],"To":[38],"further":[39],"clarify":[40],"synthesis":[42,120,152,171],"such":[44],"adenomas,":[46],"the":[47,64,81,118,175,183],"presence":[48],"messenger":[50],"ribonucleic":[51],"acid":[52],"(mRNA)":[53],"prolactin":[55],"(PRL)":[56],"growth":[57],"hormone,":[58],"and":[59,78,92,131,143,177],"adrenocorticotropic":[60],"(ACTH)":[62],"cytoplasm":[65],"16":[67],"was":[70,90,99],"determined":[71],"means":[73],"a":[75],"hybridization":[76,102,145],"technique,":[77],"compared":[79],"immunocytochemical":[82],"findings.":[83],"In":[84],"three":[85],"(19%)":[87],"PRL":[88,130,160,173],"mRNA":[89,98,161],"detected":[91],"one":[94],"case":[95],"(6%)":[96],"ACTH":[97,132],"detected.":[100],"The":[101,126,156],"technique":[103],"appears":[104],"be":[106],"more":[107],"sensitive":[108],"than":[109],"immunohistochemistry":[110],"for":[111],"detection":[112],"specific":[114],"mRNA's":[115],"assigning":[117],"potential":[121],"clinically":[123,139],"tumors.":[125],"results":[127],"suggest":[128],"that":[129,144,178],"synthesized":[134],"cases":[137],"techniques":[146],"useful":[148],"investigate":[150],"adenomas.":[155],"ability":[157],"demonstrate":[159],"tissues":[164],"allowed":[165],"differentiation":[166],"between":[167],"hyperprolactinemia":[168],"caused":[169],"due":[179],"from":[182],"adjacent":[184],"normal":[185],"pituitary.":[186]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}