{"id":"https://openalex.org/W2042359000","doi":"https://doi.org/10.1073/pnas.85.12.4123","title":"A histone H1 protein in sea urchins is encoded by a poly(A)+ mRNA.","display_name":"A histone H1 protein in sea urchins is encoded by a poly(A)+ mRNA.","publication_year":1988,"publication_date":"1988-06-01","ids":{"openalex":"https://openalex.org/W2042359000","doi":"https://doi.org/10.1073/pnas.85.12.4123","mag":"2042359000","pmid":"https://pubmed.ncbi.nlm.nih.gov/2898141","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/280378"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.85.12.4123","doi":"https://doi.org/10.1073/pnas.85.12.4123","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.85.12.4123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/280378","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045836677","display_name":"Toby Lieber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Lieber","raw_affiliation_strings":["Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113670531","display_name":"Lynne M. Angerer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L M Angerer","raw_affiliation_strings":["Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461","Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111561478","display_name":"Robert C. Angerer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R C Angerer","raw_affiliation_strings":["Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461","Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044237462","display_name":"Geoffrey J. Childs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Childs","raw_affiliation_strings":["Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9224,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.73760453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"85","issue":"12","first_page":"4123","last_page":"4127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-h1","display_name":"histone H1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sea-urchins","display_name":"sea urchins","score":0.890999972820282},{"id":"https://openalex.org/keywords/polyadenylated-mrna","display_name":"polyadenylated mRNA","score":0.8029999732971191},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C101152365","wikidata":"https://www.wikidata.org/wiki/Q838135","display_name":"Histone H1","level":4,"score":0.8584285974502563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7675265073776245},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5921304821968079},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5899920463562012},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5656555891036987},{"id":"https://openalex.org/C45946802","wikidata":"https://www.wikidata.org/wiki/Q18033449","display_name":"SAP30","level":5,"score":0.48552727699279785},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44445598125457764},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40928399562835693},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3950311541557312}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011061","descriptor_name":"Poly A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012617","descriptor_name":"Sea Urchins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.85.12.4123","doi":"https://doi.org/10.1073/pnas.85.12.4123","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.85.12.4123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:280378","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/280378","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:2898141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2898141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:280378","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/280378","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1480515035","display_name":null,"funder_award_id":"GM 25553","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G822265145","display_name":null,"funder_award_id":"GM30333","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1515473967","https://openalex.org/W1607032234","https://openalex.org/W1864421582","https://openalex.org/W1873550893","https://openalex.org/W1968239269","https://openalex.org/W1996223527","https://openalex.org/W1997585707","https://openalex.org/W2010885715","https://openalex.org/W2021839441","https://openalex.org/W2023635889","https://openalex.org/W2023775411","https://openalex.org/W2026031579","https://openalex.org/W2034422186","https://openalex.org/W2047890079","https://openalex.org/W2047992498","https://openalex.org/W2050854847","https://openalex.org/W2053517359","https://openalex.org/W2055478880","https://openalex.org/W2055551279","https://openalex.org/W2057475351","https://openalex.org/W2058031705","https://openalex.org/W2059877539","https://openalex.org/W2066121684","https://openalex.org/W2071478793","https://openalex.org/W2074260855","https://openalex.org/W2078119356","https://openalex.org/W2082108183","https://openalex.org/W2082919818","https://openalex.org/W2087844645","https://openalex.org/W2091001646","https://openalex.org/W2121448433","https://openalex.org/W2138270253","https://openalex.org/W2168150299","https://openalex.org/W2179748281","https://openalex.org/W2328712699","https://openalex.org/W4232314449","https://openalex.org/W4248538000"],"related_works":["https://openalex.org/W2075952441","https://openalex.org/W1800954659","https://openalex.org/W1973788983","https://openalex.org/W2047890079","https://openalex.org/W1828229592","https://openalex.org/W2055551279","https://openalex.org/W4247831415","https://openalex.org/W2124581290","https://openalex.org/W1971828887","https://openalex.org/W2055465887"],"abstract_inverted_index":{"Typical":[0],"histone":[1,19,40,51],"genes":[2,41],"lack":[3],"intervening":[4],"sequences":[5],"and":[6,15,32,38,114,128],"encode":[7],"small":[8],"mRNAs":[9,20],"(400-800":[10],"nucleotides)":[11],"with":[12,81],"short":[13],"leader":[14],"trailer":[16],"regions.":[17],"Most":[18],"are":[21],"not":[22],"polyadenylylated":[23,78],"but":[24],"rather":[25],"terminate":[26],"in":[27,62],"a":[28,67,75,94],"highly":[29],"conserved":[30],"stem":[31],"loop":[33],"structure.":[34,53],"The":[35,85],"early,":[36],"late,":[37],"testis-specific":[39],"of":[42,74,77,87,102,109,123],"sea":[43,63],"urchins,":[44],"described":[45],"to":[46,107],"date,":[47],"have":[48,55],"this":[49],"typical":[50],"gene":[52,83],"We":[54],"identified":[56],"an":[57],"unusual":[58],"H1":[59,82,96,112,137],"gene,":[60],"H1-delta,":[61],"urchins":[64],"that":[65,108,130],"encodes":[66,93],"poly(A)+":[68],"mRNA.":[69],"This":[70],"mRNA":[71,104],"is":[72,105,126,132],"one":[73],"group":[76],"transcripts":[79],"homologous":[80],"probes.":[84],"sequence":[86],"H1-delta":[88,92,103,131],"had":[89],"been":[90],"determined.":[91],"different":[95],"protein.":[97],"Although":[98],"the":[99,121],"temporal":[100],"expression":[101],"similar":[106],"other":[110,136],"late":[111],"(beta":[113],"gamma)":[115],"mRNAs,":[116],"its":[117],"spatial":[118],"distribution":[119],"at":[120],"time":[122],"maximal":[124],"accumulation":[125],"distinct":[127],"confirms":[129],"regulated":[133],"differently":[134],"than":[135],"genes.":[138]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}