{"id":"https://openalex.org/W2042753074","doi":"https://doi.org/10.1089/104454902760330156","title":"Design and In Vivo Immunogenicity of a Polyvalent Vaccine Based on SIVmac Regulatory Genes","display_name":"Design and In Vivo Immunogenicity of a Polyvalent Vaccine Based on SIVmac Regulatory Genes","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W2042753074","doi":"https://doi.org/10.1089/104454902760330156","mag":"2042753074","pmid":"https://pubmed.ncbi.nlm.nih.gov/12396604"},"language":"en","primary_location":{"id":"doi:10.1089/104454902760330156","doi":"https://doi.org/10.1089/104454902760330156","is_oa":false,"landing_page_url":"https://doi.org/10.1089/104454902760330156","pdf_url":null,"source":{"id":"https://openalex.org/S97146013","display_name":"DNA and Cell Biology","issn_l":"1044-5498","issn":["1044-5498","1557-7430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA and Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061139747","display_name":"Zden\u011bk Hel","orcid":"https://orcid.org/0000-0002-4923-4794","observed_orcids":["https://orcid.org/0000-0002-4923-4794"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Hel","raw_affiliation_strings":["National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland","National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090233460","display_name":"El\u017cbieta Anna Tryniszewska","orcid":"https://orcid.org/0000-0002-8428-9088","observed_orcids":["https://orcid.org/0000-0002-8428-9088"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Tryniszewska","raw_affiliation_strings":["National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland and 3rd Department of Paediatrics, Medical Academy of Bialystok, Waszyngtona 17, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland and 3rd Department of Paediatrics, Medical Academy of Bialystok, Waszyngtona 17, Poland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111341986","display_name":"W P Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W.P. Tsai","raw_affiliation_strings":["National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J.M. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.M. Johnson","raw_affiliation_strings":["National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030500123","display_name":"Robert Harrod","orcid":"https://orcid.org/0000-0003-0808-0343","observed_orcids":["https://orcid.org/0000-0003-0808-0343"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Harrod","raw_affiliation_strings":["National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055504916","display_name":"Jake Fullen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Fullen","raw_affiliation_strings":["National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015629897","display_name":"V. S. Kalyanaraman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152530","display_name":"Advanced Bioscience Laboratories (United States)","ror":"https://ror.org/04v1j8c44","country_code":"US","type":"company","lineage":["https://openalex.org/I4210152530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V.S. Kalyanaraman","raw_affiliation_strings":["Advanced BioScience Laboratories, Inc., Kensington, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced BioScience Laboratories, Inc., Kensington, Maryland","institution_ids":["https://openalex.org/I4210152530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049766003","display_name":"John D. Altman","orcid":"https://orcid.org/0000-0001-9733-2359","observed_orcids":["https://orcid.org/0000-0001-9733-2359"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.D. Altman","raw_affiliation_strings":["Emory University Vaccine Center at Yerkes, 954 Gatewood Road, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University Vaccine Center at Yerkes, 954 Gatewood Road, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062659681","display_name":"Jonathan P. McNally","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. McNally","raw_affiliation_strings":["National Cancer Institute, Fluorescence Imaging Facility, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Fluorescence Imaging Facility, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046535878","display_name":"Tatiana Karpova","orcid":"https://orcid.org/0000-0001-6025-2128","observed_orcids":["https://orcid.org/0000-0001-6025-2128"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Karpova","raw_affiliation_strings":["National Cancer Institute, Fluorescence Imaging Facility, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Fluorescence Imaging Facility, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069687616","display_name":"Barbara K. Felber","orcid":"https://orcid.org/0000-0001-8925-8128","observed_orcids":["https://orcid.org/0000-0001-8925-8128"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.K. Felber","raw_affiliation_strings":["National Cancer Institute, Human Retrovirus Pathogenesis Section, Frederick, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Human Retrovirus Pathogenesis Section, Frederick, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110053280","display_name":"JAMES TARTAGLIA","orcid":"https://orcid.org/0000-0002-3399-1926","observed_orcids":["https://orcid.org/0000-0002-3399-1926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Tartaglia","raw_affiliation_strings":["Aventis-Pasteur, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aventis-Pasteur, Toronto, Ontario, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055963852","display_name":"Genoveffa Franchini","orcid":"https://orcid.org/0000-0003-2851-6589","observed_orcids":["https://orcid.org/0000-0003-2851-6589","https://orcid.org/0000-0001-5171-9849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Franchini","raw_affiliation_strings":["Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute, Basic Research Laboratory, 41/D804, Bethesda, Maryland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5358,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.59649662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"9","first_page":"619","last_page":"626"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-vaccine","display_name":"HIV-1 vaccine","score":0.8560000061988831},{"id":"https://openalex.org/keywords/sivmac","display_name":"SIVmac","score":0.8510000109672546},{"id":"https://openalex.org/keywords/viral-regulatory-proteins","display_name":"viral regulatory proteins","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tat","display_name":"Tat","score":0.9300000071525574},{"id":"https://openalex.org/keywords/nef","display_name":"NEF","score":1.0},{"id":"https://openalex.org/keywords/multivalent-vaccine","display_name":"multivalent vaccine","score":0.7549999952316284},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.925000011920929},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.6150000095367432},{"id":"https://openalex.org/keywords/sivmac251","display_name":"SIVmac251","score":0.7400000095367432},{"id":"https://openalex.org/keywords/macaque-model","display_name":"macaque model","score":0.6140000224113464},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8625682592391968},{"id":"https://openalex.org/C2777995582","wikidata":"https://www.wikidata.org/wiki/Q1890246","display_name":"Simian immunodeficiency virus","level":3,"score":0.8281432390213013},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8255338668823242},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.8134621381759644},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.6357424259185791},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4610781669616699},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.44162997603416443},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4199206531047821},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.39666372537612915},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33105725049972534},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2227148413658142},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13417428731918335}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015683","descriptor_name":"Gene Products, gag","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015754","descriptor_name":"Genes, nef","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015756","descriptor_name":"Genes, tat","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015757","descriptor_name":"Genes, rev","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/104454902760330156","doi":"https://doi.org/10.1089/104454902760330156","is_oa":false,"landing_page_url":"https://doi.org/10.1089/104454902760330156","pdf_url":null,"source":{"id":"https://openalex.org/S97146013","display_name":"DNA and Cell Biology","issn_l":"1044-5498","issn":["1044-5498","1557-7430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA and Cell Biology","raw_type":"journal-article"},{"id":"pmid:12396604","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12396604","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA and cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Responsible consumption and production","score":0.5400000214576721,"id":"https://metadata.un.org/sdg/12"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W60866071","https://openalex.org/W1481708591","https://openalex.org/W1510952600","https://openalex.org/W1585454314","https://openalex.org/W1596667011","https://openalex.org/W1605483703","https://openalex.org/W1605749243","https://openalex.org/W1609600288","https://openalex.org/W1633472206","https://openalex.org/W1655510925","https://openalex.org/W1674854702","https://openalex.org/W1808985647","https://openalex.org/W1948199170","https://openalex.org/W1965372133","https://openalex.org/W1965569618","https://openalex.org/W1971312179","https://openalex.org/W1974889043","https://openalex.org/W1983194006","https://openalex.org/W1985288736","https://openalex.org/W1996210947","https://openalex.org/W1998559841","https://openalex.org/W2009361016","https://openalex.org/W2011837112","https://openalex.org/W2038599188","https://openalex.org/W2038665432","https://openalex.org/W2039751597","https://openalex.org/W2059551093","https://openalex.org/W2064680129","https://openalex.org/W2064896248","https://openalex.org/W2064914230","https://openalex.org/W2079504777","https://openalex.org/W2081825634","https://openalex.org/W2084229810","https://openalex.org/W2085919513","https://openalex.org/W2087259832","https://openalex.org/W2097755672","https://openalex.org/W2098590425","https://openalex.org/W2103182811","https://openalex.org/W2103663071","https://openalex.org/W2109347706","https://openalex.org/W2109669557","https://openalex.org/W2110962890","https://openalex.org/W2112783842","https://openalex.org/W2115696185","https://openalex.org/W2117543134","https://openalex.org/W2126325079","https://openalex.org/W2128717715","https://openalex.org/W2128917308","https://openalex.org/W2131974188","https://openalex.org/W2138834926","https://openalex.org/W2142529641","https://openalex.org/W2144882745","https://openalex.org/W2149791183","https://openalex.org/W2151181830","https://openalex.org/W2154235266","https://openalex.org/W2155021907","https://openalex.org/W4250184053"],"related_works":["https://openalex.org/W1974889043","https://openalex.org/W2117751118","https://openalex.org/W2049821330","https://openalex.org/W2161115472","https://openalex.org/W2738795120","https://openalex.org/W1991488912","https://openalex.org/W2071549306","https://openalex.org/W1999353044","https://openalex.org/W2098791370","https://openalex.org/W2100449403"],"abstract_inverted_index":{"Most":[0],"vaccine":[1,53,197],"modalities":[2],"for":[3,11,100,112,120,184],"human":[4],"immunodeficiency":[5,19],"virus":[6,39],"type":[7],"1":[8],"(HIV-1)":[9],"tested":[10],"immunogenicity":[12],"and":[13,42,73,102,107,114,116,153],"efficacy":[14],"in":[15,62,94,144,166,175,194],"the":[16,26,38,57,69,96,108,117,141,145,151,154,185,191],"SIVmac":[17],"(simian":[18],"virus)":[20],"macaque":[21],"model":[22],"do":[23],"not":[24],"include":[25],"viral":[27,31],"regulatory":[28,32,192],"proteins.":[29],"Because":[30],"proteins":[33,193],"are":[34],"expressed":[35],"early":[36,70],"during":[37],"life":[40],"cycle":[41],"represent":[43],"an":[44,84],"additional":[45],"source":[46],"of":[47,68,83,134,147,187],"antigens,":[48],"their":[49,79],"inclusion":[50],"as":[51,81,172,174],"a":[52,90,132,195],"component":[54],"may":[55,75,181],"increase":[56],"overall":[58],"virus-specific":[59],"immune":[60],"response":[61],"vaccinees.":[63],"However,":[64],"at":[65,140],"least":[66],"two":[67],"proteins,":[71],"Tat":[72,101,113],"Nef,":[74],"be":[76,164,182],"immunosuppressive,":[77],"limiting":[78],"usefulness":[80],"components":[82],"SIV":[85],"vaccine.":[86],"We":[87],"have":[88,104,122],"constructed":[89],"polyvalent":[91,188],"chimeric":[92],"protein":[93,133],"which":[95],"open":[97],"reading":[98],"frames":[99],"Nef":[103,121],"been":[105,123],"reassorted":[106],"nuclear":[109],"localization":[110],"sequence":[111],"Rev":[115],"myristoylation":[118],"site":[119],"removed.":[124],"The":[125],"resulting":[126],"DNA":[127],"plasmid":[128],"(pDNA-SIV-Retanef)":[129],"(pDNA-SIV-RTN)":[130],"encodes":[131],"55":[135],"kDa":[136],"(Retanef)":[137],"that":[138],"localizes":[139],"steady":[142],"state":[143],"cytoplasma":[146],"transfected":[148],"cells.":[149],"Both":[150],"DNA-SIV-RTN":[152],"highly":[155],"attenuated":[156],"recombinant":[157],"poxvirus":[158],"vector":[159],"NYVAC-SIV-RTN":[160],"were":[161],"demonstrated":[162],"to":[163],"immunogenic":[165],"SIVmac251-infected":[167],"macaques":[168],"treated":[169],"with":[170],"ART":[171],"well":[173],"naive":[176],"macaques.":[177],"An":[178],"equivalent":[179],"strategy":[180],"used":[183],"generation":[186],"antigens":[189],"encoding":[190],"HIV-1":[196],"candidate.":[198]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}