{"id":"https://openalex.org/W2042496971","doi":"https://doi.org/10.1002/jat.2550070302","title":"Structure\u2010nephrotoxicity relationships for meta\u2010substituted N\u2010phenylsuccinimides","display_name":"Structure\u2010nephrotoxicity relationships for meta\u2010substituted N\u2010phenylsuccinimides","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W2042496971","doi":"https://doi.org/10.1002/jat.2550070302","mag":"2042496971","pmid":"https://pubmed.ncbi.nlm.nih.gov/3624773"},"language":"en","primary_location":{"id":"doi:10.1002/jat.2550070302","doi":"https://doi.org/10.1002/jat.2550070302","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jat.2550070302","pdf_url":null,"source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041976538","display_name":"David J. Yang","orcid":"https://orcid.org/0000-0001-8308-0621","observed_orcids":["https://orcid.org/0000-0001-8308-0621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J. Yang","raw_affiliation_strings":["Departments of Pharmacology and Anatomy, Huntington, West Virginia 25704-2901, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Anatomy, Huntington, West Virginia 25704-2901, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109307898","display_name":"Patrick I. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88694374","display_name":"Marshall University","ror":"https://ror.org/02erqft81","country_code":"US","type":"education","lineage":["https://openalex.org/I88694374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick I. Brown","raw_affiliation_strings":["Marshall University School of Medicine, Huntington, West Virginia 25704-2901, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marshall University School of Medicine, Huntington, West Virginia 25704-2901, USA","institution_ids":["https://openalex.org/I88694374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078199942","display_name":"Herng\u2010Hsiang Lo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herng\u2010Hsiang Lo","raw_affiliation_strings":["Departments of Pharmacology and Anatomy, Huntington, West Virginia 25704-2901, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Anatomy, Huntington, West Virginia 25704-2901, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074743135","display_name":"Vonda J. Teets","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vonda J. Teets","raw_affiliation_strings":["Departments of Pharmacology and Anatomy, Huntington, West Virginia 25704-2901, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Anatomy, Huntington, West Virginia 25704-2901, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026517567","display_name":"Gary O'Neal Rankin","orcid":"https://orcid.org/0000-0002-5385-3512","observed_orcids":["https://orcid.org/0000-0002-5385-3512"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gary O. Rankin","raw_affiliation_strings":["Departments of Pharmacology and Anatomy, Huntington, West Virginia 25704-2901, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Anatomy, Huntington, West Virginia 25704-2901, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026517567"],"corresponding_institution_ids":[],"apc_list":{"value":3940,"currency":"USD","value_usd":3940},"apc_paid":null,"fwci":1.0643,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.76643439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"3","first_page":"153","last_page":"160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9089999794960022},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7839999794960022},{"id":"https://openalex.org/keywords/fungicides","display_name":"fungicides","score":0.6980000138282776},{"id":"https://openalex.org/keywords/electron-withdrawing-substituents","display_name":"electron-withdrawing substituents","score":0.7609999775886536},{"id":"https://openalex.org/keywords/electron-donating-substituents","display_name":"electron-donating substituents","score":0.8619999885559082},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6019999980926514},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hematuria","display_name":"hematuria","score":0.9629999995231628},{"id":"https://openalex.org/keywords/proximal-tubular-necrosis","display_name":"proximal tubular necrosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/blood-urea-nitrogen","display_name":"blood urea nitrogen","score":0.8159999847412109},{"id":"https://openalex.org/keywords/diuresis","display_name":"diuresis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.9454773664474487},{"id":"https://openalex.org/C2776830054","wikidata":"https://www.wikidata.org/wiki/Q419430","display_name":"Succinimide","level":2,"score":0.7905851602554321},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.753027081489563},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.5144848823547363},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49182724952697754},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4450487494468689},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.41600289940834045},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3418319821357727},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32339367270469666},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3186511993408203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2716585397720337},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1689070165157318},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15831038355827332}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004231","descriptor_name":"Diuresis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004583","descriptor_name":"Electrons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005659","descriptor_name":"Fungicides, Industrial","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006417","descriptor_name":"Hematuria","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010130","descriptor_name":"p-Aminohippuric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013388","descriptor_name":"Succinimides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D013757","descriptor_name":"Tetraethylammonium Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019789","descriptor_name":"Tetraethylammonium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jat.2550070302","doi":"https://doi.org/10.1002/jat.2550070302","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jat.2550070302","pdf_url":null,"source":{"id":"https://openalex.org/S81851855","display_name":"Journal of Applied Toxicology","issn_l":"0260-437X","issn":["0260-437X","1099-1263"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Toxicology","raw_type":"journal-article"},{"id":"pmid:3624773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3624773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied toxicology : JAT","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3117598791","display_name":null,"funder_award_id":"DK31210","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W141906119","https://openalex.org/W295055718","https://openalex.org/W1896993825","https://openalex.org/W1973179549","https://openalex.org/W1980037850","https://openalex.org/W1984669684","https://openalex.org/W1991530492","https://openalex.org/W2001642536","https://openalex.org/W2006603991","https://openalex.org/W2009553571","https://openalex.org/W2010441335","https://openalex.org/W2037093820","https://openalex.org/W2044318666","https://openalex.org/W2075425291","https://openalex.org/W2089218058","https://openalex.org/W2149480547","https://openalex.org/W2303532665","https://openalex.org/W2305844993","https://openalex.org/W2411611755","https://openalex.org/W2728785340"],"related_works":["https://openalex.org/W2089218058","https://openalex.org/W2075425291","https://openalex.org/W2069919227","https://openalex.org/W2087686317","https://openalex.org/W2037093820","https://openalex.org/W2001152559","https://openalex.org/W1973179549","https://openalex.org/W4253943877","https://openalex.org/W1991530492","https://openalex.org/W2024581337"],"abstract_inverted_index":{"The":[0,9],"N-phenylsuccinimides":[1],"are":[2],"being":[3],"evaluated":[4,177],"as":[5],"experimental":[6],"agricultural":[7],"fungicides.":[8,43],"purpose":[10],"of":[11,27,40,54,82,95,146,155],"this":[12,89,179],"study":[13],"was":[14,99,105],"to":[15,134],"examine":[16],"the":[17,20,37,41,85,92,100,140,156,160,173],"relationship":[18],"between":[19],"electron":[21,24,141],"withdrawing":[22,142],"or":[23,58,61,143],"donating":[25,144],"properties":[26],"phenyl":[28],"ring":[29],"substituents":[30],"on":[31],"meta-substituted":[32,174],"N-phenylsuccinimide":[33],"(NPS)":[34],"derivatives":[35,78,94,176],"and":[36,67,73,121],"nephrotoxic":[38,157,170],"potential":[39,158,171],"corresponding":[42,161],"Male":[44],"Fischer":[45],"344":[46],"rats":[47],"were":[48,132],"administered":[49],"a":[50,55,147,152],"single":[51],"intraperitoneal":[52],"injection":[53],"succinimide":[56],"(0.4":[57],"1.0":[59],"mmol/kg)":[60],"vehicle":[62],"(sesame":[63],"oil,":[64],"2.5":[65],"ml/kg),":[66],"renal":[68,127],"function":[69],"monitored":[70],"at":[71,84],"24":[72],"48":[74],"hr.":[75],"Non-halogen-substituted":[76],"NPS":[77,175],"produced":[79,129],"little":[80],"evidence":[81],"nephrotoxicity":[83,104],"doses":[86],"used":[87],"in":[88,178],"study.":[90,180],"Among":[91],"meta-halogen":[93],"NPS,":[96],"N-(3-chlorophenyl)succinimide":[97],"(NCPS)":[98],"most":[101],"nephrotoxic.":[102],"NCPS-induced":[103],"characterized":[106],"by":[107,130],"diuresis,":[108],"proteinuria,":[109],"hematuria,":[110],"elevated":[111],"blood":[112],"urea":[113],"nitrogen":[114],"(BUN)":[115],"concentration,":[116],"decreased":[117],"organic":[118],"ion":[119],"accumulation":[120],"proximal":[122],"tubular":[123],"necrosis.":[124],"However,":[125],"all":[126],"effects":[128],"NCPS":[131],"mild":[133],"moderate.":[135],"These":[136],"results":[137],"suggest":[138],"that":[139],"property":[145],"functional":[148],"group":[149],"is":[150],"not":[151,167],"good":[153],"predictor":[154],"for":[159,172],"fungicide.":[162],"In":[163],"addition,":[164],"lipophilicity":[165],"did":[166],"correlate":[168],"with":[169]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
