{"id":"https://openalex.org/W204264097","doi":null,"title":"Transcriptional Regulation of Neurogenic Atrophy-Induced Gene Expression by Muscle Ring Finger-1 and Myogenic Regulatory Factors","display_name":"Transcriptional Regulation of Neurogenic Atrophy-Induced Gene Expression by Muscle Ring Finger-1 and Myogenic Regulatory Factors","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W204264097","mag":"204264097"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.846.5432","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.846.5432","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://digitalcommons.unf.edu/cgi/viewcontent.cgi?article%3D1505%26context%3Detd","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Theodore A. Olson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11874761","display_name":"University of North Florida","ror":"https://ror.org/01j903a45","country_code":"US","type":"education","lineage":["https://openalex.org/I11874761"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Theodore A. Olson","raw_affiliation_strings":["[University of North Florida]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[University of North Florida]","institution_ids":["https://openalex.org/I11874761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I11874761"],"apc_list":null,"apc_paid":null,"fwci":0.1102,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.41019098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/murf1","display_name":"MuRF1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/atrogin-1","display_name":"atrogin-1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/myogenic-regulatory-factors","display_name":"myogenic regulatory factors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/myod","display_name":"MyoD","score":0.9959999918937683},{"id":"https://openalex.org/keywords/myogenin","display_name":"myogenin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/ring-finger-domain","display_name":"RING domain","score":0.7919999957084656},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.4620000123977661},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.6074639558792114},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.559641420841217},{"id":"https://openalex.org/C2781183200","wikidata":"https://www.wikidata.org/wiki/Q192298","display_name":"Ring finger","level":3,"score":0.5114120841026306},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4708501696586609},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4635562002658844},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4594714045524597},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44565722346305847},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.41000354290008545},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38548851013183594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3786145746707916},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36636412143707275},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35299617052078247}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.846.5432","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.846.5432","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://digitalcommons.unf.edu/cgi/viewcontent.cgi?article%3D1505%26context%3Detd","raw_type":"text"},{"id":"pmh:oai:digitalcommons.unf.edu:etd-1505","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.unf.edu/etd/495","pdf_url":null,"source":{"id":"https://openalex.org/S4306401214","display_name":"University of North Florida Digital Commons (University of North Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I11874761","host_organization_name":"University of North Florida","host_organization_lineage":["https://openalex.org/I11874761"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"UNF Graduate Theses and Dissertations","raw_type":"thesis"},{"id":"mag:204264097","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.unf.edu/cgi/viewcontent.cgi?article=1505&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W160560946","https://openalex.org/W1493550843","https://openalex.org/W1539814399","https://openalex.org/W1567411317","https://openalex.org/W1645045438","https://openalex.org/W1917787745","https://openalex.org/W1965047073","https://openalex.org/W1969655939","https://openalex.org/W1974543599","https://openalex.org/W1996420967","https://openalex.org/W2003924932","https://openalex.org/W2005444834","https://openalex.org/W2005909790","https://openalex.org/W2008744347","https://openalex.org/W2009794434","https://openalex.org/W2023578962","https://openalex.org/W2033797333","https://openalex.org/W2033924360","https://openalex.org/W2043550667","https://openalex.org/W2052651806","https://openalex.org/W2059511765","https://openalex.org/W2061929833","https://openalex.org/W2066056709","https://openalex.org/W2068382528","https://openalex.org/W2070345867","https://openalex.org/W2072769447","https://openalex.org/W2078718449","https://openalex.org/W2083017377","https://openalex.org/W2083381199","https://openalex.org/W2086802511","https://openalex.org/W2088689184","https://openalex.org/W2105165859","https://openalex.org/W2115039021","https://openalex.org/W2117391818","https://openalex.org/W2119551458","https://openalex.org/W2122808924","https://openalex.org/W2124239182","https://openalex.org/W2127367832","https://openalex.org/W2128674168","https://openalex.org/W2130250591","https://openalex.org/W2132024812","https://openalex.org/W2136991248","https://openalex.org/W2142349465","https://openalex.org/W2144114582","https://openalex.org/W2149291473","https://openalex.org/W2155685150","https://openalex.org/W2158964360","https://openalex.org/W2162063376","https://openalex.org/W2162506787","https://openalex.org/W2163106706","https://openalex.org/W2165718181","https://openalex.org/W2167033587","https://openalex.org/W2168476587","https://openalex.org/W2169448756","https://openalex.org/W2170061025","https://openalex.org/W2170265183","https://openalex.org/W2184656706"],"related_works":["https://openalex.org/W4389034399","https://openalex.org/W4389025424","https://openalex.org/W2724878747","https://openalex.org/W1573453922","https://openalex.org/W1483231290","https://openalex.org/W1518704701","https://openalex.org/W925701912","https://openalex.org/W1145891016","https://openalex.org/W1507218576","https://openalex.org/W2009794434"],"abstract_inverted_index":{"Skeletal":[0],"muscle":[1],"wasting":[2],"is":[3,274],"a":[4,36,62,108,186,206,212,287,294],"consequence":[5],"of":[6,65,72,82,91,96,145,157,166,175,178,185,196,203,252,263,286,297],"numerous":[7],"physiological":[8],"conditions,":[9],"including":[10,69],"denervation,":[11],"corticosteroid":[12],"treatment,":[13],"immobilization,":[14],"and":[15,22,31,74,84,112,122,152,160,182,211,229,237],"aging.":[16],"The":[17,120,218,243],"E3":[18],"ubiquitin":[19,271],"ligases,":[20],"MuRF1":[21,57,75,83,109,121,133,159,167,198,204,207,213,231,244,277,292],"MAFbx,":[23,85],"are":[24,32],"induced":[25],"under":[26],"nearly":[27],"all":[28],"atrophy":[29],"conditions":[30],"believed":[33],"to":[34,135,248],"play":[35],"key":[37],"role":[38,195],"in":[39,42,50,116,129,173,201,300],"protein":[40],"degradation":[41],"atrophying":[43],"muscle.":[44],"However,":[45,164],"the":[46,70,79,92,146,158,194,197,230,253,257,264],"preliminary":[47],"data":[48,282],"described":[49],"this":[51],"study":[52],"provides":[53],"new":[54,289],"evidence":[55,285],"that":[56,137,270],"may":[58],"also":[59],"act":[60],"as":[61,293],"transcriptional":[63,80,278,295],"modulator":[64,296],"atrophy-induced":[66,298],"gene":[67,87,118,180,199,239,301],"activity,":[68,181],"regulation":[71,81],"MAFbx":[73,123,161],"expression.":[76,302],"To":[77,191],"characterize":[78,193],"reporter":[86,117,162,179,189,232,238,254,265],"constructs":[88,220],"containing":[89],"fragments":[90],"proximal":[93],"promoter":[94],"regions":[95],"these":[97],"genes":[98],"were":[99,216,221],"developed,":[100],"transfected":[101],"into":[102,234],"C2C12":[103,235],"cells":[104,130,136,236],"with":[105,168,225],"or":[106,170],"without":[107],"expression":[110,144,227],"plasmid":[111],"monitored":[113],"for":[114,276,291],"differences":[115],"activity.":[119],"reporters":[124],"each":[125],"showed":[126],"repressed":[127],"activity":[128,240,273],"ectopically":[131],"expressing":[132],"compared":[134],"did":[138],"not":[139],"overexpress":[140],"MuRF1.":[141],"Furthermore,":[142],"ectopic":[143],"myogenic":[147],"regulatory":[148,279],"factors":[149],"(MRFs),":[150],"MyoD1":[151,169],"myogenin,":[153],"caused":[154],"significant":[155],"activation":[156,251,262],"constructs.":[163],"co-overexpression":[165],"myogenin":[171],"resulted":[172],"reversal":[174],"MRF":[176,226,250],"induction":[177],"synergistic":[183],"repression":[184,202],"constructed":[187],"E-box":[188],"system.":[190],"further":[192],"product":[200],"expression,":[205],"RING":[208,245],"domain":[209],"mutant":[210,215,219,246,259],"c-terminal":[214,258],"created.":[217],"then":[222],"co-transfected":[223],"along":[224],"plasmids":[228],"construct":[233],"was":[241],"assessed.":[242],"failed":[247],"reverse":[249],"gene,":[255],"while":[256],"successfully":[260],"reversed":[261],"gene.":[266],"These":[267,281],"findings":[268],"suggest":[269],"ligase":[272],"required":[275],"effects.":[280],"offer":[283],"exciting":[284],"potential":[288],"function":[290],"changes":[299]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}