{"id":"https://openalex.org/W2042483530","doi":"https://doi.org/10.1172/jci1662","title":"Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice.","display_name":"Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice.","publication_year":1998,"publication_date":"1998-03-15","ids":{"openalex":"https://openalex.org/W2042483530","doi":"https://doi.org/10.1172/jci1662","mag":"2042483530","pmid":"https://pubmed.ncbi.nlm.nih.gov/9502776","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/508689"},"language":"en","primary_location":{"id":"doi:10.1172/jci1662","doi":"https://doi.org/10.1172/jci1662","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci1662","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/508689","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030937895","display_name":"X F Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"X F Lei","raw_affiliation_strings":["Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055215304","display_name":"Yuichi Ohkawara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Y Ohkawara","raw_affiliation_strings":["Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066081846","display_name":"Martin R. St\u00e4mpfli","orcid":"https://orcid.org/0000-0003-4918-5889","observed_orcids":["https://orcid.org/0000-0003-4918-5889"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M R St\u00e4mpfli","raw_affiliation_strings":["Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026893377","display_name":"Claudio Mastruzzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C Mastruzzo","raw_affiliation_strings":["Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008669167","display_name":"Robert A. Marr","orcid":"https://orcid.org/0000-0001-7206-7237","observed_orcids":["https://orcid.org/0000-0001-7206-7237"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R A Marr","raw_affiliation_strings":["Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050439557","display_name":"Denis P. Snider","orcid":"https://orcid.org/0000-0002-4285-4982","observed_orcids":["https://orcid.org/0000-0002-4285-4982"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D Snider","raw_affiliation_strings":["Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019141272","display_name":"Zhimin Xing","orcid":"https://orcid.org/0000-0002-4325-9392","observed_orcids":["https://orcid.org/0000-0002-4325-9392"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Z Xing","raw_affiliation_strings":["Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065277319","display_name":"Manel Jordana","orcid":"https://orcid.org/0000-0002-5861-5994","observed_orcids":["https://orcid.org/0000-0002-5861-5994"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"M Jordana","raw_affiliation_strings":["Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Immunology and Infection Programme, McMaster University, Hamilton, Ontario, Canada L8N 3Z5","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065277319"],"corresponding_institution_ids":["https://openalex.org/I98251732"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":4.6969,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.95302385,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"101","issue":"6","first_page":"1342","last_page":"1353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/eosinophilic-inflammation","display_name":"eosinophilic inflammation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/ovalbumin-sensitization","display_name":"ovalbumin sensitization","score":0.9570000171661377},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.7400000095367432},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8159999847412109},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9520000219345093},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8240000009536743},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.7400000095367432},{"id":"https://openalex.org/keywords/allergic-airway-inflammation","display_name":"allergic airway inflammation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.8048301935195923},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.7013604640960693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5986344218254089},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5015058517456055},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.482297420501709},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.46965140104293823},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.4623832106590271},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4562467634677887},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4493645429611206},{"id":"https://openalex.org/C2777716647","wikidata":"https://www.wikidata.org/wiki/Q5381961","display_name":"Eotaxin","level":4,"score":0.4476892650127411},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.44239795207977295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3953591585159302},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2664473056793213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2653791308403015},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.21973571181297302},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20250985026359558},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1776529848575592},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.13301143050193787},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.12661075592041016},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07803145051002502},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015848","descriptor_name":"Interleukin-5","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015848","descriptor_name":"Interleukin-5","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023201","descriptor_name":"CD40 Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci1662","doi":"https://doi.org/10.1172/jci1662","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci1662","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:508689","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/508689","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:9502776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9502776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:508689","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/508689","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319962","display_name":"Canadian Lung Association","ror":"https://ror.org/037263y09"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1801988425","https://openalex.org/W1966644054","https://openalex.org/W1988227673","https://openalex.org/W1989055057","https://openalex.org/W1989668591","https://openalex.org/W1989669523","https://openalex.org/W1990572032","https://openalex.org/W1994538620","https://openalex.org/W1996134542","https://openalex.org/W1998783767","https://openalex.org/W2005432265","https://openalex.org/W2008834548","https://openalex.org/W2013125846","https://openalex.org/W2027388989","https://openalex.org/W2028293869","https://openalex.org/W2037294736","https://openalex.org/W2038007224","https://openalex.org/W2039651755","https://openalex.org/W2046696621","https://openalex.org/W2047078985","https://openalex.org/W2052140619","https://openalex.org/W2054569703","https://openalex.org/W2064327582","https://openalex.org/W2065354528","https://openalex.org/W2067701958","https://openalex.org/W2069080743","https://openalex.org/W2074537289","https://openalex.org/W2079235989","https://openalex.org/W2081205921","https://openalex.org/W2084379257","https://openalex.org/W2085593429","https://openalex.org/W2087644006","https://openalex.org/W2089324437","https://openalex.org/W2103405817","https://openalex.org/W2116525981","https://openalex.org/W2122666166","https://openalex.org/W2140686309","https://openalex.org/W2151900684","https://openalex.org/W2172658766","https://openalex.org/W2182386412","https://openalex.org/W2315018741"],"related_works":["https://openalex.org/W2109032237","https://openalex.org/W2072637423","https://openalex.org/W1972071002","https://openalex.org/W1919254458","https://openalex.org/W2142006903","https://openalex.org/W2054569703","https://openalex.org/W2030278924","https://openalex.org/W2345554603","https://openalex.org/W2095481575","https://openalex.org/W2084225449"],"abstract_inverted_index":{"The":[0],"objective":[1],"of":[2,10,54,89,122,138,146,154,161,182,228,247,254,265,278,287],"this":[3,25],"study":[4],"was":[5,73,79],"to":[6,19],"investigate":[7,113],"the":[8,11,52,55,95,99,103,114,123,266,270,276,279,284,288,292],"contribution":[9],"interaction":[12],"between":[13],"CD40":[14],"and":[15,47,98,106,127,134,144,148,158,160,190,216,235,249,260],"its":[16],"ligand":[17],"(CD40L)":[18],"antigen-induced":[20],"airways":[21],"inflammatory":[22,77,267,289],"responses.":[23],"To":[24,112],"end,":[26],"we":[27,119,176,212],"used":[28],"a":[29],"model":[30],"involving":[31],"ovalbumin":[32],"(OVA)":[33],"sensitization":[34],"followed":[35],"by":[36,197,218],"OVA":[37],"aerosol":[38],"challenge":[39],"in":[40,51,60,82,93,102,129,142,156,163,167,188,205,262,269,283,291],"CD40L":[41],"knockout":[42],"(KO)":[43],"mice.":[44,62,84,174,209],"OVA-specific":[45],"IgE":[46],"IgG1":[48],"were":[49,91,140,165],"detected":[50,141,166,196],"serum":[53,145,159],"sensitized":[56,66,104],"control,":[57],"but":[58],"not":[59,240],"CD40L-KO":[61,83,149,168,192,237],"After":[63],"antigen":[64,110],"challenge,":[65],"control":[67,147,173,208],"mice":[68,169,193,238],"developed":[69],"airway":[70,242],"inflammation":[71],"that":[72,178,203],"primarily":[74],"eosinophilic.":[75],"This":[76],"response":[78,268,290],"dramatically":[80],"reduced":[81],"In":[85,210],"contrast,":[86],"similar":[87],"numbers":[88],"eosinophils":[90],"observed":[92,204],"both":[94,130],"bone":[96],"marrow":[97],"peripheral":[100],"blood":[101],"controls":[105],"mutant":[107],"strains":[108],"after":[109],"challenge.":[111],"mechanisms":[115],"underlying":[116],"these":[117,273],"findings,":[118],"examined":[120],"levels":[121,137,153],"cytokines":[124],"IL-5,":[125],"IL-4,":[126],"TNFalpha":[128,162,217],"bronchoalveolar":[131],"lavage":[132],"(BAL)":[133],"serum.":[135],"Similar":[136],"IL-5":[139],"BAL":[143,157,164],"mice;":[150],"however,":[151],"negligible":[152],"IL-4":[155,215],"when":[170],"compared":[171,201],"with":[172,202],"Furthermore,":[175],"demonstrated":[177],"endothelial":[179,252],"cell":[180,184,256],"expression":[181,253,286],"vascular":[183,255],"adhesion":[185,257],"molecule":[186,258],"1":[187],"OVA-sensitized":[189,234],"-challenged":[191,236],"was,":[194],"as":[195],"immunohistochemistry,":[198],"markedly":[199],"decreased":[200],"similarly":[206],"treated":[207],"addition,":[211],"locally":[213],"overexpressed":[214],"using":[219],"an":[220],"adenoviral":[221],"(Ad)-mediated":[222],"gene":[223],"transfer":[224],"approach.":[225],"Intranasal":[226],"administration":[227,246],"either":[229],"Ad/TNFalpha":[230,248],"or":[231],"Ad/IL-4":[232,250],"into":[233],"did":[239],"reconstitute":[241],"eosinophilia.":[243],"However,":[244],"concurrent":[245],"upregulated":[251],"1,":[259],"resulted":[261],"full":[263,285],"reconstitution":[264],"airways.":[271,293],"Together,":[272],"findings":[274],"demonstrate":[275],"importance":[277],"CD40-CD40L":[280],"costimulatory":[281],"pathway":[282]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}