{"id":"https://openalex.org/W2042467288","doi":"https://doi.org/10.1210/endo-122-3-1133","title":"Growth Hormone-Releasing Factor and Fibroblast Growth Factor Regulate Somatostatin Gene Expression*","display_name":"Growth Hormone-Releasing Factor and Fibroblast Growth Factor Regulate Somatostatin Gene Expression*","publication_year":1988,"publication_date":"1988-03-01","ids":{"openalex":"https://openalex.org/W2042467288","doi":"https://doi.org/10.1210/endo-122-3-1133","mag":"2042467288","pmid":"https://pubmed.ncbi.nlm.nih.gov/2893728"},"language":"en","primary_location":{"id":"doi:10.1210/endo-122-3-1133","doi":"https://doi.org/10.1210/endo-122-3-1133","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-122-3-1133","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113670972","display_name":"F\u00fcs\u00fbn N. Zeytin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FUSUN N. ZEYTIN","raw_affiliation_strings":["Laboratory for Neuroendocrinology, Salk Institute, La Jolla, California 92037","Laboratories for Neuroendocrinology, The Salk InstituteLa Jolla, California 92037","The Department of Pathology, Tufts University School of Medicine (R.D.L.)Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Neuroendocrinology, Salk Institute, La Jolla, California 92037","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"Laboratories for Neuroendocrinology, The Salk InstituteLa Jolla, California 92037","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"The Department of Pathology, Tufts University School of Medicine (R.D.L.)Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109105409","display_name":"SCOTT F. RUSK","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SCOTT F. RUSK","raw_affiliation_strings":["Laboratories for Neuroendocrinology, The Salk Institute La Jolla, California 92037; The Department of Pathology, Tufts University School of Medicine (R.D.L.) Boston, Massachusetts 02111","Laboratories for Neuroendocrinology, The Salk InstituteLa Jolla, California 92037","The Department of Pathology, Tufts University School of Medicine (R.D.L.)Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories for Neuroendocrinology, The Salk Institute La Jolla, California 92037; The Department of Pathology, Tufts University School of Medicine (R.D.L.) Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Laboratories for Neuroendocrinology, The Salk InstituteLa Jolla, California 92037","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"The Department of Pathology, Tufts University School of Medicine (R.D.L.)Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050239680","display_name":"Ronald A. De Lellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RON DE LELLIS","raw_affiliation_strings":["Laboratories for Neuroendocrinology, The Salk Institute La Jolla, California 92037; The Department of Pathology, Tufts University School of Medicine (R.D.L.) Boston, Massachusetts 02111","Laboratories for Neuroendocrinology, The Salk InstituteLa Jolla, California 92037","The Department of Pathology, Tufts University School of Medicine (R.D.L.)Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratories for Neuroendocrinology, The Salk Institute La Jolla, California 92037; The Department of Pathology, Tufts University School of Medicine (R.D.L.) Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Laboratories for Neuroendocrinology, The Salk InstituteLa Jolla, California 92037","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"The Department of Pathology, Tufts University School of Medicine (R.D.L.)Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.4869,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.89264504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"122","issue":"3","first_page":"1133","last_page":"1136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-releasing-hormone","display_name":"growth hormone-releasing hormone","score":0.9879999756813049},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/somatostatin-secretion","display_name":"somatostatin secretion","score":0.9150000214576721},{"id":"https://openalex.org/keywords/peptide-absorption","display_name":"peptide absorption","score":0.4569999873638153},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.7739999890327454},{"id":"https://openalex.org/keywords/serum-free-culture","display_name":"serum-free culture","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.82002192735672},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.8184421062469482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8132527470588684},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.5892727971076965},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.5823743939399719},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5349482297897339},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.520341157913208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4687426686286926},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4656912088394165},{"id":"https://openalex.org/C106646824","wikidata":"https://www.wikidata.org/wiki/Q5425475","display_name":"FGF21","level":4,"score":0.4328486919403076},{"id":"https://openalex.org/C191709040","wikidata":"https://www.wikidata.org/wiki/Q14889334","display_name":"FGF1","level":5,"score":0.42466896772384644},{"id":"https://openalex.org/C150008808","wikidata":"https://www.wikidata.org/wiki/Q18031731","display_name":"Somatostatin receptor 2","level":4,"score":0.42147740721702576},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34763896465301514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30388349294662476},{"id":"https://openalex.org/C80115893","wikidata":"https://www.wikidata.org/wiki/Q2067077","display_name":"Somatostatin receptor","level":3,"score":0.1292458474636078},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.12660512328147888},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11427465081214905},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0899747908115387}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-122-3-1133","doi":"https://doi.org/10.1210/endo-122-3-1133","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-122-3-1133","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:2893728","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2893728","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2833466571","display_name":null,"funder_award_id":"HD-09690","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4608009408","display_name":null,"funder_award_id":"DK 18811","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1507355636","https://openalex.org/W2010998911","https://openalex.org/W2058170465","https://openalex.org/W2059153388","https://openalex.org/W2069071064","https://openalex.org/W2121179584","https://openalex.org/W2129188677"],"related_works":["https://openalex.org/W2084991980","https://openalex.org/W1971523453","https://openalex.org/W2119717758","https://openalex.org/W2086644047","https://openalex.org/W2051568947","https://openalex.org/W2016170412","https://openalex.org/W2021800931","https://openalex.org/W2009029694","https://openalex.org/W2092446191","https://openalex.org/W2165855740"],"abstract_inverted_index":{"A":[0],"multiple":[1],"peptide-synthesizing":[2],"clonal":[3],"rat":[4,56],"cell":[5],"line":[6],"was":[7,37,68],"used":[8],"to":[9],"study":[10],"the":[11,22,60,104,116],"effect(s)":[12],"of":[13,26,31,49,65,86,97,109,122],"GRF":[14,58,73],"and":[15,24,46,79,94,106,120,124],"basic":[16],"fibroblast":[17],"growth":[18],"factor":[19],"(bFGF)":[20],"on":[21],"synthesis":[23],"secretion":[25,105,119],"somatostatin":[27],"(SS).":[28],"The":[29,44],"presence":[30],"SS-specific":[32],"mRNA":[33],"in":[34,41,77],"44-2C":[35,87,100],"cells":[36,88],"shown":[38],"morphologically":[39],"by":[40,99],"situ":[42],"hybridization.":[43],"release":[45],"cellular":[47,107],"content":[48,108],"SS":[50,67,75,123,127],"increased":[51],"significantly":[52],"after":[53,84],"treatment":[54],"with":[55,89],"hypothalamic":[57],"(rGRF),":[59],"ED50":[61],"for":[62],"rGRF":[63,91,98],"stimulation":[64],"intracellular":[66],"1.9":[69],"X":[70],"10(-11)":[71],"M.":[72],"stimulated":[74,103],"production":[76],"serum-supplemented":[78],"serum-free":[80],"cultures.":[81],"Results":[82],"obtained":[83],"incubation":[85],"125I-labeled":[90],"indicated":[92],"uptake":[93],"nuclear":[95],"localization":[96],"cells.":[101],"FGF":[102],"SS.":[110],"We":[111],"propose":[112],"that":[113],"bFGF":[114],"regulates":[115],"short":[117],"term":[118],"accumulation":[121],"mediates":[125],"rGRF-stimulated":[126],"expression.":[128]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
