{"id":"https://openalex.org/W2042499459","doi":"https://doi.org/10.1016/j.bbrc.2006.04.153","title":"A novel cis-acting element in Her2 promoter regulated by Stat3 in mammary cancer cells","display_name":"A novel cis-acting element in Her2 promoter regulated by Stat3 in mammary cancer cells","publication_year":2006,"publication_date":"2006-05-06","ids":{"openalex":"https://openalex.org/W2042499459","doi":"https://doi.org/10.1016/j.bbrc.2006.04.153","mag":"2042499459","pmid":"https://pubmed.ncbi.nlm.nih.gov/16696944"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2006.04.153","doi":"https://doi.org/10.1016/j.bbrc.2006.04.153","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2006.04.153","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101846075","display_name":"Qian Lu","orcid":"https://orcid.org/0000-0002-3104-8192","observed_orcids":["https://orcid.org/0000-0002-3104-8192"]},"institutions":[{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Qian","raw_affiliation_strings":["Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China","institution_ids":["https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000803977","display_name":"Liyong Chen","orcid":"https://orcid.org/0000-0002-6735-9195","observed_orcids":["https://orcid.org/0000-0002-6735-9195"]},"institutions":[{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyong Chen","raw_affiliation_strings":["Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China","institution_ids":["https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020955864","display_name":"Ming Shi","orcid":"https://orcid.org/0000-0001-9263-6468","observed_orcids":["https://orcid.org/0000-0001-9263-6468"]},"institutions":[{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Shi","raw_affiliation_strings":["Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China","institution_ids":["https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031067040","display_name":"Ming Yu","orcid":"https://orcid.org/0000-0001-8692-6135","observed_orcids":["https://orcid.org/0000-0001-8692-6135"]},"institutions":[{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Yu","raw_affiliation_strings":["Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China","institution_ids":["https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100941387","display_name":"Baofeng Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127501","display_name":"National Center of Biomedical Analysis","ror":"https://ror.org/03k3bq214","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baofeng Jin","raw_affiliation_strings":["National Center of Biomedical Analysis, Beijing 100071, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Biomedical Analysis, Beijing 100071, PR China","institution_ids":["https://openalex.org/I4210127501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103005702","display_name":"Meiru Hu","orcid":"https://orcid.org/0000-0003-4039-0173","observed_orcids":["https://orcid.org/0000-0003-4039-0173"]},"institutions":[{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiru Hu","raw_affiliation_strings":["Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China","institution_ids":["https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100673499","display_name":"Qing Xia","orcid":"https://orcid.org/0000-0002-8191-7712","observed_orcids":["https://orcid.org/0000-0002-8191-7712"]},"institutions":[{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Xia","raw_affiliation_strings":["Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China","institution_ids":["https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030297874","display_name":"Xueming Zhang","orcid":"https://orcid.org/0000-0003-0670-2452","observed_orcids":["https://orcid.org/0000-0003-0670-2452"]},"institutions":[{"id":"https://openalex.org/I4210127501","display_name":"National Center of Biomedical Analysis","ror":"https://ror.org/03k3bq214","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueming Zhang","raw_affiliation_strings":["National Center of Biomedical Analysis, Beijing 100071, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Biomedical Analysis, Beijing 100071, PR China","institution_ids":["https://openalex.org/I4210127501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060514130","display_name":"Beifen Shen","orcid":"https://orcid.org/0000-0001-7263-4748","observed_orcids":["https://orcid.org/0000-0001-7263-4748"]},"institutions":[{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Beifen Shen","raw_affiliation_strings":["Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China","institution_ids":["https://openalex.org/I4391767653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110230054","display_name":"Ning Guo","orcid":"https://orcid.org/0000-0002-2617-4477","observed_orcids":["https://orcid.org/0000-0002-2617-4477"]},"institutions":[{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ning Guo","raw_affiliation_strings":["Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China","institution_ids":["https://openalex.org/I4391767653"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110230054"],"corresponding_institution_ids":["https://openalex.org/I4391767653"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.4812,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.6241495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"345","issue":"2","first_page":"660","last_page":"668"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.15039999783039093,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9459999799728394},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.746999979019165},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.843999981880188},{"id":"https://openalex.org/keywords/palindromic-sequences","display_name":"palindromic sequences","score":0.7149999737739563},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8399999737739563},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.621999979019165},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.7059999704360962},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5619900822639465},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.523807168006897},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4941587746143341},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49238812923431396},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4752885103225708},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4453389644622803},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.423194020986557},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.382851243019104},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.344808965921402},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3263899087905884},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2874298095703125}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018734","descriptor_name":"Genes, erbB-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018734","descriptor_name":"Genes, erbB-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D046208","descriptor_name":"Microchip Analytical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2006.04.153","doi":"https://doi.org/10.1016/j.bbrc.2006.04.153","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2006.04.153","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:16696944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16696944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1505947129","https://openalex.org/W1547600157","https://openalex.org/W1563819414","https://openalex.org/W1565466418","https://openalex.org/W1685536199","https://openalex.org/W1717791478","https://openalex.org/W1954085239","https://openalex.org/W1965755761","https://openalex.org/W1977681992","https://openalex.org/W1979107436","https://openalex.org/W1982288359","https://openalex.org/W1983166456","https://openalex.org/W1988719795","https://openalex.org/W1991498850","https://openalex.org/W1993243592","https://openalex.org/W2007897471","https://openalex.org/W2008404830","https://openalex.org/W2013178557","https://openalex.org/W2013288089","https://openalex.org/W2024282024","https://openalex.org/W2036752075","https://openalex.org/W2046439112","https://openalex.org/W2048292316","https://openalex.org/W2071164914","https://openalex.org/W2071516626","https://openalex.org/W2074356752","https://openalex.org/W2083162753","https://openalex.org/W2084220146","https://openalex.org/W2092215775","https://openalex.org/W2092970174","https://openalex.org/W2095156669","https://openalex.org/W2095422595","https://openalex.org/W2114445658","https://openalex.org/W2125607221","https://openalex.org/W2132633540","https://openalex.org/W2135442706","https://openalex.org/W2141393790","https://openalex.org/W2145084871","https://openalex.org/W2165808595","https://openalex.org/W2166364516","https://openalex.org/W2242886336","https://openalex.org/W2312647513","https://openalex.org/W2402126475","https://openalex.org/W2465722325","https://openalex.org/W4249713142","https://openalex.org/W6633729806","https://openalex.org/W6637701360","https://openalex.org/W6673604355","https://openalex.org/W6680076066","https://openalex.org/W6719689040"],"related_works":["https://openalex.org/W2069059394","https://openalex.org/W1990752239","https://openalex.org/W2031150542","https://openalex.org/W1605843957","https://openalex.org/W4403835455","https://openalex.org/W1983201135","https://openalex.org/W2053841000","https://openalex.org/W1550916550","https://openalex.org/W2113231588","https://openalex.org/W2062129127"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}