{"id":"https://openalex.org/W2042386677","doi":"https://doi.org/10.1111/j.1432-1033.1997.00260.x","title":"Purification and Characterization of Cathepsin B mRNA 3\u2032\u2010Untranslated\u2010Region\u2010Binding Protein (CBBP), A Protein that Represses Cathepsin B mRNA Translation","display_name":"Purification and Characterization of Cathepsin B mRNA 3\u2032\u2010Untranslated\u2010Region\u2010Binding Protein (CBBP), A Protein that Represses Cathepsin B mRNA Translation","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2042386677","doi":"https://doi.org/10.1111/j.1432-1033.1997.00260.x","mag":"2042386677","pmid":"https://pubmed.ncbi.nlm.nih.gov/9151951"},"language":"en","primary_location":{"id":"doi:10.1111/j.1432-1033.1997.00260.x","doi":"https://doi.org/10.1111/j.1432-1033.1997.00260.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1997.00260.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013945001","display_name":"Tamaki Yano","orcid":"https://orcid.org/0000-0002-5576-1128","observed_orcids":["https://orcid.org/0000-0002-5576-1128"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tamaki Yano","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Japan","Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, (Japan)","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084824968","display_name":"Ayako Ohashi\u2010Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayako Kobayashi","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076254729","display_name":"Shoichiro Kurata","orcid":"https://orcid.org/0000-0002-0301-872X","observed_orcids":["https://orcid.org/0000-0002-0301-872X"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoichiro Kurata","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042593421","display_name":"Shunji Natori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shunji Natori","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042593421"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":0.8296,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.70970563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"245","issue":"2","first_page":"260","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.3544999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.04960000142455101,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":0.9459999799728394},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mrna-translation-repression","display_name":"mRNA translation repression","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sarcophaga-peregrina","display_name":"Sarcophaga peregrina","score":0.9330000281333923},{"id":"https://openalex.org/keywords/sarcophagidae","display_name":"Sarcophagidae","score":0.7200000286102295},{"id":"https://openalex.org/keywords/hemocytes","display_name":"hemocytes","score":0.9210000038146973},{"id":"https://openalex.org/keywords/protein-purification","display_name":"protein purification","score":0.6330000162124634},{"id":"https://openalex.org/keywords/metamorphosis","display_name":"metamorphosis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pupal-stage","display_name":"pupal stage","score":0.7889999747276306},{"id":"https://openalex.org/keywords/embryonic-cell-line","display_name":"embryonic cell line","score":0.753000020980835},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C28021979","wikidata":"https://www.wikidata.org/wiki/Q14911946","display_name":"Cathepsin B","level":3,"score":0.7827132344245911},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7525620460510254},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.7264726161956787},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.65353924036026},{"id":"https://openalex.org/C51618164","wikidata":"https://www.wikidata.org/wiki/Q5052484","display_name":"Cathepsin H","level":4,"score":0.6532604098320007},{"id":"https://openalex.org/C174937957","wikidata":"https://www.wikidata.org/wiki/Q18248582","display_name":"Cathepsin E","level":5,"score":0.6443502902984619},{"id":"https://openalex.org/C34695024","wikidata":"https://www.wikidata.org/wiki/Q14902030","display_name":"Cathepsin O","level":4,"score":0.572629451751709},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5243987441062927},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.510351836681366},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.45711588859558105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20379683375358582},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10980799794197083},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06362280249595642}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002401","descriptor_name":"Cathepsin B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004175","descriptor_name":"Diptera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006434","descriptor_name":"Hemocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008675","descriptor_name":"Metamorphosis, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011679","descriptor_name":"Pupa","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1432-1033.1997.00260.x","doi":"https://doi.org/10.1111/j.1432-1033.1997.00260.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1997.00260.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:9151951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9151951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W139105480","https://openalex.org/W252784604","https://openalex.org/W1967010097","https://openalex.org/W1970403529","https://openalex.org/W1988344380","https://openalex.org/W1994784503","https://openalex.org/W2001644877","https://openalex.org/W2016871901","https://openalex.org/W2023236405","https://openalex.org/W2035836635","https://openalex.org/W2037485695","https://openalex.org/W2039244683","https://openalex.org/W2047841570","https://openalex.org/W2064741718","https://openalex.org/W2066743380","https://openalex.org/W2080890106","https://openalex.org/W2082811197","https://openalex.org/W2100837269","https://openalex.org/W2114762985","https://openalex.org/W2128635872","https://openalex.org/W2156923247"],"related_works":["https://openalex.org/W2112968583","https://openalex.org/W1988344380","https://openalex.org/W2108065149","https://openalex.org/W2118886433","https://openalex.org/W2087907987","https://openalex.org/W2087477609","https://openalex.org/W2093825093","https://openalex.org/W2009812425","https://openalex.org/W3199365178","https://openalex.org/W2056801392"],"abstract_inverted_index":{"We":[0,87],"reported":[1],"that":[2,89,116,125],"the":[3,19,26,60,90,94,102,110,127,132],"3'-untranslated":[4],"region":[5],"(3'-UTR)":[6],"of":[7,11,21,31,68,93,129,137],"cathepsin":[8,36,78,103,138],"B":[9,37,79,104,139],"mRNA":[10,38,80,105],"Sarcophaga":[12,142],"peregrina":[13],"(flesh":[14],"fly)":[15],"is":[16,144],"necessary":[17],"for":[18],"repression":[20],"its":[22],"translation,":[23],"and":[24],"detected":[25],"3'-UTR-binding":[27,61],"protein":[28,62,72],"in":[29,34,82,141],"lysates":[30],"larval":[32,120],"hemocytes":[33,95,143],"which":[35],"translation":[39,81],"was":[40,74],"repressed":[41],"[Yano,":[42],"T.,":[43],"Kurata,":[44],"S.":[45,48],"&":[46],"Natori,":[47],"(1995)":[49],"Eur.":[50],"J.":[51],"Biochem.":[52],"234,":[53],"39-43].":[54],"In":[55],"this":[56],"study,":[57],"we":[58,114],"purified":[59,71],"from":[63],"an":[64],"embryonic":[65],"cell":[66],"line":[67],"Sarcophaga.":[69],"The":[70],"(CBBP)":[73],"found":[75,88,115],"to":[76,131],"repress":[77],"a":[83,123],"rabbit":[84],"reticulocyte":[85],"lysate.":[86],"CBBP":[91,130],"contents":[92],"did":[96],"not":[97,119],"change":[98],"during":[99],"metamorphosis,":[100],"although":[101],"became":[106],"translatable":[107],"only":[108],"at":[109],"pupal":[111],"stage.":[112],"Moreover,":[113],"pupal,":[117],"but":[118],"hemocytes,":[121],"contained":[122],"factor":[124],"inhibited":[126],"binding":[128],"3'-UTR.":[133],"A":[134],"regulatory":[135],"mechanism":[136],"expression":[140],"discussed.":[145]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}